Specific inhibition of the halogenase for radicicol biosynthesis by bromide at the transcriptional level in Pochonia chlamydosporia

Biotechnology Letters

Volumn 33, Issue 2, 2011, Pages 333-338

  Zeng, Jia ^a   Valiente, Jonathan ^a   Zhan, Jixun ^a  

^a Utah State University   (United States)

Author keywords

Bromide; Halogenase; Inhibition; Radicicol biosynthesis; Transcription

Indexed keywords

ANTI-FUNGAL; BROMIDE; DOSE-DEPENDENT MANNER; HALOGENASE; INHIBITION; RADICICOL; RT-PCR ANALYSIS; TRANSCRIPTIONAL LEVELS;

BIOCHEMISTRY; BIOSYNTHESIS; BROMINE COMPOUNDS; CHLORINE; SODIUM CHLORIDE;

TRANSCRIPTION;

ANTIFUNGAL AGENT; BROMIDE; ENZYME INHIBITOR; MACROLIDE; MESSENGER RNA; OXIDOREDUCTASE; RADICICOL;

ARTICLE; BIOSYNTHESIS; DRUG ANTAGONISM; ENZYMOLOGY; GENE EXPRESSION PROFILING; GENETICS; HYPOCREALES; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANTIFUNGAL AGENTS; BROMIDES; ENZYME INHIBITORS; GENE EXPRESSION PROFILING; HYPOCREALES; MACROLIDES; OXIDOREDUCTASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

POCHONIA CHLAMYDOSPORIA;

EID: 78651443850     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-010-0427-1     Document Type: Article

References (17)

1. Ayer WA, Lee SP, Tsuneda A, Hiratsuka Y (1980) The isolation, identification, and bioassay of the antifungal metabolites produced by Monocillium nordinii. Can J Microbiol 26: 766-773.
2. Evans G, White NH (1966) Radicicolin and radicicol, two new antibiotics produced by Cylindrocarpon radicicola. Trans Br Mycol Soc 49: 563-576.
3. Fujita K, Irie M, Ping X, Taniguchi N (1999) Antifungal activity of radicicol against Mucor flavus IFO 9560. J Biosci Bioeng 88: 380-386.
4. McCapra F, Scott AI, Delmotte P, Delmotte-Plaquee J, Bhacca NS (1964) Constitution of monorden, an antibiotic with tranquilizing action. Tetrahedron Lett 15-16: 869-875.
5. Paranagama PA, Wijeratne EMK, Gunatilaka AAL (2007) Uncovering biosynthetic potential of plant-associated fungi: effect of culture conditions on metabolite production by Paraphaeosphaeria quadriseptata and Chaetomium chiversii. J Nat Prod 70: 1939-1945.
6. Reeves CD, Hu ZH, Reid R, Kealey JT (2008) Genes for the biosynthesis of the fungal polyketides hypothemycin from Hypomyces subiculosus and radicicol from Pochonia chlamydosporia. Appl Environ Microbiol 74: 5121-5129.
7. Scherlach K, Hertweck C (2009) Triggering cryptic natural product biosynthesis in microorganisms. Org Biomol Chem 7: 1753-1760.
8. Shan R, Anke H, Stadler M, Sterner O (1996) Papyracillic acid, a new penicillic acid analog from the ascomycete Lachnum papyraceum. Tetrahedron 52: 10249-10254.
9. Shimada Y, Ogawa T, Sato A, Kaneko I, Tsujita Y (1995) Induction of differentiation of HL-60 cells by the antifungal antibiotic, radicicol. J Antibiot 48: 824-830.
10. Shinonaga H, Kawamura Y, Ikeda A, Aoki M, Sakai N, Fujimoto N, Kawashima A (2009) Pochonins K-P: new radicicol analogues from Pochonia chlamydosporia var. chlamydosporia and their WNT-5A expression inhibitory activities. Tetrahedron 65: 3446-3453.
11. Stander MA, Steyn PS, Lübben A, Miljkovic A, Mantle PG, Marais GJ (2000) Influence of halogen salts on the production of the ochratoxins by Aspergillus ochraceus Wilh. J Agric Food Chem 48: 1865-1871.
12. Turbyville TJ, Wijeratne EMK, Liu MX, Burns AM, Seliga CJ, Luevano LA, David CL, Faeth SH, Whitesell L, Gunatilaka AAL (2006) Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert. J Nat Prod 69: 178-184.
13. Wang SH, Xu YQ, Maine EA, Wijeratne EMK, Espinosa-Artiles P, Gunatilaka AAL, Molnár I (2008) Functional characterization of the biosynthesis of radicicol, an Hsp90 inhibitor resorcylic acid lactone from Chaetomium chiversii. Chem Biol 15: 1328-1338.
14. Wijeratne EMK, Carbonezi CA, Takahashi JA, Seliga CJ, Turbyville TJ, Pierson EE, Pierson LS, VanEtten HD, Whitesell L, Bolzani VDS, Gunatilaka AAL (2004) Isolation, optimization of production and structure-activity relationship studies of monocillin I, the cytotoxic constituent of Paraphaeosphaeria quadriseptata. J Antibiot 57: 541-546.
15. Wijeratne EMK, Bashyal BP, Gunatilaka MK, Arnold AE, Gunatilaka AAL (2010) Maximizing chemical diversity of fungal metabolites: biogenetically related heptaketides of the endolichenic fungus Corynespora sp. J Nat Prod 73: 1156-1159.
16. Zeng J, Zhan J (2010) A novel fungal flavin-dependent halogenase for natural product biosynthesis. ChemBioChem (in press). doi: 10.1002/cbic. 201000439.
17. Zhou H, Qiao K, Gao Z, Meehan MJ, Li JW-H, Zhao X, Dorrestein PC, Vederas JC, Tang Y (2010) Enzymatic synthesis of resorcylic acid lactones by cooperation of fungal iterative polyketide synthases involved in hypothemycin biosynthesis. J Am Chem Soc 132: 4530-4531.