A randomized comparison of droperidol, metoclopramide, tropisetron, and ondansetron for the prevention of postoperative nausea and vomiting

Gynecologic and Obstetric Investigation

Volumn 71, Issue 1, 2011, Pages 59-65

  Ekinci, Osman ^a   Malat, Ibrahim ^a   Işitmangil, Gülbu ^a   Aydin, Neşe ^a  

^a HAYDARPASA NUMUNE HOSPITAL   (Turkey)

Author keywords

Droperidol; Gynecologic operations; Metoclopramide; Nausea, postoperative; Ondansetron; Tropisetron; Vomiting, postoperative

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CALCIUM; CREATININE; DROPERIDOL; GLUCOSE; METOCLOPRAMIDE; ONDANSETRON; POTASSIUM; SODIUM; TROPISETRON; UREA;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CALCIUM BLOOD LEVEL; CREATININE BLOOD LEVEL; DIZZINESS; ELECTROLYTE BLOOD LEVEL; EXTRAPYRAMIDAL SYMPTOM; FEMALE; GLUCOSE BLOOD LEVEL; GYNECOLOGIC SURGERY; HEADACHE; HEART RATE; HUMAN; HYPOTENSION; KIDNEY FUNCTION; LIVER FUNCTION; MAJOR CLINICAL STUDY; MEAN ARTERIAL PRESSURE; OPERATION DURATION; OXYGEN SATURATION; POSTOPERATIVE NAUSEA AND VOMITING; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL; PROPHYLAXIS; RANDOMIZED CONTROLLED TRIAL; SEDATION; SIDE EFFECT; SODIUM BLOOD LEVEL; SURGICAL PATIENT; TACHYCARDIA; TREATMENT FAILURE; UREA BLOOD LEVEL;

ADULT; ANESTHESIA RECOVERY PERIOD; ANTIEMETICS; CONSCIOUS SEDATION; DROPERIDOL; FEMALE; GYNECOLOGIC SURGICAL PROCEDURES; HUMANS; INDOLES; METOCLOPRAMIDE; MIDDLE AGED; ONDANSETRON; POSTOPERATIVE NAUSEA AND VOMITING;

EID: 78651434642     PISSN: 03787346     EISSN: None     Source Type: Journal    
DOI: 10.1159/000320747     Document Type: Article

References (35)

1. Leksowski K, Peryga P, Szyca R: Ondansetron, metoclopramide, dexamethasone and their combinations compared for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: a prospective randomized study. Surg Endosc 2006; 20: 878-882.
2. Fujii Y: Current management of vomiting after tonsillectomy in children. Curr Drug Saf 2009; 4: 62-73.
3. Gan TJ: Postoperative nausea and vomiting - can it be eliminated? JAMA 2002; 287: 1233-1236.
4. McKay WP, Yip RW: Distribution of randomised controlled trials of drugs for postoperative nausea and vomiting. Can J Anaesth 2000; 47: 421-426.
5. Carlisle JB, Stevenson CA: Drugs for preventing postoperative nausea and vomiting. Cochrane Database Syst Rev 2006; 3: CD004125.
6. Birnbach DJ, Browne IM: Anesthesia for obstetrics; in Miller RD (ed): Anesthesia, ed 4. New York, Churchill Livingstone, 1994, pp 2219-2224.
7. Tramèr MR, Walder B: Efficacy and adverse effects of prophylactic antiemetics during patient-controlled analgesia therapy: a quantitative systematic review. Anesth Analg 1999; 88: 1354-1361.
8. Ho KY, Chiu JW: Multimodal antiemetic therapy and emetic risk profiling. Ann Acad Med Singapore 2005; 34: 196-205.
9. Rust M, Cohen LA: Single oral dose ondansetron in the prevention of postoperative nausea and emesis. The European and US Study Groups. Anaesthesia 1994; 49(suppl): 16-23.
10. Elhakim M, Nafie M, Mahmoud K, Atef A: Dexamethasone 8 mg in combination with ondansetron 4 mg appears to be the prevention of nausea and vomiting after optimal dose for the laparoscopic cholecystectomy. Can J Anaesth 2002; 49: 922-926.
11. Jokela R, Koivuranta M, Kangas-Saarela T, Purhonen S, Alahuhta S: Oral ondansetron, tropisetron or metoclopramide to prevent postoperative nausea and vomiting: a comparison in high-risk patients undergoing thyroid or parathyroid surgery. Acta Anaesthesiol Scand 2002; 46: 519-524.
12. Ferrari LR, Donlon JV: Metoclopramide reduces the incidence of vomiting after tonsillectomy in children. Anesth Analg 1992; 75: 351-354.
13. Fujii Y: Prophylaxis of postoperative nausea and vomiting in patients scheduled for breast surgery. Clin Drug Investig 2006; 26: 427-437.
14. Gan TJ, Alexander R, Fennelly M, Rubin AP: Comparison of different methods of administering droperidol in patient controlled analgesia in the prevention of PONV. Anesth Analg 1995; 80: 81-85.
15. Zomers PJ, Langenberg CJ, de Bruijn KM: Tropisetron for postoperative nausea and vomiting in patients after gynecological surgery. Br J Anaesth 1993; 71: 677-680.
16. Alon E, Kocian R, Nett PC, et al: Tropisetron for the prevention of postoperative nausea and vomiting in women undergoing gynecologic surgery. Anesth Analg 1996; 82: 338-341.
17. Du Pen S, Scuderi P, Wetchler B, et al: Ondansetron in the treatment of postoperative nausea and vomiting in ambulatory outpatients: a dose-comparative, stratified, multicentre study. Eur J Anaesthesiol Suppl 1992; 6: 55-62.
18. Madej TH, Simpson KH: Comparison of the use of domperidone, droperidol and metoclopramide in the prevention of nausea and vomiting following gynaecological surgery in day cases. Br J Anaesth 1986;58:879-883.
19. Fujii Y: The benefits and risks of different therapies in preventing postoperative nausea and vomiting in patients undergoing thyroid surgery. Curr Drug Saf 2008; 3: 27-34.
20. Lin DM, Furst SR, Rodarte A: A doubleblinded comparison of metoclopramide and droperidol for prevention of emesis following strabismus surgery. Anesthesiology 1992; 76: 357-361.
21. Henzi I, Sonderegger J, Tramèr MR: Efficacy, dose-response, and adverse effects of droperidol for prevention of postoperative nausea and vomiting. Can J Anaesth 2000; 47: 537-551.
22. Gan TJ, Meyer T, Apfel CC, Chung F, Davis PJ, Eubanks S, Kovac A, Philip BK, Sessler DI, Temo J, Tramèr MR, Watcha M: Consensus guidelines for managing postoperative nausea and vomiting. Anesth Analg 2003; 97: 62-71.
23. Habib AS, Gan TJ: Food and Drug Administration black box warning on the perioperative use of droperidol: a review of the cases. Anesth Analg 2003; 96: 1377-1379.
24. Khalil SN, Berry JM, Howard G, Lawson K, Hanis C, Mazow ML, Stanley TH: The antiemetic effect of lorazepam after outpatient strabismus surgery in children. Anesthesiology 1992; 77: 915-919.
25. Williams AO, Clarke FL, Harris RW, et al: Addition of droperidol to patient-controlled analgesia: effect on nausea and vomiting. Anaesthesia 1993; 48: 881-884.
26. Mitsunari H, Ashikari E, Tanaka K: The use of droperidol decreases postoperative nausea and vomiting after gynecological laparoscopy. J Anesth 2007; 21: 507-509.
27. Pearman MH: Single dose intravenous ondansetron in the prevention of postoperative nausea and vomiting. Anaesthesia 1994; 49(suppl):11-15.
28. Zhang Y, Luo Z, White PF: A model for evaluating droperidol's effect on the median QTc interval. Anesth Analg 2004; 98: 1330-1335.
29. White PF, Song D, Abrao J, et al: Effect of low-dose droperidol on the QT interval during and after general anesthesia: a placebocontrolled study. Anesthesiology 2005; 102: 1101-1105.
30. Fischer V, Baldeck JP, Tse FL: Pharmacokinetics and metabolism of the 5-hydroxytryptamine antagonist tropisetron after single oral doses in humans. Drug Metab Dispos 1992; 20: 603-607.
31. Pitkänen MT, Niemi L, Tuominen MN, Rosenberg PH: Effect of tropisetron, a 5-HT3 receptor antagonist, on analgesia and nausea after intrathecal morphine. Br J Anaesth 1993; 71: 681-684.
32. Kovac AL: Prevention and treatment of postoperative nausea and vomiting. Drugs 2000; 59: 213-243.
33. Fujii Y: The utility of antiemetics in the prevention and treatment of postoperative nausea and vomiting in patients scheduled for laparoscopic cholecystectomy. Curr Pharm Des 2005; 11: 3173-3183.
34. McKenzie R, Uy NT, Riley TJ, Hamilton DL: Droperidol/ondansetron combination controls nausea and vomiting after tubal banding. Anesth Analg 1996; 83: 1218-1222.
35. Bolton CM, Myles PS, Nolan T, Sterne JA: Prophylaxis of postoperative vomiting in children undergoing tonsillectomy: a systematic review and meta-analysis. Br J Anaesth 2006; 97: 593-604.