Antimalarial activity of Ageratum conyzoides in combination with chloroquine and artesunate

Asian Pacific Journal of Tropical Medicine

Volumn 3, Issue 12, 2010, Pages 943-947

  Ukwe Chinwe, V ^a   Ekwunife Obinna, I ^a   Epueke Ebele, A ^b   Ubaka Chukwuemeka, M ^a  

^a UNIVERSITY OF NIGERIA   (Nigeria)

^b UNIVERSITY OF PORT HARCOURT   (Nigeria)

Author keywords

Ageratum; Antimalarial; Artesunate; Chloroquine; Drug interaction

Indexed keywords

AGERATUM CONYZOIDES EXTRACT; ARTESUNATE; CHLOROQUINE;

AGERATUM; AGERATUM CONYZOIDES; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENTIATION; FEMALE; HERB DRUG INTERACTION; MALE; MONOTHERAPY; MOUSE; NONHUMAN; PARASITEMIA; PLANT LEAF; PLASMODIUM BERGHEI; PLASMODIUM BERGHEI INFECTION; SURVIVAL;

EID: 78651423058     PISSN: 19957645     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1995-7645(11)60005-9     Document Type: Article

References (31)

1. Motlaleputa M Antimalarial medicines from the medicinal plants of Southern Africa project. Quarterly Report 2003.
2. White N, Nosten F, Bjorkman A, Marsh K, Snow RW WHO, the global fund, and medical practice in malaria treatment. Lancet 2004, 363:1160.
3. Wright CW Traditional antimalarials and the development of novel antimalarial drugs. J Ethnopharmacolog 2005, 100:67-71.
4. Sirima SB, Sawadogo R, Moran AC, Konate A, Diarra A, Yameogo M, et al. Failure of a chloroquine chemprophylaxis program to adequately prevent malaria during pregnancy in Koupela District, Burkina Faso. Clin Infect Dis 2003, 36(11):1374-1382.
5. Binder RK, Borrmann S, Adegnika AA, Missinou MA, Kremsner PG, Kun JF Polymorphisms in the parasite genes for pfcrt and pfmdr-1 as molecular maker for chloroquine resistance in Plasmodium falciparum in Lambarene, Gabon. Parastbol Res 2002, 88:475-476.
6. Trigg IK, Mbwana H, Chambo O, Hills E, Warkins W, Curtis CF Resistance to sulfadoxine/pyrimethamine in Plasmodium falciparum in 12 villages in north East Tanzania and a test of chlorguanil/dapsone. Acta Tropic 1997, 65:155-189.
7. Wilson CM, Volkman SK, Thailthoug S, Martin RK, Kyle DS, Milhous WK, et al. Amplification of pfmdrl associated with mefloquine and halofantrine resistance in Plasmodium falciparum in Thailand. Mol Biochem Parasitol 1993, 57:151-160.
8. Fivelmen QL, Adagu IS, Warnurst DC Modified fixed-ratio isobologram method for in vitro interaction between atovaquone and proguanil or dihydroartemisinin against drug resistant strain of P. falciparum. Antimicrob Agents Chemo 2004, 48:4097-4102.
9. Price RN, Nosten F, Luxemburger C, Kuile FO, Paiphum L, Chongsupajaisddhi T, et al. Effects of artemisinin derivatives on malaria transmissibility. Lancet 1996, 347:1654-1658.
10. Dondrop AM, Nosten F, Poravuth Y, Das D, Phyo AP, Tarning J, et al. Artemsinin resistance in Plasmodium falciparum malaria. N Engl J Med 2009, 361:455-467.
11. Marsh VM, Mutemi WM, Muturi J, Haaland A, Watkins WM, Otieno G, et al. Changing home treatment of childhood fevers by training shop keepers in rural Kenya. Trop Med Int Health 1999, 4(5):383-389.
12. Basco LK, Mitaku S, Skaitsounis A, Ravelomanantsoa N, Tillenquin F, Koch M, et al. In vitro activities of fluroquinoline and acridone alkaloids against Plasmodium falciparum. Antimicrobial Agent Chemother 1994, 38:1169-1171.
13. Iwu MM Handbook of African medicinal plants 1985, CRC Press, London.
14. Nyunai N, Njikam N, Mounier C, Pastoureau P Blood glucose lowering effect of aqueous extract of Ageratum conyziodes in rats. Afr J Trad CAM 2006, 3(3):76-79.
15. World Health Organisation Traditional medicine. Fact sheet 134. [Online] [Accessed on 12th August, 2010]. http://www.who.int/mediacentre/factsheets/fs134/en/print.htmL.
16. Odugbemi TO, Odunayo RA, Ibukun EA, Fabekun PO Medicinal plants useful for malaria therapy in Okeigbo, Ondo State, Southwest Nigeria. Afr J Trad CAM 2007, 4(2):191-198.
17. Kamboj A, Saluja AK Ageratum conyzoides L: a review on its phytochemical and pharmacological profile. Int J Green Pharm 2008, 2:59-68.
18. Oladejo OW, Imosemi IO, Osuagwu FC, Oyedele OO, Oluwadara OO, Ekpo OE, et al. A comparative study of the wound healing properties of honey and Ageratum conyzoides. Afr J Med Sci 2003, 32(2):193-196.
19. Ukwe CV, Epueke EA, Ekwunife OI, Okoye TC, Akudor GC, Ubaka CM Antimalarial activity of aqueous extract an fractions of leaves of Ageratum conyziodes in mice infected with Plasmodium berghei. Int J Pharm Sci 2010, 2(1):33-38.
20. Knight DJ, Peters W The antimalarial action of N-benzyloxydihydrotrazines. The action of clocigunail (BRL50216) against rodent malaria and studies on its mode of action. Annals Trop Med Parasitol 1980, 74:393-404.
21. Ryley JF, Peters W The anti malarial activity of some quinoline esters. Annals Trop Med Parasitol 1970, 104:81-85.
22. Adzu B, Abbah J, Vongtua H, Gammaniel K Studies on the use of Cassia singueana in malaria ethnopharmacy. J Ethnopharmcol 2003, 88:261-267.
23. Calvalho LH, Brando MGL, Santos-filho D, Lopes JLC, Krettli AU Antimalarial activity of crude extracts from Brazalian plants studies invivo in Plasmodium berghei infected mice and in vitro against Plasmodium falciparum in culture. Braz J Med Biol Res 1991, 24:1113-1123.
24. Ukwe CV Malaria. Therapeutic basis of clinical pharmacy in the tropics 2004, 250-270. SNAAP Press, Enugu. 3rd ed. C.N. Aguwa (Ed.).
25. Nwafor SV, Akah PA, Okoli CO, Onyirioha KC, Nworu CS Interaction between chloroquine sulphate and aqueous extract of Azadirachta indica. A. Juss. (Meliaceae) in rabbits. Acta Pharm 2003, 53:305-311.
26. lwalokun BA Enhanced antimalarial effects of chloroquine by aqueous Vernonia amygdalina leaf extract in mice infected with chloroquine resistant and sensitive Plasmodium berghei strains. J African Health Sci 2008, 8(1):25-35.
27. Singh RK Tinospora cordifolia as an adjuvant drug in the treatment of hyperactive malarious splenomegaly-case reports. J Vector Borne Dis 2005, 42:26-38.
28. Muregi FW, Chhabra SC, Njagi EN, Lang'at-Thoruwa CC, Njue WM, Orago AS, et al. Antiplasmodial activity of some Kenyan medicinal plant extracts singly and in combination with chloroquine. Phytother Res 2004, 18:379-384.
29. Bickii J, Njifutie N, Foyere JA, Basco LK, Rigwald P In vitro antimalarial activity of limonoids from Khaya grandifoliola C.D.C. (Meliaceae). J Ethnopharmacol 2000, 69:27-33.
30. Abosi AD, Raseroka BH In vivo antimalarial activity of Vernonia amygdalina. Br J Biomed Sci 2003, 60(2):80-91.
31. Masaba SC The antimalarial activity of Vernonia amygdalina Del (Compositae). Trans R Soc Trop Med Hyg 2000, 94:694-695.