Prolonged clopidogrel application reduces tissue factor expression after percutaneous coronary intervention in the porcine model

Cardiovascular Revascularization Medicine

Volumn 12, Issue 1, 2011, Pages 47-55

  Ayral, Yunus ^a   Rauch, Ursula ^a   Goldin Lang, Petra ^a   Eisenreich, Andreas ^a   Pepke, Wojciech ^a   Deiner, Carolin ^a   Schwimmbeck, Peter L ^b   Schultheiss, Heinz Peter ^a   Pels, Klaus ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b KLINIKUM LEVERKUSEN   (Germany)

Author keywords

Clopidogrel; Percutaneous coronary intervention; Tissue factor

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; FIBRIN; FIBRINOGEN; MESSENGER RNA; THROMBOPLASTIN;

ADD ON THERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INJURY; ARTICLE; BLOOD SAMPLING; BRACHYTHERAPY; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; CORONARY ARTERY; DOSAGE SCHEDULE COMPARISON; DRUG EFFECT; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; LOADING DRUG DOSE; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TRANSLUMINAL CORONARY ANGIOPLASTY;

ANGIOPLASTY, BALLOON, CORONARY; ANIMALS; ASPIRIN; BRACHYTHERAPY; CORONARY THROMBOSIS; CORONARY VESSELS; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBRIN; FIBRINOGEN; IMMUNOHISTOCHEMISTRY; MODELS, ANIMAL; PLATELET AGGREGATION INHIBITORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SUS SCROFA; THROMBOPLASTIN; TICLOPIDINE; TIME FACTORS; UP-REGULATION;

EID: 78651421853     PISSN: 15538389     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carrev.2009.12.001     Document Type: Article

References (31)

1. Cha DH, Ajani AE, Cheneau E, Waksman R Clinical trials of intracoronary gamma radiation therapy for in-stent restenosis. J Invasive Cardiol 2002, 14(7):432-437.
2. Waksman R, Bhargava B, White RL, et al. Intracoronary radiation for patients with refractory in-stent restenosis: an analysis from the WRIST-Crossover Trial. Washington Radiation for In-stent Restenosis Trial. Cardiovasc Radiat Med 1999, 1(4):317-322.
3. Jaster M, Schwimmbeck P, Spencker S, Schultheiss HP, Rauch U Randomized comparison of platelet-leukocyte aggregates and platelet activation in blood: heparin-coated coiled wire stent implantation versus balloon angioplasty in acute myocardial infarction. Thromb Res 2003, 112(5-6):285-289.
4. Liistro F, Falsini G, Angioli P, Ducci K, Bolognese L Late acute thrombosis after implantation of sirolimus-eluting stent to treat in-stent restenosis. Acute Card Care 2006, 8(2):116-118.
5. Saleem MA, Aronow WS, Ravipati G, et al. Intracoronary brachytherapy for treatment of in-stent restenosis. Cardiol Rev 2005, 13(3):139-141.
6. Teirstein PS, Kuntz RE New frontiers in interventional cardiology: intravascular radiation to prevent restenosis. Circulation 2001, 104(21):2620-2626.
7. Giesen PL, Rauch U, Bohrmann B, et al. Blood-borne tissue factor: another view of thrombosis. Proc Natl Acad Sci U S A 1999, 96(5):2311-2315.
8. Rauch U, Nemerson Y Tissue factor, the blood, and the arterial wall. Trends Cardiovasc Med 2000, 10(4):139-143.
9. Rauch U, Nemerson Y Circulating tissue factor and thrombosis. Curr Opin Hematol 2000, 7(5):273-277.
10. Mehta SR, Yusuf S, Peters RJ, et al. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet 2001, 358(9281):527-533.
11. Steinhubl SR, Berger PB, Mann JT, et al. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. JAMA 2002, 288(19):2411-2420.
12. Klinkhardt U, Bauersachs R, Adams J, Graff J, Lindhoff-Last E, Harder S Clopidogrel but not aspirin reduces P-selectin expression and formation of platelet-leukocyte aggregates in patients with atherosclerotic vascular disease. Clin Pharmacol Ther 2003, 73(3):232-241.
13. Ross DH, Lynn SC Characterization of acute tolerance to morphine using reserpine and cycloheximide. Biochem Pharmacol 1975, 24(10):1135-1137.
14. Stellbaum C, Willich T, Boltzen U, et al. Clopidogrel-mediated reduction of circulating tissue factor in patients with stable coronary artery disease. Eur J Haematol 2007, 78(4):347-352.
15. Escolar G, Lopez-Vilchez I, az-Ricart M, White JG, Galan AM Internalization of tissue factor by platelets. Thromb Res 2008, 122(Suppl 1):S37-S41.
16. Rauch U, Bonderman D, Bohrmann B, et al. Transfer of tissue factor from leukocytes to platelets is mediated by CD15 and tissue factor. Blood 2000, 96(1):170-175.
17. Xiao Z, Theroux P Clopidogrel inhibits platelet-leukocyte interactions and thrombin receptor agonist peptide-induced platelet activation in patients with an acute coronary syndrome. J Am Coll Cardiol 2004, 43(11):1982-1988.
18. Tan VP, Yan BP, Kiernan TJ, Ajani AE Risk and management of upper gastrointestinal bleeding associated with prolonged dual-antiplatelet therapy after percutaneous coronary intervention. Cardiovasc Revasc Med 2009, 10(1):36-44.
19. Vaknin-Assa H, Assali A, Ukabi S, Lev EI, Kornowski R Stent thrombosis following drug-eluting stent implantation. A single-center experience. Cardiovasc Revasc Med 2007, 8(4):243-247.
20. Eisenreich A, Malz R, Pepke W, et al. Role of the phosphatidylinositol 3-kinase/protein kinase B pathway in regulating alternative splicing of tissue factor mRNA in human endothelial cells. Circ J 2009, 73(9):1746-1752.
21. Mackman N Regulation of the tissue factor gene. Thromb Haemost 1997, 78(1):747-754.
22. Rieger KE, Chu G Portrait of transcriptional responses to ultraviolet and ionizing radiation in human cells. Nucleic Acids Res 2004, 32(16):4786-4803.
23. Pels K, Schwimmbeck PL, Rosenthal P, et al. Long-term clopidogrel administration following severe coronary injury reduces proliferation and inflammation via inhibition of nuclear factor-kappaB and activator protein 1 activation in pigs. Eur J Clin Invest 2009, 39(3):174-182.
24. Seifert PS, Huibregtse BA, Polovick J, Poff B Early vascular response to overlapped paclitaxel-eluting stents in swine coronary arteries. Cardiovasc Revasc Med 2007, 8(4):251-258.
25. Jiang MZ, Tsukahara H, Ohshima Y, et al. Effects of antioxidant and nitric oxide on chemokine production in TNF-alpha-stimulated human dermal microvascular endothelial cells. Free Radic Res 2004, 38(5):473-480.
26. Schreck R, Albermann K, Baeuerle PA Nuclear factor kappa B: an oxidative stress-responsive transcription factor of eukaryotic cells (a review). Free Radic Res Commun 1992, 17(4):221-237.
27. Hallahan DE, Spriggs DR, Beckett MA, Kufe DW, Weichselbaum RR Increased tumor necrosis factor alpha mRNA after cellular exposure to ionizing radiation. Proc Natl Acad Sci U S A 1989, 86(24):10104-10107.
28. Waksman R, Ajani AE, Pinnow E, et al. Twelve versus six months of clopidogrel to reduce major cardiac events in patients undergoing gamma-radiation therapy for in-stent restenosis: Washington Radiation for In-Stent restenosis Trial (WRIST) 12 versus WRIST PLUS. Circulation 2002, 106(7):776-778.
29. Eisenreich A, Celebi O, Goldin-Lang P, Schultheiss HP, Rauch U Upregulation of tissue factor expression and thrombogenic activity in human aortic smooth muscle cells by irradiation, rapamycin and paclitaxel. Int Immunopharmacol 2008, 8(2):307-311.
30. Goldin-Lang P, Pels K, Tran QV, et al. Effect of ionizing radiation on cellular procoagulability and co-ordinated gene alterations. Haematologica 2007, 92(8):1091-1098.
31. Eisenreich A, Bogdanov VY, Zakrzewicz A, et al. Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. Circ Res 2009, 104(5):589-599.