Cross-linked chitosan films: Effect of cross-linking density on swelling parameters

Pakistan Journal of Pharmaceutical Sciences

Volumn 23, Issue 4, 2010, Pages 443-448

  Tiwary, Ashok Kumar ^a   Rana, Vikas ^a  

^a PUNJABI UNIVERSITY   (India)

Author keywords

5 Fluorouracil; Chitosan; Equilibrium swelling ratio; Equilibrium water content; In vitro permeation; Indomethacin; Mass gain ratio; Swelling index

Indexed keywords

CHITOSAN; CITRATE SODIUM; FLUOROURACIL; INDOMETACIN; TRIPOLYPHOSPHATE;

ARTICLE; CROSS LINKING; DENSITY; FILM; INFRARED SPECTROSCOPY; WATER CONTENT; WATER TRANSPORT;

CALORIMETRY, DIFFERENTIAL SCANNING; CHITOSAN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITRATES; CROSS-LINKING REAGENTS; DIFFUSION; FLUOROURACIL; INDICATORS AND REAGENTS; INDOMETHACIN; PERMEABILITY; POLYPHOSPHATES; SPECTROPHOTOMETRY, INFRARED; SPECTROPHOTOMETRY, ULTRAVIOLET; WATER;

EID: 78651407706     PISSN: 1011601X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. 2 full factorial design. Drug Dev. Ind. Pharm., 17: 1931-1945.
2. Aiedeh K, Gianasi E, Orienti I and Zecchiv (1997). Chitosan microcapsules as controlled release system for insulin. J. Microencap., 14: 567-575.
3. Akbuga J and Bergisadi N (1996). 5-Fluorouracil loaded chitosan microspheres: Preparation and release characteristics. J. Microencap., 13: 161-168. (Pubitemid 26121877)
4. Berger J, Reist M, Mayer JM, Felt O, Peppas NA and Gurny R (2004). Structure and interactions in covalently and ionically cross-linked chitosan hydrogels for biomedical applications. Eur. J. Pharm. Biopharm., 57: 19-34. (Pubitemid 38058801)
5. Bhumkar DR and Pokharkar VB (2006). Studies on effect of pH on cross-linking of chitosan with sodium tripolyphosphate: A technical note. AAPS PharmSciTech, 7: article 50. DOI: 10.1208/pt070250.
6. Bodmeier R, Oh KH and Parmar Y (1989). Preparation and evaluation of drug containing chitosan beads. Drug Dev. Ind. Pharm., 15: 1475-1494.
7. Calvo P, Remunan-lopez C, Vila-Jato CL and Alonso MJ (1997a). Chitosan and chitosan/ethylene oxide-propylene oxide block copolymer nanoparticles as novel carriers for proteins and vaccines. Pharm. Res., 14: 1431-1436.
8. Calvo P, Remunan-lopez C, Vila-Jato CL and Alonso MJ (1997b). Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers. J. Appl. Polym. Sci., 63: 125-132.
9. Dureja H, Tiwary AK and Gupta S (2001). Simulation of skin permeability in chitosan membranes. Int. J. Pharm., 213: 193-198.
10. Genta I, Perugini P, Conti B and Pavanetto F (1997). A multiple emulsion method to entrap a lipophilic compound into chitosan microsphere. Int. J. Pharm., 152: 237-246.
11. Janes KA and Alonso MJ (2003). Depolymerized chitosan nanoparticles for protein delivery: preparation and characterization. J. Appl. Polym. Sci., 88: 2769-2776.
12. Kemp W (1991). Infrared Spectroscopy, Macmillan Press, London, pp.19-56.
13. Mi FL, Chen CT, Tseng YC, Kuan CY and Shyu SS (1997). Iron(III) carboxymethylchitin microspheres for the pH-sensitive release of 6-Mercaptopurine. J. Contr. Rel., 44: 19-32.
14. Mi FL, Shyu SS, Lee ST and Wong TB (1999). Kinetic study of chitosan-tripolyphosphate complex reaction and acid-resistive properties of the chitosan-tripolyphosphate gel beads prepared by in-liquid curing method. J. Polymer Sci. Part-B Polymer Phys., 37: 1551-1564.
15. Rana V, Babita K, Goyal D, Gorea R and Tiwary AK (2004). Optimization of chitosan films as a substitute for animal and human epidermal sheets for in vitro permeation of polar and nonpolar drugs. Acta Pharmaceutica., 54: 287-299.
16. Remunan-Lopez C and Bodmeier R (1997). Mechanical, water uptake and permeability properties of cross-linked chitosan glutamate and alginate films. J. Contr. Rel., 44: 215-225.
17. Sasaki H, Kojima M, Mori Y, Nakamura J and Shibasaki J (1991). Enhancing effect of pyrrolidone derivatives on transdermal penetration of 5- fluorouracil, Triamcinolone acetonide, indomethacin, and flurbiprofen. J. Pharm. Sci., 80: 533-538.
18. Sezer AD and Akbuga J (1995). Controlled release of piroxicam from chitosan beads. Int. J. Pharm., 121: 113-116.
19. Sezer AD and Akbuga J (1995). Controlled release of piroxicam from chitosan beads. Int. J. Pharm., 121: 113-116.
20. Suheyla HK (1997). Chitosan: Properties, preparation and application to micro particulate system. J. Microencap., 14: 689-711.
21. Tapia C, Costa E, Moris M, Sapag-Hagar J, Valenzuela F and Basualto C (2002). Study of the influence of pH media dissolution, degree of polymerization and degree of swelling of the polymers on the mechanism of release of diltiazem from matrices based on mixtures of chitosan/alginate. Drug Dev. Ind. Pharm., 28: 217-224. (Pubitemid 34218786)
22. Van der Lubben IM, Kersten G, Fretz MM, Beuvery C, Verhoef JC and Junginger HE (2003). Chitosan microparticles for mucosal vaccination against diphtheria: oral and nasal efficacy studies in mice. Vaccine, 21: 1400-1408. (Pubitemid 36263181)
23. Van der Lubben IM, Verhoef JC, Borchard G and Junginger HE (2001a). Chitosan for mucosal vaccination. Adv. Drug Deliv. Rev., 52: 139-144.
24. Van der Lubben IM, Verhoef JC, Borchard G and Junginger HE (2001b). Chitosan and its derivatives in mucosal drug and vaccine delivery. Eur. J. Pharm. Sci., 14: 201-207.
25. Wan Y, Creber KAM, Peppley B and Bui VT (2003). Synthesis, characterization and ionic conductive properties of phosphorylated chitosan membranes. Macromol. Chem. Physiol., 204: 850-858.
26. 2 system for membrane coat application. J. Pharm. Sci., 90: 1134-1142.
27. Xu Y and Du Y (2003). Effect of molecular structure of chitosan on protein delivery properties of chitosan nanoparticles. Int. J. Pharm. 250: 215-226.