Antioxidant therapies for wound healing: A clinical guide to currently commercially available products

Skin Pharmacology and Physiology

Volumn 24, Issue 3, 2011, Pages 113-126

  Fitzmaurice, S D ^a   Sivamani, R K ^a   Isseroff, R R ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b DEPARTMENT OF VETERANS AFFAIRS   (United States)

Author keywords

Antioxidant; Wound healing therapy

Indexed keywords

ALPHA TOCOPHEROL; ALPHA TOCOTRIENOL; ANTIOXIDANT; ASCORBIC ACID; BETA GLUCAN; CALCIPOTRIOL; COLECALCIFEROL; COPPER; CURCUMIN; EPIGALLOCATECHIN GALLATE; GLISODIN; MEDIHONEY; METRONIDAZOLE; PHYTOFLORA; PROANTHOCYANIDIN; PROPOLIS; RAXOFELAST; REACTIVE OXYGEN METABOLITE; SELENIUM; SUPEROXIDE DISMUTASE; THIOCTIC ACID; UNCLASSIFIED DRUG; VEREGAN; ZINC;

HONEY; HUMAN; IMMUNOHISTOCHEMISTRY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; VAGINITIS; WOUND HEALING;

ANIMALS; ANTIOXIDANTS; BIOLOGICAL AGENTS; DRUG APPROVAL; HUMANS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION; WOUND HEALING;

EID: 78651406006     PISSN: 16605527     EISSN: None     Source Type: Journal    
DOI: 10.1159/000322643     Document Type: Review

References (61)

1. Roy S, Khanna S, Nallu K, Hunt TK, Sen CK: Dermal wound healing is subject to redox control. Mol Ther 2006; 13: 211-220. (Pubitemid 41763500)
2. Sen CK: The general case for redox control of wound repair. Wound Repair Regen 2003; 11: 431-438. (Pubitemid 37467724)
3. Soneja A, Drews M, Malinski T: Role of nitric oxide, nitroxidative and oxidative stress in wound healing. Pharmacol Rep 2005; 57(suppl):108-119.
4. Maxwell SR: Anti-oxidant therapy: does it have a role in the treatment of human dis-ease? Expert Opin Investig Drugs 1997; 6: 211-236. (Pubitemid 27141790)
5. 2 production re-quires the activation of phosphatidylinositol 3-kinase. J Biol Chem 2000; 275:10527-10531. (Pubitemid 30202116)
6. Marumo T, Schini-Kerth VB, Fisslthaler B, Busse R: Platelet-derived growth factor-stimulated superoxide anion production modulates activation of transcription factor NF-?B and expression of monocyte che-moattractant protein 1 in human aortic smooth muscle cells. Circulation 1997; 96: 2361-2367.
7. Sen CK, Khanna S, Babior BM, Hunt TK, Ellison EC, Roy S: Oxidant-induced vascu-lar endothelial growth factor expression in human keratinocytes and cutaneous wound healing. J Biol Chem 2002; 277: 33284-33290. (Pubitemid 34984849)
8. Klyubin IV, Kirpichnikova KM, Gamaley IA: Hydrogen peroxide-induced chemotaxis of mouse peritoneal neutrophils. Eur J Cell Biol 1996; 70: 347-351. (Pubitemid 26268238)
9. Wenk J, Brenneisen P, Wlaschek M, Poswig A, Briviba K, Oberley TD, Scharffetter-Ko-chanek K: Stable overexpression of manga-nese superoxide dismutase in mitochondria identifies hydrogen peroxide as a major oxi-dant in the AP-1-mediated induction of matrix-degrading metalloprotease-1. J Biol Chem 1999; 274: 25869-25876.
10. Inoue YU, Asami J, Inoue T: Cadherin-6 gene regulatory patterns in the postnatal mouse brain. Mol Cell Neurosci 2008; 39: 95-104.
11. Schäfer M, Werner S: Oxidative stress in nor-mal and impaired wound repair. Pharmacol Res 2008; 58: 165-171.
12. Bossolasco P, Cova L, Calzarossa C, Rimoldi SG, Borsotti C, Deliliers GL, Silani V, Soligo D, Polli E: Neuro-glial differentiation of hu-man bone marrow stem cells in vitro. Exp Neurol 2005; 193: 312-325. (Pubitemid 40616181)
13. DerMarderosian A, Beutler JA (eds): The Re-view of Natural Products. The Most Com-plete Source of Natural Product Informa-tion, ed 5. St Louis, Wolters Kluwer Health, 2008.
14. Saitoh D, Okada Y, Ookawara T, Yamashita H, Takahara T, Ishihara S, Ohno H, Mimura K: Prevention of ongoing lipid peroxidation by wound excision and superoxide dis-mutase treatment in the burned rat. Am J Emerg Med 1994; 12:142-146. (Pubitemid 24112540)
15. Saitoh D, Okada Y, Takahara T, Yamashita H, Ohno H, Inoue M: The effect of an SOD derivative (SM-SOD) administration in a burned rat model. Tohoku J Exp Med 1994; 174:31-40.
16. Vorauer-Uhl K, Furnschlief E, Wagner A, Ferko B, Katinger H: Reepithelialization of experimental scalds effected by topically ap-plied superoxide dismutase: controlled ani-mal studies. Wound Repair Regen 2002; 10: 366-371. (Pubitemid 36025335)
17. Collins N: Adding vitamin C to the wound management mix. Adv Skin Wound Care 2004; 17:109-112.
18. Taylor TV, Rimmer S, Day B, Butcher J, Dy-mock IW: Ascorbic acid supplementation in the treatment of pressure-sores. Lancet 1974;ii:544-546.
19. ter Riet G, Kessels AG, Knipschild PG: Ran-domized clinical trial of ascorbic acid in the treatment of pressure ulcers. J Clin Epidemi-ol 1995; 48:1453-1460. (Pubitemid 26035528)
20. Wiseman H: Vitamin D is a membrane anti-oxidant: ability to inhibit iron-dependent lipid peroxidation in liposomes compared to cholesterol, ergosterol and tamoxifen and relevance to anticancer action. FEBS Lett 1993; 326: 285-288. (Pubitemid 23200295)
21. Ramesh KV, Mahindrakar MB, Bhat EP: A new role for vitamin D: cholecalciferol pro-motes dermal wound strength and re-epi-thelization. Indian J Exp Biol 1993; 31:778-779. (Pubitemid 24084548)
22. 3: a novel agent for enhanc-ing wound healing. J Cell Biochem 1995; 59: 53-56.
23. Leivo T, Kiistala U, Vesterinen M, Owaribe K, Burgeson RE, Virtanen I, Oikarinen A: Re-epithelialization rate and protein ex-pression in the suction-induced wound model: comparison between intact blisters, open wounds and calcipotriol-pretreated open wounds. Br J Dermatol 2000; 142: 991-1002. (Pubitemid 30304614)
24. Pennock JF, Hemming FW, Kerr JD: A reas-sessment of tocopherol in chemistry. Biochem Biophys Res Commun 1964; 17:542-548.
25. Bitto A, Minutoli L, Squadrito F, Polito F, Altavilla D: Raxofelast, (+/-)5-(acetyloxy)-2,3-dihydro-4,6,7-trimethyl-2-benzofura-nacetic acid: a new antioxidant to modulate the inflammatory response during isch-emia-reperfusion injury and impaired wound healing. Mini Rev Med Chem 2007; 7:339-343. (Pubitemid 46488253)
26. Musalmah M, Nizrana MY, Fairuz AH, NoorAini AH, Azian AL, Gapor MT, Wan Ngah WZ: Comparative effects of palm vitamin E and α-tocopherol on healing and wound tissue antioxidant enzyme lev-els in diabetic rats. Lipids 2005; 40:575-580. (Pubitemid 41040821)
27. Zampieri N, Zuin V, Burro R, Ottolenghi A, Camoglio FS: A prospective study in chil-dren: pre-and post-surgery use of vitamin E in surgical incisions. J Plast Reconstr Aesthet Surg 2010; 63:1474-1478.
28. Gray M, Jones DP: The effect of different for-mulations of equivalent active ingredients on the performance of two topical wound treatment products. Ostomy Wound Man-age 2004; 50: 34-38, 40, 42-44.
29. Carson SN, Wiggins C, Overall K, Herbert J: Using a castor oil-balsam of Peru-trypsin ointment to assist in healing skin graft donor sites. Ostomy Wound Manage 2003; 49:60-64.
30. Jenkins M, Alexander JW, MacMillan BG, Waymack JP, Kopcha R: Failure of topical steroids and vitamin E to reduce postopera-tive scar formation following reconstructive surgery. J Burn Care Rehabil 1986; 7:309-312. (Pubitemid 16010121)
31. Alleva R, Nasole E, di Donato F, Borghi B, Neuzil J, Tomasetti M: Alpha-lipoic acid sup-plementation inhibits oxidative damage, ac-celerating chronic wound healing in patients undergoing hyperbaric oxygen therapy. Bio-chem Biophys Res Commun 2005; 333:404-410. (Pubitemid 40848305)
32. Mallikarjuna Rao C, Ghosh A, Raghothama C, Bairy KL: Does metronidazole reduce lip-id peroxidation in burn injuries to promote healing? Burns 2002; 28:427-429. (Pubitemid 34876871)
33. Pandey S, Basheer M, Roy S, Udupa N: De-velopment and evaluation of transdermal formulations containing metronidazole and norfloxacin for the treatment of burn wound. Indian J Exp Biol 1999; 37: 450-454. (Pubitemid 29220142)
34. Finlay IG, Bowszyc J, Ramlau C, Gwiez-dzinski Z: The effect of topical 0.75% met-ronidazole gel on malodorous cutaneous ul-cers. J Pain Symptom Manage 1996; 11:158-162. (Pubitemid 26090592)
35. Berger MM, Baines M, Raffoul W, Benathan M, Chiolero RL, Reeves C, Revelly JP, Cay-eux MC, Senechaud I, Shenkin A: Trace ele-ment supplementation after major burns modulates antioxidant status and clinical course by way of increased tissue trace ele-ment concentrations. Am J Clin Nutr 2007; 85:1293-1300. (Pubitemid 46740471)
36. Desneves KJ, Todorovic BE, Cassar A, Crowe TC: Treatment with supplementary argi-nine, vitamin C and zinc in patients with pressure ulcers: a randomised controlled tri-al. Clin Nutr 2005; 24:979-987. (Pubitemid 41782455)
37. Wilkinson EA, Hawke CI: Oral zinc for arte-rial and venous leg ulcers. Cochrane Data-base Syst Rev 2000:CD001273.
38. Langer G, Schloemer G, Knerr A, Kuss O, Behrens J: Nutritional interventions for pre-venting and treating pressure ulcers. Co-chrane Database Syst Rev 2003:CD003216.
39. Sivamani RK, Maibach HI: Fruits are rich in antioxidants and ripe for topical therapy. J Dermatol Treat 2009: 20: 186-189.
40. Davis SC, Perez R: Cosmeceuticals and natu-ral products: wound healing. Clin Dermatol 2009; 27:502-506.
41. Toklu HZ, Sener G, Jahovic N, Uslu B, Arbak S, Yegen BC: β-Glucan protects against burn-induced oxidative organ damage in rats. Int Immunopharmacol 2006; 6:156-169. (Pubitemid 43052812)
42. Calabrese V, Bates TE, Mancuso C, Corne-lius C, Ventimiglia B, Cambria MT, di Renzo L, de Lorenzo A, Dinkova-Kostova AT: Cur-cumin and the cellular stress response in free radical-related diseases. Mol Nutr Food Res 2008; 52:1062-1073.
43. Jagetia GC, Rajanikant GK: Role of curcu-min, a naturally occurring phenolic com-pound of turmeric in accelerating the repair of excision wound, in mice whole-body ex-posed to various doses of 7-radiation. J Surg Res 2004; 120:127-138. (Pubitemid 38686539)
44. Panchatcharam M, Miriyala S, Gayathri VS, Suguna L: Curcumin improves wound heal-ing by modulating collagen and decreasing reactive oxygen species. Mol Cell Biochem 2006; 290:87-96. (Pubitemid 44473238)
45. Krishnaraju AV, Sundararaju D, Sengupta K Venkateswarlu S, Trimurtulu G: Safety and toxicological evaluation of demethylated curcuminoids; a novel standardized cur-cumin product. Toxicol Mech Methods 2009; 19: 447-460.
46. Chainani-Wu N: Safety and anti-inflamma-tory activity of curcumin: a component of turmeric (Curcuma longa). J Altern Comple-ment Med 2003; 9: 161-168.
47. Kapoor M, Howard R, Hall I, Appleton I: Ef-fects of epicatechin gallate on wound healing and scar formation in a full-thickness inci-sional wound healing model in rats. Am J Pathol 2004; 165:299-307. (Pubitemid 38821836)
48. Golden EB, Lam PY, Kardosh A, Gaffney KJ, Cadenas E, Louie SG, Petasis NA, Chen TC, Schönthal AH: Green tea polyphenols block the anticancer effects of bortezomib and oth-er boronic acid-based proteasome inhibitors. Blood 2009; 113:5927-5937.
49. Gu L, Kelm MA, Hammerstone JF, Beecher G, Holden J, Haytowitz D, Gebhardt S, Prior RL: Concentrations of proanthocyanidins in common foods and estimations of nor-mal consumption. J Nutr 2004; 134: 613-617. (Pubitemid 38298505)
50. Khanna S, Venojarvi M, Roy S, Sharma N, Trikha P, Bagchi D, Bagchi M, Sen CK: Der-mal wound healing properties of redox-ac-tive grape seed proanthocyanidins. Free Radic Biol Med 2002; 33:1089-1096.
51. Burdock GA: Review of the biological prop-erties and toxicity of bee propolis (propolis). Food Chem Toxicol 1998; 36: 347-363. (Pubitemid 28255348)
52. Gregory SR, Piccolo N, Piccolo MT, Piccolo MS, Heggers JP: Comparison of propolis skin cream to silver sulfadiazine: a naturo-pathic alternative to antibiotics in treatment of minor burns. J Altern Complement Med 2002; 8:77-83. (Pubitemid 34174390)
53. Russo A, Longo R, Vanella A: Antioxidant activity of propolis: role of caffeic acid phenethyl ester and galangin. Fitoterapia 2002; 73(suppl 1):S21-S29. (Pubitemid 35472200)
54. McLennan SV, Bonner J, Milne S, Lo L, Charlton A, Kurup S, Jia J, Yue DK, Twigg SM: The anti-inflammatory agent propolis improves wound healing in a rodent model of experimental diabetes. Wound Repair Re-gen 2008; 16:706-713.
55. Serarslan G, Altug E, Kontas T, Atik E, Avci G: Caffeic acid phenethyl ester accelerates cutaneous wound healing in a rat model and decreases oxidative stress. Clin Exp Derma-tol 2007; 32:709-715. (Pubitemid 47610618)
56. Hausen BM: Evaluation of the main contact allergens in propolis (1995 to 2005). Derma-titis 2005; 16:127-129.
57. Henriques A, Jackson S, Cooper R, Burton N: Free radical production and quenching in honeys with wound healing potential. J An-timicrob Chemother 2006; 58: 773-777. (Pubitemid 44390951)
58. Gheldof N, Wang XH, Engeseth N J: Identifi-cation and quantification of antioxidant components of honeys from various floral sources. J Agric Food Chem 2002; 50: 5870-5877. (Pubitemid 35155307)
59. Jull AB, Rodgers A, Walker N: Honey as a topical treatment for wounds. Cochrane Da-tabase Syst Rev 2008:CD005083.
60. Val R, Susanna D, Stephen T: Standardized antibacterial honey (Medihoney) with stan-dard therapy in wound care: randomized clinical trial. J Adv Nurs 2009; 65: 565-575.
61. Martin CR: Impediments to drug develop-ment. Wound Repair Regen 2003; 11:161-165.