Effect of glucose and insulin on oxidized low-density lipoprotein phagocytosis by human monocytes: A pilot study

Angiology

Volumn 62, Issue 2, 2011, Pages 163-166

  Sarigianni, Maria ^a   Bekiari, Eleni ^a   Tsapas, Apostolos ^a,b   Topouridou, Konstantina ^a   Kaloyianni, Martha ^a   Koliakos, George ^a   Paletas, Konstantinos ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b Harris Manchester Medical Academy   (United Kingdom)

Author keywords

atherosclerosis; glucose; insulin; insulin resistance; monocytes; obesity

Indexed keywords

CARIPORIDE; GLUCOSE; INSULIN; NEUTRAL INSULIN; OXIDIZED LOW DENSITY LIPOPROTEIN; ROSIGLITAZONE;

ADULT; ARTICLE; CELL ISOLATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLUCOSE CLAMP TECHNIQUE; HUMAN; HUMAN CELL; IN VITRO STUDY; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; MONOCYTE; OBESITY; PHAGOCYTOSIS; PILOT STUDY;

ADOLESCENT; ADULT; BODY MASS INDEX; CASE-CONTROL STUDIES; CELL CULTURE TECHNIQUES; FEMALE; GLUCOSE; GUANIDINES; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; LIPOPROTEINS, LDL; MALE; MONOCYTES; OBESITY; PHAGOCYTOSIS; PILOT PROJECTS; SULFONES; SWEETENING AGENTS; THIAZOLIDINEDIONES; YOUNG ADULT;

EID: 78651398059     PISSN: 00033197     EISSN: None     Source Type: Journal    
DOI: 10.1177/0003319710375088     Document Type: Article

References (21)

1. World Health Organization. Preventing and managing the global epidemic. Report of a World Health Organization Consultation on Obesity. 1987 ; Geneva.
2. Grundy SM Obesity, metabolic syndrome, and cardiovascular disease. J Clin Endocrinol Metab. 2004 ; 89 (6). 2595-2600.
3. Fox CS, Coady S., Sorlie PD, et al. Increasing cardiovascular disease burden due to diabetes mellitus: The FRAMINGHAM Heart Study. Circulation. 2007 ; 115 (12). 1544-1550.
4. Tabas I., Tall A., Accili D. The impact of macrophage insulin resistance on advanced atherosclerotic plaque progression. Circ Res. 2010 ; 106 (1). 58-67.
5. Liang CP, Han S., Senokuchi T., Tall AR The macrophage at the crossroads of insulin resistance and atherosclerosis. Circ Res. 2007 ; 100 (11). 1546-1555.
6. Ghanim H., Aljada A., Hofmeyer D., et al. Circulating mononuclear cells in the obese are in a proinflammatory state. Circulation. 2004 ; 110 (12). 1564-1571.
7. Witztum JL The oxidation hypothesis of atherosclerosis. Lancet. 1994 ; 344 (8933). 793-795.
8. Bar RS, Kahn CR, Koren HS Insulin inhibition of antibody-dependent cytoxicity and insulin receptors in macrophages. Nature. 1977 ; 265 (5595). 632-635.
9. Malide D., Davies-Hill TM, Levine M., Simpson IA Distinct localization of Glut-1, -3, and -5 in human monocyte-derived macrophages: effects of cell activation. Am J Physiol. 1998 ; 274 (3). E516 - E526.
10. Sarigianni M., Bekiari E., Tsapas A., et al. Effect of epinephrine and insulin resistance on human monocytes obtained from lean and obese healthy subjects: a pilot study. Angiology 2010 ; IN PRESS.
11. Sarigianni M., Bekiari E., Tsapas A., et al. Effect of leptin and insulin resistance on properties of human monocytes in lean and obese healthy subjects. Angiology 2010 ; IN PRESS.
12. Koliakos G., Zolota Z., Paletas K., Kaloyianni M. High glucose concentrations stimulate human monocyte sodium/hydrogen exchanger activity and modulate atherosclerosis-related functions. Pflugers Arch. 2004 ; 449 (3). 298-306.
13. Kaloyianni M., Zolota Z., Paletas K., Tsapas A., Koliakos G. Cariporide counteracts atherosclerosis-related functions in monocytes from obese and normal individuals. Obes Res. 2005 ; 13 (9). 1588-1595.
14. Kostidou E., Koliakos G., Kaloyianni M. Increased monocyte alphaL, alphaM and beta2 integrin subunits in diabetes mellitus. Clin Biochem. 2009 ; 42 (7-8). 634-640.
15. Liang CP, Han S., Okamoto H., et al. Increased CD36 protein as a response to defective insulin signaling in macrophages. J Clin Invest. 2004 ; 113 (5). 764-773.
16. McCarthy JJ, Somji A., Weiss LA, et al. Polymorphisms of the scavenger receptor class b member 1 are associated with insulin resistance with evidence of gene by sex interaction. J Clin Endocrinol Metab. 2009 ; 94 (5). 1789-1796.
17. Glintborg D., Hojlund K., Andersen M., et al. Soluble CD36 and risk markers of insulin resistance and atherosclerosis are elevated in polycystic ovary syndrome and significantly reduced during pioglitazone treatment. Diabetes Care. 2008 ; 31 (2). 328-334.
18. Handberg A., Levin K., Hojlund K., Beck-Nielsen H. Identification of the oxidized low-density lipoprotein scavenger receptor CD36 in plasma: a novel marker of insulin resistance. Circulation. 2006 ; 114 (11). 1169-1176.
19. Handberg A., Norberg M., Stenlund H., et al. Soluble CD36 (sCD36) clusters with markers of insulin resistance, and high sCD36 is associated with increased type 2 diabetes risk. J Clin Endocrinol Metab. 2010 ; 95 (4). 1939-1946.
20. Kunjathoor VV, Febbraio M., Podrez EA, et al. Scavenger receptors class a-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J Biol Chem. 2002 ; 277 (51). 49982-49988.
21. Morgan D., Capasso M., Musset B., et al. Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis. Proc Natl Acad Sci USA. 2009 ; 106 (42). 18022-18027.