Defective glycosylation of α-dystroglycan contributes to podocyte flattening

Kidney International

Volumn 79, Issue 3, 2011, Pages 311-316

  Kojima, Kenichiro ^a   Nosaka, Hitonari ^a   Kishimoto, Yuki ^a   Nishiyama, Yuri ^a   Fukuda, Seiichi ^a   Shimada, Masaru ^a   Kodaka, Kenzo ^a   Saito, Fumiaki ^b   Matsumura, Kiichiro ^b   Shimizu, Teruo ^b   Toda, Tatsushi ^c   Takeda, Satoshi ^d   Kawachi, Hiroshi ^e   Uchida, Shunya ^a  

^a TEIKYO UNIVERSITY   (Japan)

^b TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^e NIIGATA UNIVERSITY   (Japan)

Author keywords

adhesion molecule; dystroglycan; foot process; glycosylation; podocyte

Indexed keywords

ALPHA DYSTROGLYCAN; FUKUTIN; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; FUKUYAMA CONGENITAL MUSCULAR DYSTROPHY; GLYCOSYLATION; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION;

EID: 78651393398     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2010.403     Document Type: Article

References (31)

1. Kerjaschki D. Caught flat-footed: podocyte damage and the molecular bases of focal glomerulosclerosis. J Clin Invest 2001; 108: 1583-1587.
2. Durvasula RV, Shankland SJ. Podocyte injury and targeting therapy: an update. Curr Opin Nephrol Hypertens 2006; 15: 1-7.
3. Kerjaschki D, Ojha PP, Susani M et al. A b1-integrin receptor for fibronectin in human glomeruli. Am J Pathol 1989; 134: 481-489.
4. Adler S. Characterization of glomerular epithelial cell matrix receptors. Am J Pathol 1992; 141: 571-578.
5. Kojima K, Matsui K, Nagase M. Protection of a3 integrin-mediated podocyte shape by superoxide dismutase in the puromycin aminonucleoside nephrosis rat. Am J Kidney Dis 2000; 35: 1175-1185.
6. Regele HM, Fillipovic E, Langer B et al. Glomerular expression of dystroglycans is reduced in minimal change nephrosis but not in focal segmental glomerulosclerosis. J Am Soc Nephrol 2000; 11: 403-412.
7. Raats CJ, van Den Born J, Bakker MA et al. Expression of agrin, dystroglycan, and utrophin in normal renal tissue and in experimental glomerulopathies. Am J Pathol 2000; 156: 1749-1765.
8. Williamson RA, Henry MD, Daniels KJ et al. Dystroglycan is essential for early embryonic development: disruption of Reichert's membrane in Dag1-null mice. Hum Mol Genet 1997; 6: 831-841.
9. Fukuyama Y, Osawa M, Suzuki H. Congenital progressive muscular dystrophy of the Fukuyama type-clinical, genetic, and pathological considerations. Brain Dev 1981; 3: 1-29.
10. Toda T, Segawa M, Nomura Y et al. Localization of a gene for Fukuyama type congenital muscular dystrophy to chromosome 9q31-33. Nat Genet 1993; 5: 283-286.
11. Toda T, Miyake M, Kobayashi K et al. Linkage-disequilibrium mapping narrows the Fukuyama-type congenital muscular dystrophy (FCMD) candidate region to o100 kb. Am J Hum Genet 1996; 59: 1313-1320. (Pubitemid 26394123)
12. Takeda S, Kondo M, Sasaki J et al. Fukutin is required for maintenance of muscle integrity, cortical histiogenesis and normal eye development. Hum Mol Genet 2003; 12: 1449-1459.
13. Ruotsalainen V, Ljungberg P, Wartiovaara J et al. Nephrin is specifically located at the slit diaphragm of glomerular podocytes. Proc Natl Acad Sci USA 1999; 96: 7962-7967.
14. Hemler ME. Dystroglycan versatility. Cell 1999; 97: 543-546.
15. Durbeej M, Henry MD, Campbell KP. Dystroglycan in development and disease. Curr Opin Cell Biol 1998; 10: 594-601.
16. Hohenester E, Tisi D, Talts JF et al. The crystal structure of a laminin G-like module reveals the molecular basis of alpha-dystroglycan binding to laminins, perlecan, and agrin. Mol Cell 1999; 4: 783-792.
17. Kojima K, Davidovits A, Poczewski H et al. Podocyte flattening and disorder of glomerular basement membrane are associated with splitting of dystroglycan-matrix interaction. J Am Soc Nephrol 2004; 15: 2079-2089.
18. Vogtländer NPJ, Tamboer WPM, Bakker MAH et al. Reactive oxygen species deglycosilate glomerular a-dystroglycan. Kidney Int 2006; 69: 1526-1534.
19. Kitsiou PV, Tzinia AK, Stetler-Sterenson WG et al. Glucose-induced changes in integrins and matrix-related function in cultured human glomerular epithelial cells. Am J Physiol 2003; 285: F40-F48.
20. Kreidberg JA, Donovan MJ, Goldstein SL et al. Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis. Development 1996; 122: 3537-3547.
21. Andrews PM. Glomerular epithelial alterations resulting from sialic acid surface coat removal. Kidney Int 1979; 15: 376-385.
22. Galeano B, Klootwijk R, Manoli I et al. Mutation in the key enzyme of sialic acid biosynthesis causes severe glomerular proteinuria and is rescued by N-acetylmannosamine. J Clin Invest 2007; 117: 1585-1594.
23. Chen S, Wassenhove-McCarthy DJ, Yamaguchi Y et al. Loss of heparan sulfate glycosaminoglycan assembly in podocytes does not lead proteinuria. Kidney Int 2008; 74: 289-299.
24. Kestila M, Ienkkeri U, Mannikko M et al. Positionally cloned gene for a novel glomerular protein-nephrin-is mutated in congenital nephrotic syndrome. Mol Cell 1998; 1: 575-582.
25. Tryggvason K, Ruotsalainen V, Wartiovaara J. Discovery of the congenital nephrotic syndrome gene discloses the structure of the mysterious molecular sieve of the kidney. Int J Dev Biol 1999; 43: 445-451.
26. Doublier S, Routsalainen V, Salvidio G et al. Nephrin redistribution on podocytes is a potential mechanism for proteinuria in patients with primary acquired nephrotic syndrome. Am J Pathol 2001; 158: 1723-1731.
27. Wernerson A, Duner F, Pettersson E et al. Altered ultrastructural distribution of nephrin in minimal change nephrotic syndrome. Nephrol Dial Transplant 2003; 18: 70-76.
28. Kurahashi H, Taniguchi M, Meno C et al. Basement membrane fragility underlies embryonic lethality in fukutin-null mice. Neurobiol Dis 2005; 19: 208-217.
29. Colognato H, Winkelmann DA, Yurchenco PD. Laminin polymerization induces a receptor-cytoskeleton network. J Cell Biol 1999; 145: 619-631.
30. Saito F, Masaki T, Saito Y et al. Defective peripheral nerve myelination and neuromuscular junction formation in fukutin-deficient chimeric mice. J Neurochem 2007; 101: 1712-1722.
31. Kawachi H, Koike H, Kurihara H et al. Cloning of rat nephrin: expression in developing glomeruli and in proteinuric states. Kidney Int 2000; 57: 1949-1961.