Apoptin sensitizes radiation-induced cell death via classic mitochondrial, caspase and p53-dependent signaling in HepG2 cells

Molecular Medicine Reports

Volumn 4, Issue 1, 2011, Pages 59-63

  Han, Su Xia ^a   Zhu, Qing ^a   Ma, Jin Lu ^a   Lv, Yi ^a   Zhao, Jing ^a   Huang, Chen ^a   Jia, Xi ^a   Ou, Wei ^a   Guo, Hong Tao ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Apoptin; Apoptosis; Hepatocellular carcinoma; Radiation

Indexed keywords

APOPTIN; CASPASE 3; CASPASE 7; CASPASE 9; CYTOCHROME C; PROTEIN P53;

ARTICLE; CANCER GENE THERAPY; CANCER RADIOTHERAPY; CELL DEATH; CELL STRAIN HEPG2; ENZYME ACTIVATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LENTIVIRINAE; LIVER CELL CARCINOMA; PROTEIN EXPRESSION; RADIOSENSITIVITY; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

CAPSID PROTEINS; CARCINOMA, HEPATOCELLULAR; CASPASES; CELL DEATH; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; RADIATION-SENSITIZING AGENTS; TUMOR SUPPRESSOR PROTEIN P53;

CHICKEN ANEMIA VIRUS; LENTIVIRUS;

EID: 78651383173     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2010.391     Document Type: Article

References (19)

1. Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin 55: 74-108, 2005.
2. Stone MJ, Klintmalm GB, Polter D, et al: Neoadjuvant chemotherapy and liver transplantation for hepatocellular carcinoma: a pilot study in 20 patients. Gastroenterology 104: 196-202, 1993. (Pubitemid 23040023)
3. Llovet JM, Schwartz M, Fuster J and Bruix J: Expanded criteria for hepatocellular carcinoma through down-staging prior to liver transplantation: not yet there. Semin Liver Dis 26: 248-253, 2006. (Pubitemid 44141932)
4. Emami B, Lyman J, Brown A, et al: Tolerance of normal tissue to therapeutic radiation. Int J Radiat Oncol Biol Phys 21: 109-122, 1991.
5. Noteborn MH: Proteins selectively killing tumor cells. Eur J Pharmacol 625: 165-173, 2009.
6. Noteborn MH: Apoptin acts as a tumor-specific killer: potentials for an anti-tumor therapy. Cell Mol Biol 51: 49-60, 2005.
7. Burek M, Maddika S, Burek CJ, Daniel PT, Schulze-Osthoff K and Los M: Apoptin-induced cell death is modulated by Bcl-2 family members and is Apaf-1 dependent. Oncogene 25: 2213-2222, 2006.
8. Schoop RA, Kooistra K, De Jong RJ and Noteborn MH: Bcl-xL inhibits p53- but not apoptin-induced apoptosis in head and neck squamous cell carcinoma cell line. Int J Cancer 109: 38-42, 2004 (Pubitemid 38160659)
9. Han SX, Ma JL, Lv Y, Huang C, Liang HH and Duan KM: Secretory transactivating transcription-apoptin fusion protein induces apoptosis in hepatocellular carcinoma HepG2 cells. World J Gastroenterol 14: 3642-3649, 2008.
10. Han SX, Ma JL, Lu Y, Huang C and Duan KM: SP-TAT-apoptin induces Gl arrest in HepG2 cells. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 24: 864-866, 2008.
11. Fulda S and Debatin KM: Targeting apoptosis pathways in cancer therapy. Curr Cancer Drug Targets 4: 569-576, 2004. (Pubitemid 39536377)
12. Danen-van Oorschot AA, van der Eb AJ and Noteborn MH: BCL-2 stimulates apoptin-induced apoptosis. Adv Exp Med Biol 457: 245-249, 1999.
13. Heilman DW, Teodoro JG and Green MR: Apoptin nucleocytoplasmic shuttling is required for cell type-specific localization, apoptosis, and recruitment of the anaphase-promoting complex/ cyclosome to PML bodies. J Virol 80: 7535-7545, 2006.
14. Zheng TS and Flavell RA: Apoptosis. All's well that ends dead. Nature 400: 410-411, 1999.
15. Thornberry NA and Lazebnik Y: Caspases: enemies within. Science 281: 1312-1316, 1998.
16. Patel MP, Masood A, Patel PS and Chanan-Khan AA: Targeting the Bcl-2. Curr Opin Oncol 21: 516-523, 2009.
17. Tang WY, Chau SP, Tsang WP, Kong SK and Kwok TT: The role of Raf-1 in radiation resistance of human hepatocellular carcinoma Hep G2 cells. Oncol Rep 12: 1349-1354, 2004.
18. Singh RP, Dhanalakshmi S, Tyagi AK, Chan DC, Agarwal C and Agarwal R: Dietary feeding of silibinin inhibits advance human prostate carcinoma growth in athymic nude mice and increases plasma insulin-like growth factor-binding protein-3 levels. Cancer Res 62: 3063-3069, 2002. (Pubitemid 34602396)
19. Li X, Jin N, Mi Z, Lian H, Sun L, Li X and Zheng H: Antitumor effects of a recombinant fowlpox virus expressing apoptin in vivo and in vitro. Int J Cancer 119: 2948-2957, 2006. (Pubitemid 44846250)