The emerging role of microRNAs in multiple sclerosis

Nature Reviews Neurology

Volumn 7, Issue 1, 2011, Pages 56-59

  Junker, Andreas ^a   Hohlfeld, Reinhard ^b   Meinl, Edgar ^b  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; DICER; INTERFERON; LAMIN B; MICRORNA; STEROID; VERY LONG CHAIN FATTY ACID;

ALLERGIC ENCEPHALOMYELITIS; ASTROCYTE; ASTROCYTOSIS; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL INFILTRATION; CELL MATURATION; CYTOKINE PRODUCTION; DEMYELINATION; DOWN REGULATION; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC ANALYSIS; HUMAN; MACROPHAGE; MULTIPLE SCLEROSIS; MYELIN SHEATH; MYELINATION; NONHUMAN; OLIGODENDROGLIA; PATHOGENESIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REGULATORY T LYMPHOCYTE; REVIEW; RNA PROCESSING; TH17 CELL; TRANSCRIPTION REGULATION; UPREGULATION; WHITE MATTER;

ANIMALS; AUTOIMMUNITY; HUMANS; MICRORNAS; MULTIPLE SCLEROSIS; MYELIN SHEATH;

EID: 78651372150     PISSN: 17594758     EISSN: 17594766     Source Type: Journal    
DOI: 10.1038/nrneurol.2010.179     Document Type: Review

References (43)

1. eulalio, A., Huntzinger, e. & izaurralde, e. Getting to the root of miRNA-mediated gene silencing. Cell 132, 9-14 (2008).
2. Wu, L. & Belasco, J. G. Let me count the ways: mechanisms of gene regulation by miRNAs and siRNAs. Mol. Cell 29, 1-7 (2008).
3. Lewis, B. p., Burge, C. B. & Bartel, D. p. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120, 15-20 (2005).
4. Coolen, M. & Bally-Cuif, L. MicroRNAs in brain development and physiology. Curr. Opin. Neurobiol. 19, 461-470 (2009).
5. Kosik, K. S. The neuronal microRNA system. Nat. Rev. Neurosci. 7, 911-920 (2006).
6. Lau, p., et al. identification of dynamically regulated microRNA and mRNA networks in developing oligodendrocytes. J. Neurosci. 28, 11720-11730 (2008).
7. Junker, A., et al. MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47. Brain 132, 3342-3352 (2009).
8. Nicoloso, M. S. & Calin, G. A. MicroRNA involvement in brain tumors: from bench to bedside. Brain Pathol. 18, 122-129 (2008).
9. eacker, S. M., Dawson, T. M. & Dawson, v. L. Understanding microRNAs in neurodegeneration. Nat. Rev. Neurosci. 10, 837-841 (2009).
10. Hebert, S. S. & De Strooper, B. Alterations of the microRNA network cause neurodegenerative disease. Trends Neurosci. 32, 199-206 (2009).
11. Abelson, J. F., et al. Sequence variants in SLITRK1 are associated with Tourettes syndrome. Science 310, 317-320 (2005).
12. Liston, A., Lu, L. F., OCarroll, D., Tarakhovsky, A. & Rudensky, A. Y. Dicer-dependent microRNA pathway safeguards regulatory T cell function. J. Exp. Med. 205, 1993-2004 (2008).
13. Zhou, X., et al. Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. J. Exp. Med. 205, 1983-1991(2008).
14. Czech, M. p. MicroRNAs as therapeutic targets. N. Engl. J. Med. 354, 1194-1195 (2006).
15. Elmen J., et al. LNA-mediated microRNA silencing in non-human primates. Nature 452 896-899 (2008)
16. peterson, J. W., Bo, L., Mork, S., Chang, A. & Trapp, B. D. Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions. Ann. Neurol. 50, 389-400 (2001).
17. Stadelmann, C., Albert, M., Wegner, C. & Bruck, W. Cortical pathology in multiple sclerosis. Curr. Opin. Neurol. 21, 229-234 (2008).
18. OConnell, R. M., Rao, D. S., Chaudhuri, A. A. & Baltimore, D. physiological and pathological roles for microRNAs in the immune system. Nat. Rev. Immunol. 10, 111-122 (2010).
19. Oldenborg, p. A., et al. Role of CD47 as a marker of self on red blood cells. Science 288, 2051-2054 (2000).
20. Yamao, T., et al. Negative regulation of platelet clearance and of the macrophage phagocytic response by the transmembrane glycoprotein SHpS-1. J. Biol. Chem. 277, 39833-39839 (2002).
21. Koning, N., Bo, L., Hoek, R. M. & Huitinga, i. Downregulation of macrophage inhibitory molecules in multiple sclerosis lesions. Ann. Neurol. 62, 504-514 (2007).
22. Du, C., et al. MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat. Immunol. 10, 1252-1259 (2009).
23. Keller, A., et al. Multiple sclerosis: microRNA expression profiles accurately differentiate patients with relapsing-remitting disease from healthy controls. PLoS ONE 4, e7440 (2009).
24. Lindberg, R. L., Hoffmann, F., Mehling, M., Kuhle, J. & Kappos, L. Altered expression of miR-17-5p in CD4+ lymphocytes of relapsing- remitting multiple sclerosis patients. Eur. J. Immunol. 40, 888-898 (2010).
25. Otaegui, D., et al. Differential micro RNA expression in pBMC from multiple sclerosis patients. PLoS ONE 4, e6309 (2009).
26. Steinman, L. A rush to judgment on Th17. J. Exp. Med. 205, 1517-1522 (2008).
27. Tzartos, J. S., et al. interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. Am. J. Pathol. 172, 146-155 (2008).
28. Dugas, J. C., et al. Dicer1 and miR-219 are required for normal oligodendrocyte differentiation and myelination. Neuron 65, 597-611 (2010).
29. Zhao, X., et al. MicroRNA-mediated control of oligodendrocyte differentiation. Neuron 65, 612-626 (2010).
30. Shin, D., Shin, J. Y., McManus, M. T., ptácek, L. J. & Fu, Y. H. Dicer ablation in oligodendrocytes provokes neuronal impairment in mice. Ann. Neurol. 66, 843-857 (2009).
31. Nave, K. A. Oligodendrocytes and the "micro brake" of progenitor cell proliferation. Neuron 65, 577-579 (2010).
32. Kassmann, C. M., et al. Axonal loss and neuroinflammation caused by peroxisomedeficient oligodendrocytes. Nat. Genet. 39, 969-976 (2007).
33. Budde, H., et al. Control of oligodendroglial cell number by the miR-17-92 cluster. Development 137, 2127-2132 (2010).
34. Lin, S. T. & Fu, Y. H. miR-23 regulation of lamin B1 is crucial for oligodendrocyte development and myelination. Dis. Model. Mech. 2, 178-188 (2009).
35. pedersen, i. M., et al. interferon modulation of cellular microRNAs as an antiviral mechanism. Nature 449, 919-922 (2007).
36. Rainer, J., et al. Glucocorticoid-regulated microRNAs and mirtrons in acute lymphoblastic leukemia. Leukemia 23, 746-752 (2009).
37. Jackson, A. L. & Linsley, p. S. Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application. Nat. Rev. Drug Discov. 9, 57-67 (2010).
38. Medina, p. p. & Slack, F. J. inhibiting microRNA function in vivo. Nat. Methods 6, 37-38 (2009).
39. Davis, S., Lollo, B., Freier, S. & esau, C. improved targeting of miRNA with antisense oligonucleotides. Nucleic Acids Res. 34, 2294-2304 (2006).
40. Krtzfeldt, J., et al. Silencing of microRNAs in vivo with antagomirs. Nature 438, 685-689 (2005).
41. Chang, A., Tourtellotte, W. W., Rudick, R. & Trapp, B. D. premyelinating oligodendrocytes in chronic lesions of multiple sclerosis. N. Engl. J. Med. 346, 165-173 (2002).
42. Kuhlmann, T., et al. Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis. Brain 131, 1749-1758 (2008).
43. Letzen, B. S., et al. MicroRNA expression profiling of oligodendrocyte differentiation from human embryonic stem cells. PLoS ONE 5, e10480 (2010).