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Volumn 300, Issue 1, 2011, Pages

Vascular complications of cystathionine β-synthase deficiency: Future directions for homocysteine-to-hydrogen sulfide research

Author keywords

Arteriosclerosis; Disease risk factors; Thrombosis; Transsulfuration

Indexed keywords

CYSTATHIONINE BETA SYNTHASE; HOMOCYSTEINE; HYDROGEN SULFIDE; MICRORNA; MUSCIMOL; SIMVASTATIN;

EID: 78651339218     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00598.2010     Document Type: Review
Times cited : (99)

References (187)
  • 1
    • 0023243363 scopus 로고
    • Psychiatric manifestations of homocystinuria due to cystathionine β-synthase deficiency: Prevalence, natural history, and relationship to neurologic impairment and vitamin B6-responsiveness
    • Abbott MH, Folstein SE, Abbey H, Pyeritz RE. Psychiatric manifestations of homocystinuria due to cystathionine β-synthase deficiency: prevalence, natural history, and relationship to neurologic impairment and vitamin B6-responsiveness. Am J Med Genet 26: 959-969, 1987.
    • (1987) Am J Med Genet , vol.26 , pp. 959-969
    • Abbott, M.H.1    Folstein, S.E.2    Abbey, H.3    Pyeritz, R.E.4
  • 2
    • 0029876402 scopus 로고    scopus 로고
    • The possible role of hydrogen sulfide as an endogenous neuromodulator
    • Abe K, Kimura H. The possible role of hydrogen sulfide as an endogenous neuromodulator. J Neurosci 16: 1066-1071, 1996.
    • (1996) J Neurosci , vol.16 , pp. 1066-1071
    • Abe, K.1    Kimura, H.2
  • 4
    • 45749150751 scopus 로고    scopus 로고
    • Genetic background conversion ameliorates semi-lethality and permits behavioral analyses in cystathionine β-synthase-deficient mice, an animal model for hyperhomocysteinemia
    • Akahoshi N, Kobayashi C, Ishizaki Y, Izumi T, Himi T, Suematsu M, Ishii I. Genetic background conversion ameliorates semi-lethality and permits behavioral analyses in cystathionine β-synthase-deficient mice, an animal model for hyperhomocysteinemia. Hum Mol Genet 17: 1994-2005, 2008.
    • (2008) Hum Mol Genet , vol.17 , pp. 1994-2005
    • Akahoshi, N.1    Kobayashi, C.2    Ishizaki, Y.3    Izumi, T.4    Himi, T.5    Suematsu, M.6    Ishii, I.7
  • 5
    • 43049176549 scopus 로고    scopus 로고
    • Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: A randomized trial
    • Albert CM, Cook NR, Gaziano JM, Zaharris E, MacFadyen J, Danielson E, Buring JE, Manson JE. Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial. JAMA 299: 2027-2036, 2008.
    • (2008) JAMA , vol.299 , pp. 2027-2036
    • Albert, C.M.1    Cook, N.R.2    Gaziano, J.M.3    Zaharris, E.4    MacFadyen, J.5    Danielson, E.6    Buring, J.E.7    Manson, J.E.8
  • 8
    • 0036141841 scopus 로고    scopus 로고
    • Xanthine oxidase-derived reactive oxygen species convert flow-induced arteriolar dilation to constriction in hyperhomocysteinemia: Possible role of peroxynitrite
    • Bagi Z, Ungvari Z, Koller A. Xanthine oxidase-derived reactive oxygen species convert flow-induced arteriolar dilation to constriction in hyperhomocysteinemia: possible role of peroxynitrite. Arterioscler Thromb Vasc Biol 22: 28-33, 2002.
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , pp. 28-33
    • Bagi, Z.1    Ungvari, Z.2    Koller, A.3
  • 11
    • 0037112386 scopus 로고    scopus 로고
    • Structure of cerebral arterioles in cystathionine β-synthase- deficient mice
    • Baumbach GL, Sigmund CD, Bottiglieri T, Lentz SR. Structure of cerebral arterioles in cystathionine β-synthase-deficient mice. Circ Res 91: 931-937, 2002.
    • (2002) Circ Res , vol.91 , pp. 931-937
    • Baumbach, G.L.1    Sigmund, C.D.2    Bottiglieri, T.3    Lentz, S.R.4
  • 12
    • 78249269178 scopus 로고    scopus 로고
    • Extracellular transsulfuration generates hydrogen sulfide from homocysteine and protects endothelium from redox stress
    • Bearden SE, Beard RS Jr, Pfau JC. Extracellular transsulfuration generates hydrogen sulfide from homocysteine and protects endothelium from redox stress. Am J Physiol Heart Circ Physiol 299: H1568-H1576, 2010.
    • (2010) Am J Physiol Heart Circ Physiol , vol.299
    • Bearden, S.E.1    Beard Jr., R.S.2    Pfau, J.C.3
  • 16
    • 34249040510 scopus 로고    scopus 로고
    • Blood-brain barrier impairment in Alzheimer disease: Stability and functional significance
    • Bowman GL, Kaye JA, Moore M, Waichunas D, Carlson NE, Quinn JF. Blood-brain barrier impairment in Alzheimer disease: stability and functional significance. Neurology 68: 1809-1814, 2007.
    • (2007) Neurology , vol.68 , pp. 1809-1814
    • Bowman, G.L.1    Kaye, J.A.2    Moore, M.3    Waichunas, D.4    Carlson, N.E.5    Quinn, J.F.6
  • 17
    • 32544434962 scopus 로고    scopus 로고
    • Homocysteine transport by human aortic endothelial cells: Identification and properties of import systems
    • Budy B, O'Neill R, DiBello PM, Sengupta S, Jacobsen DW. Homocysteine transport by human aortic endothelial cells: identification and properties of import systems. Arch Biochem Biophys 446: 119-130, 2006.
    • (2006) Arch Biochem Biophys , vol.446 , pp. 119-130
    • Budy, B.1    O'Neill, R.2    DiBello, P.M.3    Sengupta, S.4    Jacobsen, D.W.5
  • 18
    • 34548379105 scopus 로고    scopus 로고
    • The novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylation
    • Cai WJ, Wang MJ, Moore PK, Jin HM, Yao T, Zhu YC. The novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylation. Cardiovasc Res 76: 29-40, 2007.
    • (2007) Cardiovasc Res , vol.76 , pp. 29-40
    • Cai, W.J.1    Wang, M.J.2    Moore, P.K.3    Jin, H.M.4    Yao, T.5    Zhu, Y.C.6
  • 23
    • 34548022648 scopus 로고    scopus 로고
    • Hydrogen sulfide induced neuronal death occurs via glutamate receptor and is associated with calpain activation and lysosomal rupture in mouse primary cortical neurons
    • Cheung NS, Peng ZF, Chen MJ, Moore PK, Whiteman M. Hydrogen sulfide induced neuronal death occurs via glutamate receptor and is associated with calpain activation and lysosomal rupture in mouse primary cortical neurons. Neuropharmacology 53: 505-514, 2007.
    • (2007) Neuropharmacology , vol.53 , pp. 505-514
    • Cheung, N.S.1    Peng, Z.F.2    Chen, M.J.3    Moore, P.K.4    Whiteman, M.5
  • 25
    • 0031597388 scopus 로고    scopus 로고
    • Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease
    • Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 55: 1449-1455, 1998.
    • (1998) Arch Neurol , vol.55 , pp. 1449-1455
    • Clarke, R.1    Smith, A.D.2    Jobst, K.A.3    Refsum, H.4    Sutton, L.5    Ueland, P.M.6
  • 26
    • 0029655250 scopus 로고    scopus 로고
    • Ultrastructural features of the blood-brain barrier in biopsy tissue from Alzheimer's disease patients
    • Claudio L. Ultrastructural features of the blood-brain barrier in biopsy tissue from Alzheimer's disease patients. Acta Neuropathol 91: 6-14, 1996.
    • (1996) Acta Neuropathol , vol.91 , pp. 6-14
    • Claudio, L.1
  • 30
    • 51649112963 scopus 로고    scopus 로고
    • Murine models of hyperhomocysteinemia and their vascular phenotypes
    • Dayal S, Lentz SR. Murine models of hyperhomocysteinemia and their vascular phenotypes. Arterioscler Thromb Vasc Biol 28: 1596-1605, 2008.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1596-1605
    • Dayal, S.1    Lentz, S.R.2
  • 31
    • 33749329880 scopus 로고    scopus 로고
    • Enhanced susceptibility to arterial thrombosis in a murine model of hyperhomocysteinemia
    • Dayal S, Wilson KM, Leo L, Arning E, Bottiglieri T, Lentz SR. Enhanced susceptibility to arterial thrombosis in a murine model of hyperhomocysteinemia. Blood 108: 2237-2243, 2006.
    • (2006) Blood , vol.108 , pp. 2237-2243
    • Dayal, S.1    Wilson, K.M.2    Leo, L.3    Arning, E.4    Bottiglieri, T.5    Lentz, S.R.6
  • 33
    • 77950287119 scopus 로고    scopus 로고
    • Homocysteine lowering in end-stage renal disease: Is there any cardiovascular benefit?
    • de Koning L, Hu FB. Homocysteine lowering in end-stage renal disease: is there any cardiovascular benefit? Circulation 121: 1379-1381, 2010.
    • (2010) Circulation , vol.121 , pp. 1379-1381
    • De Koning, L.1    Hu, F.B.2
  • 34
    • 21844477565 scopus 로고    scopus 로고
    • Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia
    • Devlin AM, Bottiglieri T, Domann FE, Lentz SR. Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia. J Biol Chem 280: 25506-25511, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 25506-25511
    • Devlin, A.M.1    Bottiglieri, T.2    Domann, F.E.3    Lentz, S.R.4
  • 36
    • 1642551072 scopus 로고    scopus 로고
    • The possible role of hydrogen sulfide as a smooth muscle cell proliferation inhibitor in rat cultured cells
    • Du J, Hui Y, Cheung Y, Bin G, Jiang H, Chen X, Tang C. The possible role of hydrogen sulfide as a smooth muscle cell proliferation inhibitor in rat cultured cells. Heart Vessels 19: 75-80, 2004.
    • (2004) Heart Vessels , vol.19 , pp. 75-80
    • Du, J.1    Hui, Y.2    Cheung, Y.3    Bin, G.4    Jiang, H.5    Chen, X.6    Tang, C.7
  • 38
    • 49949101867 scopus 로고    scopus 로고
    • Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: A randomized controlled trial
    • Ebbing M, Bleie O, Ueland PM, Nordrehaug JE, Nilsen DW, Vollset SE, Refsum H, Pedersen EK, Nygard O. Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: a randomized controlled trial. JAMA 300: 795-804, 2008.
    • (2008) JAMA , vol.300 , pp. 795-804
    • Ebbing, M.1    Bleie, O.2    Ueland, P.M.3    Nordrehaug, J.E.4    Nilsen, D.W.5    Vollset, S.E.6    Refsum, H.7    Pedersen, E.K.8    Nygard, O.9
  • 40
    • 0034056466 scopus 로고    scopus 로고
    • Association between high homocyst(e)ine and ischemic stroke due to large- and small-artery disease but not other etiologic subtypes of ischemic stroke
    • Eikelboom JW, Hankey GJ, Anand SS, Lofthouse E, Staples N, Baker RI. Association between high homocyst(e)ine and ischemic stroke due to large- and small-artery disease but not other etiologic subtypes of ischemic stroke. Stroke 31: 1069-1075, 2000.
    • (2000) Stroke , vol.31 , pp. 1069-1075
    • Eikelboom, J.W.1    Hankey, G.J.2    Anand, S.S.3    Lofthouse, E.4    Staples, N.5    Baker, R.I.6
  • 41
    • 33244486870 scopus 로고    scopus 로고
    • Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate reductase gene in selected Egyptian subjects
    • El-Sammak M, Kandil M, El-Hifni S, Hosni R, Ragab M. Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate reductase gene in selected Egyptian subjects. Int J Med Sci 1: 181-192, 2004.
    • (2004) Int J Med Sci , vol.1 , pp. 181-192
    • El-Sammak, M.1    Kandil, M.2    El-Hifni, S.3    Hosni, R.4    Ragab, M.5
  • 44
    • 0036583201 scopus 로고    scopus 로고
    • Hydrogen sulfide is produced in response to neuronal excitation
    • Eto K, Ogasawara M, Umemura K, Nagai Y, Kimura H. Hydrogen sulfide is produced in response to neuronal excitation. J Neurosci 22: 3386-3391, 2002.
    • (2002) J Neurosci , vol.22 , pp. 3386-3391
    • Eto, K.1    Ogasawara, M.2    Umemura, K.3    Nagai, Y.4    Kimura, H.5
  • 45
    • 0036785163 scopus 로고    scopus 로고
    • Alleviation of intrasteric inhibition by the pathogenic activation domain mutation, D444N, in human cystathionine β-synthase
    • Evande R, Blom H, Boers GH, Banerjee R. Alleviation of intrasteric inhibition by the pathogenic activation domain mutation, D444N, in human cystathionine β-synthase. Biochemistry 41: 11832-11837, 2002.
    • (2002) Biochemistry , vol.41 , pp. 11832-11837
    • Evande, R.1    Blom, H.2    Boers, G.H.3    Banerjee, R.4
  • 46
    • 31044450458 scopus 로고    scopus 로고
    • A cross-sectional study of homocysteine-, NO-levels, and CT-findings in Alzheimer dementia, vascular dementia and controls
    • Folin M, Baiguera S, Gallucci M, Conconi MT, Di Liddo R, Zanardo A, Parnigotto PP. A cross-sectional study of homocysteine-, NO-levels, and CT-findings in Alzheimer dementia, vascular dementia and controls. Biogerontology 6: 255-260, 2005.
    • (2005) Biogerontology , vol.6 , pp. 255-260
    • Folin, M.1    Baiguera, S.2    Gallucci, M.3    Conconi, M.T.4    Di Liddo, R.5    Zanardo, A.6    Parnigotto, P.P.7
  • 49
    • 0017346208 scopus 로고
    • The molecular defect in a case of (cystathionine β-synthase)- deficient homocystinuria
    • Griffiths R, Tudball N. The molecular defect in a case of (cystathionine β-synthase)-deficient homocystinuria. Eur J Biochem 74: 269-273, 1977.
    • (1977) Eur J Biochem , vol.74 , pp. 269-273
    • Griffiths, R.1    Tudball, N.2
  • 52
    • 33751527922 scopus 로고    scopus 로고
    • Hyperhomocysteinemia due to cystathionine β-synthase deficiency induces dysregulation of genes involved in hepatic lipid homeostasis in mice
    • Hamelet J, Demuth K, Paul JL, Delabar JM, Janel N. Hyperhomocysteinemia due to cystathionine β-synthase deficiency induces dysregulation of genes involved in hepatic lipid homeostasis in mice. J Hepatol 46: 151-159, 2007.
    • (2007) J Hepatol , vol.46 , pp. 151-159
    • Hamelet, J.1    Demuth, K.2    Paul, J.L.3    Delabar, J.M.4    Janel, N.5
  • 53
    • 34548224753 scopus 로고    scopus 로고
    • Mice lacking cystathionine β-synthase have lung fibrosis and air space enlargement
    • Hamelet J, Maurin N, Fulchiron R, Delabar JM, Janel N. Mice lacking cystathionine β-synthase have lung fibrosis and air space enlargement. Exp Mol Pathol 83: 249-253, 2007.
    • (2007) Exp Mol Pathol , vol.83 , pp. 249-253
    • Hamelet, J.1    Maurin, N.2    Fulchiron, R.3    Delabar, J.M.4    Janel, N.5
  • 55
    • 49649119223 scopus 로고    scopus 로고
    • Cystathionine β-synthase deficiency induces catalase-mediated hydrogen peroxide detoxification in mice liver
    • Hamelet J, Seltzer V, Petit E, Noll C, Andreau K, Delabar JM, Janel N. Cystathionine β-synthase deficiency induces catalase-mediated hydrogen peroxide detoxification in mice liver. Biochim Biophys Acta 1782: 482-488, 2008.
    • (2008) Biochim Biophys Acta , vol.1782 , pp. 482-488
    • Hamelet, J.1    Seltzer, V.2    Petit, E.3    Noll, C.4    Andreau, K.5    Delabar, J.M.6    Janel, N.7
  • 57
    • 35348921215 scopus 로고    scopus 로고
    • Review of the role of hyperhomocysteinemia and B-vitamin deficiency in neurological and psychiatric disorders- current evidence and preliminary recommendations
    • Herrmann W, Lorenzl S, Obeid R. [Review of the role of hyperhomocysteinemia and B-vitamin deficiency in neurological and psychiatric disorders- current evidence and preliminary recommendations]. Fortschr Neurol Psychiatr 75: 515-527, 2007.
    • (2007) Fortschr Neurol Psychiatr , vol.75 , pp. 515-527
    • Herrmann, W.1    Lorenzl, S.2    Obeid, R.3
  • 58
    • 17644436958 scopus 로고    scopus 로고
    • Apolipoprotein B(apoB100, apoB48)
    • Hisatomi A, Yamamoto K. [Apolipoprotein B(apoB100, apoB48)]. Nippon Rinsho 59, Suppl 2: 109-113, 2001.
    • (2001) Nippon Rinsho , vol.59 , Issue.SUPPL. 2 , pp. 109-113
    • Hisatomi, A.1    Yamamoto, K.2
  • 60
    • 0036094732 scopus 로고    scopus 로고
    • Plasma homocysteine levels, cerebrovascular risk factors, and cerebral white matter changes (leukoaraiosis) in patients with Alzheimer disease
    • Hogervorst E, Ribeiro HM, Molyneux A, Budge M, Smith AD. Plasma homocysteine levels, cerebrovascular risk factors, and cerebral white matter changes (leukoaraiosis) in patients with Alzheimer disease. Arch Neurol 59: 787-793, 2002.
    • (2002) Arch Neurol , vol.59 , pp. 787-793
    • Hogervorst, E.1    Ribeiro, H.M.2    Molyneux, A.3    Budge, M.4    Smith, A.D.5
  • 61
    • 0037164104 scopus 로고    scopus 로고
    • Homocysteine and risk of ischemic heart disease and stroke: A meta-analysis
    • Homocysteine Studies Collaboration
    • Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA 288: 2015-2022, 2002.
    • (2002) JAMA , vol.288 , pp. 2015-2022
  • 62
    • 0031589557 scopus 로고    scopus 로고
    • The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide
    • Hosoki R, Matsuki N, Kimura H. The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide. Biochem Biophys Res Commun 237: 527-531, 1997.
    • (1997) Biochem Biophys Res Commun , vol.237 , pp. 527-531
    • Hosoki, R.1    Matsuki, N.2    Kimura, H.3
  • 63
    • 44349096287 scopus 로고    scopus 로고
    • Hypertension and cerebrovascular dysfunction
    • Iadecola C, Davisson RL. Hypertension and cerebrovascular dysfunction. Cell Metab 7: 476-484, 2008.
    • (2008) Cell Metab , vol.7 , pp. 476-484
    • Iadecola, C.1    Davisson, R.L.2
  • 64
    • 27744463780 scopus 로고    scopus 로고
    • CBS domains: Structure, function, and pathology in human proteins
    • Ignoul S, Eggermont J. CBS domains: structure, function, and pathology in human proteins. Am J Physiol Cell Physiol 289: C1369-C1378, 2005.
    • (2005) Am J Physiol Cell Physiol , vol.289
    • Ignoul, S.1    Eggermont, J.2
  • 67
    • 64049095638 scopus 로고    scopus 로고
    • The pathophysiological hypothesis of homocysteine thiolactone-mediated vascular disease
    • Jakubowski H. The pathophysiological hypothesis of homocysteine thiolactone-mediated vascular disease. J Physiol Pharmacol 59, Suppl 9: 155-167, 2008.
    • (2008) J Physiol Pharmacol , vol.59 , Issue.SUPPL. 9 , pp. 155-167
    • Jakubowski, H.1
  • 68
    • 57349180605 scopus 로고    scopus 로고
    • Mutations in cystathionine β-synthase or methylenetetrahydrofolate reductase gene increase N-homocysteinylated protein levels in humans
    • Jakubowski H, Boers GH, Strauss KA. Mutations in cystathionine β-synthase or methylenetetrahydrofolate reductase gene increase N-homocysteinylated protein levels in humans. FASEB J 22: 4071-4076, 2008.
    • (2008) FASEB J , vol.22 , pp. 4071-4076
    • Jakubowski, H.1    Boers, G.H.2    Strauss, K.A.3
  • 71
    • 34548566329 scopus 로고    scopus 로고
    • Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: A randomized controlled trial
    • Jamison RL, Hartigan P, Kaufman JS, Goldfarb DS, Warren SR, Guarino PD, Gaziano JM. Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial. JAMA 298: 1163-1170, 2007.
    • (2007) JAMA , vol.298 , pp. 1163-1170
    • Jamison, R.L.1    Hartigan, P.2    Kaufman, J.S.3    Goldfarb, D.S.4    Warren, S.R.5    Guarino, P.D.6    Gaziano, J.M.7
  • 72
    • 60249087029 scopus 로고    scopus 로고
    • Birth prevalence of homocystinuria in Central Europe: Frequency and pathogenicity of mutation c.1105C>T (p R369C) in the cystathionine β-synthase gene
    • Janosik M, Sokolova J, Janosikova B, Krijt J, Klatovska V, Kozich V. Birth prevalence of homocystinuria in Central Europe: frequency and pathogenicity of mutation c.1105C>T (p R369C) in the cystathionine β-synthase gene. J Pediatr 154: 431-437, 2009.
    • (2009) J Pediatr , vol.154 , pp. 431-437
    • Janosik, M.1    Sokolova, J.2    Janosikova, B.3    Krijt, J.4    Klatovska, V.5    Kozich, V.6
  • 75
    • 0035377355 scopus 로고    scopus 로고
    • Pyridoxal phosphate binding sites are similar in human heme-dependent and yeast heme-independent cystathionine β-synthases. Evidence from 31P NMR and pulsed EPR spectroscopy that heme and PLP cofactors are not proximal in the human enzyme
    • Kabil O, Toaka S, LoBrutto R, Shoemaker R, Banerjee R. Pyridoxal phosphate binding sites are similar in human heme-dependent and yeast heme-independent cystathionine β-synthases. Evidence from 31P NMR and pulsed EPR spectroscopy that heme and PLP cofactors are not proximal in the human enzyme. J Biol Chem 276: 19350-19355, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 19350-19355
    • Kabil, O.1    Toaka, S.2    LoBrutto, R.3    Shoemaker, R.4    Banerjee, R.5
  • 76
    • 0026915263 scopus 로고
    • The blood-brain barrier and cerebral microcirculation in Alzheimer disease
    • Kalaria RN. The blood-brain barrier and cerebral microcirculation in Alzheimer disease. Cerebrovasc Brain Metab Rev 4: 226-260, 1992.
    • (1992) Cerebrovasc Brain Metab Rev , vol.4 , pp. 226-260
    • Kalaria, R.N.1
  • 78
    • 0015868423 scopus 로고
    • A collagen defect in homocystinuria
    • Kang AH, Trelstad RL. A collagen defect in homocystinuria. J Clin Invest 52: 2571-2578, 1973.
    • (1973) J Clin Invest , vol.52 , pp. 2571-2578
    • Kang, A.H.1    Trelstad, R.L.2
  • 80
    • 0032528375 scopus 로고    scopus 로고
    • Trypsin cleavage of human cystathionine beta-synthase into an evolutionarily conserved active core: Structural and functional consequences
    • Kery V, Poneleit L, Kraus JP. Trypsin cleavage of human cystathionine beta-synthase into an evolutionarily conserved active core: structural and functional consequences. Arch Biochem Biophys 355: 222-232, 1998.
    • (1998) Arch Biochem Biophys , vol.355 , pp. 222-232
    • Kery, V.1    Poneleit, L.2    Kraus, J.P.3
  • 81
    • 55749102084 scopus 로고    scopus 로고
    • Homocysteine and its relationship to stroke subtypes in a UK black population: The south London ethnicity and stroke study
    • Khan U, Crossley C, Kalra L, Rudd A, Wolfe CD, Collinson P, Markus HS. Homocysteine and its relationship to stroke subtypes in a UK black population: the south London ethnicity and stroke study. Stroke 39: 2943-2949, 2008.
    • (2008) Stroke , vol.39 , pp. 2943-2949
    • Khan, U.1    Crossley, C.2    Kalra, L.3    Rudd, A.4    Wolfe, C.D.5    Collinson, P.6    Markus, H.S.7
  • 82
    • 0034614354 scopus 로고    scopus 로고
    • Hydrogen sulfide induces cyclic AMP and modulates the NMDA receptor
    • Kimura H. Hydrogen sulfide induces cyclic AMP and modulates the NMDA receptor. Biochem Biophys Res Commun 267: 129-133, 2000.
    • (2000) Biochem Biophys Res Commun , vol.267 , pp. 129-133
    • Kimura, H.1
  • 83
    • 0033365298 scopus 로고    scopus 로고
    • The molecular basis of cystathionine β-synthase deficiency in Dutch patients with homocystinuria: Effect of CBS genotype on biochemical and clinical phenotype and on response to treatment
    • Kluijtmans LA, Boers GH, Kraus JP, van den Heuvel LP, Cruysberg JR, Trijbels FJ, Blom HJ. The molecular basis of cystathionine β-synthase deficiency in Dutch patients with homocystinuria: effect of CBS genotype on biochemical and clinical phenotype and on response to treatment. Am J Hum Genet 65: 59-67, 1999.
    • (1999) Am J Hum Genet , vol.65 , pp. 59-67
    • Kluijtmans, L.A.1    Boers, G.H.2    Kraus, J.P.3    Van Den Heuvel, L.P.4    Cruysberg, J.R.5    Trijbels, F.J.6    Blom, H.J.7
  • 86
    • 59349101736 scopus 로고    scopus 로고
    • Serum vitamin B12, folate, and homocysteine levels and their association with clinical and electrophysiological parameters in multiple sclerosis
    • Kocer B, Engur S, Ak F, Yilmaz M. Serum vitamin B12, folate, and homocysteine levels and their association with clinical and electrophysiological parameters in multiple sclerosis. J Clin Neurosci 16: 399-403, 2009.
    • (2009) J Clin Neurosci , vol.16 , pp. 399-403
    • Kocer, B.1    Engur, S.2    Ak, F.3    Yilmaz, M.4
  • 89
    • 0025617207 scopus 로고
    • Molecular analysis of cystathionine β-synthase-a gene on chromosome 21
    • Kraus JP. Molecular analysis of cystathionine β-synthase-a gene on chromosome 21. Prog Clin Biol Res 360: 201-214, 1990.
    • (1990) Prog Clin Biol Res , vol.360 , pp. 201-214
    • Kraus, J.P.1
  • 91
    • 0020577306 scopus 로고
    • Cystathionine β-synthase from human liver: Improved purification scheme and additional characterization of the enzyme in crude and pure form
    • Kraus JP, Rosenberg LE. Cystathionine β-synthase from human liver: improved purification scheme and additional characterization of the enzyme in crude and pure form. Arch Biochem Biophys 222: 44-52, 1983.
    • (1983) Arch Biochem Biophys , vol.222 , pp. 44-52
    • Kraus, J.P.1    Rosenberg, L.E.2
  • 94
    • 58649087623 scopus 로고    scopus 로고
    • Nitrotyrosinylation, remodeling and endothelial-myocyte uncoupling in iNOS, cystathionine β-synthase (CBS) knockouts and iNOS/CBS double knockout mice
    • Kundu S, Kumar M, Sen U, Mishra PK, Tyagi N, Metreveli N, Lominadze D, Rodriguez W, Tyagi SC. Nitrotyrosinylation, remodeling and endothelial-myocyte uncoupling in iNOS, cystathionine β-synthase (CBS) knockouts and iNOS/CBS double knockout mice. J Cell Biochem 106: 119-126, 2009.
    • (2009) J Cell Biochem , vol.106 , pp. 119-126
    • Kundu, S.1    Kumar, M.2    Sen, U.3    Mishra, P.K.4    Tyagi, N.5    Metreveli, N.6    Lominadze, D.7    Rodriguez, W.8    Tyagi, S.C.9
  • 95
    • 25444486633 scopus 로고    scopus 로고
    • Homocysteine inhibits extra-embryonic vascular development in the avian embryo
    • Latacha KS, Rosenquist TH. Homocysteine inhibits extra-embryonic vascular development in the avian embryo. Dev Dyn 234: 323-331, 2005.
    • (2005) Dev Dyn , vol.234 , pp. 323-331
    • Latacha, K.S.1    Rosenquist, T.H.2
  • 96
    • 0030610779 scopus 로고    scopus 로고
    • Homocysteine and vascular dysfunction
    • Lentz SR. Homocysteine and vascular dysfunction. Life Sci 61: 1205-1215, 1997.
    • (1997) Life Sci , vol.61 , pp. 1205-1215
    • Lentz, S.R.1
  • 97
    • 56349149888 scopus 로고    scopus 로고
    • Effect of folate on neointima formation and matrix metalloproteinase-9 expression after balloon injury in hyperhomocysteinemic rabbits
    • Liu F, Zhang J, Yu S, Wang R, Wang B, Lai L, Yin H, Liu G. Effect of folate on neointima formation and matrix metalloproteinase-9 expression after balloon injury in hyperhomocysteinemic rabbits. Int J Cardiol 131: 59-65, 2008.
    • (2008) Int J Cardiol , vol.131 , pp. 59-65
    • Liu, F.1    Zhang, J.2    Yu, S.3    Wang, R.4    Wang, B.5    Lai, L.6    Yin, H.7    Liu, G.8
  • 107
    • 67650753876 scopus 로고    scopus 로고
    • The treatment of hyperhomocysteinemia
    • Maron BA, Loscalzo J. The treatment of hyperhomocysteinemia. Annu Rev Med 60: 39-54, 2009.
    • (2009) Annu Rev Med , vol.60 , pp. 39-54
    • Maron, B.A.1    Loscalzo, J.2
  • 109
    • 0014545138 scopus 로고
    • Vascular pathology of homocysteinemia: Implications for the pathogenesis of arteriosclerosis
    • McCully KS. Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. Am J Pathol 56: 111-128, 1969.
    • (1969) Am J Pathol , vol.56 , pp. 111-128
    • McCully, K.S.1
  • 110
    • 0036792804 scopus 로고    scopus 로고
    • Moderately elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and Alzheimer disease in Northern Ireland
    • McIlroy SP, Dynan KB, Lawson JT, Patterson CC, Passmore AP. Moderately elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and Alzheimer disease in Northern Ireland. Stroke 33: 2351-2356, 2002.
    • (2002) Stroke , vol.33 , pp. 2351-2356
    • McIlroy, S.P.1    Dynan, K.B.2    Lawson, J.T.3    Patterson, C.C.4    Passmore, A.P.5
  • 111
    • 34247873000 scopus 로고    scopus 로고
    • Protective effect of hydrogen sulfide on balloon injury-induced neointima hyperplasia in rat carotid arteries
    • Meng QH, Yang G, Yang W, Jiang B, Wu L, Wang R. Protective effect of hydrogen sulfide on balloon injury-induced neointima hyperplasia in rat carotid arteries. Am J Pathol 170: 1406-1414, 2007.
    • (2007) Am J Pathol , vol.170 , pp. 1406-1414
    • Meng, Q.H.1    Yang, G.2    Yang, W.3    Jiang, B.4    Wu, L.5    Wang, R.6
  • 112
    • 3142749051 scopus 로고    scopus 로고
    • Cystathionine β-synthase: Structure, function, regulation, and location of homocystinuria-causing mutations
    • Miles EW, Kraus JP. Cystathionine β-synthase: structure, function, regulation, and location of homocystinuria-causing mutations. J Biol Chem 279: 29871-29874, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 29871-29874
    • Miles, E.W.1    Kraus, J.P.2
  • 113
    • 70349769626 scopus 로고    scopus 로고
    • Hydrogen sulfide improves survival after cardiac arrest and cardiopulmonary resuscitation via a nitric oxide synthase 3-dependent mechanism in mice
    • Minamishima S, Bougaki M, Sips PY, Yu JD, Minamishima YA, Elrod JW, Lefer DJ, Bloch KD, Ichinose F. Hydrogen sulfide improves survival after cardiac arrest and cardiopulmonary resuscitation via a nitric oxide synthase 3-dependent mechanism in mice. Circulation 120: 888-896, 2009.
    • (2009) Circulation , vol.120 , pp. 888-896
    • Minamishima, S.1    Bougaki, M.2    Sips, P.Y.3    Yu, J.D.4    Minamishima, Y.A.5    Elrod, J.W.6    Lefer, D.J.7    Bloch, K.D.8    Ichinose, F.9
  • 114
    • 1442354125 scopus 로고    scopus 로고
    • The molecular basis of cystathionine β-synthase (CBS) deficiency in UK and US patients with homocystinuria
    • Moat SJ, Bao L, Fowler B, Bonham JR, Walter JH, Kraus JP. The molecular basis of cystathionine β-synthase (CBS) deficiency in UK and US patients with homocystinuria. Hum Mutat 23: 206, 2004.
    • (2004) Hum Mutat , vol.23 , pp. 206
    • Moat, S.J.1    Bao, L.2    Fowler, B.3    Bonham, J.R.4    Walter, J.H.5    Kraus, J.P.6
  • 116
    • 0023939665 scopus 로고
    • The gene for cystathionine β-synthase (CBS) maps to the subtelomeric region on human chromosome 21q and to proximal mouse chromosome 17
    • Munke M, Kraus JP, Ohura T, Francke U. The gene for cystathionine β-synthase (CBS) maps to the subtelomeric region on human chromosome 21q and to proximal mouse chromosome 17. Am J Hum Genet 42: 550-559, 1988.
    • (1988) Am J Hum Genet , vol.42 , pp. 550-559
    • Munke, M.1    Kraus, J.P.2    Ohura, T.3    Francke, U.4
  • 118
    • 11144230938 scopus 로고    scopus 로고
    • Abnormal lipid metabolism in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia
    • Namekata K, Enokido Y, Ishii I, Nagai Y, Harada T, Kimura H. Abnormal lipid metabolism in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia. J Biol Chem 279: 52961-52969, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 52961-52969
    • Namekata, K.1    Enokido, Y.2    Ishii, I.3    Nagai, Y.4    Harada, T.5    Kimura, H.6
  • 119
    • 53949115908 scopus 로고    scopus 로고
    • Hydrogen sulfide and oxygen sensing in the cardiovascular system
    • Olson KR. Hydrogen sulfide and oxygen sensing in the cardiovascular system. Antioxid Redox Signal 211: 2727-2734, 2008.
    • (2008) Antioxid Redox Signal , vol.211 , pp. 2727-2734
    • Olson, K.R.1
  • 126
    • 0036833378 scopus 로고    scopus 로고
    • Plasma homocysteine and malondialdehyde are correlated in an age-and gender-specific manner
    • Powers RW, Majors AK, Lykins DL, Sims CJ, Lain KY, Roberts JM. Plasma homocysteine and malondialdehyde are correlated in an age-and gender-specific manner. Metabolism 51: 1433-1438, 2002.
    • (2002) Metabolism , vol.51 , pp. 1433-1438
    • Powers, R.W.1    Majors, A.K.2    Lykins, D.L.3    Sims, C.J.4    Lain, K.Y.5    Roberts, J.M.6
  • 127
    • 77958110849 scopus 로고    scopus 로고
    • Development of hydrogen sulfide-based therapeutics for cardiovascular disease
    • Predmore BL, Lefer DJ. Development of hydrogen sulfide-based therapeutics for cardiovascular disease. J Cardiovasc Transl Res 3: 487-498, 2010.
    • (2010) J Cardiovasc Transl Res , vol.3 , pp. 487-498
    • Predmore, B.L.1    Lefer, D.J.2
  • 128
    • 0014299811 scopus 로고
    • A case of homocystinuria with noteworthy dermatological features
    • Price J, Vickers CF, Brooker BK. A case of homocystinuria with noteworthy dermatological features. J Ment Defic Res 12: 111-118, 1968.
    • (1968) J Ment Defic Res , vol.12 , pp. 111-118
    • Price, J.1    Vickers, C.F.2    Brooker, B.K.3
  • 131
    • 0032771090 scopus 로고    scopus 로고
    • Folic acid and homocyst(e)ine metabolic defects and the risk of placental abruption, pre-eclampsia and spontaneous pregnancy loss: A systematic review
    • Ray JG, Laskin CA. Folic acid and homocyst(e)ine metabolic defects and the risk of placental abruption, pre-eclampsia and spontaneous pregnancy loss: a systematic review. Placenta 20: 519-529, 1999.
    • (1999) Placenta , vol.20 , pp. 519-529
    • Ray, J.G.1    Laskin, C.A.2
  • 133
    • 4844225373 scopus 로고    scopus 로고
    • Hyperkeratosis in cystathionine β-synthase-deficient mice: An animal model of hyperhomocysteinemia
    • Robert K, Maurin N, Ledru A, Delabar J, Janel N. Hyperkeratosis in cystathionine β-synthase-deficient mice: an animal model of hyperhomocysteinemia. Anat Rec A Discov Mol Cell Evol Biol 280: 1072-1076, 2004.
    • (2004) Anat Rec A Discov Mol Cell Evol Biol , vol.280 , pp. 1072-1076
    • Robert, K.1    Maurin, N.2    Ledru, A.3    Delabar, J.4    Janel, N.5
  • 141
    • 43549091613 scopus 로고    scopus 로고
    • Association of plasma total homocysteine levels with subclinical brain injury: Cerebral volumes, white matter hyperintensity, and silent brain infarcts at volumetric magnetic resonance imaging in the Framingham Offspring Study
    • Seshadri S, Wolf PA, Beiser AS, Selhub J, Au R, Jacques PF, Yoshita M, Rosenberg IH, D'Agostino RB, DeCarli C. Association of plasma total homocysteine levels with subclinical brain injury: cerebral volumes, white matter hyperintensity, and silent brain infarcts at volumetric magnetic resonance imaging in the Framingham Offspring Study. Arch Neurol 65: 642-649, 2008.
    • (2008) Arch Neurol , vol.65 , pp. 642-649
    • Seshadri, S.1    Wolf, P.A.2    Beiser, A.S.3    Selhub, J.4    Au, R.5    Jacques, P.F.6    Yoshita, M.7    Rosenberg, I.H.8    D'Agostino, R.B.9    DeCarli, C.10
  • 142
    • 3042730959 scopus 로고    scopus 로고
    • eNOS at a glance
    • Sessa WC. eNOS at a glance. J Cell Sci 117: 2427-2429, 2004.
    • (2004) J Cell Sci , vol.117 , pp. 2427-2429
    • Sessa, W.C.1
  • 143
    • 22244435580 scopus 로고    scopus 로고
    • Proteomic analysis of homocysteine inhibition of microvascular endothelial cell angiogenesis
    • Shastry S, Tyagi N, Hayden MR, Tyagi SC. Proteomic analysis of homocysteine inhibition of microvascular endothelial cell angiogenesis. Cell Mol Biol (Noisy-le-grand) 50: 931-937, 2004.
    • (2004) Cell Mol Biol (Noisy-le-grand) , vol.50 , pp. 931-937
    • Shastry, S.1    Tyagi, N.2    Hayden, M.R.3    Tyagi, S.C.4
  • 144
    • 77955878803 scopus 로고    scopus 로고
    • OxLDL-induced decrease in lipid order of membrane domains is inversely correlated with endothelial stiffness and network formation
    • Shentu TP, Titushkin I, Singh DK, Gooch KJ, Subbaiah PV, Cho M, Levitan I. oxLDL-induced decrease in lipid order of membrane domains is inversely correlated with endothelial stiffness and network formation. Am J Physiol Cell Physiol 299: C218-C229, 2010.
    • (2010) Am J Physiol Cell Physiol , vol.299
    • Shentu, T.P.1    Titushkin, I.2    Singh, D.K.3    Gooch, K.J.4    Subbaiah, P.V.5    Cho, M.6    Levitan, I.7
  • 145
    • 34249809406 scopus 로고    scopus 로고
    • Properties of an unusual heme cofactor in PLP-dependent cystathionine beta-synthase
    • Singh S, Madzelan P, Banerjee R. Properties of an unusual heme cofactor in PLP-dependent cystathionine beta-synthase. Nat Prod Rep 24: 631-639, 2007.
    • (2007) Nat Prod Rep , vol.24 , pp. 631-639
    • Singh, S.1    Madzelan, P.2    Banerjee, R.3
  • 146
    • 0031922362 scopus 로고    scopus 로고
    • A population study on blood-brain barrier function in 85-year-olds: Relation to Alzheimer's disease and vascular dementia
    • Skoog I, Wallin A, Fredman P, Hesse C, Aevarsson O, Karlsson I, Gottfries CG, Blennow K. A population study on blood-brain barrier function in 85-year-olds: relation to Alzheimer's disease and vascular dementia. Neurology 50: 966-971, 1998.
    • (1998) Neurology , vol.50 , pp. 966-971
    • Skoog, I.1    Wallin, A.2    Fredman, P.3    Hesse, C.4    Aevarsson, O.5    Karlsson, I.6    Gottfries, C.G.7    Blennow, K.8
  • 147
    • 0029852838 scopus 로고    scopus 로고
    • A 68-bp insertion found in a homocystinuric patient is a common variant and is skipped by alternative splicing of the cystathionine β-synthase mRNA
    • Sperandeo MP, de Franchis R, Andria G, Sebastio G. A 68-bp insertion found in a homocystinuric patient is a common variant and is skipped by alternative splicing of the cystathionine β-synthase mRNA. Am J Hum Genet 59: 1391-1393, 1996.
    • (1996) Am J Hum Genet , vol.59 , pp. 1391-1393
    • Sperandeo, M.P.1    De Franchis, R.2    Andria, G.3    Sebastio, G.4
  • 148
    • 0031862071 scopus 로고    scopus 로고
    • Hyperhomocysteinemia and atherosclerotic vascular disease: Pathophysiology, screening, and treatment
    • Stein JH, McBride PE. Hyperhomocysteinemia and atherosclerotic vascular disease: pathophysiology, screening, and treatment. Off Arch Intern Med 158: 1301-1306, 1998.
    • (1998) Off Arch Intern Med , vol.158 , pp. 1301-1306
    • Stein, J.H.1    McBride, P.E.2
  • 150
    • 35748959038 scopus 로고    scopus 로고
    • Hydrogen sulphide and its therapeutic potential
    • Szabo C. Hydrogen sulphide and its therapeutic potential. Nat Rev Drug Discov 6: 917-935, 2007.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 917-935
    • Szabo, C.1
  • 153
    • 1342309318 scopus 로고    scopus 로고
    • Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: The Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial
    • Toole JF, Malinow MR, Chambless LE, Spence JD, Pettigrew LC, Howard VJ, Sides EG, Wang CH, Stampfer M. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the
    • (2004) JAMA , vol.291 , pp. 565-575
    • Toole, J.F.1    Malinow, M.R.2    Chambless, L.E.3    Spence, J.D.4    Pettigrew, L.C.5    Howard, V.J.6    Sides, E.G.7    Wang, C.H.8    Stampfer, M.9
  • 154
    • 76549093011 scopus 로고    scopus 로고
    • Blood-brain barrier permeability is increased in normal-appearing white matter in patients with lacunar stroke and leucoaraiosis
    • Topakian R, Barrick TR, Howe FA, Markus HS. Blood-brain barrier permeability is increased in normal-appearing white matter in patients with lacunar stroke and leucoaraiosis. J Neurol Neurosurg Psychiatry 81: 192-197, 2010.
    • (2010) J Neurol Neurosurg Psychiatry , vol.81 , pp. 192-197
    • Topakian, R.1    Barrick, T.R.2    Howe, F.A.3    Markus, H.S.4
  • 155
    • 25644434756 scopus 로고    scopus 로고
    • The central nervous system in animal models of hyperhomocysteinemia
    • Troen AM. The central nervous system in animal models of hyperhomocysteinemia. Prog Neuropsychopharmacol Biol Psychiatry 29: 1140-1151, 2005.
    • (2005) Prog Neuropsychopharmacol Biol Psychiatry , vol.29 , pp. 1140-1151
    • Troen, A.M.1
  • 157
    • 0029829735 scopus 로고    scopus 로고
    • High prevalence of a mutation in the cystathionine beta-synthase gene
    • Tsai MY, Bignell M, Schwichtenberg K, Hanson NQ. High prevalence of a mutation in the cystathionine beta-synthase gene. Am J Hum Genet 59: 1262-1267, 1996.
    • (1996) Am J Hum Genet , vol.59 , pp. 1262-1267
    • Tsai, M.Y.1    Bignell, M.2    Schwichtenberg, K.3    Hanson, N.Q.4
  • 158
    • 77149155639 scopus 로고    scopus 로고
    • Hydrogen sulfide mitigates matrix metalloproteinase-9 activity and neurovascular permeability in hyperhomocysteinemic mice
    • Tyagi N, Givvimani S, Qipshidze N, Kundu S, Kapoor S, Vacek JC, Tyagi SC. Hydrogen sulfide mitigates matrix metalloproteinase-9 activity and neurovascular permeability in hyperhomocysteinemic mice. Neurochem Int 56: 301-307, 2010.
    • (2010) Neurochem Int , vol.56 , pp. 301-307
    • Tyagi, N.1    Givvimani, S.2    Qipshidze, N.3    Kundu, S.4    Kapoor, S.5    Vacek, J.C.6    Tyagi, S.C.7
  • 160
    • 3442894794 scopus 로고    scopus 로고
    • Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model
    • Ujiie M, Dickstein DL, Carlow DA, Jefferies WA. Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model. Microcirculation 10: 463-470, 2003.
    • (2003) Microcirculation , vol.10 , pp. 463-470
    • Ujiie, M.1    Dickstein, D.L.2    Carlow, D.A.3    Jefferies, W.A.4
  • 161
    • 2542618547 scopus 로고    scopus 로고
    • Autoantibodies against N-homocysteinylated proteins in humans: Implications for atherosclerosis
    • Undas A, Perla J, Lacinski M, Trzeciak W, Kazmierski R, Jakubowski H. Autoantibodies against N-homocysteinylated proteins in humans: implications for atherosclerosis. Stroke 35: 1299-1304, 2004.
    • (2004) Stroke , vol.35 , pp. 1299-1304
    • Undas, A.1    Perla, J.2    Lacinski, M.3    Trzeciak, W.4    Kazmierski, R.5    Jakubowski, H.6
  • 165
    • 0037164375 scopus 로고    scopus 로고
    • Homocysteine and cardiovascular disease: Evidence on causality from a meta-analysis
    • Wald DS, Law M, Morris JK. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. Br Med J 325: 1202, 2002.
    • (2002) Br Med J , vol.325 , pp. 1202
    • Wald, D.S.1    Law, M.2    Morris, J.K.3
  • 166
    • 0037926903 scopus 로고    scopus 로고
    • Hyperhomocysteinemia accelerates atherosclerosis in cystathionine β-synthase and apolipoprotein E double knock-out mice with and without dietary perturbation
    • Wang H, Jiang X, Yang F, Gaubatz JW, Ma L, Magera MJ, Yang X, Berger PB, Durante W, Pownall HJ, Schafer AI. Hyperhomocysteinemia accelerates atherosclerosis in cystathionine β-synthase and apolipoprotein E double knock-out mice with and without dietary perturbation. Blood 101: 3901-3907, 2003.
    • (2003) Blood , vol.101 , pp. 3901-3907
    • Wang, H.1    Jiang, X.2    Yang, F.3    Gaubatz, J.W.4    Ma, L.5    Magera, M.J.6    Yang, X.7    Berger, P.B.8    Durante, W.9    Pownall, H.J.10    Schafer, A.I.11
  • 167
    • 26444570966 scopus 로고    scopus 로고
    • Expression of mutant human cystathionine β-synthase rescues neonatal lethality but not homocystinuria in a mouse model
    • Wang L, Chen X, Tang B, Hua X, Klein-Szanto A, Kruger WD. Expression of mutant human cystathionine β-synthase rescues neonatal lethality but not homocystinuria in a mouse model. Hum Mol Genet 14: 2201-2208, 2005.
    • (2005) Hum Mol Genet , vol.14 , pp. 2201-2208
    • Wang, L.1    Chen, X.2    Tang, B.3    Hua, X.4    Klein-Szanto, A.5    Kruger, W.D.6
  • 168
    • 77950796610 scopus 로고    scopus 로고
    • The hydrogen sulfide donor NaHS promotes angiogenesis in a rat model of hind limb ischemia
    • Wang MJ, Cai WJ, Li N, Ding YJ, Chen Y, Zhu YC. The hydrogen sulfide donor NaHS promotes angiogenesis in a rat model of hind limb ischemia. Antioxid Redox Signal 12: 1065-1077, 2010.
    • (2010) Antioxid Redox Signal , vol.12 , pp. 1065-1077
    • Wang, M.J.1    Cai, W.J.2    Li, N.3    Ding, Y.J.4    Chen, Y.5    Zhu, Y.C.6
  • 171
    • 0037338557 scopus 로고    scopus 로고
    • Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia?
    • Wardlaw JM, Sandercock PA, Dennis MS, Starr J. Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia? Stroke 34: 806-812, 2003.
    • (2003) Stroke , vol.34 , pp. 806-812
    • Wardlaw, J.M.1    Sandercock, P.A.2    Dennis, M.S.3    Starr, J.4
  • 173
    • 0036144873 scopus 로고    scopus 로고
    • Cellular redox state and endothelial dysfunction in mildly hyperhomocysteinemic cystathionine β-synthase-deficient mice
    • Weiss N, Heydrick S, Zhang YY, Bierl C, Cap A, Loscalzo J. Cellular redox state and endothelial dysfunction in mildly hyperhomocysteinemic cystathionine β-synthase-deficient mice. Arterioscler Thromb Vasc Biol 22: 34-41, 2002.
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , pp. 34-41
    • Weiss, N.1    Heydrick, S.2    Zhang, Y.Y.3    Bierl, C.4    Cap, A.5    Loscalzo, J.6
  • 174
    • 0345169177 scopus 로고    scopus 로고
    • Influence of hyperhomocysteinemia on the cellular redox state-impact on homocysteine-induced endothelial dysfunction
    • Weiss N, Heydrick SJ, Postea O, Keller C, Keaney JF Jr, Loscalzo J. Influence of hyperhomocysteinemia on the cellular redox state-impact on homocysteine-induced endothelial dysfunction. Clin Chem Lab Med 41: 1455-1461, 2003.
    • (2003) Clin Chem Lab Med , vol.41 , pp. 1455-1461
    • Weiss, N.1    Heydrick, S.J.2    Postea, O.3    Keller, C.4    Keaney Jr., J.F.5    Loscalzo, J.6
  • 176
    • 33645102456 scopus 로고    scopus 로고
    • Evidence for the formation of a novel nitrosothiol from the gaseous mediators nitric oxide and hydrogen sulphide
    • Whiteman M, Li L, Kostetski I, Chu SH, Siau JL, Bhatia M, Moore PK. Evidence for the formation of a novel nitrosothiol from the gaseous mediators nitric oxide and hydrogen sulphide. Biochem Biophys Res Commun 343: 303-310, 2006.
    • (2006) Biochem Biophys Res Commun , vol.343 , pp. 303-310
    • Whiteman, M.1    Li, L.2    Kostetski, I.3    Chu, S.H.4    Siau, J.L.5    Bhatia, M.6    Moore, P.K.7
  • 178
    • 0020348267 scopus 로고
    • Evidence for blood-brain barrier changes in senile dementia of the Alzheimer type (SDAT)
    • Wisniewski HM, Kozlowski PB. Evidence for blood-brain barrier changes in senile dementia of the Alzheimer type (SDAT). Ann NY Acad Sci 396: 119-129, 1982.
    • (1982) Ann NY Acad Sci , vol.396 , pp. 119-129
    • Wisniewski, H.M.1    Kozlowski, P.B.2
  • 179
    • 33745672761 scopus 로고    scopus 로고
    • Hyperhomocysteinemia is associated with volumetric white matter change in patients with small vessel disease
    • Wong A, Mok V, Fan YH, Lam WW, Liang KS, Wong KS. Hyperhomocysteinemia is associated with volumetric white matter change in patients with small vessel disease. J Neurol 253: 441-447, 2006.
    • (2006) J Neurol , vol.253 , pp. 441-447
    • Wong, A.1    Mok, V.2    Fan, Y.H.3    Lam, W.W.4    Liang, K.S.5    Wong, K.S.6
  • 180
    • 20444410004 scopus 로고    scopus 로고
    • Total homocysteine is associated with white matter hyperintensity volume: The Northern Manhattan Study
    • Wright CB, Paik MC, Brown TR, Stabler SP, Allen RH, Sacco RL, DeCarli C. Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan Study. Stroke 36: 1207-1211, 2005.
    • (2005) Stroke , vol.36 , pp. 1207-1211
    • Wright, C.B.1    Paik, M.C.2    Brown, T.R.3    Stabler, S.P.4    Allen, R.H.5    Sacco, R.L.6    DeCarli, C.7
  • 181
    • 9444270380 scopus 로고    scopus 로고
    • Hydrogen sulfide-induced apoptosis of human aorta smooth muscle cells via the activation of mitogen-activated protein kinases and caspase-3
    • Yang G, Sun X, Wang R. Hydrogen sulfide-induced apoptosis of human aorta smooth muscle cells via the activation of mitogen-activated protein kinases and caspase-3. FASEB J 18: 1782-1784, 2004.
    • (2004) FASEB J , vol.18 , pp. 1782-1784
    • Yang, G.1    Sun, X.2    Wang, R.3
  • 182
    • 72449210573 scopus 로고    scopus 로고
    • Hyperhomocysteinemia promotes inflammatory monocyte generation and accelerates atherosclerosis in transgenic cystathionine β-synthase- deficient mice
    • Zhang D, Jiang X, Fang P, Yan Y, Song J, Gupta S, Schafer AI, Durante W, Kruger WD, Yang X, Wang H. Hyperhomocysteinemia promotes inflammatory monocyte generation and accelerates atherosclerosis in transgenic cystathionine β-synthase-deficient mice. Circulation 120: 1893-1902, 2009.
    • (2009) Circulation , vol.120 , pp. 1893-1902
    • Zhang, D.1    Jiang, X.2    Fang, P.3    Yan, Y.4    Song, J.5    Gupta, S.6    Schafer, A.I.7    Durante, W.8    Kruger, W.D.9    Yang, X.10    Wang, H.11
  • 184
    • 76749128435 scopus 로고    scopus 로고
    • Acceleration of brain amyloidosis in an Alzheimer's disease mouse model by a folate, vitamin B6 and B12-deficient diet
    • Zhuo JM, Pratico D. Acceleration of brain amyloidosis in an Alzheimer's disease mouse model by a folate, vitamin B6 and B12-deficient diet. Exp Gerontol 45: 195-201.
    • Exp Gerontol , vol.45 , pp. 195-201
    • Zhuo, J.M.1    Pratico, D.2
  • 185
    • 0038664379 scopus 로고    scopus 로고
    • Role of group I metabotropic glutamate receptors and NMDA receptors in homocysteine-evoked acute neurodegeneration of cultured cerebellar granule neurones
    • Zieminska E, Stafiej A, Lazarewicz JW. Role of group I metabotropic glutamate receptors and NMDA receptors in homocysteine-evoked acute neurodegeneration of cultured cerebellar granule neurones. Neurochem Int 43: 481-492, 2003.
    • (2003) Neurochem Int , vol.43 , pp. 481-492
    • Zieminska, E.1    Stafiej, A.2    Lazarewicz, J.W.3
  • 186
    • 77349104558 scopus 로고    scopus 로고
    • Elevated homocysteine levels in Parkinson's disease: Is there anything besides L-Dopa treatment?
    • Zoccolella S, Dell'aquila C, Specchio LM, Logroscino G, Lamberti P. Elevated homocysteine levels in Parkinson's disease: is there anything besides L-Dopa treatment? Curr Med Chem; http://www.benthamdirect. org/pages/content. php?cmc/2010/00000017/00000003/0003C.SGM.
    • Curr Med Chem
    • Zoccolella, S.1    Dell'Aquila, C.2    Specchio, L.M.3    Logroscino, G.4    Lamberti, P.5
  • 187
    • 0038269014 scopus 로고    scopus 로고
    • Tumor necrosis factor-α-induced targeted proteolysis of cystathionine beta-synthase modulates redox homeostasis
    • Zou CG, Banerjee R. Tumor necrosis factor-α-induced targeted proteolysis of cystathionine beta-synthase modulates redox homeostasis. J Biol Chem 278: 16802-16808, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 16802-16808
    • Zou, C.G.1    Banerjee, R.2


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