Selective detection of hyperpolarized NMR signals derived from para-hydrogen using the only Para-hydrogen SpectroscopY (OPSY) approach

Journal of Magnetic Resonance

Volumn 208, Issue 1, 2011, Pages 49-57

  Aguilar, Juan A ^a,b   Adams, Ralph W ^a   Duckett, Simon B ^a,b   Green, Gary G R ^a   Kandiah, Rathika ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Coherence order selection; Double quantum (DQ); Hydrogenation; Hyperpolarization; Multiple quantum; para hydrogen; Pulsed field gradients; Signal Amplification By Reversible Exchange (SABRE); Solvent suppression; Zero quantum (ZQ)

Indexed keywords

DOUBLE QUANTUM (DQ); HYPERPOLARIZATION; MULTIPLE QUANTUM; ORDER SELECTION; PARA-HYDROGEN; PULSED FIELD GRADIENTS; SIGNAL AMPLIFICATIONS; SOLVENT SUPPRESSION; ZERO QUANTUM (ZQ);

AMPLIFICATION; HYDROGEN; HYDROGENATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SIGNAL PROCESSING;

QUANTUM THEORY;

HYDROGEN;

ALGORITHM; ARTICLE; CHEMISTRY; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SIGNAL PROCESSING;

ALGORITHMS; HYDROGEN; MAGNETIC RESONANCE SPECTROSCOPY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SIGNAL PROCESSING, COMPUTER-ASSISTED;

EID: 78651339073     PISSN: 10907807     EISSN: 10960856     Source Type: Journal    
DOI: 10.1016/j.jmr.2010.10.002     Document Type: Article

References (46)

1. T.C. Eisenschmid, R.U. Kirss, P.P. Deutsch, S.I. Hommeltoft, R. Eisenberg, J. Bargon, R.G. Lawler, and A.L. Balch Para hydrogen induced polarization in hydrogenation reactions J. Am. Chem. Soc. 109 1987 8089 8091
2. C.R. Bowers, and D.P. Weitekamp Para-hydrogen and synthesis allow dramatically enhanced nuclear alignment J. Am. Chem. Soc. 109 1987 5541 5542
3. C.R. Bowers, and D.P. Weitekamp Transformation of symmetrization order to nuclear-spin magnetization by chemical-reaction and nuclear-magnetic-resonance Phys. Rev. Lett. 57 1986 2645 2648
4. L.T. Kuhn, J. Bargon, Transfer of parahydrogen-induced hyperpolarization to heteronuclei, in: In Situ NMR Methods in Catalysis, 2007, pp. 25-68.
5. E.Y. Chekmenev, J. Hovener, V.A. Norton, K. Harris, L.S. Batchelder, P. Bhattacharya, B.D. Ross, and D.P. Weitekamp PASADENA hyperpolarization of succinic acid for MRI and NMR spectroscopy J. Am. Chem. Soc. 130 2008 4212 4213
6. S.B. Duckett, and C.J. Sleigh Applications of the parahydrogen phenomenon: a chemical perspective Prog. Nucl. Magn. Reson. Spectrosc. 34 1999 71 92
7. C. Godard, S.B. Duckett, S. Polas, R. Tooze, and A.C. Whitwood Detection of intermediates in cobalt-catalyzed hydroformylation using para-hydrogen- induced polarization J. Am. Chem. Soc. 127 2005 4994 4995
8. A. Viale, D. Santelia, R. Napolitano, R. Gobetto, W. Dastru, and S. Aime The detection of PHIP effects allows new insights into the mechanism of olefin isomerisation during catalytic-hydrogenation Eur. J. Inorg. Chem. 2008 4348 4351
9. M. Stephan, O. Kohlmann, H.G. Niessen, A. Eichhorn, and J. Bargon Carbon-13 PHIP NMR spectra and polarization transfer during the homogeneous hydrogenation of alkynes with parahydrogen Magn. Reson. Chem. 40 2002 157 160
10. L.T. Kuhn, U. Bommerich, and J. Bargon Transfer of parahydrogen-induced hyperpolarization to F-19 J. Phys. Chem. A 110 2006 3521 3526
11. J. Lopez-Serrano, S.B. Duckett, S. Aiken, K.Q.A. Lenero, E. Drent, J.P. Dunne, D. Konya, and A.C. Whitwood A para-hydrogen investigation of palladium-catalyzed alkyne hydrogenation J. Am. Chem. Soc. 129 2007 6513 6527
12. H. Johannesson, O. Axelsson, and M. Karlsson Transfer of para-hydrogen spin order into polarization by diabatic field cycling C. R. Phys. 5 2004 315 324
13. M. Goldman, and H. Johannesson Conversion of a proton pair para order into carbon-13 polarization by rf irradiation, for use in MRI C. R. Phys. 6 2005 575 581
14. J. Wolber, F. Ellner, B. Fridlund, A. Gram, H. Johannesson, G. Hansson, L.H. Hansson, M.H. Lerche, S. Mansson, R. Servin, M. Thaning, K. Golman, and J.H. Ardenkjaer-Larsen Generating highly polarized nuclear spins in solution using dynamic nuclear polarization Nuclear Instruments & Methods in Physics Research Section a-Accelerators Spectrometers Detectors and Associated Equipment 526 2004 173 181
15. H. Johanneson, S. Macholl, and J.H. Ardenkjaer-Larsen Dynamic nuclear polarization of 1-carbon-13 pyruvic acid at 4.6 T J. Magn. Reson. 197 2009 167 175
16. K. Golman, and J.S. Petersson Metabolic imaging and other applications of hyperpolarized carbon-13 Academic Radiology 13 2006 932 942
17. E.Y. Chekmenev, V.A. Norton, D.P. Weitekamp, and P. Bhattacharya Hyperpolarized H-1 NMR employing low gamma nucleus for spin polarization storage J. Am. Chem. Soc. 131 2009 3164 3165
18. R.W. Adams, J.A. Aguilar, K.D. Atkinson, M.J. Cowley, P.I.P. Elliott, S.B. Duckett, G.G.R. Green, I.G. Khazal, J. Lopez-Serrano, and D.C. Williamson Reversible Interactions with para-hydrogen enhance NMR sensitivity by polarization transfer Science 323 2009 1708 1711
19. R.W. Adams, S.B. Duckett, R.A. Green, D.C. Williamson, and G.G.R. Green A theoretical basis for spontaneous polarization transfer in non-hydrogenative parahydrogen-induced polarization J. Chem. Phys. 131 2009 194505
20. P. Hubler, R. Giernoth, G. Kummerle, and J. Bargon Investigating the kinetics of homogeneous hydrogenation reactions using PHIPNMR spectroscopy J. Am. Chem. Soc. 121 1999 5311 5318
21. S.B. Duckett, and N.J. Wood Parahydrogen-based NMR methods as a mechanistic probe in inorganic chemistry Coord. Chem. Rev. 252 2008 2278 2291
22. R. Boelens, A. Podoplelov, and R. Kaptein Separation of net polarization and multiplet effect in coupled spin systems by two-dimensional cidnp J. Magn. Reson. 69 1986 116 123
23. A. Eichhorn, A. Koch, and J. Bargon In situ PHIP NMR - a new tool to investigate hydrogenation mediated by colloidal catalysts Journal of Molecular Catalysis a - Chemical 174 2001 293 295
24. H.G. Niessen, D. Schleyer, S. Wiemann, J. Bargon, S. Steines, and B. Driessen-Hoelscher In situ PHIP NMR studies during the stereoselective hydrogenation of sorbic acid with a CpRu (+) catalyst Magn. Reson. Chem. 38 2000 747 750
25. A. Harthun, R. Giernoth, C.J. Elsevier, and J. Bargon Rhodium- and palladium-catalysed proton exchange in styrene detected in situ by para-hydrogen induced polarization Chem. Commun. (Cambridge, UK) 1996 2483 2484
26. J. Lopez-Serrano, S.B. Duckett, and A. Lledos Palladium-catalyzed hydrogenation: detection of palladium hydrides. A joint study using para-hydrogen-enhanced NMR spectroscopy and density functional theory J. Am. Chem. Soc. 128 2006 9596 9597
27. J.P. Dunne, S. Aiken, S.B. Duckett, D. Konya, K.Q.A. Lenero, and E. Drent Detection and reactivity of Pd((C8H14)PCH2CH2P(C8H14))(CHPhCH2Ph)(H) as determined by parahydrogen-enhanced NMR spectroscopy J. Am. Chem. Soc. 126 2004 16708 16709
28. J.A. Aguilar, P.I.P. Elliott, J. Lopez-Serrano, R.W. Adams, and S.B. Duckett Only para-hydrogen spectroscopy (OPSY), a technique for the selective observation of para-hydrogen enhanced NMR signals Chem. Commun. (Cambridge, UK) 2007 1183 1185
29. R. Kandiah, Applications of the Parahydrogen Phenomenon in the Biological Field, Ph.D Thesis, University of York, 2007.
30. 2] Inorg. Chem. 25 1986 931 932
31. D. Canet, C. Aroulanda, P. Mutzenhardt, S. Aime, R. Gobetto, and F. Reineri Para-hydrogen enrichment and hyperpolarization Concepts Mag. Reson. Part A 28A 2006 321 330
32. M.G. Pravica, and D.P. Weitekamp Net NMR alignment by adiabatic transport of para-hydrogen addition products to high magnetic field Chem. Phys. Lett. 145 1988 255 258
33. J. Natterer, and J. Bargon Parahydrogen induced polarization Prog. Nucl. Magn. Reson. Spectrosc. 31 1997 293 315
34. O.W. Sorensen, G.W. Eich, M.H. Levitt, G. Bodenhausen, and R.R. Ernst Product operator-formalism for the description of NMR pulse experiments Prog. Nucl. Magn. Reson. Spectrosc. 16 1983 163 192
35. P.J. Hore, J.A. Jones, and S. Wimperis NMR: The Toolkit 2000 Oxford University Press
36. J. Keeler, R.T. Clowes, A.L. Davis, and E.D. Laue Pulsed field gradients - theory and practice Nucl. Mag. Reson. C 239 1994 145
37. A. Bax, P.G. Dejong, A.F. Mehlkopf, and J. Smidt Separation of the different orders of NMR multiple-quantum transitions by the use of pulsed field gradients Chem. Phys. Lett. 69 1980 567
38. T.C. Eisenschmid, J. McDonald, R. Eisenberg, and R.G. Lawler INEPT in a chemical way - polarization transfer from para-hydrogen to P-31 by oxidative addition and dipolar relaxation J. Am. Chem. Soc. 111 1989 7267 7269
39. H. Sengstschmid, R. Freeman, J. Barkemeyer, and J. Bargon A new excitation sequence to observe the PASADENA effect Journal of Magnetic Resonance Series A 120 1996 249 257
40. S.B. Duckett, C.L. Newell, and R. Eisenberg More than INEPT - parahydrogen and INEPT+ Give unprecedented resonance enhancement to carbon-13 by direct H-1 polarization transfer J. Am. Chem. Soc. 115 1993 1156 1157
41. S.B. Duckett, G.K. Barlow, M.G. Partridge, and B.A. Messerle Rapid characterization of rhodium dihydrides by nuclear-magnetic-resonance spectroscopy using indirect 2-dimensional methods and para-hydrogen Journal of the Chemical Society-Dalton Transactions 1995 3427 3429
42. J. Natterer, J. Barkemeyer, and J. Bargon Determination of J(CC) coupling constants using parahydrogen-induced polarization Journal of Magnetic Resonance Series A 123 1996 253 256
43. M. Haake, J. Natterer, and J. Bargon Efficient NMR pulse sequences to transfer the parahydrogen-induced polarization to hetero nuclei J. Am. Chem. Soc. 118 1996 8688 8691
44. W.S. Warren, W. Richter, A.H. Andreotti, and B.T. Farmer Generation of impossible cross-peaks between bulk water and biomolecules in solution NMR Science 262 1993 2005 2009
45. R. Kaptein, and L.J. Oosterho Chemically induced dynamic nuclear polarization Chem. Phys. Lett. 4 1969 195
46. M.S. Chinn, and R. Eisenberg Rates of catalytic-hydrogenation estimated spectroscopically through enhanced resonances J. Am. Chem. Soc. 114 1992 1908 1909