Propofol in (pre)term neonates: Consider the extensive interindividual variability in clearance within the neonatal population

Paediatric Anaesthesia

Volumn 21, Issue 2, 2011, Pages 174-175

  Allegaert, Karel ^a   Peeters, Mariska Ym ^b   Knibbe, Catherijne ^b,c  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b ST ANTONIUS HOSPITAL   (Netherlands)

^c LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

PROPOFOL;

CLINICAL FEATURE; DRUG BLOOD LEVEL; DRUG CLEARANCE; HUMAN; LETTER; PREMATURITY; PRIORITY JOURNAL; PROPOFOL INFUSION SYNDROME;

ANESTHESIA, INTRAVENOUS; ANESTHETICS, INTRAVENOUS; HUMANS; INDIVIDUALIZED MEDICINE; INFANT, NEWBORN; INFANT, PREMATURE; METABOLIC CLEARANCE RATE; OVERDOSE; PROPOFOL;

EID: 78651331706     PISSN: 11555645     EISSN: 14609592     Source Type: Journal    
DOI: 10.1111/j.1460-9592.2010.03482.x     Document Type: Letter

References (5)

1. Sammartino M, Garra R, Sbaraglia F, et al. Propofol overdose in a preterm baby: may propofol infusion syndrome arise in two hours? Pediatr Anesth 2010; 20: 973-974.
2. Mani V, Morton NS,. Overview of total intravenous anesthesia in children. Pediatr Anesth 2010; 20: 211-222.
3. Peeters MY, Allegaert K, Blussé van Oud-Alblas HJ, et al. Prediction of propofol clearance in children from an allometric model developed in rats, children and adults versus a 0.75 fixed-exponent allometric model. Clin Pharmacokinet 2010; 49: 269-275.
4. Allegaert K, Peeters MY, Verbesselt R, et al. Inter-individual variability in propofol pharmacokinetics in preterm and term neonates. Br J Anaesth 2007; 17: 1028-1034.
5. Anderson BJ,. Pediatric models for adult target-controlled infusion pumps. Pediatr Anesth 2010; 20: 223-232.