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Volumn 433, Issue 2, 2011, Pages 333-343

Role of p38 MAPK pathway in BMP4-mediated Smad-dependent premature senescence in lung cancer cells

Author keywords

Bone morphogenetic protein 4 (BMP4); p38 mitogen activated protein kinase (p38 MAPK); Premature senescence; Smad1; Smad5

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN P16; PROTEIN P21; SMAD1 PROTEIN; SMAD5 PROTEIN;

EID: 78651327656     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20100404     Document Type: Article
Times cited : (16)

References (36)
  • 1
    • 21344467705 scopus 로고    scopus 로고
    • Diverse biological effect and Smad signaling of bone morphogenetic protein 7 in prostate tumor cells
    • Yang, S., Zhong, C., Frenkel, B., Reddi, AH. and Roy-Burman, P. (2005) Diverse biological effect and Smad signaling of bone morphogenetic protein 7 in prostate tumor cells. Cancer Res. 65, 5769-5777
    • (2005) Cancer Res. , vol.65 , pp. 5769-5777
    • Yang, S.1    Zhong, C.2    Frenkel, B.3    Reddi, A.H.4    Roy-Burman, P.5
  • 2
    • 0025672641 scopus 로고
    • Identification of transforming growth factor β family members present in bone-inductive protein purified from bovine bone
    • Celeste, A. J., Iannazzi, J. A., Taylor, R. C., Hewick, R. M., Rosen, V., Wang, E. A. and Wozney, J. M. (1990) Identification of transforming growth factor β family members present in bone-inductive protein purified from bovine bone. Proc. Natl. Acad. Sci. U.S.A. 87, 9843-9847
    • (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 9843-9847
    • Celeste, A.J.1    Iannazzi, J.A.2    Taylor, R.C.3    Hewick, R.M.4    Rosen, V.5    Wang, E.A.6    Wozney, J.M.7
  • 3
    • 0031909665 scopus 로고    scopus 로고
    • Role of morphogenetic proteins in skeletal tissue engineering and regeneration
    • Reddi, A. H. (1998) Role of morphogenetic proteins in skeletal tissue engineering and regeneration. Nat. Biotechnol. 16, 247-252
    • (1998) Nat. Biotechnol. , vol.16 , pp. 247-252
    • Reddi, A.H.1
  • 4
    • 21344455768 scopus 로고    scopus 로고
    • BMP receptor signaling: Transcriptional targets, regulation of signals, and signaling cross-talk
    • Miyazono, K., Maeda, S. and Imamura, T. (2005) BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk. Cytokine Growth Factor Rev. 16, 251-263
    • (2005) Cytokine Growth Factor Rev. , vol.16 , pp. 251-263
    • Miyazono, K.1    Maeda, S.2    Imamura, T.3
  • 6
    • 0035842885 scopus 로고    scopus 로고
    • The N domain of Smad7 is essential for specific inhibition of transforming growth factor-β signaling
    • Hanyu, A., Ishidou, Y., Ebisawa, T., Shimanuki, T., Imamura, T. and Miyazono, K. (2001) The N domain of Smad7 is essential for specific inhibition of transforming growth factor-β signaling. J. Cell Biol. 155, 1017-1027
    • (2001) J. Cell Biol. , vol.155 , pp. 1017-1027
    • Hanyu, A.1    Ishidou, Y.2    Ebisawa, T.3    Shimanuki, T.4    Imamura, T.5    Miyazono, K.6
  • 7
    • 0031964859 scopus 로고    scopus 로고
    • Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
    • Hata, A., Lagna, G., Massague, J. and Hemmati-Brivanlou, A. (1998) Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes Dev. 12, 186-197
    • (1998) Genes Dev. , vol.12 , pp. 186-197
    • Hata, A.1    Lagna, G.2    Massague, J.3    Hemmati-Brivanlou, A.4
  • 8
    • 12144274863 scopus 로고    scopus 로고
    • BMP4 inhibits proliferation and promotes myocyte differentiation of lung fibroblasts via Smad1 and JNK pathways
    • Jeffery, T. K., Upton, P. D., Trembath, R. C. and Morrell, N. W. (2005) BMP4 inhibits proliferation and promotes myocyte differentiation of lung fibroblasts via Smad1 and JNK pathways. Am. J. Physiol. Lung Cell. Mol. Physiol. 288, L370-L378
    • (2005) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.288
    • Jeffery, T.K.1    Upton, P.D.2    Trembath, R.C.3    Morrell, N.W.4
  • 9
    • 33645663734 scopus 로고    scopus 로고
    • Bone morphogenetic protein 4 mediates bile duct ligation induced liver fibrosis through activation of Smad1 and ERK1/2 in rat hepatic stellate cells
    • Fan, J., Shen, H., Sun, Y., Li, P., Burczynski, F., Namaka, M. and Gong, Y. (2006) Bone morphogenetic protein 4 mediates bile duct ligation induced liver fibrosis through activation of Smad1 and ERK1/2 in rat hepatic stellate cells. J. Cell. Physiol. 207, 499-505
    • (2006) J. Cell. Physiol. , vol.207 , pp. 499-505
    • Fan, J.1    Shen, H.2    Sun, Y.3    Li, P.4    Burczynski, F.5    Namaka, M.6    Gong, Y.7
  • 10
    • 1842425809 scopus 로고    scopus 로고
    • p38MAPK acts in the BMP7-dependent stimulatory pathway during epithelial cell morphogenesis and is regulated by Smad1
    • Hu, M. C., Wasserman, D., Hartwig, S. and Rosenblum, N. D. (2004) p38MAPK acts in the BMP7-dependent stimulatory pathway during epithelial cell morphogenesis and is regulated by Smad1. J. Biol. Chem. 279, 12051-12059
    • (2004) J. Biol. Chem. , vol.279 , pp. 12051-12059
    • Hu, M.C.1    Wasserman, D.2    Hartwig, S.3    Rosenblum, N.D.4
  • 12
    • 66449087481 scopus 로고    scopus 로고
    • BMP4-Smad signaling pathway mediates adriamycin-induced premature senescence in lung cancer cells
    • Su, D., Zhu, S., Han, X., Feng, Y., Huang, H., Ren, G., Pan, L., Zhang, Y., Lu, J. and Huang, B. (2009) BMP4-Smad signaling pathway mediates adriamycin-induced premature senescence in lung cancer cells. J. Biol. Chem. 284, 12153-12164
    • (2009) J. Biol. Chem. , vol.284 , pp. 12153-12164
    • Su, D.1    Zhu, S.2    Han, X.3    Feng, Y.4    Huang, H.5    Ren, G.6    Pan, L.7    Zhang, Y.8    Lu, J.9    Huang, B.10
  • 14
    • 27144478655 scopus 로고    scopus 로고
    • Pak4 induces premature senescence via a pathway requiring p16INK4/p19ARF and mitogen-activated protein kinase signaling
    • Cammarano, M. S., Nekrasova, T., Noel, B. and Minden, A. (2005) Pak4 induces premature senescence via a pathway requiring p16INK4/p19ARF and mitogen-activated protein kinase signaling. Mol. Cell. Biol. 25, 9532-9542
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 9532-9542
    • Cammarano, M.S.1    Nekrasova, T.2    Noel, B.3    Minden, A.4
  • 15
    • 0036684674 scopus 로고    scopus 로고
    • Untying the regulation of the Raf-1 kinase
    • Dhillon, A. S. and Kolch, W. (2002) Untying the regulation of the Raf-1 kinase. Arch. Biochem. Biophys. 404, 3-9
    • (2002) Arch. Biochem. Biophys. , vol.404 , pp. 3-9
    • Dhillon, A.S.1    Kolch, W.2
  • 16
    • 34249845879 scopus 로고    scopus 로고
    • Transforming growth factor-β receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways
    • Pannu, J., Nakerakanti, S., Smith, E., ten Dijke, P. and Trojanowska, M. (2007) Transforming growth factor-β receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways. J. Biol. Chem. 282, 10405-10413
    • (2007) J. Biol. Chem. , vol.282 , pp. 10405-10413
    • Pannu, J.1    Nakerakanti, S.2    Smith, E.3    Ten Dijke, P.4    Trojanowska, M.5
  • 17
    • 0038075323 scopus 로고    scopus 로고
    • Up-regulated Smad5 mediates apoptosis of gastric epithelial cells induced by Helicobacter pylori infection
    • Nagasako, T., Sugiyama, T., Mizushima, T., Miura, Y., Kato, M. and Asaka, M. (2003) Up-regulated Smad5 mediates apoptosis of gastric epithelial cells induced by Helicobacter pylori infection. J. Biol. Chem. 278, 4821-4825
    • (2003) J. Biol. Chem. , vol.278 , pp. 4821-4825
    • Nagasako, T.1    Sugiyama, T.2    Mizushima, T.3    Miura, Y.4    Kato, M.5    Asaka, M.6
  • 19
    • 0033531948 scopus 로고    scopus 로고
    • Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells
    • Ishisaki, A., Yamato, K., Hashimoto, S., Nakao, A., Tamaki, K., Nonaka, K., ten Dijke, P., Sugino, H. and Nishihara, T. (1999) Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells. J. Biol. Chem. 274, 13637-13642
    • (1999) J. Biol. Chem. , vol.274 , pp. 13637-13642
    • Ishisaki, A.1    Yamato, K.2    Hashimoto, S.3    Nakao, A.4    Tamaki, K.5    Nonaka, K.6    Ten Dijke, P.7    Sugino, H.8    Nishihara, T.9
  • 20
    • 0031939744 scopus 로고    scopus 로고
    • Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12
    • Nishimura, R., Kato, Y., Chen, D., Harris, S. E., Mundy, G. R. and Yoneda, T. (1998) Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12. J. Biol. Chem. 273, 1872-1879
    • (1998) J. Biol. Chem. , vol.273 , pp. 1872-1879
    • Nishimura, R.1    Kato, Y.2    Chen, D.3    Harris, S.E.4    Mundy, G.R.5    Yoneda, T.6
  • 22
    • 0037126380 scopus 로고    scopus 로고
    • Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-β and bone morphogenetic protein
    • Lee, K. S., Hong, S. H. and Bae, S. C. (2002) Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-β and bone morphogenetic protein. Oncogene 21, 7156-7163
    • (2002) Oncogene , vol.21 , pp. 7156-7163
    • Lee, K.S.1    Hong, S.H.2    Bae, S.C.3
  • 24
    • 0033605559 scopus 로고    scopus 로고
    • MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells
    • Brown, J. D., DiChiara, M. R., Anderson, K. R., Gimbrone, Jr, M. A. and Topper, J. N. (1999) MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells. J. Biol. Chem. 274, 8797-8805
    • (1999) J. Biol. Chem. , vol.274 , pp. 8797-8805
    • Brown, J.D.1    DiChiara, M.R.2    Anderson, K.R.3    Gimbrone Jr., M.A.4    Topper, J.N.5
  • 25
    • 36349007768 scopus 로고    scopus 로고
    • Glutathione suppresses TGF-β-induced PAI-1 expression by inhibiting p38 and JNK MAPK and the binding of AP-1, SP-1, and Smad to the PAI-1 promoter
    • Vayalil, P. K., Iles, K. E., Choi, J., Yi, A. K., Postlethwait, E. M. and Liu, R. M. (2007) Glutathione suppresses TGF-β-induced PAI-1 expression by inhibiting p38 and JNK MAPK and the binding of AP-1, SP-1, and Smad to the PAI-1 promoter. Am. J. Physiol. Lung Cell Mol. Physiol. 293, L1281-L1292
    • (2007) Am. J. Physiol. Lung Cell Mol. Physiol. , vol.293
    • Vayalil, P.K.1    Iles, K.E.2    Choi, J.3    Yi, A.K.4    Postlethwait, E.M.5    Liu, R.M.6
  • 26
    • 0037033117 scopus 로고    scopus 로고
    • Interaction of p38 and Sp1 in a mechanical force-induced, β1 integrin-mediated transcriptional circuit that regulates the actin-binding protein filamin-A
    • D'Addario, M., Arora, P. D., Ellen, R. P. and McCulloch, C. A. (2002) Interaction of p38 and Sp1 in a mechanical force-induced, β1 integrin-mediated transcriptional circuit that regulates the actin-binding protein filamin-A. J. Biol. Chem. 277, 47541-47550
    • (2002) J. Biol. Chem. , vol.277 , pp. 47541-47550
    • D'Addario, M.1    Arora, P.D.2    Ellen, R.P.3    McCulloch, C.A.4
  • 27
    • 0034704076 scopus 로고    scopus 로고
    • Regulation of plasminogen activator inhibitor-1 expression by transforming growth factor-β-induced physical and functional interactions between smads and Sp1
    • Datta, P. K., Blake, M. C. and Moses, H. L. (2000) Regulation of plasminogen activator inhibitor-1 expression by transforming growth factor-β-induced physical and functional interactions between smads and Sp1. J. Biol. Chem. 275, 40014-40019
    • (2000) J. Biol. Chem. , vol.275 , pp. 40014-40019
    • Datta, P.K.1    Blake, M.C.2    Moses, H.L.3
  • 28
    • 3042549099 scopus 로고    scopus 로고
    • Smad3 interacts with JunB and Cbfa1/Runx2 for transforming growth factor-β1-stimulated collagenase-3 expression in human breast cancer cells
    • Selvamurugan, N., Kwok, S. and Partridge, N. C. (2004) Smad3 interacts with JunB and Cbfa1/Runx2 for transforming growth factor-β1-stimulated collagenase-3 expression in human breast cancer cells. J. Biol. Chem. 279, 27764-27773
    • (2004) J. Biol. Chem. , vol.279 , pp. 27764-27773
    • Selvamurugan, N.1    Kwok, S.2    Partridge, N.C.3
  • 29
    • 0043068003 scopus 로고    scopus 로고
    • p38 MAP kinase modulates Smad-dependent changes in human prostate cell adhesion
    • Hayes, S. A., Huang, X., Kambhampati, S., Platanias, L. C. and Bergan, R. C. (2003) p38 MAP kinase modulates Smad-dependent changes in human prostate cell adhesion. Oncogene 22, 4841-4850
    • (2003) Oncogene , vol.22 , pp. 4841-4850
    • Hayes, S.A.1    Huang, X.2    Kambhampati, S.3    Platanias, L.C.4    Bergan, R.C.5
  • 30
    • 9644281085 scopus 로고    scopus 로고
    • Regulation of GDF-8 signaling by the p38 MAPK
    • Philip, B., Lu., Z. and Gao, Y (2005) Regulation of GDF-8 signaling by the p38 MAPK. Cell. Signalling 17, 365-375
    • (2005) Cell. Signalling , vol.17 , pp. 365-375
    • Philip, B.1    Lu, Z.2    Gao, Y.3
  • 31
    • 33846817212 scopus 로고    scopus 로고
    • Cross-talk between Smad and p38 MAPK signalling in transforming growth factor β signal transduction in human glioblastoma cells
    • Dziembowska, M., Danilkiewicz, M., Wesolowska, A., Zupanska, A., Chouaib, S. and Kaminska, B (2007) Cross-talk between Smad and p38 MAPK signalling in transforming growth factor β signal transduction in human glioblastoma cells. Biochem. Biophys. Res. Commun. 354, 1101-1106
    • (2007) Biochem. Biophys. Res. Commun. , vol.354 , pp. 1101-1106
    • Dziembowska, M.1    Danilkiewicz, M.2    Wesolowska, A.3    Zupanska, A.4    Chouaib, S.5    Kaminska, B.6
  • 32
    • 2942650916 scopus 로고    scopus 로고
    • In vivo convergence of BMP and MAPK signaling pathways: Impact of differential Smad1 phosphorylation on development and homeostasis
    • Aubin, J., Davy, A. and Soriano, P. (2004) In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis. Genes Dev. 18, 1482-1494
    • (2004) Genes Dev. , vol.18 , pp. 1482-1494
    • Aubin, J.1    Davy, A.2    Soriano, P.3
  • 33
    • 18244362844 scopus 로고    scopus 로고
    • Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-β signaling
    • Wu, J. W., Hu, M., Chai, J., Seoane, J., Huse, M., Li, C., Rigotti, D. J., Kyin, S., Muir, T. W., Fairman, R. et al. (2001) Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-β signaling. Mol. Cell 8, 1277-1289
    • (2001) Mol. Cell , vol.8 , pp. 1277-1289
    • Wu, J.W.1    Hu, M.2    Chai, J.3    Seoane, J.4    Huse, M.5    Li, C.6    Rigotti, D.J.7    Kyin, S.8    Muir, T.W.9    Fairman, R.10
  • 34
    • 0033106484 scopus 로고    scopus 로고
    • A mechanism of repression of TGFβ/Smad signaling by oncogenic Ras
    • Kretzschmar, M., Doody, J., Timokhina, I. and Massague, J. (1999) A mechanism of repression of TGFβ/Smad signaling by oncogenic Ras. Genes Dev. 13, 804-816
    • (1999) Genes Dev. , vol.13 , pp. 804-816
    • Kretzschmar, M.1    Doody, J.2    Timokhina, I.3    Massague, J.4
  • 35
    • 0030613262 scopus 로고    scopus 로고
    • Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-β signaling
    • Souchelnytskyi, S., Tamaki, K., Engstrom, U., Wernstedt, C., ten Dijke, P. and Heldin, C. H. (1997) Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-β signaling. J. Biol. Chem. 272, 28107-28115
    • (1997) J. Biol. Chem. , vol.272 , pp. 28107-28115
    • Souchelnytskyi, S.1    Tamaki, K.2    Engstrom, U.3    Wernstedt, C.4    Ten Dijke, P.5    Heldin, C.H.6


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