Last word on counterpoint: Activation of the intrarenal renin-angiotensin system is the dominant contributor to systemic hypertension

Journal of Applied Physiology

Volumn 109, Issue 6, 2010, Pages 2015-

  Navar, L Gabriel ^a  

^a Section of Vascular Surgery   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 78651322708     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01169.2010     Document Type: Letter

References (5)

1. Guyton AC. Blood pressure control-special role of the kidneys and body fluids. Science 252:1813-1816, 1991.
2. Kobori H, Christensen NJ, Julien C, Moreria TS, Takakura AC, Antunes VR, Fontes MAP, Xavier CH, Charkoudian N, Hart EC, Barnes JN, Joyner MJ, Goldstein DS, Negrao CE, Negrao MV, Cohn JN, Rohrwasser A, Braga VA, Li P, Osborn JW, Fink GD, Szelenyi Z, Wehrwein EA, Cowley AW Jr, Zhao D, Head GA, Burke SL, Bie P, Damkjaer M, Mathai ML, Murphy MN, Fu Q, Levine BD, Crowley SD, Gonzalez-Villalobos RA, Fuchs S, Campos RR, Bergamaschi CT. Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: chronic activation of the sympathetic nervous system vs. activation of the intrarenal renin-angiontensin system. J Appl Physiol; doi: 10.1152/japplphysiol.01160.2010.
3. Kobori H, Nangaku M, Navar LG, Nishiyama A. The intrarenal reninangiotensin system: from physiology to the pathobiology of hypertension and kidney disease. Pharmacol Rev 59:251-287, 2007.
4. Lifton RP, Gharavi AG, Geller DS. Molecular mechanisms of human hypertension. Cell 104:545-556, 2001.
5. Navar LG, Hamm LL. The kidney in blood pressure regulation. In: Atlas of Diseases of the Kidney. Hypertension and the Kidney, edited by Wilcox CS. Philadelphia: Current Medicine, 1999, p. 1.1-1.22.