Sarcosine in prostate cancer tissue is not a differential metabolite for prostate cancer aggressiveness and biochemical progression

Journal of Urology

Volumn 185, Issue 2, 2011, Pages 706-711

  Jentzmik, Florian ^a   Stephan, Carsten ^a,b   Lein, Michael ^a,b   Miller, Kurt ^a   Kamlage, Beate ^c   Bethan, Bianca ^c   Kristiansen, Glen ^d   Jung, Klaus ^a,b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Berlin Institute for Urologic Research   (Germany)

^c Metanomics GmbH   (Germany)

^d UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

metabolome; neoplasm recurrence; prostate; prostatic neoplasms; sarcosine

Indexed keywords

PROSTATE SPECIFIC ANTIGEN; SARCOSINE;

ADULT; AGED; AMINO ACID COMPOSITION; ANTIGEN DETECTION; ARTICLE; CANCER GRADING; CANCER GROWTH; CANCER RECURRENCE; CANCER SIZE; CANCER STAGING; CANCER TISSUE; DISEASE FREE SURVIVAL; GLEASON SCORE; HUMAN; KAPLAN MEIER METHOD; MAJOR CLINICAL STUDY; MALE; MASS FRAGMENTOGRAPHY; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATECTOMY; RECEIVER OPERATING CHARACTERISTIC;

AGED; ANALYSIS OF VARIANCE; BIOPSY, NEEDLE; COHORT STUDIES; DIAGNOSIS, DIFFERENTIAL; DISEASE PROGRESSION; DISEASE-FREE SURVIVAL; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM RECURRENCE, LOCAL; POSTOPERATIVE CARE; PREOPERATIVE CARE; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; PROSTATE-SPECIFIC ANTIGEN; PROSTATECTOMY; PROSTATIC NEOPLASMS; REFERENCE VALUES; ROC CURVE; SARCOSINE; SENSITIVITY AND SPECIFICITY; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 78651318867     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.juro.2010.09.077     Document Type: Article

References (19)

1. J.L. Spratlin, N.J. Serkova, and S.G. Eckhardt Clinical applications of metabolomics in oncology: a review Clin Cancer Res 15 2009 431
2. J.K. Nicholson, and I.D. Wilson Opinion: understanding 'global' systems biology: metabonomics and the continuum of metabolism Nat Rev Drug Discov 2 2003 668
3. C. Schmidt Metabolomics takes its place as latest up-and-coming "omic" science J Natl Cancer Inst 96 2004 732
4. P.G. Lokhov, M.I. Dashtiev, and S.A. Moshkovskii Metabolite profiling of blood plasma of patients with prostate cancer Metabolomics 6 2010 156
5. M. Osl, S. Dreiseitl, and B. Pfeifer A new rule-based algorithm for identifying metabolic markers in prostate cancer using tandem mass spectrometry Bioinformatics 24 2008 2908
6. A. Sreekumar, L.M. Poisson, and T.M. Rajendiran Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression Nature 457 2009 910
7. F. Jentzmik, C. Stephan, and K. Miller Sarcosine in urine after digital rectal examination fails as a marker in prostate cancer detection and identification of aggressive tumors Eur Urol 58 2010 12
8. C. Stephan, F. Jentzmik, and K. Jung Reply from authors Re: is urinary sarcosine useful to identify patients with significant prostate cancer? The trials and tribulations of biomarker development Eur Urol 58 2010 20
9. J.A. Schalken Is urinary sarcosine useful to identify patients with significant prostate cancer? The trials and tribulations of biomarker development Eur Urol 58 2010 19
10. A. Schaefer, M. Jung, and H.J. Mollenkopf Diagnostic and prognostic implications of microRNA profiling in prostate carcinoma Int J Cancer 126 2010 1166
11. U. Roessner, C. Wagner, and J. Kopka Technical advance: simultaneous analysis of metabolites in potato tuber by gas chromatography-mass spectrometry Plant J 23 2000 131
12. B. van Ravenzwaay, G.C. Cunha, and E. Leibold The use of metabolomics for the discovery of new biomarkers of effect Toxicol Lett 172 2007 21
13. B. Schrder Evaluating the predictive performance of species distribution models http://brandenburg.geoecology.uni-potsdam.de/users/schroeder/download. html Accessed March 6, 2010
14. M. Lein, I. Stibane, and R. Mansour Complications, urinary continence, and oncologic outcome of 1000 laparoscopic transperitoneal radical prostatectomiesexperience at the Charit Hospital Berlin Campus Mitte Eur Urol 50 2006 1278
15. B. Guillonneau, H. el-Fettouh, and H. Baumert Laparoscopic radical prostatectomy: oncological evaluation after 1,000 cases a Montsouris Institute J Urol 169 2003 1261
16. C.M. Slupsky, K.N. Rankin, and J. Wagner Investigations of the effects of gender, diurnal variation, and age in human urinary metabolomic profiles Anal Chem 79 2007 6995
17. E. Altmaier, G. Kastenmuller, and W. Romisch-Margl Variation in the human lipidome associated with coffee consumption as revealed by quantitative targeted metabolomics Mol Nutr Food Res 53 2009 1357
18. F.P. Martin, S. Rezzi, and E. Pere-Trepat Metabolic effects of dark chocolate consumption on energy, gut microbiota, and stress-related metabolism in free-living subjects J Proteome Res 8 2009 5568
19. A. Scalbert, L. Brennan, and O. Fiehn Mass-spectrometry-based metabolomics: limitations and recommendations for future progress with particular focus on nutrition research Metabolomics 5 2009 435