Positive finding of colonic polymerase chain reaction for cytomegalovirus DNA is not false positive but a warning for treating patients with ulcerative colitis refractory to immunosuppressive therapies

Inflammatory Bowel Diseases

Volumn 17, Issue 2, 2011, Pages

  Nakase, Hiroshi ^a   Yoshino, Takuya ^b   Matumura, Kayoko ^a   Honzawa, Yusuke ^a   Yamamoto, Shuji ^a   Matsuura, Minoru ^a   Chiba, Tsutomu ^a  

^a KYOTO UNIVERSITY   (Japan)

^b Kitano Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; IMMUNOSUPPRESSIVE AGENT; VIRUS DNA;

ANTIVIRAL THERAPY; COLON RESECTION; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; FALSE POSITIVE RESULT; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LETTER; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REMISSION; ULCERATIVE COLITIS; VIRUS REACTIVATION;

COLITIS, ULCERATIVE; COLON; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DNA, VIRAL; DRUG RESISTANCE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; POLYMERASE CHAIN REACTION; PROGNOSIS;

EID: 78651311321     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.21401     Document Type: Letter

References (4)

1. Nakase H, Matsumura K, Yoshino T, et al. Systematic review: cytomegalovirus infection in inflammatory bowel disease. J Gastroenterol. 2008; 43: 735-740.
2. Lawlor G, Moss AC,. Cytomegalovirus in inflammatory bowel disease: pathogen or innocent bystander? Inflamm Bowel Dis. 2010 [Epub ahead of print].
3. Nakase H, Chiba T,. TNF-alpha is an important pathogenic factor contributing to reactivation of cytomegalovirus in inflamed mucosa of colon in patients with ulcerative colitis: lesson from clinical experience. Inflamm Bowel Dis. 2010; 16: 550-551.
4. Yoshino T, Nakase H, Ueno S, et al. Usefulness of quantitative real-time PCR assay for early detection of cytomegalovirus infection in patients with ulcerative colitis refractory to immunosuppressive therapies. Inflamm Bowel Dis. 2007; 13: 1516-1521.