Selective emotional processing deficits to social vignettes in schizophrenia: An ERP study

Schizophrenia Bulletin

Volumn 37, Issue 1, 2011, Pages 148-163

  Kuperberg, Gina R ^a,b,c   Kreher, Donna A ^c,d   Swain, Abigail ^c   Goff, Donald C ^a,b   Holt, Daphne J ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c TUFTS UNIVERSITY   (United States)

^d UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

affect; emotion; event related potentials; language; late positivity; negative symptoms; P300; schizophrenia; semantic

Indexed keywords

ADULT; ARTICLE; BEHAVIOR; BRAIN REGION; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; EMOTIONAL STABILITY; EVENT RELATED POTENTIAL; FEMALE; HUMAN; MALE; NEGATIVE SYNDROME; POSITIVE SYNDROME; PRIORITY JOURNAL; SCHIZOPHRENIA; SENSORY STIMULATION; SOCIAL COGNITION; VIGNETTE;

ADULT; CASE-CONTROL STUDIES; ELECTROENCEPHALOGRAPHY; EMOTIONS; EVOKED POTENTIALS; FEMALE; HUMANS; LANGUAGE; MALE; MIDDLE AGED; REACTION TIME; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SEMANTICS; SOCIAL ADJUSTMENT; VERBAL BEHAVIOR;

EID: 78651304360     PISSN: 05867614     EISSN: 17451701     Source Type: Journal    
DOI: 10.1093/schbul/sbp018     Document Type: Article

References (112)

1. DSM-IV: Diagnostic and Statistical Manual of Mental Disorders. 4th Rev ed. Washington, DC: American Psychiatric Press; 2000.
2. Kraepelin E. Dementia Praecox and Paraphrenia. New York, NY: Krieger; 1971.
3. Aleman A, Kahn RS. Strange feelings: do amygdala abnormalities dysregulate the emotional brain in schizophrenia? Prog Neurobiol. 2005;77:283-298.
4. Hall J, Harris JM, McKirdy JW, Johnstone EC, Lawrie SM. Emotional memory in schizophrenia. Neuropsychologia. 2007;45:1152-1159.
5. Herbener ES, Rosen C, Khine T, Swseeney JA. Failure of positive but not negative emotional valence to enhance memory in schizophrenia. J Abnorm Psychol. 2007;116:43-55.
6. Phillips ML, Drevets WC, Rauch SL, Lane R. Neurobiology of emotion perception II: implications for major psychiatric disorders. Biol Psychiatry. 2003;54:515-528.
7. Pinkham AE, Penn DL, Perkins DO, Lieberman J. Implications for the neural basis of social cognition for the study of schizophrenia. Am J Psychiatry. 2003;160:815-824.
8. Holt DJ, Lynn S, Kuperberg GR. Neurophysiological correlates of comprehending emotional meaning in context. J Cogn Neurosci. In press 2009; http://www.nmr.mgh.harvard.edu/ kuperberglab/publications/papers/HOLTetal- Neurophyscorr- 080508.pdf. Accessed March 10, 2009.
9. Kohler CG, Bilker W, Hagendoorn M, Gur RE, Gur RC. Emotion recognition deficit in schizophrenia: association with symptomatology and cognition. Biol Psychiatry. 2000;48:127-136.
10. Addington J, Addington D. Facial affect recognition and information processing in schizophrenia and bipolar disorder. Schizophr Res. 1998;32:171-181.
11. Hooker C, Park S. Emotion processing and its relationship to social functioning in schizophrenia patients. Psychiatry Res. 2002;112:41-50.
12. Mandal MK, Pandey R, Prasad AB. Facial expressions of emotions and schizophrenia: a review. Schizophr Bull. 1998;24:399-412.
13. Morrison RL, Bellack AS, Mueser KT. Deficits in facial-affect recognition and schizophrenia. SchizophrBull. 1988;14:67-83.
14. Sachs G, Steger-Wuchse D, Kryspin-Exner I, Gur RC, Katschnig H. Facial recognition deficits and cognition in schizophrenia. Schizophr Res. 2004;68:27-35.
15. Salem JE, Kring AM, Kerr SL. More evidence for generalized poor performance in facial emotion perception in schizophrenia. J Abnorm Psychol. 105:480-483.
16. Schneider F, Gur RC, Koch K, et al. Impairment in the specificity of emotion processing in schizophrenia. Am J Psychiatry. 163:442-447.
17. Suslow T, Droste T, Roestel C, Arolt V. Automatic processing of facial emotion in schizophrenia with and without affective negative symptoms. Cogn Neuropsychiatry. 2005; 10:35-56.
18. van't Wout M, Aleman A, Kessels RP, Cahn W, de Haan EH, Kahn RS. Exploring the nature of facial affect processing deficits in schizophrenia. Psychiatry Res. 2007;150: 227-235.
19. Bozikas VP, Kosmidis MH, Anezoulaki D, Giannakou M, Andreou C, Karavatos A. Impaired perception of affective prosody in schizophrenia. J Neuropsychiatry Clin Neurosci. 2006;18:81-85.
20. Leitman DI, Foxe JJ, Butler PD, Saperstein A, Revheim N, Javitt DC. Sensory contributions to impaired prosodic processing in schizophrenia. Biol Psychiatry. 2005;58:56-61.
21. Leitman DI, Hoptman MJ, Foxe JJ, et al. The neural substrates of impaired prosodic detection in schizophrenia and its sensorial antecedents. Am J Psychiatry. 2007;164: 474-482.
22. Shea TL, Sergejew AA, Burnham D, et al. Emotional pro-sodic processing in auditory hallucinations. Schizophr Res. 2007;90:214-220.
23. Turetsky BI, Kohler CG, Indersmitten T, Bhati MT, Char-bonnier D, Gur RC. Facial emotion recognition in schizophrenia: when and why does it go awry? Schizophr Res. 2007;94:253-263.
24. Johnston PJ, Stojanov W, Devir H, Schall U. Functional MRI of facial emotion recognition deficits in schizophrenia and their electrophysiological correlates. Eur J Neurosci. 2005;22:1221-1232.
25. An SK, Lee SJ, Lee CH, et al. Reduced P3 amplitudes by negative facial emotional photographs in schizophrenia. Schizophr Res. 2003;63:10.
26. Ueno T, Morita K, Shoji Y, Yamamoto M, Yamamoto H, Maeda H. Recognition of facial expression and visual P300 in schizophrenic patients: differences between paranoid type patients and non-paranoid patients. Psychiatry Clin Neurosci. 2004;58:585-592.
27. Herrmann MJ, Reif A, Jabs BE, Jacob C, Fallgatter AJ. Facial affect decoding in schizophrenic disorders: a study using event-related potentials. Psychiatry Res. 2006;141: 247-252.
28. Gur RE, Loughead J, Kohler CG, et al. Limbic activation associated with misidentification of fearful faces and flat affect in schizophrenia. Arch Gen Psychiatry. 2007;64: 1356-1366.
29. Holt DJ, Kunkel L, Weiss AP, et al. Increased medial temporal lobe activation during the passive viewing of emotional and neutral facial expressions in schizophrenia. Schizophr Res. 2006;82:153-162.
30. Holt DJ, Weiss AP, Rauch SL, et al. Sustained activation of the hippocampus in response to fearful faces in schizophrenia. Biol Psychiatry. 2005;57:1011-1019.
31. Hall J, Whalley HC, McKirdy JW, et al. Overactivation of fear systems to neutral faces in schizophrenia. Biol Psychiatry. 2008;64:70-73.
32. Schneider F, Weiss U, Kessler C, et al. Differential amygdala activation in schizophrenia during sadness. Schizophr Res. 1998;34:133-142.
33. Gur RE, McGrath C, Chan RM, et al. An fMRI study of facial emotion processing in patients with schizophrenia. Am J Psychiatry. 2002;159:1992-1999.
34. Williams LM, Das P, Harris AW, et al. Dysregulation of arousal and amygdala-prefrontal systems in paranoid schizophrenia. Am J Psychiatry. 2004;161:480-489.
35. Kosaka H, Omori M, Murata T, et al. Differential amygdala response during facial recognition in patients with schizophrenia: an fMRI study. Schizophr Res. 2002;57:87-95.
36. Crespo-Facorro B, Paradiso S, Andreasen NC, et al. Neural mechanisms of anhedonia in schizophrenia: a PET study of response to unpleasant and pleasant odors. JAMA. 2001;286:427-435.
37. Taylor SF, Liberzon I, Decker LR, Koeppe RA. A functional anatomic study of emotion in schizophrenia. Schizophr Res. 2002;58:159-172.
38. Takahashi H, Koeda M, Oda K, et al. An fMRI study of differential neural response to affective pictures in schizophrenia. NeuroImage.22:1247-1254.
39. Kee KS, Kern RS, Green MF. Perception of emotion and neurocognitive functioning in schizophrenia: what's the link? Psychiatry Res. 1998;81:57-65.
40. Whittaker JF, Deakin JF, Tomenson B. Face processing in schizophrenia: defining the deficit. Psychol Med. 2001;31: 499-507.
41. Silver H, Shlomo N. Perception of facial emotions in chronic schizophrenia does not correlate with negative symptoms but correlates with cognitive and motor dysfunction. Schizophr Res. 2001;52:265-273.
42. Martin F, Baudouin JY, Tiberghien G, Franck N. Processing emotional expression and facial identity in schizophrenia. Psychiatry Res. 2005;134:43-53.
43. Mueser K, Doonan R, Penn D, et al. Emotion recognition and social competence in chronic schizophrenia. J Abnorm Psychol. 1996;105:271-275.
44. Kee KS, Green MF, Mintz J, Brekke JS. Is emotion processing a predictor of functional outcome in schizophrenia? Schizophr Bull. 2003;29:487-497.
45. Addington J, Saeedi H, Addington D. Facial affect recognition: a mediator between cognitive and social functioning in psychosis? Schizophr Res. 2006;85:142-150.
46. Johnston PJ, Devir H, Karayanidis F. Facial emotion processing in schizophrenia: no evidence for a deficit specific to negative emotions in a differential deficit design. Psychiatry Res. 2006;143:51-61.
47. Kerr SL, Neale JM. Emotion perception in schizophrenia: specific deficit or further evidence of generalized poor performance? J Abnorm Psychol. 1993;102:312-318.
48. Corlett PR, Honey GD, Fletcher PC. From prediction error to psychosis: ketamine as a pharmacological model of delusions. J Psychopharmacol. 2007;21:238-252.
49. Kapur S. Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Am J Psychiatry. 2003;160:13-23.
50. Maher B. Anomalous experience in everyday life: its significance for psychopathology. Monist. 1999;82:23.
51. Phillips ML, Senior C, David AS. Perception of threat in schizophrenics with persecutory delusions: an investigation using visual scan paths. Psychol Med. 2000;30: 157-167.
52. Holt DJ, Titone D, Long LS, et al. The misattribution of salience in delusional patients with schizophrenia. Schizophr Res. 2006;83:247-256.
53. Kohler CG, Turner TH, Bilker WB, et al. Facial emotion recognition in schizophrenia: intensity effects and error pattern. Am J Psychiatry. 2003;160:1768-1774.
54. Phillips ML, Williams L, Senior C, et al. A differential neural response to threatening and non-threatening negative facial expressions in paranoid and non-paranoid schizophrenics. Psychiatry Res. 1999;92:11-31.
55. Holt DJ, Lakshmanan B, Freudenreich O, Goff DC, Rauch SL, Kuperberg GR. Dysfunction of a Cortical Midline Network during Emotional Appraisals in Schizophrenia. Schizophrenia Bulletin. In press.
56. Surguladze S, Russell T, Kucharska-Pietura K, et al. A reversal of the normal pattern of parahippocampal response to neutral and fearful faces is associated with reality distortion in schizophrenia. Biol Psychiatry. 2006;60: 423-431.
57. Hempel A, Hempel E, Schonknecht P, Stippich C, Schroder J. Impairment in basal limbic function in schizophrenia during affect recognition. Psychiatry Res. 2003;122:115-124.
58. Russell TA, Reynaud E, Kucharska-Pietura K, et al. Neural responses to dynamic expressions of fear in schizophrenia. Neuropsychologia. 2007;45:107-123.
59. Krolak-Salmon P, Fischer C, Vighetto A, Mauguiere F. Processing of facial emotional expression: spatio-temporal data as assessed by scalp event-related potentials. Eur J Neurosci. 2001;13:987-994.
60. Vanderploeg RD, Brown WS, Marsh JT. Judgments of emotion in words and faces: ERP correlates. Int J Psychophysiol. 1987;5:193-205.
61. Schupp HT, Junghofer M, Weike AI, Hamm AO. The selective processing of briefly presented affective pictures: an ERP analysis. Psychophysiology. 2004;41:441-449.
62. Palomba D, Angrilli A, Mini A. Visual evoked potentials, heart rate responses and memory to emotional pictorial stimuli. Int J Psychophysiol. 1997;27:55-67.
63. Schupp HT, Cuthbert BN, Bradley MM, Cacioppo JT, Ito T, Lang PJ. Affective picture processing: the late positive potential is modulated by motivational relevance. Psycho-physiology. 2000;37:257-261.
64. Ito TA, Larsen JT, Smith NK, Cacioppo JT. Negative informa- tionweighsmoreheavilyonthebrain:thenegativitybiasineval-uative categorizations. J Pers Soc Psychol. 1998;75:887-900.
65. Johnston VS, Miller DR, Burleson MH. Multiple P3s to emotional stimuli and their theoretical significance. Psycho-physiology. 1986;23:684-693.
66. Kanske P, Kotz SA. Concreteness in emotional words: ERP evidencefromahemifield study. Brain Res. 2007;1148:138-148.
67. Naumann E, Bartussek D, Diedrich O, Laufer ME. Assessing cognitive and affective information processing functions of the brain by means of the late positive complex of the event-related potential. J Psychophysiol. 1992;6:285-298.
68. Naumann E, Maier S, Diedrich O, Becker G, Bartussek D. Structural, semantic and emotion-focussed processing of neutral and negative nouns: event-related potential correlates. J Psychophysiol. 1997;11:158-172.
69. Kiehl KA, Hare RD, McDonald JJ, Brink J. Semantic and affective processing in psychopaths: an event-related potential (ERP) study. Psychophysiology. 1999;36:765-774.
70. Herbert C, Kissler J, Junghofer M, Peyk P, Rockstroh B. Processing of emotional adjectives: evidence from startle EMG and ERPs. Psychophysiology. 2006;43:197-206.
71. Donchin E, Coles MGH. Is the P300 component a manifestation of context updating? Behav Brain Sci. 1988;11:355-372.
72. Schupp HT, Stockburger J, Codispoti M, Junghofer M, Weike AI, Hamm AO. Selective visual attention to emotion. J Neurosci. 2007;27:1082-1089.
73. Ford JM. Schizophrenia: the broken P300 and beyond. Psy-chophysiology. 1999;36:667-682.
74. Barsalou LW, Kyle Simmons W, Barbey AK, Wilson CD. Grounding conceptual knowledge in modality-specific systems. Trends Cogn Sci. 2003;7:84-91.
75. Glenberg A, Havas D, Becker R, Rinck M. Grounding language in bodily states: the case for emotion. In: Pecher D, Zwaan RA, eds. The Grounding of Cognition: The Role of Perception and Action in Memory, Language and Thinking. Cambridge: Cambridge University Press; 2005.
76. Zwaan RA, Radvansky GA. Situation models in language comprehension and memory. Psychol Bull. 1998;123: 162-185.
77. Johnson-Laird PN. Mental Models. Cambridge, Mass: Harvard University Press; 1983.
78. Bernat E, Bunce S, Shevrin H. Event-related brain potentials differentiate positive and negative mood adjectives during both supraliminal and subliminal visual processing. Int J Psychophysiol. 2001;42:11-34.
79. Kiehl KA, Liddle PF, Smith AM, Mendrek A, Forster BB, Hare RD. Neural pathways involved in the processing of concrete and abstract words. Hum Brain Mapp. 1999;7:225-233.
80. First MB, Spitzer RL, Miriam G, Williams JBW. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. (SCID-I/P). New York, NY: New York State Psychiatric Institute; 2002.
81. Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull. 1987;13:261-276.
82. Blair JR, Spreen O. Predicting premorbid IQ: a revision of the National Adult Reading Test. Clin Neuropsychol. 1989;129-136.
83. Hollingshead AB. Two Factor Index of Social Position. New Haven, Conn: Yale University Press; 1965.
84. Greenhouse S, Geisser S. On methods in the analysis of profile data. Psychometrika. 1959;24:95-112.
85. Kissler J, Assadollahi R, Herbert C. Emotional and semantic networks in visual word processing: insights from ERP studies. Prog Brain Res. 2006;156:147-183.
86. Williamson S, Harpur TJ, Hare RD. Abnormal processing of affective words by psychopaths. Psychophysiology. 1991;28:260-273.
87. Schupp HT, Ohman A, Junghofer M, Weike AI, Stockbur-ger J, Hamm AO. The facilitated processing of threatening faces: an ERP analysis. Emotion. 2004;4:189-200.
88. Strange BA, Henson RN, Friston KJ, Dolan RJ. Brain mechanisms for detecting perceptual, semantic, and emotional deviance. NeuroImage. 2000;12:425-433.
89. Fichtenholtz HM, Dean HL, Dillon DG, Yamasaki H, McCarthy G, LaBar KS. Emotion-attention network interactions during a visual oddball task. Brain Res. 2004;20:67-80.
90. Whalen PJ, Rauch SL, Etcoff NL, McInerney SC, Lee MB, Jenike MA. Masked presentations of emotional facial expressions modulate amygdala activity without explicit knowledge. J Neurosci. 1998;18:411-418.
91. Vuilleumier P, Armony JL, Driver J, Dolan RJ. Effects of attention and emotion on face processing in the human brain: an event-related fMRI study. Neuron. 2001;30: 829-841.
92. Vuilleumier P, Armony JL, Clarke K, Husain M, Driver J, Dolan RJ. Neural response to emotional faces with and without awareness: event-related fMRI in a parietal patient with visual extinction and spatial neglect. Neuropsychologia. 2002;40:2156-2166.
93. Yamasaki H, LaBar KS, McCarthy G. Dissociable prefron-tal brain systems for attention and emotion. Proc Natl Acad Sci USA. 2002;99:11447-11451.
94. Ruchsow M, Trippel N, Groen G, Spitzer M, Kiefer M. Semantic and syntactic processes during sentence comprehension in patients with schizophrenia: evidence from event-related potentials. Schizophr Res. 2003;64:147-156.
95. Kuperberg GR, Sitnikova T, Goff D, Holcomb PJ. Making sense of sentences in schizophrenia: electrophysiologi-cal evidence for abnormal interactions between semantic and syntactic processing. J Abnorm Psychol. 2006;115: 243-256.
96. Kuperberg GR, Kreher DA, Ditman T. What can event-related potentials tell us about language, and perhaps even thought, in schizophrenia? Int J Psychophysiol. Special Issue. In press; http://www.nmr.mgh.harvard.edu/ kuperberglab/ publications/papers/ERP&language&scz-spissue-IJP- Kuperberg-inpress.pdf. Accessed March 10, 2009.
97. Sitnikova T, Goff D, Kuperberg GR. Abnormalities in conceptual processing dissociate disorganization and negative symptomatology during real-world behavior in schizophrenia. J Abnorm Psychol. In press.
98. Kutas M, Hillyard SA. Brain potentials during reading reflect word expectancy and semantic association. Nature. 1984;307:161-163.
99. Kutas M, Federmeier KD. Electrophysiology reveals semantic memory use in language comprehension. Trends Cogn Sci. 2000;4:463-470.
100. Hagoort P, Hald L, Bastiaansen M, Petersson KM. Integration of word meaning and world knowledge in language comprehension. Science. 2004;304:438-441.
101. Van Berkum JJA, Holleman B, Nieuwland M, Otten M, Murrel J. Right or wrong? The brain's fast response to morally objectionable statements. Psychol Sci. In press; http:// www.mpi.nl/world/persons/private/josber/vanberkum-nsre- vision-final.pdf. Accessed march 10, 2009.
102. Yeap S, Kelly SP, Sehatpour P, et al. Early visual sensory deficits as endophenotypes for schizophrenia: high-density electrical mapping in clinically unaffected first-degree relatives. Arch Gen Psychiatry. 2006;63:1180-1188.
103. Doniger GM, Foxe JJ, Murray MM, Higgins BA, Javitt DC. Impaired visual object recognition and dorsal/ventral stream interaction in schizophrenia. Arch Gen Psychiatry. 2002;59:1011-1020.
104. Butler PD, Schechter I, Zemon V, et al. Dysfunction of early-stage visual processing in schizophrenia. Am J Psychiatry. 2001;158:1126-1133.
105. Butler PD, Zemon V, Schechter I, et al. Early-stage visual processing and cortical amplification deficits in schizophrenia. Arch Gen Psychiatry. 2005;62:495-504.
106. Jackendoff R.Foundations of Language. Brain, Meaning, Grammar, Evolution. Oxford, NY: Oxford University Press; 2002.
107. Yaxley RH, Zwaan RA. Simulating visibility during language comprehension. Cognition. 2007;105:229-236.
108. Gaillard R, Del Cul A, Naccache L, Vinckier F, Cohen L, Dehaene S. Nonconscious semantic processing of emotional words modulates conscious access. Proc Natl Acad Sci USA. 2006;7524-7529.
109. Grainger J, Holcomb PJ. Watching the word go by: on the time-course of component processes in visual word recognition. Lang Linguist Compass. 2009;3:128-156.
110. Mathews A, MacLeod C. Cognitive approaches to emotion and emotional disorders. Annu Rev Psychol. 1994;45:25-50.
111. Williams JM, Mathews A, MacLeod C. The emotional Strooptaskandpsychopathology.PsycholBull. 1996;120:3-24.
112. LeDoux JE. The Emotional Brain: The Mysterious Underpinnings of Emotional Life. New York: Simon and Schuster; 1998.