Endothelial dysfunction in systemic lupus erythematosus: Evaluation with13N-ammonia PET

Journal of Nuclear Medicine

Volumn 51, Issue 12, 2010, Pages 1927-1931

  Alexánderson Rosas, Erick ^a,b   Ochoa, Juan M ^b   Calleja, Rodrigo ^b   Juárez Rojas, Juan G ^a   Prior, John O ^c   Jácome, Rodrigo ^b   Romero, Edgar ^b   Meave, Aloha ^a,b   Posadas Romero, Carlos ^a  

^a INSTITUTO NACIONAL DE CARDIOLOGÍA IGNACIO CHÁVEZ   (Mexico)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^c LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

13N ammonia PET; Endothelial dysfunction; Endothelium dependent vasodilatation index; MFR; Systemic lupus erythematosus

Indexed keywords

AMMONIA N 13; STEROID;

ADULT; ARTICLE; CLINICAL ARTICLE; COLD PRESSOR TEST; COMPUTED TOMOGRAPHY SCANNER; CONTROL GROUP; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; ENDOTHELIAL DYSFUNCTION; FEMALE; HEART MUSCLE BLOOD FLOW; HUMAN; LOW DRUG DOSE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; STRESS; SYSTEMIC LUPUS ERYTHEMATOSUS; VASODILATATION;

ADULT; AMMONIA; COLD TEMPERATURE; CORONARY ARTERY DISEASE; CORONARY CIRCULATION; ENDOTHELIUM, VASCULAR; FEMALE; HEMODYNAMICS; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; LUPUS ERYTHEMATOSUS, SYSTEMIC; NITROGEN RADIOISOTOPES; POSITRON-EMISSION TOMOGRAPHY; PRESSURE; RADIOPHARMACEUTICALS; STRESS, PSYCHOLOGICAL;

EID: 78651287384     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.110.078212     Document Type: Article

References (20)

1. Rubin LA, Urowitz MB, Gladman DD. Mortality in systemic lupus erythematosus: the bimodal pattern revisited. Q J Med. 1985;55:87-98.
2. Esdaile JM, Abrahamowicz M, Grodzicky T, et al. Traditional Framingham risk factors fail to fully account for accelerated atherosclerosis in systemic lupus erythematosus. Arthritis Rheum. 2001;44:2331-2337.
3. Bruce IN. 'Not only. . .but also': factors that contribute to accelerated atherosclerosis and premature coronary heart disease in systemic lupus erythematosus. Rheumatology. 2005;44:1492-1502.
4. Bulkley BH, Roberts WC. The heart in systemic lupus erythematosus and the changes induced in it by corticosteroid therapy: a study of 36 necropsy patients. Am J Med. 1975;58:243-264.
5. El-Magadmi M, Bodill H, Ahmad Y, et al. Systemic lupus erythematosus: an independent risk factor for endothelial dysfunction in women. Circulation. 2004;110:399-404. (Pubitemid 38993848)
6. Bonetti PO, Lerman LO, Lerman A. Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol. 2003;23:168-175.
7. Piper MK, Raza K, Nuttall SL, et al. Impaired endothelial function in systemic lupus erythematosus. Lupus. 2007;16:84-88.
8. Recio-Mayoral A, Mason JC, Kaski JC, et al. Chronic inflammation and coronary microvascular dysfunction in patients without risk factors for coronary artery disease. Eur Heart J. 2009;30:1837-1843.
9. Schelbert HR. Quantification of myocardial blood flow: what is the clinical role? Cardiol Clin. 2009;27:277-289.
10. Guzman J, Cardiel MH, Arce-Salinas A, Sanchez-Guerrero J, Alarcon-Segovia D. Measurement of disease activity in systemic lupus erythematosus: prospective validation of 3 clinical indices. J Rheumatol. 1992;19:1551-1558.
11. Townsend D, Jakoby B, Long M, et al. Performance and clinical workflow of a new combined PET/CT scanner [abstract]. J Nucl Med. 2007;48(suppl):437P.
12. Nagamachi S, Czernin J, Kim AS, et al. Reproducibility of measurements of regional resting and hyperemic myocardial blood flow assessed with PET. J Nucl Med. 1996;37:1626-1631.
13. Hutchins GD, Schwaiger M, Rosenspire KC, et al. Noninvasive quantification of regional blood flow in the human heart using N13 ammonia and dynamic positron emission tomographic imaging. J Am Coll Cardiol. 1990;15:1032-1042.
14. 15O and PET. J Nucl Med. 2006;47:1420-1426.
15. Prior JO, Schindler TH, Facta AD, et al. Determinants of myocardial blood flow response to cold pressor testing and pharmacologic vasodilation in healthy humans. Eur J Nucl Med Mol Imaging. 2007;34:20-27.
16. Alexanderson E, Rodriguez-Valero M, Martinez A, et al. Endothelial dysfunction in recently diagnosed type 2 diabetic patients evaluated by PET. Mol Imaging Biol. 2009;11:1-5.
17. Czernin J, Muller P, Chan S, et al. Influence of age and hemodynamic on myocardial blood flow and flow reserve. Circulation. 1993;88:62-69.
18. Kozora E, Ellison MC, West S. Depression, fatigue, and pain in systemic lupus erythematosus (SLE): relationship to the American College of Rheumatology SLE neuropsychological battery. Arthritis Rheum. 2006;55:628-635.
19. Prior JO, Quinones MJ, Hernadez-Pampaloni M, et al. Coronary circulatory dysfunction in insulin resistance, impaired glucose tolerance, and type 2 diabetes mellitus. Circulation. 2005;111:2291-2298.
20. 13N-ammonia myocardial perfusion positron emission tomography: added value of coronary flow reserve. J Am Coll Cardiol. 2009;54:150-156.