Intestinal epithelial cell proliferation, apoptosis and expression of tight junction proteins in patients with obstructive jaundice

European Journal of Clinical Investigation

Volumn 41, Issue 2, 2011, Pages 117-125

  Assimakopoulos, Stelios F ^a   Tsamandas, Athanassios C ^a   Louvros, Emanuel ^b   Vagianos, Constantine E ^c   Nikolopoulou, Vassiliki N ^b   Thomopoulos, Konstantinos C ^b   Charonis, Aristidis ^d   Scopa, Chrisoula D ^a  

^a Department of Internal Medicine ^*  (Greece)

^b UNIVERSITY HOSPITAL OF PATRAS   (Greece)

^c GENERAL HOSPITAL OF NIKEA   (Greece)

^d BIOMEDICAL RESEARCH FOUNDATION   (Greece)

Author keywords

Apoptosis; Claudin 1; Claudin 4; Claudin 7; Obstructive jaundice; Occludin; Proliferation

Indexed keywords

CLAUDIN 1; CLAUDIN 4; CLAUDIN 7; OCCLUDIN;

ADULT; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DUODENUM BIOPSY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INTESTINE CELL; INTESTINE EPITHELIUM CELL; INTESTINE MUCOSA PERMEABILITY; MALE; OBSTRUCTIVE JAUNDICE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AGED; AGED, 80 AND OVER; APOPTOSIS; CELL PROLIFERATION; FEMALE; HUMANS; INTESTINAL MUCOSA; JAUNDICE, OBSTRUCTIVE; MALE; MEMBRANE PROTEINS; MIDDLE AGED; TIGHT JUNCTIONS;

EID: 78651286218     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2010.02379.x     Document Type: Article

References (36)

1. Greig JD, Krukowski ZH, Matheson NA. Surgical morbidity and mortality in one hundred and twenty-nine patients with obstructive jaundice. Br J Surg 1988;75:216-9.
2. Pain JA, Cahill CJ, Bailey ME. Perioperative complications in obstructive jaundice: therapeutic considerations. Br J Surg 1985;72:942-5.
3. Sewnath ME, Karsten TM, Prins MH, Rauws EJ, Obertop H, Gouma DJ. A meta-analysis on the efficacy of preoperative biliary drainage for tumors causing obstructive jaundice. Ann Surg 2002;236:17-27.
4. Parks RW, Clements WD, Smye MG, Pope C, Rowlands BJ, Diamond T. Intestinal barrier dysfunction in clinical and experimental obstructive jaundice and its reversal by internal biliary drainage. Br J Surg 1996;83:1345-9.
5. Parks RW, Halliday MI, McCrory DC, Erwin P, Smye M, Diamond T et al. Host immune responses and intestinal permeability in patients with jaundice. Br J Surg 2003;90:239-45.
6. Kimmings AN, van Deventer SJ, Obertop H, Rauws EA, Huibregtse K, Gouma DJ. Endotoxin, cytokines, and endotoxin binding proteins in obstructive jaundice and after preoperative biliary drainage. Gut 2000;46:725-31.
7. Welsh FK, Ramsden CW, MacLennan K, Sheridan MB, Barclay GR, Guillou PJ et al. Increased intestinal permeability and altered mucosal immunity in cholestatic jaundice. Ann Surg 1998;227:205-12.
8. Assimakopoulos SF, Scopa CD, Zervoudakis G, Mylonas PG, Georgiou C, Nikolopoulou V et al. Bombesin and neurotensin reduce endotoxemia, intestinal oxidative stress, and apoptosis in experimental obstructive jaundice. Ann Surg 2005;241:159-67.
9. Assimakopoulos SF, Scopa CD, Charonis A, Spiliopoulou I, Georgiou C, Nikolopoulou V et al. Experimental obstructive jaundice disrupts intestinal mucosal barrier by altering occludin expression: beneficial effect of bombesin and neurotensin. J Am Coll Surg 2004;198:748-57.
10. Assimakopoulos SF, Vagianos CE, Charonis AS, Alexandris IH, Spiliopoulou I, Thomopoulos KC et al. Experimental obstructive jaundice alters claudin-4 expression in intestinal mucosa: effect of bombesin and neurotensin. World J Gastroenterol 2006;12:3410-5.
11. Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease. J Gastroenterol Hepatol 2003;18:479-97.
12. Arrieta MC, Bistritz L, Meddings JB. Alterations in intestinal permeability. Gut 2006;55:1512-20.
13. Madara JL. Warner-Lambert/Parke-Davis Award lecture. Pathobiology of the intestinal epithelial barrier. Am J Pathol 1990;137:1273-81.
14. Anderson JM, Van Itallie CM. Tight junctions and the molecular basis for regulation of paracellular permeability. Am J Physiol 1995;269:G467-75.
15. Lee RG, Nakamura K, Tsamandas AC, Abu-Elmagd K, Furukawa H, Hutson WR et al. Pathology of human intestinal transplantation. Gastroenterology 1996;110:1820-34.
16. Assimakopoulos SF, Thomopoulos KC, Patsoukis N, Georgiou CD, Scopa CD, Nikolopoulou VN et al. Evidence for intestinal oxidative stress in patients with obstructive jaundice. Eur J Clin Invest 2006;36:181-7.
17. Scopa CD, Koureleas S, Tsamandas AC, Spiliopoulou I, Alexandrides T, Filos KS et al. Beneficial effects of growth hormone and insulin-like growth factor I on intestinal bacterial translocation, endotoxemia, and apoptosis in experimentally jaundiced rats. J Am Coll Surg 2000;190:423-31.
18. Yamaguchi J, Toledo A, Bass BL, Celeste FA, Rao JN, Wang JY et al. Taurodeoxycholate increases intestinal epithelial cell proliferation through c-myc expression. Surgery 2004;135:215-21.
19. Parks RW, Stuart Cameron CH, Gannon CD, Pope C, Diamond T, Rowlands BJ. Changes in gastrointestinal morphology associated with obstructive jaundice. J Pathol 2000;192:526-32.
20. Ypsilantis P, Tentes L, Assimakopoulos SF, Kortsaris A, Scopa CD, Pitiakoudis M et al. Dose related effects of ifosfamide on enterocyte apoptosis in different sites of the rabbit intestine. Toxicology 2004;200:135-43.
21. Inoue K, Takahashi T, Uehara K, Shimuzu H, Ido K, Morimatsu H et al. Protective role of heme oxygenase 1 in the intestinal tissue injury in hemorrhagic shock in rats. Shock 2008;29:252-61.
22. Madara JL, Nash S, Moore R, Atisook K. Structure and function of the intestinal epithelial barrier in health and disease. Monogr Pathol 1990;31:306-24.
23. Fanning AS, Mitic LL, Anderson JM. Transmembrane proteins in the tight junction barrier. J Am Soc Nephrol 1999;10:1337-45.
24. Wang N, Yu H, Ma J, Wu W, Zhao D, Shi X et al. Evidence for tight junction protein disruption in intestinal mucosa of malignant obstructive jaundice patients. Scand J Gastroenterol 2010;45:191-9.
25. Furuse M, Sasaki H, Tsukita S. Manner of interaction of heterogeneous claudin species within and between tight junction strands. J Cell Biol 1999;147:891-903.
26. Kucharzik T, Walsh SV, Chen J, Parkos CA, Nusrat A. Neutrophil transmigration in inflammatory bowel disease is associated with differential expression of epithelial intercellular junction proteins. Am J Pathol 2001;159:2001-9.
27. Peterson CY, Costantini TW, Loomis WH, Putnam JG, Wolf P, Bansal V et al. Toll-like receptor-4 mediates intestinal barrier breakdown after thermal injury. Surg Infect (Larchmt) 2010;11:137-44.
28. Sun YJ, Chen WM, Zhang TZ, Cao HJ, Zhou J. Effects of cardiopulmonary bypass on tight junction protein expressions in intestinal mucosa of rats. World J Gastroenterol 2008;14:5868-75.
29. Sun X, Yang H, Nose K, Nose S, Haxhija EQ, Koga H et al. Decline in intestinal mucosal IL-10 expression and decreased intestinal barrier function in a mouse model of total parenteral nutrition. Am J Physiol Gastrointest Liver Physiol 2008;294:G139-47.
30. Soderholm JD, Olaison G, Peterson KH, Franzen LE, Lindmark T, Wiren M et al. Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn's disease. Gut 2002;50:307-13.
31. Simonovic I, Rosenberg J, Koutsouris A, Hecht G. Enteropathogenic Escherichia coli dephosphorylates and dissociates occludin from intestinal epithelial tight junctions. Cell Microbiol 2000;2:305-15.
32. McCall IC, Betanzos A, Weber DA, Nava P, Miller GW, Parkos CA. Effects of phenol on barrier function of a human intestinal epithelial cell line correlate with altered tight junction protein localization. Toxicol Appl Pharmacol 2009;241:61-70.
33. Heiskala M, Peterson PA, Yang Y. The roles of claudin superfamily proteins in paracellular transport. Traffic 2001;2:93-8.
34. Tamagawa H, Takahashi I, Furuse M, Yoshitake-Kitano Y, Tsukita S, Ito T et al. Characteristics of claudin expression in follicle-associated epithelium of Peyer's patches: preferential localization of claudin-4 at the apex of the dome region. Lab Invest 2003;83:1045-53.
35. Assimakopoulos SF, Scopa CD, Vagianos CE. Pathophysiology of increased intestinal permeability in obstructive jaundice. World J Gastroenterol 2007;13:6458-64.
36. Portincasa P, Grattagliano I, Testini M, Caruso ML, Wang DQ, Moschetta A et al. Parallel intestinal and liver injury during early cholestasis in the rat: modulation by bile salts and antioxidants. Free Radic Biol Med 2007;42:1381-91.