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Volumn 35, Issue 12, 2010, Pages 1966-1969

Calpains and delayed calcium deregulation in excitotoxicity

Author keywords

Calpain; Excitotoxicity; Glutamate; Neurodegeneration; Neuronal death; Sodium calcium exchanger

Indexed keywords

CALCIUM ION; CALPAIN; CYSTEINE PROTEINASE; GLUTAMATE RECEPTOR;

EID: 78651283944     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-010-0323-z     Document Type: Article
Times cited : (24)

References (41)
  • 1
    • 0029827804 scopus 로고    scopus 로고
    • Mitochondria, calcium regulation, and acute glutamate excitotoxicity in cultured cerebellar granule cells
    • 1:CAS:528:DyaK28Xnt1Squ70%3D 10.1046/j.1471-4159.1996.67062282.x 8931459
    • SL Budd DG Nicholls 1996 Mitochondria, calcium regulation, and acute glutamate excitotoxicity in cultured cerebellar granule cells J Neurochem 67 6 2282 2291 1:CAS:528:DyaK28Xnt1Squ70%3D 10.1046/j.1471-4159.1996.67062282.x 8931459
    • (1996) J Neurochem , vol.67 , Issue.6 , pp. 2282-2291
    • Budd, S.L.1    Nicholls, D.G.2
  • 2
    • 2342636810 scopus 로고    scopus 로고
    • Glutamate-induced deregulation of calcium homeostasis and mitochondrial dysfunction in mammalian central neurones
    • 1:CAS:528:DC%2BD2cXmt1Wjs78%3D 10.1016/j.pbiomolbio.2003.10.002 15288761
    • B Khodorov 2004 Glutamate-induced deregulation of calcium homeostasis and mitochondrial dysfunction in mammalian central neurones Prog Biophys Mol Biol 86 2 279 351 1:CAS:528:DC%2BD2cXmt1Wjs78%3D 10.1016/j.pbiomolbio.2003.10.002 15288761
    • (2004) Prog Biophys Mol Biol , vol.86 , Issue.2 , pp. 279-351
    • Khodorov, B.1
  • 3
    • 0042536473 scopus 로고    scopus 로고
    • Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity
    • 1:CAS:528:DC%2BD3sXlvFGgs78%3D 10.1016/S0143-4160(03)00141-6 12909079
    • M Arundine M Tymianski 2003 Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity Cell Calcium 34 4-5 325 337 1:CAS:528:DC%2BD3sXlvFGgs78%3D 10.1016/S0143-4160(03)00141-6 12909079
    • (2003) Cell Calcium , vol.34 , Issue.45 , pp. 325-337
    • Arundine, M.1    Tymianski, M.2
  • 4
    • 0033289947 scopus 로고    scopus 로고
    • Excitotoxicity and mitochondria
    • 1:CAS:528:DC%2BD3cXkvVOmuw%3D%3D 10989657
    • DG Nicholls SL Budd MW Ward, et al. 1999 Excitotoxicity and mitochondria Biochem Soc Symp 66 55 67 1:CAS:528:DC%2BD3cXkvVOmuw%3D%3D 10989657
    • (1999) Biochem Soc Symp , vol.66 , pp. 55-67
    • Nicholls, D.G.1    Budd, S.L.2    Ward, M.W.3
  • 5
    • 41149174763 scopus 로고    scopus 로고
    • Mechanistic role of calpains in postischemic neurodegeneration
    • 1:CAS:528:DC%2BD1cXjs1aqurw%3D 10.1038/sj.jcbfm.9600595 18073773
    • MB Bevers RW Neumar 2008 Mechanistic role of calpains in postischemic neurodegeneration J Cereb Blood Flow Metab 28 4 655 673 1:CAS:528: DC%2BD1cXjs1aqurw%3D 10.1038/sj.jcbfm.9600595 18073773
    • (2008) J Cereb Blood Flow Metab , vol.28 , Issue.4 , pp. 655-673
    • Bevers, M.B.1    Neumar, R.W.2
  • 6
    • 84856583036 scopus 로고    scopus 로고
    • Calpain in the CNS: From synaptic function to neurotoxicity
    • Liu J, Liu MC, and Wang KK (2008) Calpain in the CNS: from synaptic function to neurotoxicity. Sci Signal 1(14): re1
    • (2008) Sci Signal , vol.1 , Issue.14
    • Liu, J.1    Liu, M.C.2    Wang, K.K.3
  • 7
    • 23144449951 scopus 로고    scopus 로고
    • Role of nitric oxide and calpain activation in neuronal death and survival
    • 1:CAS:528:DC%2BD2MXmvVykt7g%3D 10.2174/1568007054546126 16101551
    • IM Araujo CM Carvalho 2005 Role of nitric oxide and calpain activation in neuronal death and survival Curr Drug Targets CNS Neurol Disord 4 4 319 324 1:CAS:528:DC%2BD2MXmvVykt7g%3D 10.2174/1568007054546126 16101551
    • (2005) Curr Drug Targets CNS Neurol Disord , vol.4 , Issue.4 , pp. 319-324
    • Araujo, I.M.1    Carvalho, C.M.2
  • 8
    • 0027535084 scopus 로고
    • Excitatory amino acid-mediated cytotoxicity and calcium homeostasis in cultured neurons
    • 1:CAS:528:DyaK3sXhvVemu7c%3D 10.1111/j.1471-4159.1993.tb03278.x 8455022
    • A Frandsen A Schousboe 1993 Excitatory amino acid-mediated cytotoxicity and calcium homeostasis in cultured neurons J Neurochem 60 4 1202 1211 1:CAS:528:DyaK3sXhvVemu7c%3D 10.1111/j.1471-4159.1993.tb03278.x 8455022
    • (1993) J Neurochem , vol.60 , Issue.4 , pp. 1202-1211
    • Frandsen, A.1    Schousboe, A.2
  • 9
    • 0022455319 scopus 로고
    • Intracellular calcium homeostasis
    • 1:CAS:528:DyaL2sXhs1Wiug%3D%3D 3307995
    • DG Nicholls 1986 Intracellular calcium homeostasis Br Med Bull 42 4 353 358 1:CAS:528:DyaL2sXhs1Wiug%3D%3D 3307995
    • (1986) Br Med Bull , vol.42 , Issue.4 , pp. 353-358
    • Nicholls, D.G.1
  • 10
    • 0027497936 scopus 로고
    • Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons
    • 1:CAS:528:DyaK3sXksVKku78%3D 8097530
    • M Tymianski MP Charlton PL Carlen, et al. 1993 Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons J Neurosci 13 5 2085 2104 1:CAS:528:DyaK3sXksVKku78%3D 8097530
    • (1993) J Neurosci , vol.13 , Issue.5 , pp. 2085-2104
    • Tymianski, M.1    Charlton, M.P.2    Carlen, P.L.3
  • 11
    • 0029931573 scopus 로고    scopus 로고
    • Voltage-sensitive calcium channels mediate calcium entry into cultured mammalian sympathetic neurons following neurite transection
    • 1:CAS:528:DyaK28XjsVOgsbY%3D 10.1016/0006-8993(96)00125-4 8782889
    • R Sattler M Tymianski I Feyaz, et al. 1996 Voltage-sensitive calcium channels mediate calcium entry into cultured mammalian sympathetic neurons following neurite transection Brain Res 719 1-2 239 246 1:CAS:528: DyaK28XjsVOgsbY%3D 10.1016/0006-8993(96)00125-4 8782889
    • (1996) Brain Res , vol.719 , Issue.12 , pp. 239-246
    • Sattler, R.1    Tymianski, M.2    Feyaz, I.3
  • 12
    • 34548022118 scopus 로고    scopus 로고
    • Changes in calcium dynamics following the reversal of the sodium-calcium exchanger have a key role in AMPA receptor-mediated neurodegeneration via calpain activation in hippocampal neurons
    • 1:CAS:528:DC%2BD2sXptFymtbg%3D 10.1038/sj.cdd.4402171 17585341
    • IM Araujo BP Carreira T Pereira, et al. 2007 Changes in calcium dynamics following the reversal of the sodium-calcium exchanger have a key role in AMPA receptor-mediated neurodegeneration via calpain activation in hippocampal neurons Cell Death Differ 14 9 1635 1646 1:CAS:528:DC%2BD2sXptFymtbg%3D 10.1038/sj.cdd.4402171 17585341
    • (2007) Cell Death Differ , vol.14 , Issue.9 , pp. 1635-1646
    • Araujo, I.M.1    Carreira, B.P.2    Pereira, T.3
  • 13
    • 0032504708 scopus 로고    scopus 로고
    • Mitochondria and neuronal glutamate excitotoxicity
    • 1:CAS:528:DyaK1cXltFWksLo%3D 9714760
    • DG Nicholls SL Budd 1998 Mitochondria and neuronal glutamate excitotoxicity Biochim Biophys Acta 1366 1-2 97 112 1:CAS:528:DyaK1cXltFWksLo%3D 9714760
    • (1998) Biochim Biophys Acta , vol.1366 , Issue.12 , pp. 97-112
    • Nicholls, D.G.1    Budd, S.L.2
  • 14
    • 0032421139 scopus 로고    scopus 로고
    • Neuronal excitotoxicity: The role of mitochondria
    • 1:CAS:528:DyaK1MXltFWisQ%3D%3D 10.1002/biof.5520080317 9914831
    • DG Nicholls SL Budd 1998 Neuronal excitotoxicity: the role of mitochondria Biofactors 8 3-4 287 299 1:CAS:528:DyaK1MXltFWisQ%3D%3D 10.1002/biof.5520080317 9914831
    • (1998) Biofactors , vol.8 , Issue.34 , pp. 287-299
    • Nicholls, D.G.1    Budd, S.L.2
  • 15
    • 76749154427 scopus 로고    scopus 로고
    • Impaired mitochondrial bioenergetics determines glutamate-induced delayed calcium deregulation in neurons
    • 1:CAS:528:DC%2BC3cXitlWit7g%3D 19695307
    • AY Abramov MR Duchen 2010 Impaired mitochondrial bioenergetics determines glutamate-induced delayed calcium deregulation in neurons Biochim Biophys Acta 1800 3 297 304 1:CAS:528:DC%2BC3cXitlWit7g%3D 19695307
    • (2010) Biochim Biophys Acta , vol.1800 , Issue.3 , pp. 297-304
    • Abramov, A.Y.1    Duchen, M.R.2
  • 16
    • 46349104861 scopus 로고    scopus 로고
    • Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity
    • 1:CAS:528:DC%2BD1cXnsFClsrs%3D 18471431
    • AY Abramov MR Duchen 2008 Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity Biochim Biophys Acta 1777 7-8 953 964 1:CAS:528:DC%2BD1cXnsFClsrs%3D 18471431
    • (2008) Biochim Biophys Acta , vol.1777 , Issue.78 , pp. 953-964
    • Abramov, A.Y.1    Duchen, M.R.2
  • 17
    • 0033199019 scopus 로고    scopus 로고
    • Glutamate-induced mitochondrial depolarization and perturbation of calcium homeostasis in cultured rat hippocampal neurones
    • Vergun O, Keelan J, Khodorov BI et al. (1999) Glutamate-induced mitochondrial depolarization and perturbation of calcium homeostasis in cultured rat hippocampal neurones. J Physiol 519 Pt 2: 451-466
    • (1999) J Physiol , vol.519 , Issue.PART 2 , pp. 451-466
    • Vergun, O.1    Keelan, J.2    Khodorov, B.I.3
  • 18
    • 36349012569 scopus 로고    scopus 로고
    • Contribution of Na(+)/Ca(2+) exchange to excessive Ca(2+) loading in dendrites and somata of CA1 neurons in acute slice
    • 1:CAS:528:DC%2BD2sXhsVCmsLjJ 10.1002/hipo.20336 17598158
    • RM Dietz L Kiedrowski CW Shuttleworth 2007 Contribution of Na(+)/Ca(2+) exchange to excessive Ca(2+) loading in dendrites and somata of CA1 neurons in acute slice Hippocampus 17 11 1049 1059 1:CAS:528:DC%2BD2sXhsVCmsLjJ 10.1002/hipo.20336 17598158
    • (2007) Hippocampus , vol.17 , Issue.11 , pp. 1049-1059
    • Dietz, R.M.1    Kiedrowski, L.2    Shuttleworth, C.W.3
  • 19
    • 0028256101 scopus 로고
    • Glutamate impairs neuronal calcium extrusion while reducing sodium gradient
    • 1:CAS:528:DyaK2cXhvVektL4%3D 10.1016/0896-6273(94)90272-0 7906528
    • L Kiedrowski G Brooker E Costa, et al. 1994 Glutamate impairs neuronal calcium extrusion while reducing sodium gradient Neuron 12 2 295 300 1:CAS:528:DyaK2cXhvVektL4%3D 10.1016/0896-6273(94)90272-0 7906528
    • (1994) Neuron , vol.12 , Issue.2 , pp. 295-300
    • Kiedrowski, L.1    Brooker, G.2    Costa, E.3
  • 20
    • 33846783274 scopus 로고    scopus 로고
    • 2+] elevations in cultured hippocampal CA1 neurons during anoxic depolarization
    • 1:CAS:528:DC%2BD2sXisFGnurg%3D 10.1111/j.1471-4159.2006.04308.x 17241128
    • 2+] elevations in cultured hippocampal CA1 neurons during anoxic depolarization J Neurochem 100 4 915 923 1:CAS:528:DC%2BD2sXisFGnurg%3D 10.1111/j.1471-4159.2006. 04308.x 17241128
    • (2007) J Neurochem , vol.100 , Issue.4 , pp. 915-923
    • Kiedrowski, L.1
  • 21
    • 76849109144 scopus 로고    scopus 로고
    • Neuroprotective effect of KB-R7943 against glutamate excitotoxicity is related to mild mitochondrial depolarization
    • 1:CAS:528:DC%2BD1MXhtFGgsbzI 10.1007/s11064-009-0058-x 19771515
    • TP Storozhevykh YE Senilova T Brustovetsky, et al. 2010 Neuroprotective effect of KB-R7943 against glutamate excitotoxicity is related to mild mitochondrial depolarization Neurochem Res 35 2 323 335 1:CAS:528: DC%2BD1MXhtFGgsbzI 10.1007/s11064-009-0058-x 19771515
    • (2010) Neurochem Res , vol.35 , Issue.2 , pp. 323-335
    • Storozhevykh, T.P.1    Senilova, Y.E.2    Brustovetsky, T.3
  • 22
    • 12944297732 scopus 로고    scopus 로고
    • 2+ exchanger in excitotoxicity
    • 1:CAS:528:DC%2BD2MXht1emurk%3D 10.1016/j.cell.2004.11.049 15680332
    • 2+ exchanger in excitotoxicity Cell 120 2 275 285 1:CAS:528:DC%2BD2MXht1emurk%3D 10.1016/j.cell.2004.11.049 15680332
    • (2005) Cell , vol.120 , Issue.2 , pp. 275-285
    • Bano, D.1    Young, K.W.2    Guerin, C.J.3
  • 23
    • 67650484137 scopus 로고    scopus 로고
    • Real-time visualization of cytoplasmic calpain activation and calcium deregulation in acute glutamate excitotoxicity
    • 1:CAS:528:DC%2BD1MXptlensL0%3D 10.1111/j.1471-4159.2009.06194.x 19493161
    • AA Gerencser KA Mark AE Hubbard, et al. 2009 Real-time visualization of cytoplasmic calpain activation and calcium deregulation in acute glutamate excitotoxicity J Neurochem 110 3 990 1004 1:CAS:528:DC%2BD1MXptlensL0%3D 10.1111/j.1471-4159.2009.06194.x 19493161
    • (2009) J Neurochem , vol.110 , Issue.3 , pp. 990-1004
    • Gerencser, A.A.1    Mark, K.A.2    Hubbard, A.E.3
  • 24
    • 77951607970 scopus 로고    scopus 로고
    • 2+ exchanger degradation occur downstream of calcium deregulation in hippocampal neurons exposed to excitotoxic glutamate
    • 1:CAS:528:DC%2BC3cXisFaktbk%3D 19937813
    • 2+ exchanger degradation occur downstream of calcium deregulation in hippocampal neurons exposed to excitotoxic glutamate J Neurosci Res 88 6 1317 1328 1:CAS:528:DC%2BC3cXisFaktbk%3D 19937813
    • (2010) J Neurosci Res , vol.88 , Issue.6 , pp. 1317-1328
    • Brustovetsky, T.1    Bolshakov, A.2    Brustovetsky, N.3
  • 25
    • 38749106974 scopus 로고    scopus 로고
    • 2+ exchanger 3 (NCX3) gene leads to a worsening of ischemic brain damage
    • 1:CAS:528:DC%2BD1cXhvVSksb8%3D 10.1523/JNEUROSCI.4671-07.2008 18234895
    • 2+ exchanger 3 (NCX3) gene leads to a worsening of ischemic brain damage J Neurosci 28 5 1179 1184 1:CAS:528:DC%2BD1cXhvVSksb8%3D 10.1523/JNEUROSCI.4671-07.2008 18234895
    • (2008) J Neurosci , vol.28 , Issue.5 , pp. 1179-1184
    • Molinaro, P.1    Cuomo, O.2    Pignataro, G.3
  • 26
    • 55549130488 scopus 로고    scopus 로고
    • Differential hippocampal protection when blocking intracellular sodium and calcium entry during traumatic brain injury in rats
    • 10.1089/neu.2008.0635 18847376
    • X Zhao FA Gorin RF Berman, et al. 2008 Differential hippocampal protection when blocking intracellular sodium and calcium entry during traumatic brain injury in rats J Neurotrauma 25 10 1195 1205 10.1089/neu.2008.0635 18847376
    • (2008) J Neurotrauma , vol.25 , Issue.10 , pp. 1195-1205
    • Zhao, X.1    Gorin, F.A.2    Berman, R.F.3
  • 27
    • 0032589229 scopus 로고    scopus 로고
    • 2+ exchange inhibitor KB-R7943 protects CA1 neurons in rat hippocampal slices against hypoxic/hypoglycemic injury
    • 1:CAS:528:DyaK1MXhvVOqt7s%3D 10.1016/S0028-3908(98)00198-1 10218875
    • 2+ exchange inhibitor KB-R7943 protects CA1 neurons in rat hippocampal slices against hypoxic/hypoglycemic injury Neuropharmacology 38 2 319 321 1:CAS:528:DyaK1MXhvVOqt7s%3D 10.1016/S0028-3908(98)00198-1 10218875
    • (1999) Neuropharmacology , vol.38 , Issue.2 , pp. 319-321
    • Schroder, U.H.1    Breder, J.2    Sabelhaus, C.F.3
  • 28
    • 0035914207 scopus 로고    scopus 로고
    • Inhibition of Na(+)/Ca(2+) exchange by KB-R7943, a novel selective antagonist, attenuates phosphoethanolamine and free fatty acid efflux in rat cerebral cortex during ischemia-reperfusion injury
    • 1:CAS:528:DC%2BD3MXnsVSms78%3D 10.1016/S0006-8993(01)02896-7 11597606
    • JG Pilitsis FG Diaz MH O'Regan, et al. 2001 Inhibition of Na(+)/Ca(2+) exchange by KB-R7943, a novel selective antagonist, attenuates phosphoethanolamine and free fatty acid efflux in rat cerebral cortex during ischemia-reperfusion injury Brain Res 916 1-2 192 198 1:CAS:528: DC%2BD3MXnsVSms78%3D 10.1016/S0006-8993(01)02896-7 11597606
    • (2001) Brain Res , vol.916 , Issue.12 , pp. 192-198
    • Pilitsis, J.G.1    Diaz, F.G.2    O'Regan, M.H.3
  • 29
    • 0034976176 scopus 로고    scopus 로고
    • 2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models
    • 1:CAS:528:DC%2BD3MXksFChurw%3D 11408549
    • 2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models J Pharmacol Exp Ther 298 1 249 256 1:CAS:528:DC%2BD3MXksFChurw%3D 11408549
    • (2001) J Pharmacol Exp Ther , vol.298 , Issue.1 , pp. 249-256
    • Matsuda, T.1    Arakawa, N.2    Takuma, K.3
  • 30
    • 0027215039 scopus 로고
    • Protective effects of calpain inhibitors against neuronal damage caused by cytotoxic hypoxia in vitro and ischemia in vivo
    • 1:CAS:528:DyaK3sXkt1Sgurg%3D 10.1016/0006-8993(93)90856-I 8508322
    • A Rami J Krieglstein 1993 Protective effects of calpain inhibitors against neuronal damage caused by cytotoxic hypoxia in vitro and ischemia in vivo Brain Res 609 1-2 67 70 1:CAS:528:DyaK3sXkt1Sgurg%3D 10.1016/0006-8993(93) 90856-I 8508322
    • (1993) Brain Res , vol.609 , Issue.12 , pp. 67-70
    • Rami, A.1    Krieglstein, J.2
  • 31
    • 77953719968 scopus 로고    scopus 로고
    • RNAi targeting micro-calpain increases neuron survival and preserves hippocampal function after global brain ischemia
    • 1:CAS:528:DC%2BC3cXnsVarurc%3D 10.1016/j.expneurol.2010.03.007 20298691
    • MB Bevers LP Ingleton D Che, et al. 2010 RNAi targeting micro-calpain increases neuron survival and preserves hippocampal function after global brain ischemia Exp Neurol 224 1 170 177 1:CAS:528:DC%2BC3cXnsVarurc%3D 10.1016/j.expneurol.2010.03.007 20298691
    • (2010) Exp Neurol , vol.224 , Issue.1 , pp. 170-177
    • Bevers, M.B.1    Ingleton, L.P.2    Che, D.3
  • 32
    • 0032496057 scopus 로고    scopus 로고
    • Postischemic treatment with calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia
    • 1:CAS:528:DyaK1cXisFaktbY%3D 10.1016/S0304-3940(98)00266-3 9637399
    • PA Li W Howlett QP He, et al. 1998 Postischemic treatment with calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia Neurosci Lett 247 1 17 20 1:CAS:528:DyaK1cXisFaktbY%3D 10.1016/S0304-3940(98)00266-3 9637399
    • (1998) Neurosci Lett , vol.247 , Issue.1 , pp. 17-20
    • Li, P.A.1    Howlett, W.2    He, Q.P.3
  • 33
    • 0031984802 scopus 로고    scopus 로고
    • Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats
    • 1:CAS:528:DyaK1cXntVKqsQ%3D%3D 9445345
    • CG Markgraf NL Velayo MP Johnson, et al. 1998 Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats Stroke 29 1 152 158 1:CAS:528:DyaK1cXntVKqsQ%3D%3D 9445345
    • (1998) Stroke , vol.29 , Issue.1 , pp. 152-158
    • Markgraf, C.G.1    Velayo, N.L.2    Johnson, M.P.3
  • 34
    • 14944383996 scopus 로고    scopus 로고
    • Calpain inhibitor MDL 28170 protects hypoxic-ischemic brain injury in neonatal rats by inhibition of both apoptosis and necrosis
    • 1:CAS:528:DC%2BD2MXitleqt7w%3D 10.1016/j.brainres.2004.12.050 15777753
    • M Kawamura W Nakajima A Ishida, et al. 2005 Calpain inhibitor MDL 28170 protects hypoxic-ischemic brain injury in neonatal rats by inhibition of both apoptosis and necrosis Brain Res 1037 1-2 59 69 1:CAS:528:DC%2BD2MXitleqt7w%3D 10.1016/j.brainres.2004.12.050 15777753
    • (2005) Brain Res , vol.1037 , Issue.12 , pp. 59-69
    • Kawamura, M.1    Nakajima, W.2    Ishida, A.3
  • 35
    • 0035153398 scopus 로고    scopus 로고
    • The novel calpain inhibitor SJA6017 improves functional outcome after delayed administration in a mouse model of diffuse brain injury
    • 1:STN:280:DC%2BD3Mnns1Kiuw%3D%3D 10.1089/089771501317095269 11721741
    • NC Kupina R Nath EE Bernath, et al. 2001 The novel calpain inhibitor SJA6017 improves functional outcome after delayed administration in a mouse model of diffuse brain injury J Neurotrauma 18 11 1229 1240 1:STN:280: DC%2BD3Mnns1Kiuw%3D%3D 10.1089/089771501317095269 11721741
    • (2001) J Neurotrauma , vol.18 , Issue.11 , pp. 1229-1240
    • Kupina, N.C.1    Nath, R.2    Bernath, E.E.3
  • 36
    • 73849113384 scopus 로고    scopus 로고
    • Calpain inhibition reduces axolemmal leakage in traumatic axonal injury
    • 1:CAS:528:DC%2BD1MXhsFKru7rJ 10.3390/molecules14125115 20032879
    • E Czeiter A Buki P Bukovics, et al. 2009 Calpain inhibition reduces axolemmal leakage in traumatic axonal injury Molecules 14 12 5115 5123 1:CAS:528:DC%2BD1MXhsFKru7rJ 10.3390/molecules14125115 20032879
    • (2009) Molecules , vol.14 , Issue.12 , pp. 5115-5123
    • Czeiter, E.1    Buki, A.2    Bukovics, P.3
  • 37
    • 0033985303 scopus 로고    scopus 로고
    • Behavioral efficacy of posttraumatic calpain inhibition is not accompanied by reduced spectrin proteolysis, cortical lesion, or apoptosis
    • 1:CAS:528:DC%2BD3cXhtV2qu7Y%3D 10.1097/00004647-200001000-00010 10616794
    • KE Saatman C Zhang RT Bartus, et al. 2000 Behavioral efficacy of posttraumatic calpain inhibition is not accompanied by reduced spectrin proteolysis, cortical lesion, or apoptosis J Cereb Blood Flow Metab 20 1 66 73 1:CAS:528:DC%2BD3cXhtV2qu7Y%3D 10.1097/00004647-200001000-00010 10616794
    • (2000) J Cereb Blood Flow Metab , vol.20 , Issue.1 , pp. 66-73
    • Saatman, K.E.1    Zhang, C.2    Bartus, R.T.3
  • 38
    • 0030004873 scopus 로고    scopus 로고
    • Calpain inhibitor AK295 attenuates motor and cognitive deficits following experimental brain injury in the rat
    • 1:CAS:528:DyaK28XisVWitrk%3D 10.1073/pnas.93.8.3428 8622952
    • KE Saatman H Murai RT Bartus, et al. 1996 Calpain inhibitor AK295 attenuates motor and cognitive deficits following experimental brain injury in the rat Proc Natl Acad Sci USA 93 8 3428 3433 1:CAS:528:DyaK28XisVWitrk%3D 10.1073/pnas.93.8.3428 8622952
    • (1996) Proc Natl Acad Sci USA , vol.93 , Issue.8 , pp. 3428-3433
    • Saatman, K.E.1    Murai, H.2    Bartus, R.T.3
  • 39
    • 42449116702 scopus 로고    scopus 로고
    • Calpain activation is involved in early caspase-independent neurodegeneration in the hippocampus following status epilepticus
    • 1:CAS:528:DC%2BD1cXlsl2hur0%3D 10.1111/j.1471-4159.2007.05181.x 18088374
    • IM Araujo JM Gil BP Carreira, et al. 2008 Calpain activation is involved in early caspase-independent neurodegeneration in the hippocampus following status epilepticus J Neurochem 105 3 666 676 1:CAS:528:DC%2BD1cXlsl2hur0%3D 10.1111/j.1471-4159.2007.05181.x 18088374
    • (2008) J Neurochem , vol.105 , Issue.3 , pp. 666-676
    • Araujo, I.M.1    Gil, J.M.2    Carreira, B.P.3
  • 40
    • 41449109239 scopus 로고    scopus 로고
    • Mu-calpain mediates hippocampal neuron death in rats after lithium-pilocarpine-induced status epilepticus
    • 1:CAS:528:DC%2BD1cXktlGhsLg%3D 10.1016/j.brainresbull.2007.12.006 18395616
    • S Wang P Shan Z Song, et al. 2008 Mu-calpain mediates hippocampal neuron death in rats after lithium-pilocarpine-induced status epilepticus Brain Res Bull 76 1-2 90 96 1:CAS:528:DC%2BD1cXktlGhsLg%3D 10.1016/j.brainresbull.2007.12. 006 18395616
    • (2008) Brain Res Bull , vol.76 , Issue.12 , pp. 90-96
    • Wang, S.1    Shan, P.2    Song, Z.3
  • 41
    • 17644393902 scopus 로고    scopus 로고
    • Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors
    • 1:CAS:528:DC%2BD2MXjtFSlt70%3D 10.1074/jbc.M500939200 15699033
    • M Higuchi M Tomioka J Takano, et al. 2005 Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors J Biol Chem 280 15 15229 15237 1:CAS:528:DC%2BD2MXjtFSlt70%3D 10.1074/jbc.M500939200 15699033
    • (2005) J Biol Chem , vol.280 , Issue.15 , pp. 15229-15237
    • Higuchi, M.1    Tomioka, M.2    Takano, J.3


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