Bacopa monniera L.: Pharmacological aspects and case study involving piriformospora indica

International Journal of Integrative Biology

Volumn 3, Issue 2, 2008, Pages 100-110

  Prasad, R ^a   Bagde, U S ^b   Puspangadan, P ^c   Varma, A ^a  

^a AMITY UNIVERSITY   (India)

^b UNIVERSITY OF MUMBAI   (India)

^c Biotech Products Development   (India)

Author keywords

Arbuscular mycorrhizal fungus (AMF); Bacopa monniera; Bacosides; Brahmi; Nootropic; Piriformospora indica; Saponins

Indexed keywords

BACOPA MONNIERI EXTRACT; HERBACEOUS AGENT;

ANTINEOPLASTIC ACTIVITY; AYURVEDA; BACOPA MONNIERI; CASE STUDY; COCULTURE; DRUG DETERMINATION; DRUG INDICATION; DRUG MECHANISM; FUNGAL COLONIZATION; FUNGUS; FUNGUS CULTURE; FUNGUS HYPHAE; HUMAN; MEMORY CONSOLIDATION; MENTAL PERFORMANCE; MICROPROPAGATION; NONHUMAN; PIRIFORMOSPORA INDICA; PLANT PATHOGEN INTERACTION; REVIEW; ROOT SYSTEM; SPECIES CONSERVATION; SPOROGENESIS;

BACOPA MONNIERI; FUNGI; PIRIFORMOSPORA INDICA;

EID: 78651267873     PISSN: 09738363     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (93)

1. Anbarasi K, et al.(2005a) Effect of bacoside-A on membrane-bound ATPases in the brain of rats exposed to cigarette smoke. J. Biochem. Mole. Toxicol.19: 59–65.
2. Anbarasi K, Vani G, Shyamala Devi CS (2005b) Protective effect of bacoside-A on cigarette smoking-induced brain mitochondrial dysfunction in rats. J. Env. Pathol., Toxicol. Oncol.24: 225–234.
3. Anbarasi K, et al.(2005c) Induction of Hsp70 and apoptosis during cigarette smoking in rat brain: Modulation by bacoside A. Presented at the 6th IBRO School of Neuroscience, Bangalore, India, Aug 8–20, 2005.
4. Anbarasi K, et al.(2006) Effect of bacoside-A on brain antioxidant status in cigarette smoke exposed rats. Life Sci. 78: 1378-84.
5. Aoshiba K, Tamaoki, J, Nagai A (2001) Acute cigarette smoke exposure induces apoptosis of alveolar macrophages. AJP- Lung Cellular and Molecular Physiology 281, L1392–L1401.
6. Anon (2004) Bacopa monnieri. Monograph. Altern. Med. Rev.9: 79–85.
7. Banerjee M, Shrivastava S (2008) An improved protocol for in vitro multiplication of Bacopa monnieri (L.). World J. Microbiol. Biotechnol., Springer Netherlands, 24: 1355-1359.
8. Bhakuni DS, et al.(1969) Screening of Indian plants for biological activity. part II. Indian J. Expt. Biol.7: 250-62.
9. Bhattacharya SK, Kumar A, Ghosal S (1999) Effect of Bacopa monniera on animal models of Alzheimer's disease and perturbed central cholinergic markers of cognition in rats. Res. Comm. Pharmacol. Toxicol. 4: ii1 -ii12.
10. Bhattacharya SK, et al.(2000) Antioxidant activity of Bacopa monniera in rat frontal cortex, striatum, and hippocampus. Phytotherapy Res. 14: 174-179.
11. Blumenthal ME (2003) The American Botanical Council (ABC) clinical guide to herbs. Austin, Texas: The American Botanical Council. pp. 215.
12. Bone K (1996) Clinical Applications of Ayurvedic and Chinese Herbs: Monographs for the Western Herbal Practitioner. Warwick, Queensland: Phytother. Press. 131-41.
13. Carlson N (2002) Physiological Psychology, 5th edn. Boston: A Pearson Education Company.
14. Chakravarty AK, et al.(2001) Bacopaside I and II: two pseudojujubogenin glycosides from Bacopa monniera. Phytochem. 58: 553-556.
15. Chakravarty AK, Garai S, Masuda K (2003) Bacopasides III-V: three new triterpenoid glycosides from Bacopa monniera. Chemical and Pharmaceutical Bulletin, Tokyo 51: 215-217.
16. Channa S, et al.(2003) Broncho-vasodilatory activity of fractions and pure constituents isolated from Bacopa monniera. J. Ethnopharmacol.86: 27–35.
17. Chatterji N, Rastogi RP, Dhar ML (1963) Chemical examination of Bacopa monniera Wettst.: Part I - Isolation of chemical constituents. Indian J. Chem.1: 212-215.
18. Chopra RN (1958) Indigenous Drugs of India. 2nd ed. Calcutta, India: U.N. Dhur and Sons. 341.
19. Chopra RN, Nayar SL, Chopra IC (1956) Glossary of Indian medicinal plants, New Delhi, CSIR. p 32.
20. Chowdhuri DK, et al.(2002) Antistress effects of bacosides of Bacopa monnieri: modulation of Hsp70 expression, Superoxide dismutase and cytochrome P450 activity in rat brain. Phytotherapy Res. 16: 639–645.
21. Dar A, Channa S (1997) Relaxant effect of ethanolic extract of Bacopa monniera on trachea, pulmonary artery and aorta from rabbit and guinea pig. Phytotherapy Res. 11: 323–325.
22. Dar A, Channa, S (1999) Calcium antagonistic activity of Bacopa monniera on vascular and intestinal smooth muscles of rabbit and guinea pig. J. Ethnopharmacol. 66: 167–174.
23. Dave UP, Chauvan V, Dalvi J (1993) Evaluation of BR-16 A (Mentat) in cognitive and behavioural dysfunction of mentally retarded children: a placebo-controlled study. Indian J. Pediatr.60: 423-428.
24. Deb DD, et al.(2008) In vitro safety evaluation and anticlastogenic effect of BacoMindTM on human lymphocytes. Biomed. Environ. Sci. 21: 7-23.
25. Deshmukh S, et al.(2006) The root endophytic fungus Piriformospora indica requires host cell death for proliferation during mutualistic symbiosis with barley. Proc. Natl. Acad. Sci., USA.103: 18450-184557.
26. Dhawan BN, Singh HK (1996) Pharmacological studies on Bacopa monniera, an Ayuredic nootropic agent. Europ. Neuropsychopharmacol.653: 144.
27. Dhyani PP, Kala CP (2005) Current research on medicinal plants: five lesser known but valuable aspects. Curr. Sci.88: 335.
28. Deepak M, Amit A (2004) The need for establishing identities of bacoside A and B, the putative major bioactive saponins of Indian medicinal plant Bacopa monnieri. Phytomedicine11: 264–268.
29. Deepak M, et al.(2005) Quantitative determination of the major saponin mixture bacoside A in Bacopa monnieri by HPLC. Phytochem. Anal.16: 24–29.
30. Drüüge U, Baltruschat H, Franken P (2007) Piriformospora indica promotes adventitious root formation in cuttings. Sci. Hortic. 112: 422–426.
31. Elangovan V, et al.(1995) In vitro studies on the anticancer activity of Bacopa monnieri. Fitoterapia 66: 211-215.
32. Enz A, Amstutz R, Boddeke H et al. (1993) Brain selective inhibition of acetylcholinesterase: a novel approach to therapy for Alzheimer’s disease. Progress in Brain Res. 98: 431-438.
33. Hill TW, Käfer E (2001) Improved protocols for Aspergillus medium: trace elements and minimum medium salt stock solutions. Fungal Genetics Newsletter48: 20-21.
34. Hou CC, et al.(2002) Bacopaside III, Bacopa saponin G, and bacopasides A, B, and C from Bacopa monniera. J. Nat. Prod.65: 1759-1763.
35. Himi T, Saito H, Nishiyama N (1989) Effect of Ginseng saponins on the survival of cerebral cortex neurons in cell cultures. Chemical and Pharmaceutical Bulletin, 37: 481-484.
36. Jain P, et al.(1994) Antiinflammatory effects of an Ayurvedic preparation, Brahmi Rasayan, in rodents. Indian J. Expt. Biol.32: 633-636.
37. Jyoti A, Sharma D (2006) Neuroprotective role of Bacopa monniera extract against aluminium-induced oxidative stress in the hippocampus of rat brain. Neuro Toxicol. 27: 451–457.
38. Kapoor LD (1990) CRC Handbook of Ayurvedic Medicinal Plants. Florida: CRC Press, Boca Raton.
39. Kishore M, Singh M (2005) Effect of bacosides, alcoholic extract of Bacopa monniera Linn. (brahmi), on experimental amnesia in mice. Indian J. Expt. Biol., 43: 640-645.
40. Mahato SB, Garai S, Chakravarty AK (2000) Bacopasaponins E and F: two jujubogenin bisdesmosides from Bacopa monniera. Phytochemistry53: 711-714.
41. Malhotra CL, Das PK (1959) Pharmacological studies on Herpestis monniera. Indian J. Medical Research47: 244–305.
42. Mathur S, et al.(2002) Herb yield and bacoside A content of field grown Bacopa monniera accessions. J. Herbal, Spices and Medicinal Plants9: 11–18.
43. Ma TC, Yu QH (1993) Effect of 20-(S)-Ginsenoside-R2 and cyproheptadine on two-way active avoidance learning and memory in rats. Arzneim-Forsch/Drug Research, 43: 1049-1052.
44. Ma TC, Yu QH, Chen MH (1991) Effects of ginseng stem-leaves saponins on one way avoidance behaviour in rats. Zhongguo Yao Li Xue Bao, 12: 403-406.
45. Nadkarni KM (1976) Indian materia medica, Bombay: Popular Prakashan Pvt. Ltd. Pp. 624–625.
46. Nathan PJ, et al.(2001) The acute effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy normal subjects. Human Psychopharmacology16: 345–351.
47. Nathan PJ, et al.(2004) Effects of a combined extract of Gingko biloba and Bacopa monniera on cognitive function in healthy humans. Human Psychopharmacology, 19: 91-96.
48. Negi KS, et al.(2000) Clinical evaluation of memory enhancing properties of Memory Plus in children with attention deficit hyperactivity disorder'. Indian Journal of Psychiatry, 42, Supplement
49. Oelmüller R, et al.(2005) MATH-domain proteins represent a novel protein family in Arabidopsis thaliana and at least one member is modified in roots in the course of a plant/microbe interaction. Physiologia Plantarum124: 152-166.
50. Peškan-Berghöfer T, et al.(2004) Association of Piriformospora indica with Arabidopsis thaliana roots represent a novel system to study beneficial plant-microbe interactions and involve in early plant protein modifications in the endocytoplasmic reticulum and in the plasma membrane. Plant Physiol. 122: 465-471.
51. Pham HG, et al.(2004a) Interaction of Piriformospora indica with diverse microorganisms and plants. In: Plant Surface Microbiology. Springer-Verlag, Germany. pp. 237-265.
52. Pham HG, et al.(2004b) Axenic culture of symbiotic fungus Piriformospora indica. In: Plant Surface Microbiology. Springer-Verlag, Germany. pp. 593-613.
53. Pinot F, et al.(1997) Induction of stress proteins by tobacco smoke in human monocytes: modulation by antioxidants. Cell Stress Chaperones2, 156–161.
54. Prasad R, Garg AP, Varma A (2004) Interaction of medicinal plants with plant growth promoting rhizobacteria and symbiotic fungi. In: Basic Research and Applications: Mycorrhizae. IK International-India, New York and Kluwer academic Press, Holland, pp. 363-407.
55. Prasad R, et al.(2005) Sebacinaceae: culturable mycorrhiza-like endophytic fungi and their interaction with non-transformed and transformed roots. In: Root Organ Culture of Mycorrhizal Fungi. Springer-Verlag, Germany. pp. 293-312.
56. Prasad R, et al.(2008) Interactions of Piriformospora indica with medicinal plants. In: Mycorrhiza, Springer-Verlag Berlin Heidelberg. pp. 655-678.
57. Pravina K, et al.(2007) Safety evaluation of BacoMindTM in healthy volunteers: A phase I study. Phytomedicine14: 301–308.
58. Rahman LU, et al.(2002) Bacoside production by suspension cultures of Bacopa monnieri (L.) Pennell. Biotechnol. Letters24: 1427–1429.
59. Rai MK, Varma A, Pandey AK (2004) Enhancement of antimycotic potential in Spilanthes calva after inoculation of Piriformospora indica, a new growth promoter. Mycoses, Germany 47: 479-481.
60. Rastogi S, et al.(1994b) Bacoside A3-A triterpenoid saponin from Bacopa monniera. Phytochem. 36: 133–137.
61. Roodernrys S, et al.(2002) Chronic effects of Brahmi (Bacopa monnieri) on human memory. Neuropsychopharmacology27: 279–281.
62. Russo A, et al.(2003a) Nitric oxide-related toxicity in cultured astrocytes: effect of Bacopa monniera. Life Sci. 73: 1517–1526.
63. Russo A, et al.(2003b) Free radical scavenging capacity and protective effect of Bacopa monniera on DNA damage. Phytotherapy Res. 17: 870–875.
64. Russo A, Borrelli F (2005) Bacopa monniera, a reputed nootropic plant: an overview. Phytomedicine 12: 305-317.
65. Sairam K, et al.(2002) Antidepressant activity of standardized extract of Bacopa monniera in experimental models of depression in rats. Phytomedicine 9: 207–211.
66. Sairam K, et al.(2001) Prophylactic and curative effects of Bacopa monniera in gastric ulcer models. Phytomedicine8: 423–430.
67. Samiulla DS, Prashanth D, Amit A (2001) Mast cell stabilising activity of Bacopa monnieri. Fitoterapia72: 284–285.
68. Serfling A, et al.(2007) Performance of the biocontrol fungus Piriformospora indica on wheat under greenhouse and field conditions. Phytopathol. 97: 523-531.
69. Shahollari B, et al.(2007) A leucine rich repeat protein is required for growth promotion and enhanced seed production mediated by the endophytic fungus Piriformospora indica in Arabidopsis thaliana. The Plant J. 50: 1-13.
70. Shahollari B, Varma A, Oelmüller R (2005) Expression of a receptor kinase in roots is stimulated by the basidiomycete Piriformospora indica and the protein accumulates in Triton-X-100 insoluble plasma membrane microdomains. J. Plant. Physiol.162: 945-958.
71. Sharma R, Chaturvedi C, Tewari PV (1987) Efficacy of Bacopa Monnieri in revitalizing intellectual functions in children. J. Res. Edu. Ind. Medi., 6: 1-10.
72. Sherameti I, et al.(2008a) PYK10, a ß-glucosidase located in the endoplasmatic reticulum, is crucial for the beneficial interaction between Arabidopsis thaliana and the endophytic fungus Piriformospora indica. The Plant J. 54: 428-439
73. Sherameti I, et al.(2008b) The root colonizing endophyte Pirifomospora indica confers drought tolerance in Arabidopsis by stimulating the expression of drought-stress related genes in leaves. Mol. Plant Microbe Int.21: 799-807.
74. Shukia B, et al.(1987) Effect of Brahmi Rasayan on the central nervous system. J. Ethnopharmacol.21: 65–74.
75. Singh RH, Singh L (1980) Studies on the anti-anxiety effect of the medhya rasayana drug, Brahmi (Bacopa monniera Wettst.)-part 1. J. Res. Ayurveda and Siddha, 1: 133-148
76. Singh HK, et al.(1988) Effect of Bacosides A and B on avoidance responses in rats. Phytotherapy Res. 2: 70–75
77. Singh HK, Dhawan BN (1997) Neuropsychopharmacological effects of the Ayurvedic nootropic Bacopa Monniera Linn. (Brahmi). Indian J. Pharmacol.29: 359–365
78. Singh HK, Dhawan BN (1982) Effect of Bacopa monniera Linn. (Brahmi) extract on avoidance responses in rats. Journal of Ethnopharmacol., 5: 205-214
79. Sinha J, et al.(2002) Bacosaponin C.: critical evaluation of anti-leishmanial properties in various delivery models. Drug Delivery9: 55–62.
80. Sivarajan VV, Balachandran I (1994) Ayurvedic drugs and their plant sources, Oxford and IBH Publishing Co. New Delhi. Pp. 97–99.
81. Sivaramakrishna C, et al.(2005) Triterpenoid glycosides from Bacopa monniera. Phytochemistry66: 2719–2728
82. Stough C, et al.(2001) The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology, 156: 481-484
83. Sumathi T, Nongbri A (2008) Hepatoprotective effect of Bacoside-A, a major constituent of Bacopa monniera Linn. Phytomedicine. Online.
84. Sumathy T, et al.(2002) Protective role of Bacopa monniera on morphine-induced brain mitochondrial enzyme activity in rats. Fitoterapia73: 381–385.
85. Sumathy T, et al.(2001) Protective role of Bacopa monniera on morphine induced hepatotoxicity in rats. Phytotherapy Res. 15: 643–645
86. Tripathi YB, et al.(1996) Bacopa monniera Linn. as antioxidant: mechanism of action. Indian J. Exp. Biol. 34: 523–526.
87. Tiwari V, Tiwari TN, Singh BD (2006) Shoot bud regeneration from different explants of Bacopa monniera (L.) Wettst. by trimethoprim and bavistin. Plant Cell Rep. 25: 629–635.
88. Uphof JC (1968) The dictionary of economic plants, vol. 62. Verlag von J Cramer, NewYork
89. Varma A, et al.(1999) Piriformospora indica, a cultivable plant-growth-promoting root endophyte. Appl. Env. Microbiol. 65: 2741–2744.
90. Verma S, et al.(1998) Piriformospora indica gen. nov., a new root-colonizing fungus. Mycologia 90: 895-909.
91. Waller F, et al.(2005) The endophytic fungus Piriformospora indica reprograms barley to salt stress tolerance, disease resistance and higher yield. Proc. Natl. Acad. Sci. USA102: 13386-13391.
92. Weiß M, et al.(2004) Sebacinales: a hitherto overlooked cosm of heterobasidiomycetes with a broad mycorrhizal potential. Mycol. Res.108: 1003–1010.
93. World Health Organisation (WHO) (1992) The international classification of mental and behavioural disorders, 10th Revision, (ICD-10). Clinical descriptions and diagnostic guidelines. Geneva.