Discovery of novel class 1 phosphatidylinositide 3-kinases (PI3K) fragment inhibitors through structure-based virtual screening

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 2, 2011, Pages 829-835

  Giordanetto, Fabrizio ^a   Kull, Bengt ^a   Dellsén, Anita ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

Docking; Fragment based; p110 inhibitor; Phosphatidylinositide 3 kinase; PI3K; Virtual screening

Indexed keywords

ISOENZYME; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; WORTMANNIN;

ARTICLE; BINDING AFFINITY; DRUG STRUCTURE; ENZYME INHIBITION; HYDROGEN BOND; IC 50; LIPOPHILICITY;

BINDING SITES; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; LIGANDS; MODELS, MOLECULAR; PHOSPHATIDYLINOSITOL 3-KINASE; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78651258569     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.11.087     Document Type: Article

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