Immunohistochemical identification of prevalent right ventricular ischemia causing right heart failure in cases of pulmonary fat embolism

International Journal of Legal Medicine

Volumn 124, Issue 6, 2010, Pages 537-542

  Fracasso, Tony ^a   Karger, Bernd ^a   Pfeiffer, Heidi ^a   Sauerland, Cristina ^a   Schmeling, Andreas ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Acute cor pulmonale; Immunohistochemistry; Ischemic damage; Pulmonary fat embolism; Right ventricular failure

Indexed keywords

AGED; ARTICLE; CAUSE OF DEATH; COMPARATIVE STUDY; FAT EMBOLISM; FEMALE; FRACTURE; HEART FAILURE; HEART MUSCLE ISCHEMIA; HEART RIGHT VENTRICLE FUNCTION; HEART VENTRICLE; HUMAN; IMMUNOHISTOCHEMISTRY; LUNG EMBOLISM; MALE; MIDDLE AGED; MULTIPLE TRAUMA; NECROSIS; PATHOLOGY;

AGED; CAUSE OF DEATH; EMBOLISM, FAT; FEMALE; FRACTURES, BONE; HEART FAILURE; HEART VENTRICLES; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MULTIPLE TRAUMA; MYOCARDIAL ISCHEMIA; NECROSIS; PULMONARY EMBOLISM; VENTRICULAR DYSFUNCTION, RIGHT;

EID: 78651229260     PISSN: 09379827     EISSN: 14371596     Source Type: Journal    
DOI: 10.1007/s00414-009-0382-3     Document Type: Article

References (49)

1. Levy DL (1990) The fat embolism syndrome. Clin Orthop 261:281-286
2. Talbot M, Schemitsch EH (2006) Fat embolism syndrome: history, definition, epidemiology. Injury 37S:S3-S7
3. Gurd AR, Wilson RI (1974) The fat embolism syndrome. J Bone Jt Surg 56B:408-416
4. Peltier LF (1984) Fat embolism an appraisal to the problem of. Clin Orthop Relat Res 187:3-17
5. Peltier LF (1988) Fat embolism a perspective. Clin Orthop Relat Res 232:263-270
6. Glover P, Worthley LIG (1999) Fat embolis. Criti Care Resusc 1:276-284
7. Hurford WE, Zapol WM (1988) The right ventricle and critical illness: a review of anatomy, physiology, and clinical evaluation of its functions. Intensive Care Med 14:448-457
8. Pitto RP, Blunk J, Kößler M (2000) Transesophageal echocardiography and clinical features of fat embolism during cemented total hip arthroplasty. Arch Orthop Trauma Surg 120:53-58
9. Tanus-Santos JE, Theodorakis MJ (2002) Is there a place for inhaled nitric oxide in the therapy of acute pulmonary embolism? Am J Resp Med 1:167-176
10. Mellor A, Soni N (2001) Fat embolism. Anaesthesia 56:145-154
11. Fabian TC (1993) Unraveling the fat embolism syndrome. N Engl J Med 329:961-963
12. Hulman G (1995) The pathogenesis of fat embolism. J Pathol 176:3-9
13. Sevitt S (1962) Pathology of systemic embolism-the brain. In: Fat embolism, Butterworths, London, pp 129-158
14. Wyatt JP, Khoo P (1950) Fat embolism in trauma. Am J Clin Pathol 20:637-640
15. Alexander-Katz A (1924) Über die Fettembolie in den Lungen. Dtsch Z ges Gerichtl Med 1:466-480
16. Brandt G, Sasse P, Gunselmann W (1976) Mineralgehalt und Morphologie bei unterschiedlicher Todesursache. Virchows Arch A Path Anat Histopathol 369:335-345
17. Wintritz E (1896) Ueber die gerichtsärztliche Beurtheilung von Fettembolien. Vierteljahresschrift gerichtl öffentl Med 11:44-62
18. Stuelp (1903) Ueber den Tod durch Embolie und den Nachweis desselben an der Leiche vom gerichtsärtzlichen Standpunkt aus. Vierteljahresschrift gerichtl öffentl Med 25:330-352
19. Strassmann G (1933) Über Fettembolie nach Verletzungen durch stumpfe Gewalt und nach Verbrennung. Dtsch Zschr ges Rechtmed 22:272-298
20. Falzi G, Henn R, Spann W (1964) Über pulmonale fettembolien nach traumen mit verschieden langer Überlebenszeit. Münch Med Wochenschr 106:978-981
21. Brinkmann B, Borgner M, von Bülow M (1976) Die Fettembolie der Lungen als Todoseursache. Ätiologie, pathogenese, beweisführung. Z Rechtsmedizin 78:255-272
22. Turillazzi E, Riezzi I, Neri M, Pomara C, Cecchi R, Fineschi V (2008) The diagnosis of fatal pulmonary embolism using quantitative morphometry and confocal laser scanning microscopy. Pathol Res Pract 204:259-266
23. Wehner W (1968) Fettembolisches Geschehen im kleinen Kreislauf. In: Die Fettembolie, Veb Verlag Volk und Gesundheit, Berlin, pp 57-70
24. Klosterhalfen B, Mittermayer C, Bajanowski T (2004) Sekundärfolgen mechanischer Gewalteinwirkung - Fettembolie. In: Brinkmann B, Madea B, Hrgbs. Handbuch gerichtliche Medizin, Springer Verlag, Berlin, Heidelberg, Band 1, p 276
25. Arai F, Kita T, Nakai T, Hori T, Maki N, Kakiuchi M, Sasaki S (2007) Histopathologic features of fat embolism in fulminant fat embolism syndrome. Anesthesiol 107:509-511
26. Von Euler US, Liljestrand G (1946) Observations on the pulmonary arterial blood pressure in the cat. Acta Physiol Scand 12:301-320
27. Ward JPT, Aaronson PI (1999) Mechanism of hypoxic pulmonary vasoconstriction: can anyone be right? Resp Physiol 115:261-271
28. Anrep G (1912) On the part played by the suprarenals in the normal vascular reactions of the body. J Physiol 45:307-317
29. Hurford WE, Barlai-Kovach M, Strauss HW, Zapol WM (1987) Canine biventricular performance during acute progressive pulmonary microembolisation: regional myocardial perfusion and fatty acid uptake. J Crit Care 2:270-281
30. Fineberg MH, Wiggers CJ (1936) Compensation and failure of the right ventricle. Am Heart J 11:255-263
31. Laver MB, Strauss W, Pohost GM (1979) Right and left ventricular geometry: adjustments during acute respiratory failure. Crit Care Med 7:509-519
32. Lowensohn HS, Khouri EM, Gregg DE, Pyle RL, Patterson RE (1976) Phasic right coronary artery blood flow in conscious dogs with normal and elevated right ventricular pressures. Circ Res 39:760-766
33. Gold FL, Bache RJ (1982) Transmural right ventricular blood flow during acute pulmonary artery hypertension in sedated dog. Evidence for subendocardial ischemia despite residual vasodilator reserve. Circ Res 51:196-204
34. Walder R (1939) Elektrokardiographische und histologische Untersuchungen des Herzens bei experimenteller Luft- und Fettembolie sowie bei Embolie durch Stärkesuspension. Beitr path Anat 102:485-511
35. Hecht A, Korb G (1960) Über die Drückverhältnisse im rechten Ventrikel bei der Fettembolie als ein Beitrag zum akuten Cor pulmonale. Z ges inn Med 2:51-56
36. Hecht A, Korb G (1960) b) Über Beziehungen zwischen rechtsseitigem intracardialem Druck und dem Auftreten von Herzmuskelnekrosen sowie Fettdurchtritt durch die Lungenkapillaren bei der experimentellen Fettembolie. Beitr path Anat 123:383-397
37. Harman JW, Ragaz FJ (1950) The pathogenesis of fat embolism. Am J Pathol 26:551-560
38. Friedberg J (1942) Anatomische Untersuchungen des Herzmuskels bei Fettembolie. Dtsch Zschr Chir 255:239-248
39. Brinkmann B (1999) Harmonisation of medico-legal autopsy rules. Committee ofMinisters. Council of Europe. Int J Leg Med 113:1-14
40. Brinkmann B, Sepulchre MA, Fechner G (1993) The application of selected histochemical and immunohistochemical markers and procedures to the diagnosis of early myocardial damage. Int J Legal Med 106:135-141
41. Ortmann C, Pfeiffer H, Brinkmann B (2000) A comparative study on the immunohistochemical detection of early myocardial damage. Int J Legal Med 113:215-220
42. Thomsen H, Held H (1994) Susceptibility of C5b9 to post-mortem changes. Int J Legal Med 106:291-293
43. Iwadate K, Doi M, Tanno K, Katsumura S, Ito H, Sato K, Yonemura I, Ito Y (2003) Right ventricular damage due to pulmonary embolism: examination of the number of infiltrating macrophages. For Sci Int 134:147-153
44. Bogieneman MPV, van de Goot FRW, van der Bilt IAC, Vonk Noordegraaf A, Speeuwenberg MD, Paulus WJ, van Hinsbergh VWM, Visser FC, Niessen HWM (2008) Pulmonary embolism causes endomyocarditits in the human heart. Heart 94:450-456
45. Barnard D, Alpert JS (1987) Right ventricular function in health and disease. Curr Probl Cardiol 12:423-449
46. Hayashi T, Ishida Y, Mizunuma S, Kimura A, Kondo T (2009) Differential diagnosis between freshwater drowning and saltwater drowning based on intrapulmonary aquaporin-5 expression. Int J Legal Med 123:7-13
47. Matschke J, Püschel K, Glatzel M (2009) Ocular pathology in shaken baby syndrome and other forms of infantile non-accidental head injury. Int J Legal Med 123:189-197
48. Nosaka S, Ishida Y, Kimura A, Kondo K (2009) Time-dependent appearance of intrathrombus neutrophils and macrophages in a stasis-induced deep vein thrombosis model and its application to thrombus age determination. Int J Legal Med 123:235-240
49. Sinicina I, Pankratz H, Bise K, Matevossian E (2009) Forensic aspects of post-mortem histological detection of amniotic fluid embolism. Int J Legal Med. doi:10.1007/s00414-009-0351-x