Proteomic basis of the antibody response to monkeypox virus infection examined in cynomolgus macaques and a comparison to human smallpox vaccination

PLoS ONE

Volumn 5, Issue 12, 2010, Pages

  Keasey, Sarah ^a   Pugh, Christine ^a   Tikhonov, Alexander ^b   Chen, Gengxin ^b   Schweitzer, Barry ^b   Nalca, Aysegul ^a   Ulrich, Robert G ^a  

^a UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^b Life Technologies   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; PROTEOME; SMALLPOX VACCINE; VIRUS PROTEIN;

ACTIVE IMMUNIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY DETECTION; ANTIBODY RESPONSE; ANTIGEN DETECTION; ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; CONVALESCENCE; FEMALE; HUMAN; HUMAN EXPERIMENT; HUMAN VERSUS ANIMAL COMPARISON; HUMORAL IMMUNITY; IMMUNOGLOBULIN BLOOD LEVEL; MACACA; MALE; MOLECULAR CLONING; MONKEYPOX; NONHUMAN; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; PROTEIN MICROARRAY; SMALLPOX; VACCINIA VIRUS; VIRUS GENE; VIRUS NEUTRALIZATION; VIRUS STRAIN; AMINO ACID SEQUENCE; ANIMAL; CERCOPITHECUS; COMPARATIVE STUDY; DNA MICROARRAY; IMMUNOLOGY; MACACA FASCICULARIS; METHODOLOGY; MOLECULAR GENETICS; MONKEYPOX VIRUS; PROTEOMICS; VERO CELL;

MACACA; MONKEYPOX VIRUS; VACCINIA VIRUS; VARIOLA VIRUS;

AMINO ACID SEQUENCE; ANIMALS; CERCOPITHECUS AETHIOPS; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MACACA FASCICULARIS; MOLECULAR SEQUENCE DATA; MONKEYPOX; MONKEYPOX VIRUS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEOME; PROTEOMICS; SMALLPOX; VERO CELLS;

EID: 78651225669     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015547     Document Type: Article

References (29)

1. Fenner F, Henderson DA, Arita I, Jezek Z, Ladnyi ID (1988) Human monkeypox and other poxvirus infections of man In: Fenner F, ed. Smallpox and its Eradication. Geneva: World Health Organization. pp 1287-1319.
2. Nalca A, Rimoin AW, Bavari S, Whitehouse CA (2005) Reemergence ofmonkeypox: prevalence, diagnostics, and countermeasures. Clin Infect Dis 41: 1765-1771.
3. Khodakevich L, Jezek Z, Messinger D (1988) Monkeypox virus: ecology and public health significance. Bull World Health Organ 66: 747-752.
4. Learned LA, Reynolds MG, Wassa DW, Li Y, Olson VA, et al. (2005) Extended interhuman transmission of monkeypox in a hospital community in the Republic of the Congo, 2003. Am J Trop Med Hyg 73: 428-434.
5. Reed KD, Melski JW, Graham MB, Regnery RL, Sotir M J, et al. (2004) The detection of monkeypox in humans in the Western Hemisphere. N Engl J Med 350: 342-350.
6. Chen N, Li G, Liszewski MK, Atkinson JP, Jahrling PB, et al. (2005) Virulence differences between monkeypox virus isolates from West Africa and the Congo basin. Virology 340: 46-63.
7. Likos AM, Sammons SA, Olson VA, Frace AM, Li Y, et al. (2005) A tale of two clades: monkeypox viruses. J Gen Virol 86: 2661-2672.
8. Jezek Z, Grab B, Szczeniowski M, Paluku KM, Mutombo M (1988) Clinicoepidemiological features of monkeypox patients with an animal or human source of infection. Bull World Health Organ 66: 459-464.
9. Smith GL, Law M (2004) The exit of vaccinia virus from infected cells. Virus Res 106: 189-197.
10. Earl PL, Americo JL, Wyatt LS, Eller LA, Whitbeck JC, et al. (2004) Immunogenicity of a highly attenuated MVA smallpox vaccine and protection against monkeypox. Nature 428: 182-185.
11. Edghill-Smith Y, Golding H, Manischewitz J, King LR, Scott D, et al. (2005) Smallpox vaccine-induced antibodies are necessary and sufficient for protection against monkeypox virus. Nat Med 11: 740-747.
12. Karem KL, Reynolds M, Hughes C, Braden Z, Nigam P, et al. (2007) Monkeypox-induced immunity and failure of childhood smallpox vaccination to provide complete protection. Clin Vaccine Immunol 14: 1318-1327.
13. Parker S, Nuara A, Buller RM, Schultz DA (2007) Human monkeypox: an emerging zoonotic disease. Future Microbiol 2: 17-34.
14. Davies DH, Molina DM, Wrammert J, Miller J, Hirst S, et al. (2007) Proteomewide analysis of the serological response to vaccinia and smallpox. Proteomics 7: 1678-1686.
15. Keasey SL, Schmid KE, Lee MS, Meegan J, Tomas P, et al. (2009) Extensive antibody cross-reactivity among infectious gram-negative bacteria revealed by proteome microarray analysis. Mol Cell Proteomics 8: 924-935.
16. Schmid K, Keasey SL, Pittman P, Emerson GL, Meegan J, et al. (2008) Analysis of the human immune response to vaccinia by use of a novel protein microarrray suggests that antibodies recognize less than 10% of the total viral proteome. Proteomics Clinical Applications 2: 1528-1538.
17. Chung C, Chen C, Ho M, Huang C, Liao C, et al. (2006) Vaccinia virus proteome: Identification of proteins in vaccinia virus intracellular mature virion particles. J Virol 80: 2127-2140.
18. Resch W, Hixon KK, Moore RJ, Lipton MS, Moss B (2007) Protein composition of the vaccinia virus mature virion. Virology 358: 233-247.
19. Manes NP, Estep RD, Mottaz HM, Moore RJ, Clauss TRW, et al. (2008) Comparative proteomics of human monkeypox and vaccinia intracellular mature and extracellular enveloped virions. J Proteome Res 7: 960-968.
20. Yoder JD, Chen TS, Gagnier CR, Vemulapalli S, Maier CS, et al. (2006) Pox proteomics: mass spectrometry analysis and identification of vaccinia virion proteins. Virol J doi: 10.1186/1743-422X-3-10.
21. Weaver JR, Isaacs SN (2008) Monkeypox virus and insights into its immunomodulatory proteins. Immunol Rev 225: 96-113.
22. Updated Interim Case Definition for Human Monkeypox (2004) Centers for Disease Control and Prevention. Available: http://www.cdc.gov/ncidod/monkeypox/casedefinition.htm. Accessed: 2010 Jun 9.
23. Karem KL, Reynolds M, Braden Z, Lou G, Bernard N, et al. (2005) Characterization of acute-phase humoral immunity to monkeypox: use of immunoglobulin M enzyme-linked immunosorbent assay for detection of monkeypox infection during the 2003 North American outbreak. Clin Diagn Lab Immunol 12: 867-872.
24. Benhnia MR, McCausland MM, Su HP, Singh K, Hoffmann J, et al. (2008) Redundancy and plasticity of neutralizing antibody responses are cornerstone attributes of the human immune response to the smallpox vaccine. J Virol 82: 3751-3768.
25. Putz MM, Midgley CM, Law M, Smith GL (2006) Quantification of antibody responses against multiple antigens of the two infectious forms of Vaccinia virus provides a benchmark for smallpox vaccination. Nat Med 12: 1310-1315.
26. Hammarlund E, Lewis MW, Carter SV, Amanna I, Hansen SG, et al. (2005) Multiple diagnostic techniques identify previously vaccinated individuals with protective immunity against monkeypox. Nat Med 11: 1005-1011.
27. Jarvis DL (2003) Developing baculovirus-insect cell expression systems for humanized recombinant glycoprotein production. Virology 310: 1-7.
28. Heimburg-Molinaro J, Rittenhouse-Olson K (2009) Development and characterization of antibodies to carbohydrate antigens. Methods Mol Biol 534: 341-357.
29. Sette A, Moutaftsi M, Moyron-Quiroz J, McCausland MM, Davies DH, et al. (2008) Selective CD4+ T cell help for antibody responses to a large viral pathogen: deterministic linkage of specificities. Immunity 28: 847-858.