Thalamocortical model for a propofol-induced α-rhythm associated with loss of consciousness

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 52, 2010, Pages 22665-22670

  Ching, Shinung ^a,b,c   Cimenser, Aylin ^a,b,d   Purdon, Patrick L ^a,b,d   Brown, Emery N ^a,b,d   Kopell, Nancy J ^c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c Boston University   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

GABA; General anesthesia; Global coherence; Oscillations

Indexed keywords

PROPOFOL;

ALPHA RHYTHM; ARTICLE; BRAIN CORTEX; BRAIN DEPTH STIMULATION; BRAIN NERVE CELL; COMPUTER MODEL; CONSCIOUSNESS DISORDER; ELECTROENCEPHALOGRAM; GENERAL ANESTHESIA; OSCILLATION; PRIORITY JOURNAL; STIMULUS RESPONSE; SYNAPSE; THALAMOCORTICAL TRACT;

ALGORITHMS; ALPHA RHYTHM; ANESTHETICS, INTRAVENOUS; CEREBRAL CORTEX; COMPUTER SIMULATION; CORTICAL SYNCHRONIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MODELS, NEUROLOGICAL; NEURONS; PROPOFOL; RECEPTORS, GABA-A; THALAMUS; UNCONSCIOUSNESS;

EID: 78651112737     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1017069108     Document Type: Article

References (38)

1. Feshchenko VA, Veselis RA, Reinsel RA (2004) Propofol-induced alpha rhythm. Neuropsychobiology 50:257-266.
2. Cimenser A, et al. (2009) Developing new neurophysiological signatures of general anesthesia induced loss of consciousness. BMC Neurosci, 10.1186/1471-2202-10-S1-P79.
3. Cimenser A, et al. (2010) Collective dynamics of high density EEG reveals a single dominant mode of activity during general anesthesia-induced unconsciousness. Neuroscience Meeting Planner (Society for Neuroscience, San Diego), program no. 343.4.
4. McCarthy MM, Brown EN, Kopell N (2008) Potential network mechanisms mediating electroencephalographic beta rhythm changes during propofol-induced paradoxical excitation. J Neurosci 28:13488-13504.
5. Alkire MT, Hudetz AG, Tononi G (2008) Consciousness and anesthesia. Science 322: 876-880.
6. Alkire MT, Haier RJ, Fallon JH (2000) Toward a unified theory of narcosis: Brain imaging evidence for a thalamocortical switch as the neurophysiologic basis of anesthetic-induced unconsciousness. Conscious Cogn 9:370-386.
7. Tinker JH, Sharbrough FW, Michenfelder JD (1977) Anterior shift of the dominant EEG rhythm during anesthesia in the Java monkey: Correlation with anesthetic potency. Anesthesiology 46:252-259.
8. John ER, et al. (2001) Invariant reversible QEEG effects of anesthetics. Conscious Cogn 10:165-183, and correction (2002) 11:138.
9. Shaw JC (2003) The Brain's Alpha Rhythms and the Mind (Elsevier Health Sciences, Amsterdam).
10. Contreras D, Steriade M (1995) Cellular basis of EEG slow rhythms: A study of dynamic corticothalamic relationships. J Neurosci 15:604-622.
11. Steriade M, McCormick DA, Sejnowski TJ (1993) Thalamocortical oscillations in the sleeping and aroused brain. Science 262:679-685.
12. Goldman-Rakic PS, Porrino LJ (1985) The primate mediodorsal (MD) nucleus and its projection to the frontal lobe. J Comp Neurol 242:535-560.
13. Kievit J, Kuypers HG (1977) Organization of the thalamo-cortical connexions to the frontal lobe in the rhesus monkey. Exp Brain Res 29:299-322.
14. Destexhe A, Sejnowski TJ (2001) Thalamocortical Assemblies: How Ion Channels, Single Neurons and Large-Scale Networks Organize Sleep Oscillations (Oxford Univ Press, New York).
15. Destexhe A, McCormick DA, Sejnowski TJ (1993) A model for 8-10 Hz spindling in interconnected thalamic relay and reticularis neurons. Biophys J 65:2473-2477.
16. Hughes SW, Crunelli V (2005) Thalamic mechanisms of EEG alpha rhythms and their pathological implications. Neuroscientist 11:357-372.
17. Goldman RI, Stern JM, Engel J, Jr., Cohen MS (2002) Simultaneous EEG and fMRI of the alpha rhythm. NeuroReport 13:2487-2492.
18. da Silva FH, van Lierop TH, Schrijer CF, van Leeuwen WS (1973) Organization of thalamic and cortical alpha rhythms: Spectra and coherences. Electroencephalogr Clin Neurophysiol 35:627-639.
19. Börgers C, Epstein S, Kopell NJ (2005) Background gamma rhythmicity and attention in cortical local circuits: A computational study. Proc Natl Acad Sci USA 102:7002-7007.
20. Destexhe A, Bal T, McCormick DA, Sejnowski TJ (1996) Ionic mechanisms underlying synchronized oscillations and propagating waves in a model of ferret thalamic slices. J Neurophysiol 76:2049-2070.
21. Börgers C, Kopell N (2003) Synchronization in networks of excitatory and inhibitory neurons with sparse, random connectivity. Neural Comput 15:509-538.
22. Gibson JR, Beierlein M, Connors BW(2005) Functional properties of electrical synapses between inhibitory interneurons of neocortical layer 4. J Neurophysiol 93:467-480.
23. Gibson JR, Beierlein M, Connors BW (1999) Two networks of electrically coupled inhibitory neurons in neocortex. Nature 402:75-79.
24. Steriade M, Contreras D, Curró Dossi R, Nuñez A (1993) The slow (<1 Hz) oscillation in reticular thalamic and thalamocortical neurons: Scenario of sleep rhythm generation in interacting thalamic and neocortical networks. J Neurosci 13:3284-3299.
25. Steriade M, Nuñez A, Amzica F (1993) A novel slow (<1 Hz) oscillation of neocortical neurons in vivo: Depolarizing and hyperpolarizing components. J Neurosci 13:3252-3265.
26. Compte A, Sanchez-Vives MV, McCormick DA, Wang XJ (2003) Cellular and network mechanisms of slow oscillatory activity (<1 Hz) and wave propagations in a cortical network model. J Neurophysiol 89:2707-2725.
27. Cunningham MO, et al. (2006) Neuronal metabolism governs cortical network response state. Proc Natl Acad Sci USA 103:5597-5601.
28. Jones SR, Pinto DJ, Kaper TJ, Kopell N (2000) Alpha-frequency rhythms desynchronize over long cortical distances: A modeling study. J Comput Neurosci 9:271-291.
29. Jones SR, et al. (2009) Quantitative analysis and biophysically realistic neural modeling of the MEG mu rhythm: Rhythmogenesis and modulation of sensory-evoked responses. J Neurophysiol 102:3554-3572.
30. Vierling-Claassen D, Cardin J, Moore C, Jones S Computational modeling of distinct neocortical oscillations driven by cell-type selective optogenetic drive: Separable resonant circuits controlled by low-threshold spiking and fast-spiking interneurons. Frontiers in Human Neuroscience 4:198.
31. Lachaux JP, et al. (2007) Relationship between task-related gamma oscillations and BOLD signal: New insights from combined fMRI and intracranial EEG. Hum Brain Mapp 28:1368-1375.
32. Tancredi V, et al. (2000) Spindle-like thalamocortical synchronization in a rat brain slice preparation. J Neurophysiol 84:1093-1097.
33. Silva A, Cardoso-Cruz H, Silva F, Galhardo V, Antunes L (2010) Comparison of anesthetic depth indexes based on thalamocortical local field potentials in rats. Anesthesiology 112:355-363.
34. Jones SR, et al. (2010) Cued spatial attention drives functionally relevant modulation of the mu rhythm in primary somatosensory cortex. J Neurosci 30:13760-13765.
35. Worden MS, Foxe JJ, Wang N, Simpson GV (2000) Anticipatory biasing of visuospatial attention indexed by retinotopically specific alpha-band electroencephalography increases over occipital cortex. J Neurosci 20:1-6.
36. Dayan P, Abbott LF (2005) Theoretical Neuroscience (MIT Press, Cambridge, MA).
37. Bai D, Pennefather PS, MacDonald JF, Orser BA (1999) The general anesthetic propofol slows deactivation and desensitization of GABA(A) receptors. J Neurosci 19: 10635-10646.
38. Nunez PL, Srinivasan R (2005) Electric Fields of the Brain: The Neurophysics of EEG (Oxford Univ Press, New York), 2nd Ed.