Vascular-mesenchymal cross-talk through Vegf and Pdgf drives organ patterning

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 1, 2011, Pages 167-172

  Cool, Jonah ^a   DeFalco, Tony J ^a   Capel, Blanche ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Organogenesis; Sex determination; Testis formation

Indexed keywords

PLATELET DERIVED GROWTH FACTOR; VASCULOTROPIN A;

ARTICLE; CELL MIGRATION; CELL PROLIFERATION; ENDOTHELIUM CELL; GONAD DEVELOPMENT; LEYDIG CELL; MESENCHYME CELL; MOLECULAR INTERACTION; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN SECRETION; TESTIS DEVELOPMENT; VASCULARIZATION;

ANIMALS; BETA-GALACTOSIDASE; BODY PATTERNING; CELL MOVEMENT; DNA PRIMERS; ENDOTHELIUM, VASCULAR; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; MALE; MESODERM; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; PLATELET-DERIVED GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TESTIS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 78651104745     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1010299108     Document Type: Article

References (26)

1. Matsumoto K, Yoshitomi H, Rossant J, Zaret KS (2001) Liver organogenesis promoted by endothelial cells prior to vascular function. Science 294:559-563.
2. Lammert E, Cleaver O, Melton D (2001) Induction of pancreatic differentiation by signals from blood vessels. Science 294:564-567.
3. Shen Q, et al. (2004) Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells. Science 304:1338-1340.
4. Shen Q, et al. (2008) Adult SVZ stem cells lie in a vascular niche: A quantitative analysis of niche cell-cell interactions. Cell Stem Cell 3:289-300.
5. Cool J, Carmona FD, Szucsik JC, Capel B (2008) Peritubular myoid cells are not the migrating population required for testis cord formation in the XY gonad. Sex Dev 2:128-133.
6. Combes AN, et al. (2009) Endothelial cell migration directs testis cord formation. Dev Biol 326:112-120.
7. Yamamoto H, et al. (2007) Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis. Dev Biol 308:44-53.
8. Brennan J, Karl J, Capel B (2002) Divergent vascular mechanisms downstream of Sry establish the arterial system in the XY gonad. Dev Biol 244:418-428.
9. Coveney D, Cool J, Oliver T, Capel B (2008) Four-dimensional analysis of vascularization during primary development of an organ, the gonad. Proc Natl Acad Sci USA 105:7212-7217.
10. Shalaby F, et al. (1995) Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 376:62-66.
11. Bott RC, McFee RM, Clopton DT, Toombs C, Cupp AS (2006) Vascular endothelial growth factor and kinase domain region receptor are involved in both seminiferous cord formation and vascular development during testis morphogenesis in the rat. Biol Reprod 75:56-67.
12. Ferrara N, et al. (1996) Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380:439-442.
13. Holash J, et al. (2002) VEGF-Trap: A VEGF blocker with potent antitumor effects. Proc Natl Acad Sci USA 99:11393-11398.
14. Schmahl J, Eicher EM, Washburn LL, Capel B (2000) Sry induces cell proliferation in the mouse gonad. Development 127:65-73.
15. Schmahl J, Capel B (2003) Cell proliferation is necessary for the determination of male fate in the gonad. Dev Biol 258:264-276.
16. Jeays-Ward K, et al. (2003) Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad. Development 130:3663-3670.
17. Brennan J, Tilmann C, Capel B (2003) Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad. Genes Dev 17:800-810.
18. Coveney D, Ross AJ, Slone JD, Capel B (2007) A microarray analysis of the XX Wnt4 mutant gonad targeted at the identification of genes involved in testis vascular differentiation. Gene Expr Patterns 7:82-92.
19. Gnessi L, et al. (2000) Leydig cell loss and spermatogenic arrest in platelet-derived growth factor (PDGF)-A-deficient mice. J Cell Biol 149:1019-1026.
20. Colvin JS, Green RP, Schmahl J, Capel B, Ornitz DM (2001) Male-to-female sex reversal in mice lacking fibroblast growth factor 9. Cell 104:875-889.
21. Schmahl J, Kim Y, Colvin JS, Ornitz DM, Capel B (2004) Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination. Development 131:3627-3636.
22. Nikolova G, et al. (2006) The vascular basement membrane: A niche for insulin gene expression and Beta cell proliferation. Dev Cell 10:397-405.
23. Yoshida S, Sukeno M, Nabeshima Y (2007) A vasculature-associated niche for undifferentiated spermatogonia in the mouse testis. Science 317:1722-1726.
24. Jacquemin P, et al. (2006) An endothelial-mesenchymal relay pathway regulates early phases of pancreas development. Dev Biol 290:189-199.
25. Martineau J, Nordqvist K, Tilmann C, Lovell-Badge R, Capel B (1997) Male-specific cell migration into the developing gonad. Curr Biol 7:958-968.
26. Corada M, et al. (1999) Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo. Proc Natl Acad Sci USA 96:9815-9820.