Lasting effects of an impairment of Th1-like immune response in γ-irradiated mice: A resemblance between irradiated mice and aged mice

Cellular Immunology

Volumn 267, Issue 1, 2011, Pages 1-8

  Park, Hae Ran ^a   Jo, Sung Kee ^a  

^a Korea Atomic Energy Research Institute   (South Korea)

Author keywords

Aging; Immune function; Ionizing radiation; Th1 Th2 balance

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 12P70; INTERLEUKIN 18 RECEPTOR; INTERLEUKIN 4; INTERLEUKIN 5;

AGED; AGING; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; GAMMA IRRADIATION; IMMUNE FUNCTION TEST; IMMUNE RESPONSE; IONIZING RADIATION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TH1 CELL; WHOLE BODY RADIATION;

AGING; ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; GAMMA RAYS; MICE; MICE, INBRED C57BL; TH1 CELLS;

MUS;

EID: 78651098371     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2010.10.004     Document Type: Article

References (55)

1. Solana R., Villanueva J.L., Pena J., De la Fuente M. Cell mediated immunity in ageing. Comp. Biochem. Physiol. 1991, 99A:1-4.
2. Grubeck-Loebenstein B., Wick G. The aging of the immune system. Ann. Rev. Immunol. 2002, 80:248-290.
3. Globerson A. T lymphocytes and aging. Int. Arch. Allergy Immunol. 1995, 107:491-497.
4. Linton P.J., Dorshkind K. Age-related changes in lymphocyte development and function. Nat. Immunol. 2004, 5:133-139.
5. Shearer G.M. Th1/Th2 changes in aging. Mech. Ageing Dev. 1997, 94:1-5.
6. Rink L., Cakman I., Kirchner H. Altered cytokine production in the elderly. Mech. Ageing Dev. 1998, 102:199-209.
7. Albers R., Antoine J.M., Bourdet-Sicard R., Calder P.C., Gleeson M., Lesourd B., Samartin S., Sanderson I.R., Loo J.V., Vas Dias F.W., Watzl B. Markers to measure immunomodulation in human nutrition intervention studies. British J. Nutr. 2005, 94:452-481.
8. Alberti S., Cevenini E., Ostan R., Capri M., Salvioli S., Bucci L., Ginaldi L., De Martinis M., Franceschi C., Monti D. Age-dependent modifications of Type 1 and Type 2 cytokines within virgin and memory CD4+ T cells in humans. Mech. Aging Dev. 2006, 127:560-566.
9. Cakman I., Rohwer J., Schutz R.M., Kirchner H., Rink L. Dysregulation between Th1 and Th2 T cell subpopulations in the elderly. Mech. Ageing Dev. 1996, 87:197-209.
10. Romagnani S., Kapsenberg M., Radbruch A., Adorini L. Th1 and Th2 cells. Res. Immunol. 1998, 149:71-873.
11. Szabo S.J., Sullivan B.M., Peng S.L., Glimcher L.H. Molecular mechanisms regulating Th1 immune responses. Annu. Rev. Immunol. 2003, 21:713-758.
12. Chua A.O., Chizzonite R., Desai B.B., Truitt T.P., Nunes P., Minetti L.J., Warrier P.P., Presky D.H., Levine J.F., Gately M.K. Expression cloning of a human IL-12 recoptor component. A new member of the cytokine recpeptor superfamily with strong homology to gp130. J. Immunol. 1994, 153:128-136.
13. Chua A.O., Wilkinson W.L., Presky D.H., Gubler U. Cloning and characterization of a mouse IL-12 receptor-β component. J. Immunol. 1995, 155:4286-4294.
14. Szabo S.J., Dighe A.S., Gubler U., Murphy K.M. Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 1997, 185:817-824.
15. Rogge L., Papi A., Presky D.H., Biffi M., Minetti L.J., Miotto D., Agostini C., Semenzato G., Fabbri L.M., Sinigaglia F. Antibodies to the IL-12 receptor beta 2 chain mark human Th1 but not Th2 cells in vitro and in vivo. J. Immunol. 1999, 162:3926-3932.
16. Sinigaglia F., D'Ambrosio D., Panina-Bordignon P., Rogge L. Regulation of the IL-12/IL-12R axis: A critical step in T-helper cell differentiation and effector function. Immunol. Rev. 1999, 170:65-72.
17. Nakanishi K., Yoshimoto T., Tsutsui H., Okamura H. Interleukin-18 regulates both Th1 and Th2 responses. Annu. Rev. Immunol. 2001, 19:423-474.
18. Nakahira M., Tomura M., Iwasaki M., Ahn H.J., Blan Y., Hamaoka T., Ohta T., Kurimoto M., Fujiwara H. An absolute requirement for Stat4 and a role for IFN-γ as an amplifying factor in IL-12 induction of the functional IL-18 receptor complex. J. Immunol. 2001, 167:1306-1312.
19. Smeltz R.B., Chen J., Hu-Li J., Shevach E.M. Regulation of interleukin (IL)-18 receptor (chain expression on CD4+ T cells during T helper (Th)1/Th2 differentiation: critical down regulatory role of IL-4. J. Exp. Med. 2001, 194:143-153.
20. Tanay A., Strober S. Opposite effects of total lymphoid irradiation on T cell-dependent and T cell-independent antibody responses. J. Immunol. 1984, 132:979-984.
21. Bass H., Mosmann T., Strober S. Evidence for mouse Th1- and Th2-like helper T cells in vivo. Selective reduction of Th1-like cells after total lymphoid irradiation. J. Exp. Med. 1989, 170:1495-1511.
22. Park H.R., Jo S.K., Paik S.G. Factors effecting the Th2-like immune response after gamma-irradiation: low production of IL-12 heterodimer in antigen-presenting cells and small expression of the IL-12 receptor in T cells. Int. J. Radiat. Biol. 2005, 81:221-231.
23. Park H.R., Jung U.H., K Jo S. Impairment of Natural Killer (NK) Cells is an Important Factor in a Weak Th1-lkie Response in Irradiated Mice. Radiat. Res. 2007, 168:446-452.
24. Harman D. Aging: a theory based on free radicals and radiation chemistry. J. Gerontol. 1956, 11:298-300.
25. Yu B.P. Aging and oxidative stress: modulation by dietary restriction. Free Radic. Biol. Med. 1996, 21:651-668.
26. Miquel J., Weber H.U. Aging and increased oxidation of the sulfur pool. Glutathione Metabolism and Physiological Functions 1990, 187-192. CRC Press, Boca Raton, FL. J. Vina (Ed.).
27. Lin M.T., Beal M.F. The oxidative damage theory of aging. Clin. Neurosci. Res. 2003, 2:305-315.
28. Barja G. Free radicals and aging. Trends Neurosci. 2004, 27:595-600.
29. Le O.N., Rodier F., Fontaine F., Coppe J.P., Campisi J., DeGregori J., Laverdiere C., Kokta V., Haddad E., Beausejor C.M. Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status. Aging cell 2010, 9:398-409.
30. Quick Q.A., Gewirtz D.A. An accelerated senescence response to radiation in wild-type p53 glioblastoma multiform cells. J. Neurosurg. 2006, 105:111-118.
31. Igarashi K., Sakimoto I., Kataoka K., Ohta K., Miura M. Radiation-induced senescence-like phenotype in proliferating and plateau-phase vascular endothelial cells. Exp. Cell Res. 2007, 313:3326-3336.
32. Soler D., Pampalona J., Tusell L., Genesca A. Radiation sensitivity increases with proliferation-associated telomere dysfunction in nontransformed human epithelial cells. Aging cell 2009, 8:414-425.
33. Wang Y., Schulte B.A., LaRue A.C., Ogawa M., Zhou D. Total body irradiation selectively induces murine hematopoietic stem cell senescence. Blood 2009, 107:358-366.
34. Park H.R., Jo S.K., Jung U.H., Yee S.T. Restoration of the immune functions in aged mice by supplementation with a new herbal composition, HemoHIM. Phytother. Res. 2008, 22:36-42.
35. Hobbs M.V., Weigle W.O., Noonan D.J., Torbett B., McEvilly E., Koch R.J., Cardenas G.J., Ernast D.N. Patterns of cytokine gene expression by CD4+ T cells from young and old mice. J. Immunol. 1993, 150:3602-3614.
36. Albright J.W., Zuiga-Pflcker J.C., Albright J.F. Transcriptional control of IL-2 and IL-4 in T cells of young and old mice. Cell. Immunol. 1995, 164:170-175.
37. Monobe M., Uzawa A., Hino M., Ando K., Kojima S. Glycine betaine, a beer component, protects radiation-induced injury. J. Radiat. Res. 2005, 46:117-121.
38. Robbins M.E., Zhao W. Chromic oxidative stress and radiation-induced late normal tissue injury. Int. J. Radiat. Biol. 2004, 80:251-259.
39. Chung S.W., Kim J.M., Kim D.H., Kim J.Y., Lee E.K., Anton S., Jeong K.S., Lee J., Yoo M.A., Kim Y.J., Yu B.P., Chung H.Y. Molecular delineation of γ-ray-induced NF-κB activation and pro-inflammatory genes in SMP30 knockout mice. Radiat. Res. 2010, 173:629-634.
40. Gillis S., Kozak R., Durante M., Weksler M.E. Immunological studies of aging. Decreased production of and response to T cell growth factor by lymphocytes from aged humans. J. Clin. Invest. 1981, 67:937-942.
41. Fulop T., Larbi A., Douziech N., Levesque I., Varin A., Herbein G. Cytokine receptor signaling and aging. Mech. Aging Dev. 2006, 127:526-537.
42. Abbas A.K., Murphy K.M., Sher A. Functional diversity of helper T lymphocytes. Nature 1996, 383:787-793.
43. Romagnani S. The Th1/Th2 paradigm. Immunol. Today 1997, 19:263-266.
44. Snapper C.M., Paul W.E. Interferon-γ and B cell stimulatory-factor-I reciprocally regulate Ig isotype production. Science 1987, 263:944-947.
45. Coffman R.L., Catry J. A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-γ. J. Immunol. 1986, 136:949-954.
46. Magram J., Connaughton S.E., Warrier R.R., Carvajal D.M., Wu C.Y., Ferrante J., Stewart C., Sarmiento U., Faharty D.A., Gately M.K. IL-12-deficient mice are defective in IFN-γ production and type 1 cytokine responses. Immunity 1996, 4:471-481.
47. Gillessen S., Carvajal D., Ling P., Podlaski F.J., Stremlo D.L., Familetti P.C., Gubler U., Presky D.H., Stern A.S., Gately M.K. Mouse interleukin 12 (IL-12) p40 homodimer: a potent IL-12 antagonist. Eur. J. Immunol. 1995, 25:200-2006.
48. Scharton T.M., Scott P. Natural killer cells are a source of interferon that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice. J. Exp. Med. 1993, 178:567-577.
49. Martin-Fontecha A., Thomsen L.L., Brett S., Gerard C., Lipp M., Lanzavecchia A., Sallusto F. Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming. Nat. Immunol. 2004, 5:1260-1265.
50. Thoman M.L. The pattern of T lymphocyte differentiation is altered during thymic involution. Mech. Ageing Dev. 1995, 82:155-170.
51. Haynes B.F., Markert M.L., Sempowski G.D., Patel D.D., Hale L.P. The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-I infection. Annu. Rev. Immunol. 2000, 18:529-560.
52. Hsu H.C., et al. Age-related thymic involution in C57BL/6J (DBA/2J recombinant-inbred mice maps to chromosomes 9 and 10. Genes Immunol. 2003, 4:402-410.
53. Sansoni P., Cossarizza A., Brianti V., Fagnoni F., Snelli G., Monti D., Marcato A., Passeri G., Ortolani C., Forti E., Fagiolo U., Passeri M., Franceschi C. Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians. Blood 1933, 82:2767-2773.
54. Xu X., Beckman I., Ahern M., Bradley J. A comprehensive analysis of peripheral blood lymphocytes in healthy aged humans by flow cytometry. Immunol. Cell Biol. 1993, 71:549-557.
55. Mocchegiani E., Malavolta M. NK and NKT cell functions in immunosenescence. Aging Cell 2004, 3:177-184.