Reply to Bell et al.: Nrf2-dependent and -independent mechanisms of astrocytic neuroprotection

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 1, 2011, Pages

  Haskew Layton, Renée E ^a,b   Ma, Thong C ^a,b   Ratan, Rajiv R ^a,b  

^a Burke Cornell Medical Research Institute   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN PEROXIDE; TRANSCRIPTION FACTOR NRF2;

ASTROCYTE; GENE EXPRESSION; GENETIC TRANSCRIPTION; LETTER; NEUROPROTECTION; NEUROTOXICITY; OXIDATIVE STRESS; PRIORITY JOURNAL;

EID: 78651087396     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1016621108     Document Type: Letter

References (6)

1. Bell KF, et al. (2011) Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning. Proc Natl Acad Sci USA 108:E1-E2.
2. Haskew-Layton RE, et al. (2010) Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway. Proc Natl Acad Sci USA 107:17385-17390.
3. Vargas MR, Johnson JA (2009) The Nrf2-ARE cytoprotective pathway in astrocytes. Expert Rev Mol Med 11:e17.
4. Hyslop PA, Zhang Z, Pearson DV, Phebus LA (1995) Measurement of striatal H2O2 by microdialysis following global forebrain ischemia and reperfusion in the rat: Correlation with the cytotoxic potential of H2O2 in vitro. Brain Res 671:181-186.
5. Ndubuizu O, LaManna JC (2007) Brain tissue oxygen concentration measurements. Antioxid Redox Signal 9:1207-1219.
6. Yusa T, Beckman JS, Crapo JD, Freeman BA (1987) Hyperoxia increases H2O2 production by brain in vivo. J Appl Physiol 63:353-358.