Evolution in a family of chelatases facilitated by the introduction of active site asymmetry and protein oligomerization

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 1, 2011, Pages 97-102

  Romão, Célia V ^a   Ladakis, Dimitrios ^b   Lobo, Susana A L ^a   Carrondo, Maria A ^a   Brindley, Amanda A ^b   Deery, Evelyne ^b   Matias, Pedro M ^a   Pickersgill, Richard W ^c   Saraiva, Lígia M ^a   Warren, Martin J ^b  

^a INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^b UNIVERSITY OF KENT   (United Kingdom)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Enzyme mechanism; Tetrapyrrole biosynthesis

Indexed keywords

BACTERIAL ENZYME; CBIK ENZYME; CBIX ENZYME; CHELATASE; CHLORINE; COLBALTOCHELATASE; FERROCHELATASE; LYASE; PROTOPORPHYRIN; SIROHYDROCHLORIN; UNCLASSIFIED DRUG;

ARCHAEOGLOBUS FULGIDUS; ARTICLE; CHELATION; CRYSTAL STRUCTURE; CYTOPLASM; DESULFOVIBRIO VULGARIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME STABILITY; ENZYME STRUCTURE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL;

ARCHAEOGLOBUS FULGIDUS; CATALYTIC DOMAIN; COBALT; CRYSTALLIZATION; DESULFOVIBRIO VULGARIS; EVOLUTION, MOLECULAR; FERROCHELATASE; MODELS, MOLECULAR; MULTIGENE FAMILY; PORPHYRINS; SALMONELLA ENTERICA; UROPORPHYRINS; VITAMIN B 12;

ARCHAEOGLOBUS FULGIDUS; DESULFOVIBRIO VULGARIS SUBSP. VULGARIS STR. HILDENBOROUGH; SALMONELLA ENTERICA;

EID: 78651075909     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1014298108     Document Type: Article

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