Characterizing the contribution of stem/progenitor cells to tumorigenesis in the Pten-/-TP53-/- prostate cancer model

Stem Cells

Volumn 28, Issue 12, 2010, Pages 2129-2140

  Abou Kheir, Wassim G ^a   Hynes, Paul G ^a   Martin, Philip L ^a   Pierce, Rachel ^a   Kelly, Kathleen ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cancer stem cells; Differentiation; Prostate; PTEN; Self renewal; TP53

Indexed keywords

ANDROGEN RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER MODEL; CARCINOGENESIS; CASTRATION; CELL DIFFERENTIATION; CELL EXPANSION; CELL FUNCTION; CELL RENEWAL; CLONOGENIC ASSAY; CONTROLLED STUDY; EPITHELIUM CELL; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; NULL CELL; ORTHOTOPIC TRANSPLANTATION; PRIMARY TUMOR; PROSTATE ADENOCARCINOMA; PROSTATE CANCER; PROSTATE EPITHELIUM; PROSTATIC INTRAEPITHELIAL NEOPLASIA; STEM CELL; TUMOR GROWTH; WILD TYPE;

ANIMALS; CELL LINEAGE; CELL PROLIFERATION; CELL SEPARATION; CELL SHAPE; COLONY-FORMING UNITS ASSAY; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; GENE DELETION; IMMUNOPHENOTYPING; MALE; MICE; NEOPLASTIC STEM CELLS; PRECANCEROUS CONDITIONS; PROSTATE; PROSTATIC NEOPLASMS; PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RECEPTORS, ANDROGEN; SPHEROIDS, CELLULAR; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 78651073049     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.538     Document Type: Article

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