Maximizing the native concentration and shelf life of protein: A multiobjective optimization to reduce aggregation

Applied Microbiology and Biotechnology

Volumn 89, Issue 1, 2011, Pages 99-108

  Khan, Saif ^a   Bhakuni, Vinod ^b   Praveen, Vandana ^b   Tewari, R ^c   Tripathi, C K M ^b   Gupta, V D ^a  

^a INTEGRAL UNIVERSITY   (India)

^b CENTRAL DRUG RESEARCH INSTITUTE   (India)

^c PANJAB UNIVERSITY   (India)

Author keywords

Aggregation; Genetic algorithm; Multiobjective optimization; Neural network; Shelf life

Indexed keywords

AGGREGATION; ARTIFICIAL NEURAL NETWORK; BATCH CULTURE; CENTRAL COMPOSITE DESIGNS; ECONOMICAL PRODUCTION; GLYCEROL CONCENTRATION; MATHEMATICAL RELATIONSHIP; MEDIUM COMPONENTS; NATIVE PROTEINS; NATIVE STATE; OPTIMUM COMBINATION; OPTIMUM PH; PROTEIN CONCENTRATIONS; SHELF LIFE; STORAGE TEMPERATURES; TURBIDITY CHANGES; TWIN-OBJECTIVE;

BATCH CELL CULTURE; CONCENTRATION (PROCESS); GENETIC ALGORITHMS; GLYCEROL; NEURAL NETWORKS; PROTEINS; SIZE EXCLUSION CHROMATOGRAPHY; SODIUM CHLORIDE; TURBIDITY;

MULTIOBJECTIVE OPTIMIZATION;

DACTINOMYCIN; GLYCEROL;

AGGREGATION; ARTIFICIAL NEURAL NETWORK; GAS CHROMATOGRAPHY; GENETIC ALGORITHM; OPTIMIZATION; PH; PROTEIN;

ARTICLE; ARTIFICIAL NEURAL NETWORK; CHROMATOGRAPHY; ECONOMIC ASPECT; GENETIC ALGORITHM; MATHEMATICAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PH; PROCESS OPTIMIZATION; PROTEIN AGGREGATION; SHELF LIFE; STORAGE; STORAGE TEMPERATURE; TURBIDITY;

ALGORITHMS; BACTERIAL PROTEINS; HYDROGEN-ION CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NEURAL NETWORKS (COMPUTER); PROTEIN STABILITY; TEMPERATURE;

EID: 78651063956     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-010-2835-5     Document Type: Article

References (25)

1. T Arakawa SN Timasheff 1982 Stabilization of protein structure by sugars Biochemistry 21 6536 6544 1:CAS:528:DyaL38XmtFSktLY%3D 10.1021/bi00268a033
2. RC Ball DA Weitz TA Witten F Leyvraz 1987 Universal kinetics in reaction-limited aggregation Phys Rev Lett 58 274 277 10.1103/PhysRevLett.58.274
3. Baughman DR, Liu YA (1995) Neural networks in bioprocessing and chemical engineering. Academic, San Diego
4. SE Bondos A Bicknell 2003 Detection and prevention of protein aggregation before, during, and after purification Anal Biochem 316 223 231 1:CAS:528:DC%2BD3sXjtFWns7o%3D 10.1016/S0003-2697(03)00059-9 (Pubitemid 36444552)
5. SE Bondos S Sligar J Jonas 2000 High pressure denaturation of apomyoglobin Biochem Biophys Acta 1480 353 364 1:CAS:528:DC%2BD3cXks12qur8%3D
6. Box GEP, Hunter WG, Hunter JS (1978) Statistics for experiments. Wiley, New York, pp 291-334
7. MM Bradford 1976 A rapid and sensitive method for the quantization of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 248 254 1:CAS:528:DyaE28XksVehtrY%3D 10.1016/0003-2697(76)90527- 3
8. JC Calvo J Ortega M Anguita JM Urquiza JP Florido 2009 Protein structure prediction by evolutionary multi-objective optimization: search space reduction by using rotamers LNCS 5517 861 868
9. EY Chi S Krishnan TW Randolph JF Carpenter 2003 Physical stability of proteins in aqueous solution: mechanism and driving forces in nonnative protein aggregation Pharm Res 20 9 1325 1336 1:CAS:528:DC%2BD3sXnt1KitLY%3D 10.1023/A:1025771421906 (Pubitemid 37164039)
10. I Das JE Dennis 1998 Normal-boundary intersection: a new method for generating the pareto surface in nonlinear multicriteria optimization problems SIAM J Optim 8 631 657 10.1137/S1052623496307510
11. Goldberg D (1989) Genetic algorithms in search, optimization, and machine learning. Addison-Wesley, Reading
12. DM Gritschneder H Graeb U Schlichtmann 2009 A successive approach to compute the bounded pareto front of practical multiobjective optimization problems SIAM J Optim 20 2 915 934 10.1137/080729013
13. K Hornik M Stinchcombe H White 1989 Multilayer feed-forward networks are universal approximators Neural Netw 2 359 366 10.1016/0893-6080(89)90020-8 (Pubitemid 20609008)
14. BA Kerwin MC Heller SH Levin TW Randolph 1998 Effects of Tween 80 and sucrose on acute short-term stability and long-term storage at 20 °C of a recombinant hemoglobin J Pharm Sci 87 1062 1068 1:CAS:528:DyaK1cXkvVKjtr0%3D 10.1021/js980140v (Pubitemid 28452104)
15. BG Lefebvre MJ Gage AS Robinson 2008 Maximizing recovery of native protein from aggregates by optimizing pressure treatment Biotechnol Prog 20 2 623 629 10.1021/bp034221v
16. K Levenberg 1944 A method for the solution of certain problems in least squares Quart Appl Math 2 164 168
17. D Marquardt 1963 An algorithm for least-squares estimation of nonlinear parameters SIAM J Appl Math 11 431 441 10.1137/0111030
18. SH McLaughlin SE Jackson 2002 Folding and stability studies on the ligand-binding domain of the glucocorticoid receptor Protein Sci 11 1926 1936 1:CAS:528:DC%2BD38XlslKntr8%3D 10.1110/ps.5000102 (Pubitemid 34791412)
19. A Messac AI Yahaya CA Mattson 2003 The normalized normal constraint method for generating the Pareto frontier Struct multidiscipl Optim 25 2 86 98 10.1007/s00158-002-0276-1
20. J Modak K Konde 2009 Multiobjective optimization of Pichia pastoris fermentations New Biotechnol 25 1 241 10.1016/j.nbt.2009.06.233
21. S Shafiani P Sharma RM Vohra R Tewari 2005 Cloning and characterization of aspartate-β-semialdehyde dehydrogenase from Mycobacterium tuberculosis H37Rv J Appl Microbiol 98 832 838 1:CAS:528:DC%2BD2MXjvV2qsrg%3D 10.1111/j.1365-2672.2004.02505.x (Pubitemid 40477258)
22. V Singh M Khan S Khan CKM Tripathi 2009 Optimization of actinomycin V production by Streptomyces triostinicus using artificial neural network and genetic algorithm Appl Microbiol Biotechnol 82 379 385 1:CAS:528: DC%2BD1MXhtlOqurc%3D 10.1007/s00253-008-1828-0
23. Snyman JA (2005) Practical mathematical optimization: an introduction to basic optimization theory and classical and new gradient-based algorithms. Springer Publishing. ISBN 0-387-24348-8
24. JN Webb SD Webb JL Cleland JF Carpenter TW Randolph 2001 Partial molar volume, surface area, and hydration changes for equilibrium unfolding and formation of aggregation transition state: high pressure and co-solute studies on recombinant human IFN-c Proc Natl Acad Sci USA 98 7259 7264 1:CAS:528:DC%2BD3MXkslWmtLk%3D 10.1073/pnas.131194798 (Pubitemid 32567936)
25. JH Woo YY Liu DM Neville Jr 2006 Minimization of aggregation of secreted bivalent anti-human T cell immunotoxin in Pichia pastoris bioreactor culture by optimizing culture conditions for protein secretion J Biotechnol 121 1 75 85 1:CAS:528:DC%2BD2MXht12ksbjF 10.1016/j.jbiotec.2005.07.004 (Pubitemid 41739667)