Stimulation and inhibition of FVIII-specific memory B-cell responses by CpG-B (ODN 1826), a ligand for Toll-like receptor 9

Blood

Volumn 117, Issue 1, 2011, Pages 259-267

  Allacher, Peter ^a   Baumgartner, Christina K ^b,c   Pordes, Aniko G ^a,b   Ahmad, Rafi U ^a   Schwarz, Hans Peter ^a   Reipert, Birgit M ^a,b  

^a BAXTER BIOSCIENCE   (Austria)

^b Biomolecular Therapeutics (BMT) Research   (Austria)

^c BLOOD RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 8; CPG OLIGODEOXYNUCLEOTIDE; RECOMBINANT BLOOD CLOTTING FACTOR 8; SYNDECAN 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR AGONIST;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; CONTROLLED STUDY; HEMOPHILIA; IMMUNE RESPONSE; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; MALE; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL;

EID: 78650983953     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-06-289009     Document Type: Article

References (50)

1. McHeyzer-Williams LJ, McHeyzer-Williams MG. Antigen-specific memory B cell development. Annu Rev Immunol. 2005;23:487-513.
2. Dörner T, Radbruch A, Burmester GR. B-cell-directed therapies for autoimmune disease. Nat Rev Rheumatol. 2009;5(8):433-441.
3. Bar-Or A, Oliveira EM, Anderson DE, et al. Immunological memory: contribution of memory B cells expressing costimulatory molecules in the resting state. J Immunol. 2001;167(10):5669-5677.
4. Lang I, Windyga J, Klukowska A, Ilas J, Schwarz HP, Reipert BM. Towards the detection of factor VIII-specific memory B cells in hemophilia A patients with factor VIII inhibitors. In: Scharrer I, Schramm W, eds. 35th Haemophilia Symposium. Hamburg, Germany, Berlin, Germany, Heidelberg, Germany, New York, NY: Springer; 2006:25-36.
5. van Helden PM, Kaijen PH, Fijnvandraat K, van den Berg HM, Voorberg J. Factor VIII-specific memory B cells in patients with hemophilia A. J Thromb Haemost. 2007;5(11):2306-2308.
6. Mamani-Matsuda M, Cosma A, Weller S, et al. The human spleen is a major reservoir for long-lived vaccinia virus-specific memory B cells. Blood. 2008;111(9):4653-4659.
7. Hausl C, Ahmad RU, Schwarz HP, et al. Preventing restimulation of memory B cells in hemophilia A: a potential new strategy for the treatment of antibody-dependent immune disorders. Blood. 2004;104(1):115-122.
8. Hausl C, Ahmad RU, Sasgary M, et al. High dose factor VIII inhibits factor VIII-specific memory B cells in hemophilia A with factor VIII inhibitors. Blood. 2005;106(10):3415-3422.
9. Janeway CA, Medzhitov R. Innate immune recognition. Annu Rev Immunol. 2002;20:197-216.
10. Iwasaki A, Medzhitov R. Regulation of adaptive immunity by the innate immune system. Science. 2010;327(5963):291-295.
11. Palm NW, Medzhitov R. Pattern recognition receptors and control of adaptive immunity. Immunol Rev. 2009;227(1):221-233.
12. Akira S. Innate immunity to pathogens: diversity of receptors for microbial recognition. Immunol Rev. 2009;227(1):5-8.
13. Pasare C, Medzhitov R. Toll-like receptors: linking innate and adaptive immunity. Adv Exp Med Biol. 2005;560:11-18.
14. Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell. 2006;124(4):783-801.
15. Kumar H, Kawai T, Akira S. Toll-like receptors and innate immunity. Biochem Biophys Res Commun. 2009;388(4):621-625.
16. Kawai T, Akira S. TLR signaling. Cell Death Differ. 2006;13(5):816-825.
17. Bernasconi NL, Traggiai E, Lanzavecchia A. Maintenance of serological memory by polyclonal activation of human memory B cells. Science. 2002;298(5601):2199-202.
18. Meyer-Bahlburg A, Khim S, Rawlings DJ. B cell intrinsic TLR signals amplify but are not required for humoral immunity. J Exp Med. 2007;204(13):3095-3101.
19. Crampton SP, Voynova E, Bolland S. Innate pathways to B-cell activation and tolerance. Ann N Y Acad Sci. 2010;1183:58-68.
20. Traggiai E, Puzone R, Lanzavecchia A. Antigen dependent and independent mechanisms that sustain serum antibody levels. Vaccine. 2003;21(2 suppl):S35-S37.
21. Bi L, Lawler AM, Antonarakis SE, High KA, Gearhart JD, Kazazian HH Jr. Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A. Nat Genet. 1995;10(1):119-121.
22. Bi L, Sarkar R, Naas T, Lawler AM, et al. Further characterization of factor VIII-deficient mice created by gene targeting: RNA and protein studies. Blood. 1996;88(9):3446-3450.
23. Muchitsch EM, Turecek PL, Zimmermann K, et al. Phenotypic expression of murine hemophilia [letter]. Thromb Haemost. 1999;82(4):1371-1373.
24. Hausl C, Maier E, Schwarz HP, Ahmad RU, Turecek PL, Reipert BM. Long-term persistence of anti-factor VIII antibody-secreting cells in hemophilic mice after treatment with human factor VIII. Thromb Haemost. 2002;87(5):840-845.
25. Reipert BM,Ahmad RU, Turecek PL, Schwarz HP. Characterization of antibodies induced by human factor VIII in a murine knockout model of hemophilia A. Thromb Haemost. 2000;84(5):826-832.
26. Bonate PL, Sung C, Welch K, Richards S. Conditional modeling of antibody titers using a zeroinflated poisson random effects model: application to Fabrazyme. J Pharmacokinet Pharmacodynam. 2009;36(5):443-459.
27. Krishnamachari Y, Salem AK. Innovative strategies for co-delivering antigens and CpG oligonucleotides. Adv Drug Deliv Rev. 2009;61(3):205-217.
28. Akira S. TLR signaling. Curr Top Microbiol Immunol. 2006;311:1-16.
29. Jego G, Pascual V, Palucka K, Banchereau J. Dendritic cells control B cell growth and differentiation. Curr Dir Autoimmun. 2005;8:124-139.
30. Martins G, Calame K. Regulation and functions of Blimp-1 in T and B lymphocytes. Annu Rev Immunol. 2008;26:133-169.
31. Green NM, Laws A, Kiefer K, et al. Murine B cell response to TLR7 ligands depends on an IFNbeta feedback loop. J Immunol. 2009;183(3):1569-1576.
32. Steinman RM, Hemmi H. Dendritic cells: translating innate to adaptive immunity. Curr Top Microbiol Immunol. 2006;311:17-58.
33. Rothenfusser S, Tuma E, Wagner M, Endres S, Hartmann G. Recent advances in immunostimulatory CpG oligonucleotides. Cur Opin Mol Ther. 2003;5(2):98-106.
34. Bauer S, Müller T, Hamm S. Pattern recognition by Toll-like receptors. Adv Exp Med Biol. 2009;653:15-34.
35. Mutwiri G, van Drunnen Little-van den Hurk S, Babiuk LA. Approaches of enhancing immune responses stimulated with CpG oligodeoxynucleotides. Adv Drug Deliv Rev. 2009;61(3):226-232.
36. Grohmann U, Fallarino F, Puccetti P. Tolerance, DCs, and tryptophan: much ado about IDO. Trends Immunol. 2003;24(6):242-248.
37. Mellor AL, Munn DH. 2004. IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol. 2004;4(10):762-774.
38. Puccetti P, Grohmann U. IDO and regulatory T cells: a role for reverse signalling and non-canonical NFkappaB activation. Nat Rev Immunol. 2007;7(10):817-823.
39. Belladonna ML, Grohmann U, Guidetti P, et al. Kynurenine pathway enzymes in dendritic cells initiate tolerogenesis in the absence of functional IDO. J Immunol. 2006;177(1):130-137.
40. Liew FY, Xu D, Brint EK, O'Neill LA. Negative regulation of Toll-like receptor-mediated immune responses. Nat Rev Immunol. 2005;5(6):446-458.
41. Maniscassamy S, Pulendram B. Modulation of adaptive immunity with Toll-like receptors. Sem Immunol. 2009;21(4):185-193.
42. Duramad O, Fearon KL, Chan JH, et al. IL-10 regulates plasmacytoid dendritic cell response to CpG-containing immunostimulatory sequences. Blood. 2003;102(13):4487-4492.
43. Macfarlane DE, Manzel L, Krieg AM. Unmethylated CpG-containing oligodeoxynucleotides inhibit apoptosis in WEHI 231 B lymphocytes induced by several agents: evidence for blockade of apoptosis at a distal signaling step. Immunology. 1997;91(4):586-593.
44. Park Y, Lee SW, Sung YC. Cutting edge: CpG DNA inhibits dendritic cell apoptosis by up-regulating cellular inhibitor of apoptosis proteins through the phosphatidylinositide-3′-OH kinase pathway. J Immunol. 2002;168(1):5-8.
45. Kuo CC, Liang CM, Lai CY, Liang SM. Involvement of heat shock protein (Hsp)90beta, but not Hsp90(alpha), in anti-apoptotic effect of CpG-B oligonucleotides. J Immunol. 2007;178(10):6100-6108.
46. Benson MJ, Elgueta R, Schpero W, et al. Distinction of the memory B cell response to cognate antigen versus bystander inflammatory signals. J Exp Med. 2009;206(9):2013-2025.
47. Slifka MK, Antia R, Whitmire JK, Ahmad R. Humoral immunity due to long-lived plasma cells. Immunity. 1998;8(3):363-372.
48. Di Genova GJ, Roddick J, McNicholl F, Stevenson FK. Vaccination of human subjects expands both specific and bystander memory T cells, but antibody production remains vaccine specific. Blood. 2006;107(7):2806-2813.
49. Amanna IJ, Carlson NE, Slifka MK. Duration of humoral immunity to common viral and vaccine antigens. N Engl J Med. 2007;357(19):1903-1915.
50. Richard K, Pierce SK, Song W. The agonists for TLR 4 and 9 are sufficient to activate memory B cells to differentiate into plasma cells in vitro but not in vivo. J Immunol. 2008;181(3):1746-1752.