Cancer-associated p53 tetramerization domain mutants: Quantitative analysis reveals a low threshold for tumor suppressor inactivation

Journal of Biological Chemistry

Volumn 286, Issue 1, 2011, Pages 252-258

  Kamada, Rui ^a   Nomura, Takao ^a   Anderson, Carl W ^b   Sakaguchi, Kazuyasu ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b BROOKHAVEN NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; CELL-CYCLE ARREST; DNA BINDING; ELECTROSTATIC SURFACES; GENE MUTATIONS; GENOTOXIC STRESS; HUMAN TUMORS; LOW THRESHOLDS; OLIGOMERIC STRUCTURE; POST-TRANSLATIONAL MODIFICATIONS; PROTEIN-PROTEIN INTERACTIONS; QUANTITATIVE ANALYSIS; TARGET GENES; TETRAMERIC STRUCTURES; TETRAMERIZATION; TETRAMERS; TUMOR GROWTH; TUMOR PROGRESSIONS; TUMOR SUPPRESSOR ACTIVITY; TUMOR SUPPRESSORS;

AMINO ACIDS; CELL DEATH; CHEMICAL ANALYSIS; GENES; OLIGOMERS; PEPTIDES; TRANSCRIPTION; TRANSCRIPTION FACTORS;

TUMORS;

PROTEIN P53;

ARTICLE; BINDING SITE; CONTROLLED STUDY; GENE DISRUPTION; HUMAN; MISSENSE MUTATION; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; THERMODYNAMICS; THERMOSTABILITY; TUMOR SUPPRESSOR GENE;

AMINO ACID SEQUENCE; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; MUTATION; NEOPLASMS; PEPTIDE FRAGMENTS; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; TEMPERATURE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 78650959608     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.174698     Document Type: Article

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