Mono- and tri-cationic porphyrin-monoclonal antibody conjugates: Photodynamic activity and mechanism of action

Immunology

Volumn 132, Issue 2, 2011, Pages 256-265

  Smith, Karen ^a   Malatesti, Nela ^a   Cauchon, Nicole ^b   Hunting, Darel ^b   Lecomte, Roger ^b   Van Lier, Johan E ^b   Greenman, John ^a   Boyle, Ross W ^a  

^a UNIVERSITY OF HULL   (United Kingdom)

^b CENTRE HOSPITALIER UNIVERSITAIRE DE SHERBROOKE   (Canada)

Author keywords

Bioconjugation; Head and neck cancer; Monoclonal antibody; Photodynamic therapy

Indexed keywords

ANTIBODY CONJUGATE; CASPASE 3; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD 104; MONOCLONAL ANTIBODY CD 146; MONOCLONAL ANTIBODY CD 326; PHOTOFRIN; PHOTOSENSITIZING AGENT; PORPHYRIN 1; PORPHYRIN 2; PORPHYRIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY LABELING; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; DRUG CONJUGATION; DRUG STRUCTURE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; LD 50; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; PHOTOTOXICITY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL;

ADENOCARCINOMA; ANIMALS; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; CELL DEATH; CELL LINE, TUMOR; COLONIC NEOPLASMS; DIHEMATOPORPHYRIN ETHER; HUMANS; IMMUNOCONJUGATES; IMMUNOTHERAPY; INTEGRIN BETA4; ISOTHIOCYANATES; LIGHT; MICE; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; PORPHYRINS; TREATMENT OUTCOME;

EID: 78650930803     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2010.03359.x     Document Type: Article

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