Intravenous human umbilical cord blood transplantation for stroke: Impact on infarct volume and caspase-3-dependent cell death in spontaneously hypertensive rats

Experimental Neurology

Volumn 227, Issue 1, 2011, Pages 218-223

  Riegelsberger, Ute Maria ^a   Deten, Alexander ^a   Pösel, Claudia ^a   Zille, Marietta ^a   Kranz, Alexander ^a   Boltze, Johannes ^a,b   Wagner, Daniel Christoph ^a  

^a FRAUNHOFER INSTITUTE FOR CELL THERAPY AND IMMUNOLOGY   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Apoptosis; Caspase 3; Cerebral ischemia; Cord blood cell transplantation; Spontaneously hypertensive rat; Survivin

Indexed keywords

CASPASE 3; GLIAL FIBRILLARY ACIDIC PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 2; SURVIVIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELL DEATH; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CORD BLOOD STEM CELL TRANSPLANTATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RAT; SPONTANEOUSLY HYPERTENSIVE RAT;

ANIMALS; BRAIN INFARCTION; CASPASE 3; CELL COUNT; CELL DEATH; CORD BLOOD STEM CELL TRANSPLANTATION; DISEASE MODELS, ANIMAL; FETAL BLOOD; GENE EXPRESSION REGULATION; HUMANS; INJECTIONS, INTRAVENOUS; MALE; MICROTUBULE-ASSOCIATED PROTEINS; RATS; RATS, INBRED SHR; RNA, MESSENGER; STROKE; TIME FACTORS;

EID: 78650929587     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2010.11.008     Document Type: Article

References (31)

1. Acarin L., Villapol S., Faiz M., Rohn T.T., Castellano B., Gonzalez B. Caspase-3 activation in astrocytes following postnatal excitotoxic damage correlates with cytoskeletal remodeling but not with cell death or proliferation. Glia 2007, 55:954-965.
2. Aspey B.S., Cohen S., Patel Y., Terruli M., Harrison M.J. Middle cerebral artery occlusion in the rat: consistent protocol for a model of stroke. Neuropathol. Appl. Neurobiol. 1998, 24:487-497.
3. Broughton B.R., Reutens D.C., Sobey C.G. Apoptotic mechanisms after cerebral ischemia. Stroke 2009, 40:e331-e339.
4. Chandra S., White R.F., Everding D., Feuerstein G.Z., Coatney R.W., Sarkar S.K., Barone F.C. Use of diffusion-weighted MRI and neurological deficit scores to demonstrate beneficial effects of isradipine in a rat model of focal ischemia. Pharmacology 1999, 58:292-299.
5. Chen J., Sanberg P.R., Li Y., Wang L., Lu M., Willing A.E., Sanchez-Ramos J., Chopp M. Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke 2001, 32:2682-2688.
6. Dasari V.R., Veeravalli K.K., Saving K.L., Gujrati M., Fassett D., Klopfenstein J.D., Dinh D.H., Rao J.S. Neuroprotection by cord blood stem cells against glutamate-induced apoptosis is mediated by Akt pathway. Neurobiol. Dis. 2008, 32:486-498.
7. Endres M., Engelhardt B., Koistinaho J., Lindvall O., Meairs S., Mohr J.P., Planas A., Rothwell N., Schwaninger M., Schwab M.E., Vivien D., Wieloch T., Dirnagl U. Improving outcome after stroke: overcoming the translational roadblock. Cerebrovasc. Dis. 2008, 25:268-278.
8. Garcia J.H., Yoshida Y., Chen H., Li Y., Zhang Z.G., Lian J., Chen S., Chopp M. Progression from ischemic injury to infarct following middle cerebral artery occlusion in the rat. Am. J. Pathol. 1993, 142:623-635.
9. Hacke W., Kaste M., Bluhmki E., Brozman M., Davalos A., Guidetti D., Larrue V., Lees K.R., Medeghri Z., Machnig T., Schneider D., von, K.R., Wahlgren N., Toni D. Thrombolysis with alteplase 3 to 4.5hours after acute ischemic stroke. N. Engl. J. Med. 2008, 359:1317-1329.
10. Hau S., Reich D.M., Scholz M., Naumann W., Emmrich F., Kamprad M., Boltze J. Evidence for neuroprotective properties of human umbilical cord blood cells after neuronal hypoxia in vitro. BMC Neurosci. 2008, 9:30.
11. Ishii H., Arai T., Morikawa S., Inubushi T., Tooyama I., Kimura H., Mori K. Evaluation of focal cerebral ischemia in rats by magnetic resonance imaging and immunohistochemical analyses. J. Cereb. Blood Flow Metab. 1998, 18:931-934.
12. Le D.A., Wu Y., Huang Z., Matsushita K., Plesnila N., Augustinack J.C., Hyman B.T., Yuan J., Kuida K., Flavell R.A., Moskowitz M.A. Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation. Proc. Natl Acad. Sci. USA 2002, 99:15188-15193.
13. Legos J.J., Lenhard S.C., Haimbach R.E., Schaeffer T.R., Bentley R.G., McVey M.J., Chandra S., Irving E.A., Andrew A.P., Barone F.C. SB 234551 selective ET(A) receptor antagonism: perfusion/diffusion MRI used to define treatable stroke model, time to treatment and mechanism of protection. Exp. Neurol. 2008, 212:53-62.
14. Lo E.H. T time in the brain. Nat. Med. 2009, 15:844-846.
15. Love S. Apoptosis and brain ischaemia. Prog. Neuropsychopharmacol. Biol. Psychiatry 2003, 27:267-282.
16. Makinen S., Kekarainen T., Nystedt J., Liimatainen T., Huhtala T., Narvanen A., Laine J., Jolkkonen J. Human umbilical cord blood cells do not improve sensorimotor or cognitive outcome following transient middle cerebral artery occlusion in rats. Brain Res. 2006, 1123:207-215.
17. Newcomb J.D., Ajmo C.T., Sanberg C.D., Sanberg P.R., Pennypacker K.R., Willing A.E. Timing of cord blood treatment after experimental stroke determines therapeutic efficacy. Cell Transplant. 2006, 15:213-223.
18. Pan Y., Nastav J.B., Zhang H., Bretton R.H., Panneton W.M., Bicknese A.R. Engraftment of freshly isolated or cultured human umbilical cord blood cells and the effect of cyclosporin A on the outcome. Exp. Neurol. 2005, 192:365-372.
19. Pantano P., Caramia F., Bozzao L., Dieler C., von K.R. Delayed increase in infarct volume after cerebral ischemia: correlations with thrombolytic treatment and clinical outcome. Stroke 1999, 30:502-507.
20. Park D.H., Borlongan C.V., Willing A.E., Eve D.J., Cruz L.E., Sanberg C.D., Chung Y.G., Sanberg P.R. Human umbilical cord blood cell grafts for brain ischemia. Cell Transplant. 2009, 18:985-998.
21. Reich D.M., Hau S., Stahl T., Scholz M., Naumann W., Emmrich F., Boltze J., Kamprad M. Neuronal hypoxia in vitro: investigation of therapeutic principles of HUCB-MNC and CD133+ stem cells. BMC Neurosci. 2008, 9:91.
22. Tamura A., Graham D.I., McCulloch J., Teasdale G.M. Focal cerebral ischaemia in the rat. 1. Description of technique and early neuropathological consequences following middle cerebral artery occlusion. J. Cereb. Blood Flow Metab. 1981, 1:53-60.
23. Touzani O., Young A.R., Derlon J.M., Beaudouin V., Marchal G., Rioux P., Mezenge F., Baron J.C., MacKenzie E.T. Sequential studies of severely hypometabolic tissue volumes after permanent middle cerebral artery occlusion. A positron emission tomographic investigation in anesthetized baboons. Stroke 1995, 26:2112-2119.
24. Truelsen T., Bonita R. Chapter 16: The worldwide burden of stroke: current status and future projections. Handb. Clin. Neurol. 2008, 92:327-336.
25. Vendrame M., Cassady J., Newcomb J., Butler T., Pennypacker K.R., Zigova T., Sanberg C.D., Sanberg P.R., Willing A.E. Infusion of human umbilical cord blood cells in a rat model of stroke dose-dependently rescues behavioral deficits and reduces infarct volume. Stroke 2004, 35:2390-2395.
26. Vendrame M., Gemma C., de, M.D., Collier L., Bickford P.C., Sanberg C.D., Sanberg P.R., Pennypacker K.R., Willing A.E. Anti-inflammatory effects of human cord blood cells in a rat model of stroke. Stem Cells Dev. 2005, 14:595-604.
27. Vendrame M., Gemma C., Pennypacker K.R., Bickford P.C., Davis S.C., Sanberg P.R., Willing A.E. Cord blood rescues stroke-induced changes in splenocyte phenotype and function. Exp. Neurol. 2006, 199:191-200.
28. Villapol S., Acarin L., Faiz M., Castellano B., Gonzalez B. Survivin and heat shock protein 25/27 colocalize with cleaved caspase-3 in surviving reactive astrocytes following excitotoxicity to the immature brain. Neuroscience 2008, 153:108-119.
29. Xiao J., Nan Z., Motooka Y., Low W.C. Transplantation of a novel cell line population of umbilical cord blood stem cells ameliorates neurological deficits associated with ischemic brain injury. Stem Cells Dev. 2005, 14:722-733.
30. Yu G., Borlongan C.V., Stahl C.E., Hess D.C., Ou Y., Kaneko Y., Yu S.J., Yang T., Fang L., Xie X. Systemic delivery of umbilical cord blood cells for stroke therapy: a review. Restor. Neurol. Neurosci. 2009, 27:41-54.
31. Zawadzka M., Lukasiuk K., Machaj E.K., Pojda Z., Kaminska B. Lack of migration and neurological benefits after infusion of umbilical cord blood cells in ischemic brain injury. Acta Neurobiol. Exp. (Wars.) 2009, 69:46-51.