Neurotoxic cycad components and Western Pacific ALS/PDC

Annals of Neurology

Volumn 68, Issue 6, 2010, Pages 975-976

  Spencer, Peter S ^a   Lasarev, Michael R ^a   Palmer, Valerie S ^a   Kisby, Glen E ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLAZOXYMETHANOL; METHYLAZOXYMETHANOL GLUCOSIDE; SITOGLUSIDE; SITOSTEROL;

ABSENCE OF SIDE EFFECTS; AMYOTROPHIC LATERAL SCLEROSIS; CYCAS; FOOD CONTAMINATION; HUMAN; LETTER; MULTICENTER STUDY (TOPIC); NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PARKINSONISM; PLANT SEED; PRIORITY JOURNAL; PROSTATE HYPERTROPHY; RANDOMIZED CONTROLLED TRIAL (TOPIC); TAUOPATHY;

AMYOTROPHIC LATERAL SCLEROSIS; CYCAS; HUMANS; NEUROTOXINS; PACIFIC ISLANDS; PARKINSON DISEASE;

EID: 78650913511     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.22261     Document Type: Letter

References (5)

1. Shen W-B, McDowell KA, Siebert AA, et al. Environmental neurotoxin-induced progressive model of parkinsonism in rats. Ann Neurol 2010; 68: 70-80.
2. Spencer PS, Palmer VS, Ludolph AC,. On the decline and etiology of high-incidence motor system disease in West Papua (southwest New Guinea). Mov Disord 2005; 20: S119-S126.
3. Borenstein AR, Mortimer JA, Schofield E, et al. Cycad exposure and risk of dementia, MCI, and PDC in the Chamorro population of Guam. Neurology 2007; 68: 1764-1771.
4. Roman GC, Zhang Z-H, Ellenberg JH,. The neuroepidemiology of Parkinson's disease. In:, Ellenberg JH, Koller WC, Langston JW, eds. Etiology of Parkinson's Disease. New York: Marcel Dekker; 1995: 203-243.
5. Klippel KF, Hilti DM, Schipp B,. A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. German BPH-Phyto Study Group. Br J Urol 1997; 80: 427-432.