pH-dependent localization of Btn1p in the yeast model for Batten disease

DMM Disease Models and Mechanisms

Volumn 4, Issue 1, 2011, Pages 120-125

  Wolfe, Devin M ^a   Padilla Lopez, Sergio ^a,b   Vitiello, Seasson Phillips ^a,b   Pearce, David A ^a,b,c  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b SANFORD RESEARCH   (United States)

^c UNIVERSITY OF SOUTH DAKOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL PROTEIN; PROTEIN BTN1P; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; FUNGAL GENE; GENETIC TRANSCRIPTION; NEURONAL CEROID LIPOFUSCINOSIS; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; PROTEIN LOCALIZATION; YEAST;

CULTURE MEDIA; CYCLINS; EXTRACELLULAR SPACE; GENE EXPRESSION REGULATION, FUNGAL; HYDROGEN-ION CONCENTRATION; MODELS, BIOLOGICAL; NEURONAL CEROID-LIPOFUSCINOSES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 78650912761     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.006114     Document Type: Article

References (37)

1. Arai, H., Pink, S. and Forgac, M. (1989). Interaction of anions and ATP with the coated vesicle proton pump. Biochemistry 28, 3075-3082.
2. Chung, J. H., Lester, R. L. and Dickson, R. C. (2003). Sphingolipid requirement for generation of a functional v1 component of the vacuolar ATPase. J. Biol. Chem. 278, 28872-28881.
3. Cismondi, I. A., Kohan, R., Ghio, A., Ramirez, A. M. and Halac, I. N. (2008). Gene symbol: CLN6. Disease: Neuronal ceroid lipofuscinosis, late Infantile. Hum. Genet. 124, 324.
4. Codlin, S. and Mole, S. E. (2009). S. pombe btn1, the orthologue of the Batten disease gene CLN3, is required for vacuole protein sorting of Cpy1p and Golgi exit of Vps10p. J. Cell Sci. 122, 1163-1173.
5. Croopnick, J. B., Choi, H. C. and Mueller, D. M. (1998). The subcellular location of the yeast Saccharomyces cerevisiae homologue of the protein defective in the juvenile form of Batten disease. Biochem. Biophys. Res. Commun. 250, 335-341.
6. Fisher, C. L. and Pei, G. K. (1997). Modification of a PCR-based site-directed mutagenesis method. Biotechniques 23, 570-571, 574.
7. Forgac, M. (1999). Structure and properties of the vacuolar (H+)-ATPases. J. Biol. Chem. 274, 12951-12954.
8. Gachet, Y., Codlin, S., Hyams, J. S. and Mole, S. E. (2005). btn1, the Schizosaccharomyces pombe homologue of the human Batten disease gene CLN3, regulates vacuole homeostasis. J. Cell Sci. 118, 5525-5536.
9. Graham, L. A., Powell, B. and Stevens, T. H. (2000). Composition and assembly of the yeast vacuolar H(+)-ATPase complex. J. Exp. Biol. 203, 61-70.
10. Guldener, U., Heck, S., Fielder, T., Beinhauer, J. and Hegemann, J. H. (1996). A new efficient gene disruption cassette for repeated use in budding yeast. Nucleic Acids Res. 24, 2519-2524.
11. Jarvela, I., Sainio, M., Rantamaki, T., Olkkonen, V. M., Carpen, O., Peltonen, L. and Jalanko, A. (1998). Biosynthesis and intracellular targeting of the CLN3 protein defective in Batten disease. Hum. Mol. Genet. 7, 85-90.
12. Jones, D. C., Mehlert, A., Guther, M. L. and Ferguson, M. A. (2005). Deletion of the glucosidase II gene in Trypanosoma brucei reveals novel N-glycosylation mechanisms in the biosynthesis of variant surface glycoprotein. J. Biol. Chem. 280, 35929-35942.
13. Kane, P. M. (1995). Disassembly and reassembly of the yeast vacuolar H(+)-ATPase in vivo. J. Biol. Chem. 270, 17025-17032.
14. Kane, P. M. and Parra, K. J. (2000). Assembly and regulation of the yeast vacuolar H(+)-ATPase. J. Exp. Biol. 203, 81-87.
15. Kim, Y., Ramirez-Montealegre, D. and Pearce, D. A. (2003). A role in vacuolar arginine transport for yeast Btn1p and for human CLN3, the protein defective in Batten disease. Proc. Natl. Acad. Sci. USA 100, 15458-15462.
16. Kyttala, A., Ihrke, G., Vesa, J., Schell, M. J. and Luzio, J. P. (2004). Two motifs target Batten disease protein CLN3 to lysosomes in transfected nonneuronal and neuronal cells. Mol. Biol. Cell 15, 1313-1323. (Pubitemid 38316237)
17. Lebrun, A. H., Storch, S., Ruschendorf, F., Schmiedt, M. L., Kyttala, A., Mole, S. E., Kitzmuller, C., Saar, K., Mewasingh, L. D., Boda, V. et al. (2009). Retention of lysosomal protein CLN5 in the endoplasmic reticulum causes neuronal ceroid lipofuscinosis in Asian sibship. Hum. Mutat. 30, E651-E661.
18. Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Randall, R. J. (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
19. Menne, T. F., Goyenechea, B., Sanchez-Puig, N., Wong, C. C., Tonkin, L. M., Ancliff, P. J., Brost, R. L., Costanzo, M., Boone, C. and Warren, A. J. (2007). The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast. Nat. Genet. 39, 486-495.
20. Ohsumi, Y. and Anraku, Y. (1981). Active transport of basic amino acids driven by a proton motive force in vacuolar membrane vesicles of Saccharomyces cerevisiae. J. Biol. Chem. 256, 2079-2082.
21. Oluwatosin, Y. E. and Kane, P. M. (1997). Mutations in the CYS4 gene provide evidence for regulation of the yeast vacuolar H+-ATPase by oxidation and reduction in vivo. J Biol. Chem. 272, 28149-28157.
22. Padilla-Lopez, S. and Pearce, D. A. (2006). Saccharomyces cerevisiae lacking Btn1p modulate vacuolar ATPase activity to regulate pH imbalance in the vacuole. J. Biol. Chem. 281, 10273-10280.
23. Pearce, D. A. and Sherman, F. (1997). BTN1, a yeast gene corresponding to the human gene responsible for Batten's disease, is not essential for viability, mitochondrial function, or degradation of mitochondrial ATP synthase. Yeast 13, 691-697.
24. Pearce, D. A. and Sherman, F. (1998). A yeast model for the study of Batten disease. Proc. Natl. Acad. Sci. USA 95, 6915-6918.
25. Pearce, D. A., Ferea, T., Nosel, S. A., Das, B. and Sherman, F. (1999). Action of BTN1, the yeast orthologue of the gene mutated in Batten disease. Nat. Genet. 22, 55-58.
26. Peirson, S. N., Butler, J. N. and Foster, R. G. (2003). Experimental validation of novel and conventional approaches to quantitative real-time PCR data analysis. Nucleic Acids Res. 31, e73.
27. Pfaffl, M. W., Horgan, G. W. and Dempfle, L. (2002). Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res. 30, e36.
28. Phillips, S. N., Benedict, J. W., Weimer, J. M. and Pearce, D. A. (2005). CLN3, the protein associated with batten disease: structure, function and localization. J. Neurosci. Res. 79, 573-583.
29. Qi, J. and Forgac, M. (2007). Cellular environment is important in controlling V-ATPase dissociation and its dependence on activity. J. Biol. Chem. 282, 24743-24751. (Pubitemid 47347540)
30. Russnak, R., Konczal, D. and McIntire, S. L. (2001). A family of yeast proteins mediating bidirectional vacuolar amino acid transport. J. Biol. Chem. 276, 23849-23857.
31. Sheff, M. A. and Thorn, K. S. (2004). Optimized cassettes for fluorescent protein tagging in Saccharomyces cerevisiae. Yeast 21, 661-670.
32. Shimazu, M., Sekito, T., Akiyama, K., Ohsumi, Y. and Kakinuma, Y. (2005). A family of basic amino acid transporters of the vacuolar membrane from Saccharomyces cerevisiae. J. Biol. Chem. 280, 4851-4857.
33. Storch, S., Pohl, S. and Braulke, T. (2004). A dileucine motif and a cluster of acidic amino acids in the second cytoplasmic domain of the batten disease-related CLN3 protein are required for efficient lysosomal targeting. J. Biol. Chem. 279, 53625-53634.
34. Storch, S., Pohl, S., Quitsch, A., Falley, K. and Braulke, T. (2007). C-terminal prenylation of the CLN3 membrane glycoprotein is required for efficient endosomal sorting to lysosomes. Traffic 8, 431-444.
35. The International Batten Disease Consortium (1995). Isolation of a novel gene underlying Batten disease, CLN3. Cell 82, 949-957.
36. Vitiello, S. P., Wolfe, D. M. and Pearce, D. A. (2007). Absence of Btn1p in the yeast model for juvenile Batten disease may cause arginine to become toxic to yeast cells. Hum. Mol. Genet. 16, 1007-1016.
37. Vitiello, S. P., Benedict, J. W., Padilla-Lopez, S. and Pearce, D. A. (2010). Interaction between Sdo1p and Btn1p in the Saccharomyces cerevisiae model for Batten disease. Hum. Mol. Genet. 19, 931-942.