GH response to oral glucose tolerance test: A comparison between patients with acromegaly and other pituitary disorders

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 1, 2011, Pages

  Verrua, Elisa ^a,b   Filopanti, M ^a,b   Ronchi, C L ^a,b   Olgiati, L ^a,b   Ferrante, E ^a,b   Giavoli, C ^a,b   Sala, E ^a,b   Mantovani, G ^a,b   Arosio, M ^a,c   Beck Peccoz, P ^a,b   Lania, A G ^a,b   Spada, A ^a,b  

^a UNIVERSITY OF MILAN   (Italy)

^b FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^c IRCCS MULTIMEDICA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GROWTH HORMONE; SOMATOMEDIN C;

ACROMEGALY; ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GLUCOSE BLOOD LEVEL; GROWTH HORMONE RELEASE; HORMONE RESPONSE; HUMAN; HYPERPROLACTINEMIA; HYPOPHYSIS ADENOMA; HYPOPHYSIS DISEASE; MALE; NEUROSURGERY; ORAL GLUCOSE TOLERANCE TEST; OUTCOME ASSESSMENT; PITUITARY STALK; PRIORITY JOURNAL;

EID: 78650905989     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2010-1115     Document Type: Article

References (30)

1. Melmed S 2006 Medical progress: acromegaly. N Engl J Med 355: 2558-2573
2. Giustina A, Barman A, Casanueva FF, Cavagnini F, Frohman L, Ho K, Veldhuis J, Wass J, Von Werder K, Melmed S 2000 Criteria for cure of acromegaly: a consensus statement. J Clin Endocrinol Metab 85:526-529
3. Costa AC, Rossi A, Martinelli Jr CE, Machado HR, Moreira AC 2002 Assessment of disease activity in treated acromegalic patients using a sensitive GH assay: should we achieve strict normal GH levels for a biochemical cure? J Clin Endocrinol Metab 87:3142-3147
4. Minniti G, Jaffrain-Rea ML, Esposito V, Santoro A, Tamburrano G, Cantore G 2003 Evolving criteria for post-operative biochemical remission of acromegaly: can we achieve a definitive cure? An audit of surgical results on a large series and a review of the literature. Endocr Relat Cancer 10:611-619
5. Ronchi CL, Varca V, Giavoli C, Epaminonda P, Beck-Peccoz P, Spada A, Arosio M 2005 Long-term evaluation of postoperative acromegalic patients in remission with previous and newly proposed criteria. J Clin Endocrinol Metab 90:1377-1382
6. Ronchi CL, Arosio M, Rizzo E, Lania AG, Beck-Peccoz P, Spada A 2007 Adequacy of current postglucose GH nadir limit (<1 microgram/ liter) to define long-lasting remission of acromegalic disease. Clin Endocrinol (Oxf) 66:538-542
7. Freda PU, Post KD, Powell JS, Wardlaw SL 1998 Evaluation of disease status with sensitive measures of growth hormone secretion in 60 postoperative patients with acromegaly. J Clin Endocrinol Metab 83:3808-3816
8. Serri O, Beauregard C, Hardy J 2004 Long-term biochemical status and disease-related morbidity in 53 postoperative patients with acromegaly. J Clin Endocrinol Metab 89:658-661 (Pubitemid 38269873)
9. Freda PU, Nuruzzaman AT, Reyes CM, Sundeen RE, Post KD 2004 Significance of "abnormal" nadir growth hormone levels after oral glucose in postoperative patients with acromegaly in remission with normal insulin-like growth factor-I levels. J Clin Endocrinol Metab 89:495-500
10. Carmichael JD, Bonert VS, Mirocha JM, Melmed S 2009 The utility of oral glucose tolerance testing for diagnosis and assessment of treatment outcomes in 166 patients with acromegaly. J Clin Endocrinol Metab 94:523-527
11. Minuto F, Resmini E, Boschetti M, Arvigo M, Soriani MP, Giusti M, Ferone D, Barreca A 2004 Assessment of disease activity in acromegaly by means of a single blood sample: comparison of the 120th minute postglucose value with spontaneous GH secretion and with the IGF system. Clin Endocrinol (Oxf) 61:138-144
12. Elias PC, Lugao HB, Pereira MC, Machado HR, Castro M, Moreira AC 2010 Discordant nadirGHafter oral glucose and IGF-I levels on treated acromegaly: refining the biochemical markers of mild disease activity. Horm Metab Res 42:50-55
13. Giustina A, Chanson M, Bronstein D, Klibanski A, Lamberts S, Casanueva FF, Trainer P, Ghigo E, Ho K, Melmed S 2010 A consensus on criteria for cure of acromegaly. J Clin Endocrinol Metab 95:3141-3148
14. Roth J, Glick SM, Yalow RS, Berson SA 1963 Secretion of human growth hormone: physiological and experimental modification . Metabolism 12:577-579
15. Glick SM 1968 Normal and abnormal secretion of growth hormone. Ann NY Acad Sci 148:471-487
16. Grottoli S, Procopio M, Maccario M, Zini M, Oleandri SE, Tassone F, Valcavi R, Ghigo E 1997 In obesity, glucose load loses its early inhibitory, but maintains its late stimulatory, effect on somatotrope secretion. J Clin Endocrinol Metab 82:2261-2265
17. Attanasio R, Oppizzi G, Lodrini S, Dallabonzana D, Barausse M, Orlandi P, Da Re N, Cozzi R 1999 Neurosurgery restores late GH rise after glucose-induced suppression in cured acromegalics. Eur J Endocrinol 140:23-28
18. Tannenbaum GS 1990 Interrelationship of somatostatin and growth hormone-releasing hormone in the genesis of the rhythmic secretion of growth hormone. Acta Paediatr Scand Suppl 367:76-80
19. Valcavi R 1996 Oral glucose tolerance test: an inhibitory or stimulatory input to growth hormone secretion? J Endocrinol Invest 19:253-255
20. Shibasaki T, Masuda A, Hotta M, Yamauchi N, Hizuka N, Takano K, Demura H, Shizume K 1989 Effects of ingestion of glucose on GH and TSH secretion: evidence for stimulation of somatostatin release from the hypothalamic by acute hyperglycemia in normal man and its impairment in acromegalic patients. Life Sci 44:431-438 (Pubitemid 19048569)
21. Hattori N, Shimatsu A, Tanoh T, Koshiyama H, Kato Y, Imura H 1990 Evaluation of activity in postoperative acromegalics-plasma growth hormone levels during oral glucose tolerance test, daytime blood sampling and urinary GH excretion. Endocrinol Jpn 37:629-637
22. Markkanen H, Pekkarinen T, Välimäki MJ, Alfthan H, Kauppinen- Mäkelin R, Sane T, Stenman UH 2006 Effect of sex and assay method on serum concentrations of growth hormone in patients with acromegaly and in healthy controls. Clin Chem 52:468-473 (Pubitemid 43306471)
23. Rosário PW, Furtado MS 2008 Growth hormone after oral glucose overload: revision of reference values in normal subjects. Arq Bras Endocrinol Metab 52:1139-1144
24. Arafat AM, Möhlig M, Weickert MO, Perschel FH, Puschwitz J, Spranger J, Strasburger CJ, Schöfl C, Pfeiffer AF 2008 Growth hormone response during oral glucose tolerance test: the impact of assay method on the estimation of reference values in patients with acromegaly and in healthy controls, and the role of gender, age and body mass index. J Clin Endocrinol Metab 93:1254-1262
25. Corneli G, Di Somma C, Baldelli R, Rovere S, Gasco V, Croce CG, Grottoli S, Maccario M, Colao A, Lombardi G, Ghigo E, Camanni F, Aimaretti G 2005 The cut-off limits of the GH-response to GH-releasing hormone-arginine test related to body mass index. Eur J Endocrinol 153:257-264
26. Ghigo E, Aimaretti G, Gianotti L, Bellone J, Arvat E, Camanni F 1996 New approach to the diagnosis of growth hormone deficiency in adults. Eur J Endocrinol 134:352-356
27. Vierhapper H, Heinze G, Gessl A, Exner M, Bieglmayr C 2003 Use of the oral glucose tolerance test to define remission in acromegaly. Metabolism 52:181-185
28. Kinsley BT, Widom B, Utzschneider K, Simonson DC 1994 Stimulus specificity of defects in counterregulatory hormone secretion in insulin-dependent diabetes mellitus: effect of glycemic control. J Clin Endocrinol Metab 79:1383-1389 (Pubitemid 24369853)
29. Hansen AP 1971 The effect of intravenous glucose infusion on the exercise-induced serum growth hormone rise in normals and juvenile diabetics. Scand J Clin Lab Invest 28:195-205
30. Mims RB, Scott CL, Modebe OM, Bethune JE 1973 Prevention of L-dopa-induced growth hormone stimulation by hyperglycemia. J Clin Endocrinol Metab 37:660-663