An implantable optical stimulation delivery system for actuating an excitable biosubstrate

IEEE Journal of Solid-State Circuits

Volumn 46, Issue 1, 2011, Pages 321-332

  Paralikar, Kunal ^a   Cong, Peng ^a   Yizhar, Ofer ^b   Fenno, Lief Ericsson ^b   Santa, Wesley ^a   Nielsen, Chris ^a   Dinsmoor, David ^a   Hocken, Bob ^a   Munns, Gordon O ^a   Giftakis, Jon ^a   Deisseroth, Karl ^b   Denison, Timothy ^a  

^a MEDTRONIC INC   (United States)

^b Stanford University   (United States)

Author keywords

Implantable optical stimulator; in vivo optical excitation; optical neuromodulation; optogenetics

Indexed keywords

DELIVERY SYSTEMS; HANDLING POWER; HARDWARE SYSTEM; IC ARCHITECTURES; IMPLANTABLE OPTICAL STIMULATOR; IN-VITRO TESTS; IN-VIVO; MANAGE INFORMATION; MODULATION TECHNIQUES; NEURAL SUBSTRATES; NEUROMODULATION; OPTICAL STIMULATION; OPTOGENETICS; PROTOTYPE SYSTEM; SYSTEM LEVEL DESIGN; TECHNICAL LIMITATIONS; TISSUE INTERFACE;

LIGHT SOURCES;

PHOTOEXCITATION;

EID: 78650877056     PISSN: 00189200     EISSN: None     Source Type: Journal    
DOI: 10.1109/JSSC.2010.2074110     Document Type: Conference Paper

References (31)

1. T. Wichmann and M. R. DeLong, "Deep brain stimulation for neurologic and neuropsychiatric disorders," Neuron, vol. 52, pp. 197-204, Oct. 2006.
2. A. Csavoy, G. Molnar, and T. Denison, "Creating support circuits for the nervous system: Considerations for "brain-machine" interfacing," in Symp. VLSI Circuits Dig., Jun. 2009, pp. 4-7.
3. D. R. Merrill, M. Bikson, and J. G. R. Jefferys, "Electrical stimulation of excitable tissue: Design of efficacious and safe protocols," J. Neurosci. Meth., vol. 141, pp. 171-198, 2005.
4. A. R. Rezai, M. Philips, K. B. Baker, A. D. Sharan, J. Nyenhuis, J. Tkach, J. Henderson, and F. Shellock, "Neurostimulation system used for deep brain stimulation (DBS):MR safety issues and implications of failing to follow safety recommendations," Investigative Radiol., vol. 39, no. 5, pp. 300-303, 2004.
5. C. R. Butson and C. C. McIntyre, "Current steering to control the volume of tissue activated during deep brain stimulation," Brain Stimul., vol. 1, pp. 7-15, 2008.
6. M. Filali, W. D. Hutchison, V. N. Palter, A. M. Lozano, and J. O. Dostrovsky, "Stimulation-induced inhibition of neuronal firing in human subthalamic nucleus," Experiment. Brain Res., vol. 156, pp. 274-281, 2004.
7. A. T. Avestruz, W. Santa, D. Carlson, R. Jensen, S. Stanslaski, A. Helfinstine, and T. Denison, "A 5 μW/channel spectral analysis IC for chronic bidirectional brain-machine interfaces," IEEE J. Solid-State Circuits, vol. 43, no. 12, pp. 3006-3024, Dec. 2008.
8. S. Stanslaski, P. Cong, D. Carlson, W. Santa, R. Jensen, G. Molnar,W. J. Marks, A. Shafquat, and T. Denison, "An implantable bidirectional brain-machine interface system for chronic neuroprosthesis research," in Proc. IEEE Annu. EMBC, Sep. 2009, pp. 5494-5497.
9. A. L. Benabid, S. Chabardes, J. Mitrofanis, and P. Pollak, "Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease," Lancet Neurol., vol. 8, pp. 67-81, 2009.
10. K. Deisseroth, G. Feng, A. K. Majewska, G. Miesenbo, A. Ting, and M. J. Schnitzer, "Next-generation optical technologies for illuminating genetically targeted brain circuits," J. Neurosci., vol. 26, pp. 10380-10386, Oct. 2006.
11. R. L. Testerman, M. T. Rise, and P. H. Stypulkowski, "Electrical stimulation as therapy for neurological disorders-The basics of implantable neurological stimulators," IEEE Eng. Med. Biol. Mag., vol. 25, pp. 74-78, 2006.
12. J. Jakobsson and C. Lundberg, "Lentiviral vectors for use in the central nervous system," Molecular Therapy, vol. 13, no. 3, pp. 484-493, Mar. 2006.
13. G. Nagel, T. Szellas, W. Huhn, S. Kateriya, N. Adeishvili, P. Berthold, D. Ollig, P. Hegemann, and E. Bamberg, "Channelrhodopsin-2, a directly light-gated cation-selective membrane channel," PNAS, vol. 100, no. 24, pp. 13940-13945.
14. A. Berndt, O. Yizhar, L. Gunaydin, P. Hegemann, and K. Deisseroth, "Bi-stable neural state switches," Nature Neurosci., vol. 12, pp. 229-234, 2008, (and O. Yizhar et al., unpublished data).
15. B. Y. Chow, H. Xue, A. S. Dobry, Q. Xiaofeng, A. S. Chuong, L. Mingjie, A. Michael, G. M. Belfort, L. Yingxi, P. E. Monahan, and E. S. Boyden, "High-performance genetically targetable optical neural silencing by light-driven proton pumps," Nature, vol. 463, pp. 98-102, 2010.
16. X. Han and E. S. Boyden, "Multiple-color optical activation, silencing, and desynchronization of neural activity, with single-spike temporal resolution," PLoS ONE, vol. 2, no. 3, e299.
17. X. Han, X. Qian, J. G. Bernstein, H. Zhou, G. T. Franzesi, P. Stern, R. T. Bronson, A. M. Graybiel, R. Desimone, and E. S. Boyden, "Millisecond- timescale optical control of neural dynamics in the nonhuman primate brain," Neuron, vol. 62, pp. 191-198, Apr. 2009.
18. E. Fino, R. Araya1, D. S. Peterka1, M. Salierno, R. Etchenique, and R. Yuste1, "RuBi-Glutamate: Two-photon and visible-light photoactivation of neurons and dendritic spines," Frontiers in Neural Circuits, vol. 3, May 2009, article 2.
19. V. Gradinaru, M. Mogri, K. R. Thompson, J. M. Henderson, and K. Deisseroth, "Optical deconstruction of parkinsonian neural circuitry," Science, vol. 324, pp. 354-359, 2009.
20. C. S. Nelson and T. T. Bomstad, "Optical feedthrough assembly for use in implantable medical device," U.S. Patent 7,349,618 B2, Mar. 25, 2008.
21. P. Degenaar, N. Grossman, M. A. Memon, J. Burrone, M. Dawson, E. Drakakis, M. Neil, and K. Nikolic, "Optobionic vision-A new genetically enhanced light on retinal prosthesis," J. Neural Eng., vol. 6, 2009.
22. C. C. Enz and G. C. Temes, "Circuit techniques for reducing the effects of op-amp imperfections: Autozeroing, correlated double sampling, and chopper stabilization," Proc. IEEE, vol. 84, no. 11, pp. 1584-1614, Nov. 1996.
23. T. Denison, K. Consoer, W. Santa, A.-T. Avestruz, J. Cooley, and A. Kelly, "A 2 μW 100 nV/rtHz chopper-stabilized instrumentation amplifier for chronic measurement of neural field potentials," IEEE J. Solid-State Circuits, vol. 43, no. 12, pp. 2934-2945, Nov. 2007.
24. R. Harrison, P.Watkins, R. Kier, R. Lovejoy, D. Black, B. Greger, and F. Solzbacher, "A low-power integrated circuit for a wireless 100-electrode neural recording system," IEEE J. Solid-State Circuits, vol. 42, no. 1, pp. 123-133, Jan. 2007.
25. M. Ghovanloo and S. Atluri, "An integrated full-wave CMOS rectifier with built-in back telemetry for RFID and implantable biomedical applications," IEEE Trans. Circuits Syst. I, Reg. Papers, vol. 55, no. 10, pp. 3328-3334, Nov. 2008.
26. E. M. Rial Verde, L. Zayat, R. Etchenique, and R. Yuste, "Photorelease of GABA with visible light using an inorganic caging group," Front. Neural Circuits, vol. 2, 2008, art. 2.
27. L. A. Gunaydin, O. Yizhar, A. Berndt, V. S. Sohal, K. Deisseroth, and P. Hegemann, "Ultrafast optogenetic control," Nature Neurosci., vol. 13, no. 3, Mar. 2010.
28. V. S. Polikov, P. A. Tresco, and W. M. Reichert, "Response of brain tissue to chronically implanted neural electrodes," J. Neurosci. Meth., vol. 148, pp. 1-18, 2005.
29. L. Zayat, M. G. Noval, J. Campi, C. I. Calero, D. J. Calvo, and R. Etchenique, "A new inorganic photolabile protecting group for highly efficient visible light GABA uncaging," ChemBioChem, vol. 8, pp. 2035-2038, 2007.
30. V. Gradinaru, K. R. Thompson, F. Zhang, M. Mogri, K. Kay, M. B. Schneider, and K. Deisseroth, "Targeting and readout strategies for fast optical neural control in vitro and in vivo," J. Neurosci., vol. 27, no. 52, pp. 14231-14238, Dec. 2007.
31. V. Gradinaru, F. Zhang, C. Ramakrishnan, J. Mattis, R. Prakash, I. Diester, I. Goshen, K. R. Thompson, and K. Deisseroth, "Molecular and cellular approaches for diversifying and extending optogenetics," Cell, vol. 141, no. 1, pp. 154-165, Mar. 2010.