Is sudden unexpected death in epilepsy due to postictal brain shutdown?

Annals of Neurology

Volumn 68, Issue 6, 2010, Pages 773-775

  Hirsch, Lawrence J ^a  

^a NEUROLOGICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CAUSE OF DEATH; ELECTROCARDIOGRAPHY MONITORING; ELECTROENCEPHALOGRAPHY; EPILEPSY; HUMAN; HYPERCAPNIA; HYPOXEMIA; PRIORITY JOURNAL; REVIEW; SEIZURE; SPIKE WAVE; SUDDEN DEATH;

ANIMALS; BRAIN; DEATH, SUDDEN; ELECTROENCEPHALOGRAPHY; EPILEPSY; HUMANS; INFANT; MONITORING, PHYSIOLOGIC; SUDDEN INFANT DEATH;

EID: 78650872688     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.22242     Document Type: Review

References (20)

1. So EL, Bainbridge J, Buchhalter JR, et al. Report of the American Epilepsy Society and the Epilepsy Foundation joint task force on sudden unexplained death in epilepsy. Epilepsia 2009; 50: 917-922.
2. Lhatoo SD, Faulkner HJ, Dembny K, et al. An electroclinical case control study of sudden unexpected death in epilepsy. Ann Neurol 2010; 68: 787-796.
3. Bateman LM, Spitz M, Seyal M., Ictal hypoventilation contributes to cardiac arrhythmia and SUDEP: report on two deaths in video-EEG-monitored patients. Epilepsia 2010; 51: 916-920.
4. Tomson T, Nashef L, Ryvlin P., Sudden unexpected death in epilepsy: current knowledge and future directions. Lancet Neurol 2008; 7: 1021-1031.
5. Bateman LM, Li CS, Seyal M., Ictal hypoxemia in localization-related epilepsy: analysis of incidence, severity and risk factors. Brain 2008; 131 (pt 12): 3239-3245.
6. Seyal M, Bateman LM, Albertson TE, et al. Respiratory changes with seizures in localization-related epilepsy: analysis of periictal hypercapnia and airflow patterns. Epilepsia 2010; 51(8): 1359-1364.
7. Kinney HC, Richerson GB, Dymecki SM, et al. The brainstem and serotonin in the sudden infant death syndrome. Annu Rev Pathol 2009; 4: 517-550.
8. Kinney HC, Thach BT., The sudden infant death syndrome. N Engl J Med 2009; 361: 795-805.
9. Langan Y, Nashef L, Sander JW., Case-control study of SUDEP. Neurology 2005; 64: 1131-1133.
10. Nashef L, Fish DR, Garner S, et al. Sudden death in epilepsy: a study of incidence in a young cohort with epilepsy and learning difficulty. Epilepsia 1995; 36: 1187-1194.
11. Tupal S, Faingold CL., Evidence supporting a role of serotonin in modulation of sudden death induced by seizures in DBA/2 mice. Epilepsia 2006; 47: 21-26.
12. Uteshev VV, Tupal S, Mhaskar Y, Faingold CL., Abnormal serotonin receptor expression in DBA/2 mice associated with susceptibility to sudden death due to respiratory arrest. Epilepsy Res 2010; 88: 183-188.
13. Bateman LM, Li CS, Lin TC, Seyal M., Serotonin reuptake inhibitors are associated with reduced severity of ictal hypoxemia in medically refractory partial epilepsy. Epilepsia 2010 (epub only).
14. Venit EL, Shepard BD, Seyfried TN., Oxygenation prevents sudden death in seizure-prone mice. Epilepsia 2004; 45: 993-996.
15. Shen HY, Li T, Boison D., A novel mouse model for sudden unexpected death in epilepsy (SUDEP): role of impaired adenosine clearance. Epilepsia 2010; 51: 465-468.
16. Schuele SU., Effects of seizures on cardiac function. J Clin Neurophysiol 2009; 26: 302-308.
17. Dasheiff RM, Dickinson LJ., Sudden unexpected death of epileptic patient due to cardiac arrhythmia after seizure. Arch Neurol 1986; 43: 194-196.
18. Espinosa PS, Lee JW, Tedrow UB, et al. Sudden unexpected near death in epilepsy: malignant arrhythmia from a partial seizure. Neurology 2009; 72: 1702-1703.
19. Goldman AM, Glasscock E, Yoo J, et al. Arrhythmia in heart and brain: KCNQ1 mutations link epilepsy and sudden unexplained death. Sci Transl Med 2009; 1:2ra6.
20. Lehnart SE, Mongillo M, Bellinger A, et al. Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice. J Clin Invest 2008; 118: 2230-2245.