Photostability studies of ketoconazole: Isolation and structural elucidation of the main photodegradation products

Latin American Journal of Pharmacy

Volumn 29, Issue 7, 2010, Pages 1100-1106

  Staub, Inara ^a   Flores, Letícia ^a   Gosmann, Grace ^a   Pohlmann, Adriana ^a   Fröehlich, Pedro E ^a   Schapoval, Elfrides E S ^a   Bergold, Ana M ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Antifungal activity; Ketoconazole; Liquid chromatography; Photoproduct characterization; Photostability

Indexed keywords

ALIPHATIC AMINE; AMMONIUM ACETATE; KETOCONAZOLE; METHANOL; MONOISOPROPYLAMINE; PLASTIC; SHAMPOO; UNCLASSIFIED DRUG; WATER;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; DECHLORINATION; DRUG ISOLATION; DRUG STABILITY; DRUG STORAGE; DRUG STRUCTURE; FLOW RATE; FUNGUS CULTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PACKAGING MATERIAL; PHOTOCHEMISTRY; PHOTODEGRADATION; SUNLIGHT; ULTRAVIOLET A RADIATION; ULTRAVIOLET C RADIATION;

EID: 78650852362     PISSN: 03262383     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Tonnesen, H.M (2006) Int. J. Pharm. 225: 1-14.
2. De Vries, H., G.M.J.B. Van Henegouwen & F.A. Huf (1984) Int. J. Pharm. 20: 265-71.
3. International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (1996) "Stability testing: photostability testing of new drug substances and products". ICH, Geneva.
4. Peter, R.U. & U.B. Richarz (1995) Br. J. Dermatol. 132: 441-5.
5. Abounassif, A.M. & B.M. El Shazly (1989) Anal. Lett. 22: 2233-47.
6. Kedor-Hackmann, E.R.M., M.F.M. Nery & M.I.R.M. Santoro (1994) Anal. Lett. 27: 363-76.
7. Kelani, K., L.I. Bebawy, L. Abdel-Fattah & A.K.S. Ahmad (1997) Anal. Lett. 30: 1843-60.
8. Staub, I., E.E.S. Schapoval & A.M. Bergold (2005) Int. J. Pharm. 292: 195-9.
9. Heyden, Y.V., A.N.M. Nguyet, M.R. Detaevernier, D.L. Massart & J.P. Vercammen (2002) J. Chromatogr. A 958: 191-201.
10. Nguyet, A.N.M., L. Tallieu, J.P. Vercammen, D.L. Massart & Y.V. Heyden (2003) J. Pharm. Biomed. Anal. 32: 1-19.
11. Staub, I. & A.M. Bergold (2004) Acta Farm. Bonaerense 23: 387-90.
12. Thoma, K. & N. Kübler (1996) Pharmazie 51: 885-93.
13. Skiba, M., M. Skiba-Lahiani, H. Marchais, R. Duclos & P. Arnaud (2000) Int. J. Pharm. 198: 1-6.
14. Allen, L.V. & M.A. Erickson (1996) Am. J. Health-Syst. Pharm. 53: 2073-8.
15. USP (2007) "The United States Pharmacopeia". United States Pharmacopeial Convention, Rockville.
16. International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (1996) "Guideline on validation of analytical procedures: methodology". ICH, Geneva.
17. Waterman, K.C. & R.C. Adami (2005) Int. J. Pharm. 293: 101-25.
18. Chen, Y.L., L. Felder, X. Jiang & W. Naidong (2002) J. Chromatogr. B 774: 67-8.
19. Nudelman, N.S. & C.G. Cabrere (2000) J. Pharm. Sci. 91: 1274-86.
20. Siegman, J.R. & J.J. Houser (1982) J. Org. Chem. 47: 2773-9.