Genetic predisposition of white matter infarction with protein S deficiency and R355C mutation

Neurology

Volumn 75, Issue 24, 2010, Pages 2185-2189

  Leung, T W ^a   Yip, S F ^b   Lam, C W ^c   Chan, T L ^b   Lam, W W M ^a   Siu, D Y W ^a   Fan, Y H ^a   Chan, N P H ^a   Liu, H S Y ^d   Chan, L C ^b   Wong, K S ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b Departments of Pediatrics and Medicine   (United States)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d PAMELA YOUDE NETHERSOLE EASTERN HOSPITAL   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CYSTEINE; LAMININ; LAMININ A; MEMBRANE PROTEIN; PROS1 PROTEIN; PROTEIN S ALPHA; THREONINE; UNCLASSIFIED DRUG;

ADULT; AMINO ACID SEQUENCE; ARTICLE; AUTOSOMAL DOMINANT DISORDER; BRAIN INFARCTION; BRAIN ISCHEMIA; CHINESE; DISEASE ASSOCIATION; EXON; GENE MUTATION; GENETIC PREDISPOSITION; GENOTYPE; HAPLOTYPE; HUMAN; MISSENSE MUTATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN S DEFICIENCY; SINGLE NUCLEOTIDE POLYMORPHISM; SUBSTITUTION REACTION; THROMBOSIS; TOPOGRAPHY; WHITE MATTER INFARCTION; WILD TYPE;

EID: 78650852015     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e3182020379     Document Type: Article

References (10)

1. Sacco RL, Owen J, Mohr JP, Tatemichi TK, Grossman BA. Free protein S deficiency: a possible association with cerebrovascular occlusion. Stroke 1989;20:1657-1661.
2. Barinagarrementeria F, Cantubrito C, Delapena A, Iza-guirre R. Prothrombotic states in young people with idiopathic stroke: a prospective study. Stroke 1994;25: 287-290.
3. Kristensen B, Malm J, Carlberg B, et al. Epidemiology and etiology of ischemic stroke in young adults aged 18 to 44 years in Northern Sweden. Stroke 1997;28:1702-1709.
4. Hankey GJ, Eikelboom JW, van Bockxmeer FM, et al. Inherited thrombophilia in ischemic stroke and its pathogenic subtypes. Stroke 2001;32:1793-1799.
5. Sørensen HT, Horvath-Puho E, Pedersen L, et al. Venous thromboembolism and subsequent hospitalisation due to acute arterial cardiovascular events: a 20-year cohort study. Lancet 2007;370:1773-1779.
6. Rezende SM, Simmonds RE, Lane DA. Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S-C4b binding protein complex. Blood 2004;103:1192-1201.
7. Liu D, Guo H, Griffin JH, et al. Protein S confers neuro-nal protection during ischemic/hypoxic injury in mice. Circulation 2003;107:1791-1796.
8. Pullicino PM. Pathogenesis of lacunar infarcts and small deep infarcts. Adv Neurol 1993;62:125-140.
9. Caplan LR, Hennerici MG. Impaired clearance of emboli (washout) is an important link between hypoperfusion, embolism, and ischemic stroke. Arch Neurol 1998;55:1475-1482.
10. Caplan LR, Wong KS, Gao S, Hennerici MG. Is hypoper-fusion an important cause of strokes? If so, how? Cerebro-vasc Dis 2006;21:145-153.