The acute effects of caffeinated versus non-caffeinated alcoholic beverage on driving performance and attention/reaction time

Addiction

Volumn 106, Issue 2, 2011, Pages 335-341

  Howland, Jonathan ^a,b   Rohsenow, Damaris J ^c   Arnedt, J Todd ^d   Bliss, Caleb A ^a   Hunt, Sarah K ^a   Calise, Tamara Vehige ^a   Heeren, Timothy ^a   Winter, Michael ^a   Littlefield, Caroline ^a   Gottlieb, Daniel J ^e  

^a BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^b BOSTON MEDICAL CENTER   (United States)

^c BROWN UNIVERSITY   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e VA BOSTON HEALTHCARE SYSTEM   (United States)

Author keywords

Alcohol; Attention; Caffeine; Driving; Energy drinks; Reaction time

Indexed keywords

ALCOHOL; CAFFEINE; CENTRAL DEPRESSANT AGENT; CENTRAL STIMULANT AGENT; PLACEBO;

ADULT; ALCOHOL INTOXICATION; ARTICLE; ATTENTION; BEER; CAR DRIVING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRINKING BEHAVIOR; DRUG EFFECT; DRUG INTERACTION; FEMALE; HUMAN; MALE; PSYCHOLOGICAL ASPECT; PSYCHOMOTOR PERFORMANCE; RANDOMIZED CONTROLLED TRIAL; REACTION TIME; STUDENT;

ADULT; ALCOHOL DRINKING; ALCOHOLIC INTOXICATION; ATTENTION; AUTOMOBILE DRIVING; BEER; CAFFEINE; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CENTRAL NERVOUS SYSTEM STIMULANTS; DRUG INTERACTIONS; ETHANOL; FEMALE; HUMANS; MALE; PLACEBOS; PSYCHOMOTOR PERFORMANCE; REACTION TIME; STUDENTS; YOUNG ADULT;

EID: 78650845189     PISSN: 09652140     EISSN: 13600443     Source Type: Journal    
DOI: 10.1111/j.1360-0443.2010.03219.x     Document Type: Article

References (37)

1. Pronsky Z. M. Food Medication Interaction, 10th edn. Pottstown: J.P. Crowe; 1997.
2. O'Brien M. C., McCoy T. P., Rhodes S. D., Wagoner A., Wolfson M. Caffeinated cocktails: energy drink consumption, high-risk drinking, and alcohol-related consequences among college students. Acad Emerg Med 2008; 15: 453-60.
3. Reissig C. J., Strain E. C., Griffiths R. R. Caffeinated energy drinks-a growing problem. Drug Alcohol Depend 2009; 99: 1-10.
4. Simon M., Mosher J. Alcohol, Energy Drinks, and Youth: A Dangerous Mix. San Rafael, CA: Marin Institute; 2007.
5. Arria A. M., Caldeira K. M., Kasperski S. J., O'Grady K. E., Vincent K. B., Griffiths R. R. Increased alcohol consumption, nonmedical prescription drug use and illicit drug use are associated with energy drink consumption among college students. J Addict Med 2010; 4: 74-80.
6. Ferreira S. E., de Mello M. T., Pompeia S., de Souza-Formigoni M. L. Effects of energy drink ingestion on alcohol intoxication. Alcohol Clin Exp Res 2006; 30: 598-605.
7. Marczinski C. A., Fillmore M. T. Clubgoers and their trendy cocktails: implications of mixing caffeine into alcohol on information processing and subjective reports of intoxication. Exp Clin Psychopharmacol 2006; 14: 450-8.
8. Thombs D. L., O'Mara R. J., Tsukamoto M., Rossheim M. E., Weiler R. M., Merves M. L. et al. Event-level analyses of energy drink consumption and alcohol intoxication in bar patrons. Addict Behav 2010; 35: 325-30.
9. Burns M., Moskowitz H. Two experiments on alcohol-caffeine interaction. Alcohol Drugs Driving 1990; 5: 303-15.
10. Fillmore M., Vogel-Sprott M. Behavioral effects of combining alcohol and caffeine: the contribution of drug-related expectancies. Exp Clin Psychopharmacol 1995; 3: 33-8.
11. Franks H. M., Hagedorn H., Hensley V. R., Hensley W. J., Starmer G. A. The effect of caffeine on human performance, alone and in combination with ethanol. Psychopharmacologia 1975; 45: 177-81.
12. Hasenfratz M., Bunge A., Dal Pra G., Battig K. Antagonistic effects of caffeine and alcohol on mental performance parameters. Pharmacol Biochem Behav 1993; 46: 463-5.
13. Fillmore M., Vogel-Sprott M. Psychomotor performance under alcohol and under caffeine: expectancy and pharmacological effects. Exp Clin Psychopharmacol 1994; 2: 319-28.
14. Fillmore M. T., Roach E. L., Rice J. T. Does caffeine counteract alcohol-induced impairment? The ironic effects of expectancy. J Stud Alcohol 2002; 63: 745-54.
15. Liguori A., Robinson J. H. Caffeine antagonism of alcohol-induced driving impairment. Drug Alcohol Depend 1991; 63: 123-9.
16. Marczinski C. A., Fillmore M. T. Dissociative antagonistic effects of caffeine on alcohol-induced impairment of behavioral control. Exp Clin Psychopharmacol 2003; 11: 228-36.
17. Liguori A., Robinson J. H. Caffeine antagonism of alcohol-induced driving impairment. Drug Alcohol Depend 2001; 63: 123-9.
18. Rohsenow D. J., Howland J., Minsky S. J., Greece J., Almeida A., Roehrs T. A. The Acute Hangover Scale: a new measure of immediate hangover symptoms. Addict Behav 2007; 32: 1314-20.
19. Howland J., Rohsenow D., Greece J., Littlefield C. A., Almeida A. B., Heeren T. et al. The effects of binge drinking on college students' next-day academic test-taking performance and mood state. Addiction 2010; 105: 655-65.
20. Rohsenow D. J., Howland J., Arnedt J. T., Almeida A. B., Greece J., Minsky S. et al. Intoxication with bourbon versus vodka: effects on hangover, sleep, and next-day neurocognitive performance in young adults. Alcohol Clin Exp Res 2010; 34: 1-10.
21. Arnedt J. T., Wilde G. J., Munt P. W., MacLean A. W. How do prolonged wakefulness and alcohol compare in the decrements they produce on a simulated driving task? Accid Anal Prev 2001; 33: 337-44.
22. Selzer M. L., Vinokur A., van Rooijen L. A self-administered Short Michigan Alcoholism Screening Test (SMAST). J Stud Alcohol 1975; 36: 117-26.
23. Brick J., Nathan P. E., Westrick E., Frankenstein W., Shapiro A. The effect of menstrual cycle on blood alcohol levels and behavior. J Stud Alcohol 1986; 47: 472-7.
24. Niaura R. S., Nathan P. E., Frankenstein W., Shapiro A. P., Brick J. Gender differences in acute psychomotor, cognitive, and pharmacokinetic response to alcohol. Addict Behav 1987; 12: 345-56.
25. Terner J. M., de Wit H. Menstrual cycle phase and responses to drugs of abuse in humans. Drug Alcohol Depend 2006; 84: 1-13.
26. Rohsenow D. J., Marlatt G. A. The balanced placebo design: methodological considerations. Addict Behav 1981; 6: 107-22.
27. National Institute on Alcohol Abuse and Alcoholism. National Advisory Council on Alcohol Abuse and Alcoholism-Recommneded Council Guidelines on Ethyl Alcohol Administration in Human Experimentation. Revised May 2005. Available at: (accessed 21 June 2010; archived by Webcite at).
28. Friel P. N., Logan B. K., O'Malley D., Baer J. S. Development of dosing guidelines for reaching selected target breath alcohol concentrations. J Stud Alcohol 1999; 60: 555-65.
29. Keane T. M., Lisman S. A., Kreutzer J. Alcoholic beverages and their placebos: an empirical evaluation of expectancies. Addict Behav 1980; 5: 313-28.
30. Arnedt J. T., Owens J., Crouch M., Stahl J., Carskadon M. A. Neurobehavioral performance of residents after heavy night call vs after alcohol ingestion. JAMA 2005; 294: 1025-33.
31. Arnedt J. T., Wilde G. J., Munt P. W., MacLean A. W. Simulated driving performance following prolonged wakefulness and alcohol consumption: separate and combined contributions to impairment. J Sleep Res 2000; 9: 233-41.
32. Van Dongen H. P., Maislin G., Mullington J. M., Dinges D. F. The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation. Sleep 2003; 26: 117-26.
33. Tabachnick B. G., Fidell L. S., editors. Using Multivariate Statistics, 3rd edn. New York: Harper and Collins; 1996.
34. Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd ed. Hillside, NJ: Erlbaum Associates.
35. Fillmore M. T., Blackburn J. Compensating for alcohol-induced impairment: alcohol expectancies and behavioral disinhibition. J Stud Alcohol 2002; 63: 237-46.
36. Fillmore M. T., Mulvihill L. E., Vogel-Sprott M. The expected drug and its expected effect interact to determine placebo responses to alcohol and caffeine. Psychopharmacology (Berl) 1994; 115: 383-8.
37. Fillmore M. T., Vogel-Sprott M. Evidence that expectancies mediate behavioral impairment under alcohol. J Stud Alcohol 1996; 57: 598-603.