Kidney-derived mesenchymal stromal cells modulate dendritic cell function to suppress alloimmune responses and delay allograft rejection

Transplantation

Volumn 90, Issue 12, 2010, Pages 1307-1311

  Huang, Yanfei ^a   Chen, Ping ^a   Zhang, Cassie B ^a   Ko, Gang Jee ^a,b   Ruiz, Miriam ^a   Fiorina, Paolo ^c   Hussain, Mehboob A ^a   Wasowska, Barbara A ^a   Rabb, Hamid ^a   Womer, Karl L ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Korea University College of Medicine   (South Korea)

^c BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Antigen presenting cells; Dendritic cells; Islet transplantation; Mesenchymal stem cells

Indexed keywords

B7 ANTIGEN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ALLOIMMUNITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; BAGG ALBINO MOUSE; CONTROLLED STUDY; DENDRITIC CELL; FLUORESCENCE ACTIVATED CELL SORTING; GRAFT REJECTION; KIDNEY INTERSTITIUM; LEUKOCYTE; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE;

ANIMALS; ANTIBODY FORMATION; ANTIGENS, CD80; B-LYMPHOCYTES; BONE MARROW CELLS; CELL CULTURE TECHNIQUES; DENDRITIC CELLS; FLOW CYTOMETRY; GRAFT REJECTION; HISTOCOMPATIBILITY ANTIGENS CLASS II; ISLETS OF LANGERHANS TRANSPLANTATION; LYMPHOCYTE ACTIVATION; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; TRANSPLANTATION, HOMOLOGOUS; TRANSPLANTATION, ISOGENEIC;

EID: 78650842941     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181fdd9eb     Document Type: Article

References (12)

1. Majumdar MK, Keane-Moore M, Buyaner D, et al. Characterization and functionality of cell surface molecules on human mesenchymal stem cells. J Biomed Sci 2003; 10: 228.
2. Tse WT, Pendleton JD, Beyer WM, et al. Suppression of allogeneic T-cell proliferation by human marrow stromal cells: Implications in transplantation. Transplantation 2003; 75: 389.
3. Le Blanc K, Samuelsson H, Gustafsson B, et al. Transplantation of mesenchymal stem cells to enhance engraftment of hematopoietic stem cells. Leukemia 2007; 21: 1733.
4. Maitra B, Szekely E, Gjini K, et al. Human mesenchymal stem cells support unrelated donor hematopoietic stem cells and suppress T-cell activation. Bone Marrow Transplant 2004; 33: 597.
5. Le Blanc K, Frassoni F, Ball L, et al. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: A phase II study. Lancet 2008; 371: 1579.
6. Itakura S, Asari S, Rawson J, et al. Mesenchymal stem cells facilitate the induction of mixed hematopoietic chimerism and islet allograft tolerance without GVHD in the rat. Am J Transplant 2007; 7: 336.
7. Aksu AE, Horibe E, Sacks J, et al. Co-infusion of donor bone marrow with host mesenchymal stem cells treats GVHD and promotes vascularized skin allograft survival in rats. Clin Immunol 2008; 127: 348.
8. Bartholomew A, Sturgeon C, Siatskas M, et al. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol 2002; 30: 42.
9. Huang Y, Johnston P, Zhang B, et al. Kidney-derived stromal cells modulate dendritic and T cell responses. J Am Soc Nephrol 2009; 20: 831.
10. Inaba K, Inaba M, Romani N, et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 1992; 176: 1693.
11. Fiorina P, Jurewicz M, Vergani A, et al. Phenotypic and functional differences between wild-type and CCR2-/- dendritic cells: Implications for islet transplantation. Transplantation 2008; 85: 1030.
12. Huang Y, Parker M, Xia C, et al. Rabbit polyclonal mouse antithymocyte globulin administration alters dendritic cell profile and function in NOD mice to suppress diabetogenic responses. J Immunol 2009; 182: 4608.