Hsp90 inhibition increases p53 expression and destabilizes MYCN and MYC in neuroblastoma

International Journal of Oncology

Volumn 38, Issue 1, 2011, Pages 105-112

  Regan, Paul L ^a   Jacobs, Joshua ^a   Wang, Gerald ^a   Torres, Jaime ^a   Edo, Robby ^a   Friedmann, Jennifer ^a   Tang, Xao X ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

Author keywords

Hsp90 inhibition; MYC destabilization; MYCN; Neuroblastoma

Indexed keywords

HEAT SHOCK PROTEIN 90; ONCOPROTEIN; ONCOPROTEIN MYC; ONCOPROTEIN MYCN; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; EFNB2 GENE; GENE; HUMAN; HUMAN CELL; MIZ 1 GENE; NEUROBLASTOMA; NTRK1 GENE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACETYLATION; BENZOQUINONES; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, MYC; GENES, P53; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; NEUROBLASTOMA; NUCLEAR PROTEINS; ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-MYC; TRANSFECTION; TUBULIN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 78650829442     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo-00000829     Document Type: Article

References (38)

1. Maris JM, Hogarty MD, Bagatell R and Cohn SL: Neuroblastoma. Lancet 369: 2106-2120, 2007.
2. Modak S and Cheung NK: Neuroblastoma: Therapeutic strategies for a clinical enigma. Cancer Treat Rev 36: 307-317, 2010.
3. Brodeur GM, Seeger RC, Schwab M, Varmus HE and Bishop JM: Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science 224: 1121-1124, 1984.
4. Schwab M, Varmus HE, Bishop JM, et al: Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc. Nature 308: 288-291, 1984.
5. Seeger RC, Brodeur GM, Sather H, et al: Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas. New Engl J Med 313: 1111-1116, 1985.
6. Fredlund E, Ringner M, Maris JM and Pahlman S: High Myc pathway activity and low stage of neuronal differentiation associate with poor outcome in neuroblastoma. Proc Natl Acad Sci USA 105: 14094-14099, 2008.
7. Tang XX, Zhao H, Robinson ME, et al: Implications of EPHB6, EFNB2, and EFNB3 expressions in human neuroblastoma. Proc Natl Acad Sci USA 97: 10936-10941, 2000.
8. Combaret V, Gross N, Lasset C, et al: Clinical relevance of CD44 cell-surface expression and N-myc gene amplification in a multicentric analysis of 121 pediatric neuroblastomas. J Clin Oncol 14: 25-34, 1996.
9. Ikegaki N, Gotoh T, Kung B, et al: De novo identification of MIZ-1 (ZBTB17) encoding a MYC-interacting zinc-finger protein as a new favorable neuroblastoma gene. Clin Cancer Res 13: 6001-6009, 2007.
10. Kogner P, Barbany G, Dominici C, Castello MA, Raschella G and Persson H: Coexpression of messenger RNA for TRK protooncogene and low affinity nerve growth factor receptor in neuroblastoma with favorable prognosis. Cancer Res 53: 2044-2050, 1993. (Pubitemid 23145723)
11. Nakagawara A, Arima-Nakagawara M, Scavarda NJ, Azar CG, Cantor AB and Brodeur GM: Association between high levels of expression of the TRK gene and favorable outcome in human neuroblastoma. N Engl J Med 328: 847-854, 1993.
12. Suzuki T, Bogenmann E, Shimada H, Stram D and Seeger RC: Lack of high-affinity nerve growth factor receptors in aggressive neuroblastomas. J Nat Cancer Inst 85: 377-384, 1993.
13. Tang XX, Robinson ME, Riceberg JS, et al: Favorable neuroblastoma genes and molecular therapeutics of neuroblastoma. Clin Cancer Res 10: 5837-5844, 2004.
14. Banerji U: Heat shock protein 90 as a drug target: some like it hot. Clin Cancer Res 15: 9-14, 2009.
15. Bagatell R, Beliakoff J, David CL, Marron MT and Whitesell L: Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin. Int J Cancer 113: 179-188, 2005.
16. Kang J, Kamal A, Burrows FJ, Evers BM and Chung DH: Inhibition of neuroblastoma xenograft growth by Hsp90 inhibitors. Anticancer Res 26: 1903-1908, 2006.
17. Smith MA, Morton CL, Phelps DA, et al: Stage 1 testing and pharmacodynamic evaluation of the HSP90 inhibitor alvespimycin (17-DMAG, KOS-1022) by the pediatric preclinical testing program. Pediatr Blood Cancer 51: 34-41, 2008.
18. Ikegaki N and Kennett RH: Glutaraldehyde fixation of the primary antibody-antigen complex on nitrocellulose paper increases the overall sensitivity of immunoblot assay. J Immunol Methods 124: 205-210, 1989.
19. Tang XX, Evans AE, Zhao H, et al: High-level expression of EPHB6, EFNB2, and EFNB3 is associated with low tumor stage and high TrkA expression in human neuroblastomas. Clin Cancer Res 5: 1491-1496, 1999.
20. Torres J, Regan PL, Edo R, et al: Biological effects of induced MYCN hyper-expression in MYCN-amplified neuroblastomas. Int J Oncol 37: 983-991, 2010.
21. Nakamura Y, Ozaki T, Niizuma H, Ohira M, Kamijo T and Nakagawara A: Functional characterization of a new p53 mutant generated by homozygous deletion in a neuroblastoma cell line. Biochem Biophys Res Commun 354: 892-898, 2007.
22. Goldschneider D, Horvilleur E, Plassa LF, et al: Expression of C-terminal deleted p53 isoforms in neuroblastoma. Nucleic Acids Res 34: 5603-5612, 2006.
23. Basso AD, Solit DB, Chiosis G, Giri B, Tsichlis P and Rosen N: Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function. J Biol Chem 277: 39858-39866, 2002.
24. Hostein I, Robertson D, DiStefano F, Workman P and Clarke PA: Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17- demethoxygeldanamycin results in cytostasis and apoptosis. Cancer Res 61: 4003-4009, 2001.
25. Sato S, Fujita N and Tsuruo T: Modulation of Akt kinase activity by binding to Hsp90. Proc Natl Acad Sci USA 97: 10832-10837, 2000.
26. Sears R, Nuckolls F, Haura E, Taya Y, Tamai K and Nevins JR: Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev 14: 2501-2514, 2000.
27. Chesler L, Schlieve C, Goldenberg DD, et al: Inhibition of phosphatidylinositol 3-kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma. Cancer Res 66: 8139-8146, 2006.
28. Gross N, Balmas Bourloud K and Brognara CB: MYCN-related suppression of functional CD44 expression enhances tumorigenic properties of human neuroblastoma cells. Exp Cell Res 260: 396-403, 2000.
29. Eggert A, Grotzer MA, Ikegaki N, Liu XG, Evans AE and Brodeur GM: Expression of the neurotrophin receptor TrkA down-regulates expression and function of angiogenic stimulators in SH-SY5Y neuroblastoma cells. Cancer Res 62: 1802-1808, 2002.
30. Chua YL, Ito Y, Pole JC, et al: The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene. Oncogene 28: 4041-4052, 2009.
31. Liu T, Laurell C, Selivanova G, Lundeberg J, Nilsson P and Wiman KG: Hypoxia induces p53-dependent transactivation and Fas/CD95-dependent apoptosis. Cell Death Differ 14: 411-421, 2007.
32. Herold S, Wanzel M, Beuger V, et al: Negative regulation of the mammalian UV response by Myc through association with Miz-1. Mol Cell 10: 509-521, 2002.
33. Staller P, Peukert K, Kiermaier A, et al: Repression of p15INK4b expression by Myc through association with Miz-1. Nat Cell Biol 3: 392-399, 2001.
34. Wu S, Cetinkaya C, Munoz-Alonso MJ, et al: Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter. Oncogene 22: 351-360, 2003.
35. Niikura Y, Ohta S, Vandenbeldt KJ, Abdulle R, McEwen BF and Kitagawa K: 17-AAG, an Hsp90 inhibitor, causes kinetochore defects: a novel mechanism by which 17-AAG inhibits cell proliferation. Oncogene 25: 4133-4146, 2006.
36. Zajac M, Moneo MV, Carnero A, Benitez J and Martinez- Delgado B: Mitotic catastrophe cell death induced by heat shock protein 90 inhibitor in BRCA1-deficient breast cancer cell lines. Mol Cancer Ther 7: 2358-2366, 2008.
37. Wanzel M, Kleine-Kohlbrecher D, Herold S, et al: Akt and 14-3-3eta regulate Miz1 to control cell-cycle arrest after DNA damage. Nat Cell Biol 7: 30-41, 2005.
38. Ikegaki N, Bukovsky J and Kennett RH: Identification and characterization of the NMYC gene product in human neuroblastoma cells by monoclonal antibodies with defined specificities. Proc Natl Acad Sci USA 83: 5929-5933, 1986.