Time-domain features of epileptic spikes as potential bio-markers of the epileptogenesis process

2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10

Volumn , Issue , 2010, Pages 6007-6010

  Huneau, Clément ^a   Demont Guignard, Sophie ^a   Benquet, Pascal ^a   Martin, Benoît ^a   Wendling, Fabrice ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTATIONAL MODEL; EPILEPTIC SPIKES; EPILEPTOGENESIS; EXPERIMENTAL MODELS; FUNCTION OF TIME; IN-VIVO; NEUROLOGICAL DISORDERS; NEURONAL CIRCUITS; NEURONAL SYSTEMS; TEMPORAL LOBE EPILEPSY; TIME DOMAIN; TRANSIENT EVENTS; UNDERLYING MECHANISM;

ELECTROPHYSIOLOGY;

BRAIN;

4 AMINOBUTYRIC ACID; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; BIOLOGICAL MARKER; KAINIC ACID;

ACTION POTENTIAL; ANIMAL; ARTICLE; BIOLOGICAL MODEL; C57BL MOUSE; COMPUTER SIMULATION; DISEASE MODEL; ELECTROPHYSIOLOGY; METABOLISM; MOUSE; PATHOPHYSIOLOGY; PHYSIOLOGY; TEMPORAL LOBE EPILEPSY; TIME;

ACTION POTENTIALS; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; BIOLOGICAL MARKERS; COMPUTER SIMULATION; DISEASE MODELS, ANIMAL; ELECTROPHYSIOLOGICAL PHENOMENA; EPILEPSY, TEMPORAL LOBE; GAMMA-AMINOBUTYRIC ACID; KAINIC ACID; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; TIME FACTORS;

EID: 78650818056     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/IEMBS.2010.5627592     Document Type: Conference Paper

References (15)

1. M. A. Dichter, "Emerging concepts in the pathogenesis of epilepsy and epileptogenesis," Arch Neurol, vol. 66, pp. 443-7, 2009.
2. R. A. Bender and T. Z. Baram, "Epileptogenesis in the developing brain: what can we learn from animal models?," Epilepsia, vol. 48 Suppl 5, pp. 2-6, 2007.
3. A. Pitkanen, I. Kharatishvili, H. Karhunen, K. Lukasiuk, R. Immonen, J. Nairismagi, O. Grohn, and J. Nissinen, "Epileptogenesis in experimental models," Epilepsia, vol. 48 Suppl 2, pp. 13-20, 2007.
4. V. Bouilleret, V. Ridoux, A. Depaulis, C. Marescaux, A. Nehlig, and G. Le Gal La Salle, "Recurrent seizures and hippocampal sclerosis following intrahippocampal kainate injection in adult mice: electroencephalography, histopathology and synaptic reorganization similar to mesial temporal lobe epilepsy," Neuroscience, vol. 89, pp. 717-29, 1999.
5. M. Avoli, G. Biagini, and M. de Curtis, "Do Interictal Spikes Sustain Seizures and Epileptogenesis?," Epilepsy Curr., vol. 6, pp. 203-207., 2006.
6. J. Bourien, F. Bartolomei, J. J. Bellanger, M. Gavaret, P. Chauvel, and F. Wendling, "A method to identify reproducible subsets of co-activated structures during interictal spikes. Application to intracerebral EEG in temporal lobe epilepsy," Clin Neurophysiol, vol. 116, pp. 443-55, 2005.
7. S. Demont-Guignard, P. Benquet, U. Gerber, and F. Wendling, "Analysis of intracerebral EEG recordings of epileptic spikes: insights from a neural network model," IEEE Trans Biomed Eng, vol. 56, pp. 2782-95, 2009.
8. D. Hinkley, "Inference about the change point from cumulative sumtests," Biometrika, vol. 58, pp. 509-523, 1970.
9. A. L. Hodgkin and A. F. Huxley, "The components of membrane conductance in the giant axon of Loligo," J Physiol, vol. 116, pp. 473-96, 1952.
10. A. L. Hodgkin, A. F. Huxley, and B. Katz, "Measurement of currentvoltage relations in the membrane of the giant axon of Loligo," J Physiol,vol. 116, pp. 424-48, 1952.
11. A. White, P. A. Williams, J. L. Hellier, S. Clark, F. Edward Dudek, and K. J. Staley, "EEG spike activity precedes epilepsy after kainateinduced status epilepticus," Epilepsia, vol. 51, pp. 371-83.
12. F. Wendling, "Computational models of epileptic activity: a bridge between observation and pathophysiological interpretation," Expert Rev Neurother, vol. 8, pp. 889-96, 2008.
13. D. Debanne, S. M. Thompson, and B. H. Gahwiler, "A brief period of epileptiform activity strengthens excitatory synapses in the rat hippocampus in vitro," Epilepsia, vol. 47, pp. 247-56, 2006.
14. V. Lopantsev, M. Both, and A. Draguhn, "Rapid plasticity at inhibitory and excitatory synapses in the hippocampus induced by ictal epileptiform discharges," Eur J Neurosci, vol. 29, pp. 1153-64, 2009.
15. M. H. Abegg, N. Savic, M. U. Ehrengruber, R. A. McKinney, and B. H. Gahwiler, "Epileptiform activity in rat hippocampus strengthens excitatory synapses," J Physiol, vol. 554, pp. 439-48, 2004.