Modeling the effects of nanoparticles on neuronal cells: From ionic channels to network dynamics

2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10

Volumn , Issue , 2010, Pages 3816-3819

  Busse, Michael ^a   Kraegeloh, Annette ^b   Stevens, David ^a   Cavelius, Christian ^b   Rettig, Jens ^a   Arzt, Eduard ^b   Strauss, Daniel J ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b INM LEIBNIZ INSTITUTE FOR NEW MATERIALS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BARRIER-FREE; CHROMAFFIN CELLS; COMPUTATIONAL MODEL; DIFFERENTIAL EVOLUTION ALGORITHMS; DYNAMIC BEHAVIORS; IONIC CHANNELS; IONIC CURRENT; LIVING ORGANISMS; MEDICAL SCIENCE; NETWORK DYNAMICS; NEURONAL CELL; NEURONAL NETWORKS; ORGANIC TISSUES; PATCH-CLAMP; SILVER-NANOPARTICLES; UNDERLYING MECHANISM; WHOLE-CELL CONFIGURATION;

BEHAVIORAL RESEARCH; CHEMICAL INDUSTRY; ENERGY MANAGEMENT; EVOLUTIONARY ALGORITHMS; MEDICINE; NANOPARTICLES; NEURAL NETWORKS; SODIUM;

BIOLOGY;

METAL NANOPARTICLE; SILVER;

ALGORITHM; ANIMAL; ARTICLE; CHEMISTRY; CHROMAFFIN CELL; CYTOLOGY; MOUSE; NERVE CELL; THEORETICAL MODEL;

ALGORITHMS; ANIMALS; CHROMAFFIN CELLS; METAL NANOPARTICLES; MICE; MODELS, THEORETICAL; NEURONS; SILVER;

EID: 78650802410     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/IEMBS.2010.5627595     Document Type: Conference Paper

References (16)

1. A. Ajay Kumar Gupta and M. Gupta, "Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications." Biomaterials., vol. 26, pp. 3995-4021, 2005.
2. B. Chithrani, A. Ghazani, and W. Chan, "Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells." Nano Lett., vol. 6, pp. 662-668, 2006.
3. W. Jiang, B. Kim, J. Rutka, and W. Chan, "Nanoparticle-mediated cellular response is size-dependent." Nat Nanotechnol., vol. 3, pp. 131-132, 2008.
4. K. Unfried, C. Albrecht, L. Klotz, A. Von Mikecz, S. Grether-Beck, and R. Schin, "Cellular responses to nanoparticles: Target structures and mechanisms." Nanotoxicology., vol. 1, pp. 52-71, 2007.
5. G. Oberdörster, "Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology." J Intern Med., vol. 267, pp. 89-105, 2010.
6. A. El-Ansary and S. Al-Daihan, "On the toxicity of therapeutically used nanoparticles: an overview." J Toxicol., 2009.
7. S. Wijnhoven, W. Peijnenburg, C. Herberts, W. Hagens, A. Oomen, E. Heugens, B. Roszek, J. Bisschops, I. Gosens, D. Van De Meent, S. Dekkers, W. De Jong, H. van Zijverden, A. Sips, and R. Geertsma, "Nano-silver - a review of available data and knowledge gaps in human and environmental risk assessment." Nanotoxicology., vol. 3, pp. 109-138, 2009.
8. L. Xu, J. Zhao, T. Zhang, G. Ren, and Z. Yang, "In vitro study on influence of nano particles of cuo on ca1 pyramidal neurons of rat hippocampus potassium currents." Environ Toxicol., vol. 24, pp. 211-217, 2009.
9. J. Zhao, L. Xu, T. Zhang, G. Ren, and Z. Yang, "Influences of nanoparticle zinc oxide on acutely isolated rat hippocampal ca3 pyramidal neurons." Neurotoxicology., vol. 30, pp. 220-230, 2009.
10. Z. Liu, G. Ren, T. Zhang, and Z. Yang, "Action potential changes associated with the inhibitory effects on voltage-gated sodium current of hippocampal ca1 neurons by silver nanoparticles." Toxicology., vol. 264, pp. 179-174, 2009.
11. O. Hamill, A. Marty, E. Neher, B. Sakmann, and F. Sigworth, "Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches." Pflugers Arch., vol. 391, pp. 85-100, 1981.
12. A. Hodgkin and A. Huxley, "A quantitative description of membrane current and its application to conduction and excitation in nerve." J Physiol., vol. 117, pp. 500-544, 1952.
13. K. Price, R. Storn, and J. Lampinen, Differential Evolution: A Prictical Approach to Global Optimization. Berlin/Heidelberg: Springer-Verlag, 2005.
14. M. Praetorius, C. Brunner, B. Lehnert, C. Klingmann, H. Schmidt, H. Staecker, and B. Schick, "Transsynaptic delivery of nanoparticles to the central auditory nervous system." Acta Otolaryngol., vol. 127, pp. 486-490, 2007.
15. T. Pellegrino, L. Manna, S. Kudera, T. Liedl, D. Koktysh, A. Rogach, S. Keller, J. Rdler, G. Natile, and W. Parak, "Hydrophobic nanocrystals coated with an amphiphilic polymer shell: A general route to water soluble nanocrystals." Nano Lett., vol. 127, pp. 703-707, 2004.
16. J. Malmivuo and R. Plonsey, Bioelectromagnetism. New York: New York: Oxford University Press, 1995.