Characterization, biodistribution and targeting evaluation of breviscapine lipid emulsions following intravenous injection in mice

Drug Delivery

Volumn 18, Issue 2, 2011, Pages 159-165

  Xiong, Fei ^a   Wang, Hao ^b   Chen, Yue Jian ^b   Geng, Kun Kun ^b   Gu, Ning ^a   Zhu, Jia Bi ^b  

^a SOUTHEAST UNIVERSITY   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Breviscapine; Lipid emulsions; Liposomes contamination; Pharmacokinetics; Tissue distribution

Indexed keywords

BREVISCAPINE; CREMOPHOR; LIPID EMULSION; LIPOSOME; POLOXAMER; POLYSORBATE 80; SURFACTANT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG DOSAGE FORM COMPARISON; DRUG EFFECT; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG SOLUBILITY; DRUG STABILITY; DRUG TARGETING; HUMAN; LUNG; MOUSE; NONHUMAN; PARTICLE SIZE; PLASMA; PRIORITY JOURNAL; SUSTAINED DRUG RELEASE; TISSUE DISTRIBUTION;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; EMULSIONS; FLAVONOIDS; INJECTIONS, INTRAVENOUS; LIPIDS; LIPOSOMES; MICE; PARTICLE SIZE; SURFACE-ACTIVE AGENTS; TISSUE DISTRIBUTION;

EID: 78650792699     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.3109/10717544.2010.528068     Document Type: Article

References (27)

1. Alvarez-Núñez, F., Rosin, D.A., Yalkowsky, S.H. (1999). A spin filter method for continuous evaluation of hemolysis. J Pharm Sci. 88:1041-3.
2. Baldeschweiler, J.D. (1990). Int Patent. 9012595.
3. Cai, X.L. (1981). Absorption, distribution and excretion of 3H-scutellarin in vivo. Chin Trad Herb Drugs. 12:26.
4. Chao, T.C., Chu, Z., Tseng, L.M., Chiou, T.J., Hsieh, R.K., Wang, W.S., Yen, C.C., Yang, M.H., Hsiao, L.T., Liu, J.H., Chen, P.M. (2005). Paclitaxel in a novel formulation containing less Cremophor EL as first-line therapy for advanced breast cancer: A phase II trial. Invest New Drugs. 23:171-7.
5. Chen, P., Wang, D.H., Lei, W.Y., Shen, Z.Q. (2006). Effects of scutellarin on thrombosis and platelet aggregation. J Kunming Med Univ. 27:1-5.
6. Dass, C.R., Walker, T.L., Kalle, W.H., Burton, M.A. (2000). A microsphere- liposome (microplex) vector for targeted gene therapy of cancer. II. In vivo biodistribution study in a solid tumor model. Drug Deliv. 7:15-9.
7. Gao, R., Zhu, B.H., Tang, S.B., Wang, J.F., Ren, J. (2008). Scutellarein inhibits hypoxia- and moderately-high glucose-induced proliferation and VEGF expression in human retinal endothelial cells. Acta Pharmacol Sin. 29:707-12.
8. Gelderblom, H., Verweij, J., Nooter, K., Sparreboom, A. (2001). Cremophor EL: The drawbacks and advantages of vehicle selection for drug formulation. Eur J Cancer. 37:1590-8.
9. Grindel, J.M., Jaworski, T., Emanuele, R.M., Culbreth, P. (2002). Pharmacokinetics of a novel surface-active agent, purified poloxamer 188, in rat, rabbit, dog and man. Biopharm Drug Dispos. 23:87-103.
10. Groves, M.J., Wineberg, M., Brain, A.P.R. (1985). The presence of liposomal material in phosphatide stabilized emulsion. J Dispersion Sci Technol. 6:237-43.
11. Hong, M.S., Lim, S.J., Lee, M.K., Kim, Y.B., Kim, C.K. (2001). Prolonged blood circulation of methotrexate by modulation of liposomal composition. Drug Deliv. 8:231-237.
12. Ji, C., Na, W., Fei, X., Sheng-Jun, C., Jia-Bi, Z. (2006). Characterization, lung targeting profile and therapeutic efficiency of dipyridamole liposomes. J Drug Target. 14:717-24.
13. Kurihara, A., Shibayama, Y., Mizota, A., Yasuno, A., Ikeda, M., Sasagawa, K., Kobayashi, T., Hisaoka, M. (1996). Lipid emulsion of palmitoylrhizoxin: Effects of composition on lipolysis and biodistribution. Biopharm Drug Dispos. 17:331-42.
14. Li, A.M. (2009). Research on intervention effect of breviscapme injection on rats with pulmonary fibrosis. Proc Clin Med. 18: 511-4.
15. Li, S.G., Zhang, H., Xue, W.T. (2007). A novel method for the determination of acid value of vegetable oils. Eur J Lipid Sci Technol. 109:1088-94.
16. Park, K.M., Lee, M.K., Hwang, K.J., Kim, C.K. (1999). Phospholipidsbased microemulsion of flurbiprofen by the spontaneous emulsification process. Int J Pharm. 183:145-54.
17. Ping, Q.N. (1998). Modern pharmaceutics. Beijing, PR China: China Medico-Pharmaceutical Sciences &Technology Publishing House.
18. Shahidi, F., Zhong, Y. (2007). Measurement of antioxidant activity in food and biological systems. In: Shahidi, F., Ho, C.T., eds. Antioxidant measurement and applications. Oxford: Oxford University Press, 36-66.
19. Stewart, J.C. (1980). Colorimetric determination of phospholipids with ammonium ferrothiocyanate. Anal Biochem. 104:10-14.
20. Tang, J., Wei, H., Liu, H., Ji, H., Dong, D., Zhu, D., Wu, L. (2010). Pharmacokinetics and biodistribution of itraconazole in rats and mice following intravenous administration in a novel liposome formulation. Drug Deliv. 7:223-30.
21. Wheeler, J.J., Wong, K.F., Ansell, S.M., Masin, D., Bally, M. (1994). Polyethylene glycol modified phospholipids stabilize emulsion prepared from triacetylglycerol. J Pharm Sci. 83:1558-64.
22. Xiong, F., Li, J., Wang, H., Chen, Y.J., Cheng, J., Zhu, J.B. (2006a). Synthesis, properties and application of a novel series of one ended monooleate-modified poly(ethylene glycol) with active carboxylic terminal. Polymer. 47:6636-41.
23. Xiong, F., Wang, H., Cheng, J., Zhu, J.B. (2006b). Determination of scutellarin in mouse plasma and different tissues by high-performance liquid chromatography. J Chromatogr B. 835:114-8.
24. Xiong, F., Wang, H., Geng, K.K., Zhu, J.B., Gu, N. (2010). Optimized preparation, characterization and stability of breviscapine lipid emulsion. Chem Pharm Bull. in press.
25. Xiong, F., Xiong, C., Ge, L., Chen, Y.J., Wang, H., Gu, N., Zhu, J.B. (2009). Preparation, characterization, and biodistribution of breviscapine proliposomes in heart. J Drug Target. 17:408-14.
26. Zhu, B.H., Guan, Y.Y., He, H., Lin, M.J. (2000). Effects of Scutellarein on diabetic rat aorta. Acta Pharmacol Sin. 21:353-6.
27. Zhu, Z.A. (1937). Dian Nan Ben Cao. Shanghai, PR China: The World Book Co., Ltd.