Nicotine modulates gelatinase B (MMP-9) and epilysin (MMP-28) expression in reconstituted human oral epithelium

Journal of Oral Pathology and Medicine

Volumn 40, Issue 1, 2011, Pages 33-36

  Renò, Filippo ^a   Rocchetti, Vincenzo ^a   Migliario, Mario ^a   Cannas, Mario ^a  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

Keratinocyte; MMP 28; MMP 9; Nicotine

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; EPILYSIN; GELATINASE B; MATRIX METALLOPROTEINASE; MECAMYLAMINE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NICOTINE; NICOTINIC RECEPTOR BLOCKING AGENT; PROTEIN KINASE C INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL METABOLISM; CELL MIGRATION; CHOLINERGIC SYSTEM; CIGARETTE SMOKING; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; MOUTH MUCOSA; PRIORITY JOURNAL; WOUND HEALING; ZYMOGRAPHY;

CELL PROLIFERATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EPITHELIUM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; GENE EXPRESSION REGULATION; HUMANS; KERATINOCYTES; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASES, SECRETED; MECAMYLAMINE; MOUTH MUCOSA; NICOTINE; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; PROTEIN KINASE C; SMOKING; WOUND HEALING;

EID: 78650790098     PISSN: 09042512     EISSN: 16000714     Source Type: Journal    
DOI: 10.1111/j.1600-0714.2010.00949.x     Document Type: Article

References (20)

1. Wessler I, Kirkpatrick CJ. Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans. Br J Pharmacol 2008; 154: 1558-71.
2. Arredondo J, Nguyen VT, Chernyavsky AI, Jolkovsky DL, Pinkerton KE, Grando SA. A receptor-mediated mechanism of nicotine toxicity in oral keratinocytes. Lab Invest 2001; 81: 1653-68.
3. Lee HJ, Guo HY, Lee SK, et al. Effects of nicotine on proliferation, cell cycle, and differentiation in immortalized and malignant oral keratinocytes. J Oral Pathol Med 2005; 34: 436-43.
4. Kwon OS, Chung JH, Cho KH, et al. Nicotine-enhanced epithelial differentiation in reconstructed human oral mucosa in vitro. Skin Pharmacol Appl Skin Physiol 1999; 12: 227-34.
5. Zia S, Ndoye A, Lee TX, Webber RJ, Grando SA. Receptor-mediated inhibition of keratinocyte migration by nicotine involves modulations of calcium influx and intracellular concentration. J Pharmacol Exp Ther 2000; 293: 973-81.
6. Arredondo J, Chernyavsky AI, Marubio LM, et al. Receptor-mediated tobacco toxicity: regulation of gene expression through alpha3beta2 nicotinic receptor in oral epithelial cells. Am J Pathol 2005; 166: 597-613.
7. Conti-Fine BM, Navaneetham D, Lei S, Maus AD. Neuronal nicotinic receptors in non-neuronal cells: new mediators of tobacco toxicity? Eur J Pharmacol 2000; 393: 279-94.
8. Saarialho-Kere U, Kerkela E, Jahkkola T, Suomela S, Keski-Oja J, Lohi J. Epilysin (MMP-28) expression is associated with cell proliferation during epithelial repair. J Invest Dermatol 2002; 119: 14-21.
9. Parks WC. Matrix metalloproteinases in repair. Wound Repair Regen. 1999; 7: 423-32.
10. 2+, and matrix metalloproteinase-9 in primary keratinocyte migration. Wound Repair Regen. 2007; 15: 907-15.
11. Lohi J, Wilson CL, Roby JD, Parks WC. Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injury. J Biol Chem 2001; 276: 10134-44.
12. Nielsen HM, Rassing MR. TR146 cells grown on filters as a model of human buccal epithelium: IV. Permeability of water, mannitol, testosterone and beta-adrenoceptor antagonists. Comparison to human, monkey and porcine buccal mucosa. Int J Pharm 2000; 194: 155-67.
13. Grando SA, Horton RM, Mauro TM, Kist DA, Lee TX, Dahl MV. Activation of keratinocyte nicotinic cholinergic receptors stimulates calcium influx and enhances cell differentiation. J Invest Dermatol 1996; 107: 412-8.
14. Sharma G, Vijayaraghavan S. Nicotinic receptor signaling in nonexcitable cells. J Neurobiol 2002; 53: 524-34.
15. Arredondo J, Chernyavsky AI, Jolkovsky DL, Pinkerton KE, Grando SA. Receptor-mediated tobacco toxicity: acceleration of sequential expression of alpha5 and alpha7 nicotinic receptor subunits in oral keratinocytes exposed to cigarette smoke. FASEB J 2008; 22: 1356-68.
16. Chernyavsky AI, Arredondo J, Qian J, Galitovskiy V, Grando SA. Coupling of ionic events to protein kinase signaling cascades upon activation of alpha7 nicotinic receptor: cooperative regulation of alpha2-integrin expression and Rho kinase activity. J Biol Chem 2009; 284: 22140-8.
17. Chernyavsky AI, Arredondo J, Marubio LM, Grando SA. Differential regulation of keratinocyte chemokinesis and chemotaxis through distinct nicotinic receptor subtypes. J Cell Sci 2004; 117: 5665-79.
18. Arredondo J, Chernyavsky AI, Jolkovsky DL, Pinkerton KE, Grando SA. Receptor-mediated tobacco toxicity: acceleration of sequential expression of alpha5 and alpha7 nicotinic receptor subunits in oral keratinocytes exposed to cigarette smoke. FASEB J 2008; 22: 1356-68.
19. Rodger UR, Kevorkian L, Surridge AK, et al. Expression and function of matrix metalloproteinase (MMP)-28. Matrix Biol 2009; 28: 263-72.
20. Maus AD, Pereira EF, Karachunski PI, Horton RM, et al. Human and rodent bronchial epithelial cells express functional nicotinic acetylcholine receptors. Mol Pharmacol 1998; 54: 779-88.